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Search Results: 1 - 10 of 86857 matches for " Dong-Yu Lai "
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Weakly Nonlinear Stability Analysis of a Thin Magnetic Fluid during Spin Coating
Cha'o-Kuang Chen,Dong-Yu Lai
Mathematical Problems in Engineering , 2010, DOI: 10.1155/2010/987891
Abstract: This paper investigates the stability of a thin electrically conductive fluid under an applied uniform magnetic filed during spin coating. A generalized nonlinear kinematic model is derived by the long-wave perturbation method to represent the physical system. After linearizing the nonlinear evolution equation, the method of normal mode is applied to study the linear stability. Weakly nonlinear dynamics of film flow is studied by the multiple scales method. The Ginzburg-Landau equation is determined to discuss the necessary conditions of the various critical flow states, namely, subcritical stability, subcritical instability, supercritical stability, and supercritical explosion. The study reveals that the rotation number and the radius of the rotating circular disk generate similar destabilizing effects but the Hartmann number gives a stabilizing effect. Moreover, the optimum conditions can be found to alter stability of the film flow by controlling the applied magnetic field.
Wrist blood flow signal-based computerized pulse diagnosis using spatial and spectrum features  [PDF]
Dong-Yu Zhang, Wang-Meng Zuo, David Zhang, Hong-Zhi Zhang, Nai-Min Li
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.34050
Abstract: ABSTRACT Current computerized pulse diagnosis is mainly based on pressure and photoelectric signal. Considering the richness and complication of pulse diagnosis information, it is valuable to explore the feasibility of novel types of signal and to develop appropriate feature representation for diagnosis. In this paper, we present a study on computerized pulse diagnosis based on blood flow velocity signal. First, the blood flow velocity signal is collected using Doppler ultrasound device and preprocessed. Then, by locating the fiducial points, we extract the spatial features of blood flow velocity signal, and further present a Hilbert-Huang transform-based method for spectrum feature extraction. Finally, support vector machine is applied for computerized pulse diagnosis. Experiment results show that the proposed method is effective and promising in distinguishing healthy people from patients with cho- lecystitis or nephritis.
Bin Dong,Yu Zhang,Dong-Yu Wang
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810039267
Abstract: In the title compound, C13H17NO, the cyclohexane ring adopts a chair conformation and the amide C(=O)—N moiety is almost coplanar with the phenyl ring [C—N—C—O = 4.1 (2)°]. In the crystal, molecules are linked to form a C(4) infinite [001] chain via N—H...O hydrogen bonds, unlike the cyclic motif seen in related structures.
A 485ps 64-Bit Parallel Adder in 0.18μm CMOS
A 485ps 64-Bit Parallel Adder in 0.18$\mu$m CMOS

Dong-Yu Zheng,Yan Sun,Shao-Qing Li,Liang Fang,
Dong-Yu Zheng
,Yan Sun,Shao-Qing Li,and Liang Fang

