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Search Results: 1 - 10 of 65238 matches for " Dong Xu "
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A Research on Franchise Mode of China’s Clothing Enterprises
Dong Xu
International Journal of Business and Management , 2009,
Abstract: This paper analyzes the importance of franchise, a high class business form in the globalization market, discusses the conditions of franchise t for China’s clothing enterprises development and franchise mode suitable for Chinese enterprises, and proposes relevant measures to solve the problems that clothing enterprises are facing when developing franchise, which has significant value for the application and development of franchise mode in China’s clothing enterprises.
Fractional Differential Equations with Initial Conditions at Inner Points in Banach Spaces  [PDF]
Xiaoping Xu, Guangxian Wu, Qixiang Dong
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.514075
Abstract: This paper is concerned with nonlinear fractional differential equations with the Caputo fractional derivatives in Banach spaces. Local existence results are obtained for initial value problems with initial conditions at inner points for the cases that the nonlinear parts are Lipschitz and non-Lipschitz, respectively. Hausdorff measure of non-compactness and Darbo-Sadovskii fixed point theorem are employed to deal with the non-Lipschitz case. The results obtained in this paper extend the classical Peano’s existence theorem for first order differential equations partly to fractional cases.
Flutter Suppression of Long-Span Bridges Using Suboptimal Control  [PDF]
Lingjun Zhuo, Yunjin Dong, Xinyu Xu
World Journal of Engineering and Technology (WJET) , 2018, DOI: 10.4236/wjet.2018.62B004
Based on the Theodorsen’s Theory of the aerodynamic forces on wing-aileron, the Scanlan’s Theory is expanded considering a deck-flap system. It is suggested that a new forced vibration method can acquire aerodynamic derivatives of this deck-flap system theoretically. After obtaining the wind induced forces, a deck-flap equation of motion in time domain is established to investigate its control law. Numerical simulation results indicate suboptimal control law of the deck-flap system can suppress the flutter effectively, and the flutter speed can be increased for desirable purpose.
Generating Triangulated Macromolecular Surfaces by Euclidean Distance Transform
Dong Xu,Yang Zhang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008140
Abstract: Macromolecular surfaces are fundamental representations of their three-dimensional geometric shape. Accurate calculation of protein surfaces is of critical importance in the protein structural and functional studies including ligand-protein docking and virtual screening. In contrast to analytical or parametric representation of macromolecular surfaces, triangulated mesh surfaces have been proved to be easy to describe, visualize and manipulate by computer programs. Here, we develop a new algorithm of EDTSurf for generating three major macromolecular surfaces of van der Waals surface, solvent-accessible surface and molecular surface, using the technique of fast Euclidean Distance Transform (EDT). The triangulated surfaces are constructed directly from volumetric solids by a Vertex-Connected Marching Cube algorithm that forms triangles from grid points. Compared to the analytical result, the relative error of the surface calculations by EDTSurf is <2–4% depending on the grid resolution, which is 1.5–4 times lower than the methods in the literature; and yet, the algorithm is faster and costs less computer memory than the comparative methods. The improvements in both accuracy and speed of the macromolecular surface determination should make EDTSurf a useful tool for the detailed study of protein docking and structure predictions. Both source code and the executable program of EDTSurf are freely available at http://zhang.bioinformatics.ku.edu/EDTSu?rf.
Quantitative assessment of relationship between sequence similarity and function similarity
Trupti Joshi, Dong Xu
BMC Genomics , 2007, DOI: 10.1186/1471-2164-8-222
Abstract: We present an analysis of the relationship between sequence similarity and function similarity for the proteins in four model organisms, i.e., Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorrhabditis elegans, and Drosophila melanogaster