计算机科学技术学报 , 2007,
Abstract: This paper presents an optimized 64-bit parallel adder. Sparse-tree architecture enables low carry-merge fan-outs and inter-stage wiring complexity. Single-rail and semi-dynamic circuit improves operation speed. Simulation results show that the proposed adder can operate at 485ps with power of 25.6mW in 0.18μm CMOS process. It achieves the goal of higher speed and lower power. Supported by the National Natural Science Foundation of China under Grant Nos. 60273069, 60376018, 90207011, the National High Technology Development 863 Program of China under Grant No. 2002AA110020, and the Advanced Research Foundation of NUDT under Grant No. JC03-06-007.
A new gene expression signature, the ClinicoMolecular Triad Classification, may improve prediction and prognostication of breast cancer at the time of diagnosis
Dong-Yu Wang, Susan J Done, David R McCready, Scott Boerner, Supriya Kulkarni, Wey Leong
Breast Cancer Research , 2011, DOI: 10.1186/bcr3017
Abstract: We investigated the molecular basis of such clinical practice by grouping Her2+ and TN BC together during clustering analyses of the genome-wide gene expression profiles of our training cohort, mostly derived from fine-needle aspiration biopsies (FNABs) of 149 consecutive evaluable BC. The analyses consistently divided these tumors into a three-cluster pattern, similarly to clinical risk stratification groups, that was reproducible in published microarray databases (n = 2,487) annotated with clinical outcomes. The clinicopathological parameters of each of these three molecular groups were also similar to clinical classification.The low-risk group had good outcomes and benefited from endocrine therapy. Both the intermediate- and high-risk groups had poor outcomes, and their BC was resistant to endocrine therapy. The latter group demonstrated the highest rate of complete pathological response to neoadjuvant chemotherapy; the highest activities in Myc, E2F1, Ras, β-catenin and IFN-γ pathways; and poor prognosis predicted by 14 independent prognostic signatures. On the basis of multivariate analysis, we found that this new gene signature, termed the "ClinicoMolecular Triad Classification" (CMTC), predicted recurrence and treatment response better than all pathological parameters and other prognostic signatures.CMTC correlates well with current clinical classifications of BC and has the potential to be easily integrated into routine clinical practice. Using FNABs, CMTC can be determined at the time of diagnostic needle biopsies for tumors of all sizes. On the basis of using public databases as the validation cohort in our analyses, CMTC appeared to enable accurate treatment guidance, could be made available in preoperative settings and was applicable to all BC types independently of tumor size and receptor and nodal status. The unique oncogenic signaling pathway pattern of each CMTC group may provide guidance in the development of new treatment strategies. Further valida
The effects of timing of fine needle aspiration biopsies on gene expression profiles in breast cancers
Vietty Wong, Dong-Yu Wang, Keisha Warren, Supriya Kulkarni, Scott Boerner, Susan Done, Wey Leong
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-277
Abstract: From 16 patients, we obtained paired fine needle aspiration biopsies (FNABs) of breast cancers taken before (PRE) and after (POST) their surgeries and compared the microarray data to determine the genes that were differentially expressed between the FNABs taken at the two time points. qRT-PCR was used to validate our findings. To examine effects of longer exposure to hypoxia on gene expression, we also compared the gene expression profiles of 10 breast cancers from clinical tissue bank.Using hierarchical clustering analysis, 12 genes were found to be differentially expressed between the FNABs taken before and after surgical removal. Remarkably, most of the genes were linked to FOS in an early hypoxia pathway. The gene expression of FOS also increased with longer exposure to hypoxia.Our study demonstrated that the timing of fine needle aspiration biopsies can be a confounding factor in microarray data analyses in breast cancer. We have shown that FOS-related genes, which have been implicated in early hypoxia as well as the development of breast cancers, were differentially expressed before and after surgery. Therefore, it is important that future studies take timing of tissue acquisition into account.DNA microarray analysis is an evolving high-throughput molecular technology that enables scientists to survey thousands of genes simultaneously. The resulting gene profiles (GPs) have been employed for the investigation of complex multi-factorial diseases such as breast cancer. In breast cancer, GPs have been shown to correlate with many clinically relevant clinico-pathological parameters, to prognosticate survival and predict treatment responses to specific chemotherapeutic regimens [1-9]. Despite its potential in clinical applications, one of the main hurdles to be overcome is the reproducibility of DNA microarray data due to several variables that may influence the results. These variables include different protocols used in tissue handling, RNA extractions and amplif
A Brief Introduction of Existential Anxiety Research

CHEN Jian,WANG Dong-Yu,

心理科学进展 , 2009,
Abstract: 存在焦虑是焦虑本体论的一种定义,是哲学、文学和心理学领域的重要概念之一.在心理学领域,存在焦虑理论主要包括罗洛-梅的焦虑本体论,布根塔尔的存在焦虑理论及存在焦虑与心理健康关系理论等等.目前的研究方法主要是量表测量法,但尚不成熟.为数不多的实证研究主要集中在:存在焦虑与心理健康的关系,与同一性地位的关系,与焦虑、抑郁的关系等等.今后研究的重点应包括概念研究的丰富、研究对象的拓宽及研究方法的改进和完善等.
A Particle Resistance Model for Flow through Porous Media

WU Jin-Sui,YIN Shang-Xian,ZHAO Dong-Yu,

中国物理快报 , 2009,
Abstract: A particle model for resistance of flow in isotropic porous media is developed based on the fractal geometry theory and on the drag force flowing around sphere. The proposed model is expressed as a function of porosity, fluid property, particle size, fluid velocity (or Reynolds number) and fractal characters Df of particles in porous media. The model predictions are in good agreement with the experimental data. The validity of the proposed model is thus verified.
Poly[[triaqua(μ3-4-oxidopyridine-2,6-dicarboxylato)thulium(III)] monohydrate]
Zhu-Qing Gao,Dong-Yu Lv,Jin-Zhong Gu,Hong-Jin Li
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811007628
Abstract: In the title coordination polymer, {[Tm(C7H2NO5)(H2O)3]·H2O}n, the TmIII atom is eight-coordinated by a tridentate 4-oxidopyridine-2,6-dicarboxylate trianion, two monodentate anions and three water molecules, forming a distorted bicapped trigonal–prismatic TmNO7 coordination geometry. The anions bridge adjacent TmIII ions into double chains. Adjacent chains are further connected into sheets. O—H...O hydrogen bonds involving both coordinated and uncoordinated water molecules generate a three-dimensional supramolecular framework.
Poly[[triaqua(μ3-4-oxidopyridine-2,6-dicarboxylato)europium(III)] monohydrate]
Dong-Yu Lv,Zhu-Qing Gao,Jin-Zhong Gu
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810048518
Abstract: In the title coordination polymer, {[Eu(C7H2NO5)(H2O)3]·H2O}n, the EuIII atom is eight-coordinated by a tridentate 4-oxidopyridine-2,6-dicarboxylate (hpc) trianion, two monodentate hpc anions and three water molecules, forming a distorted bicapped trigonal–prismatic coordination geometry. The hpc ligands bridge adjacent EuIII ions, forming infinite double chains. Adjacent chains are further connected by hpc ligands into sheets. O—H...O hydrogen bonds then generate a three-dimensional supramolecular framework.
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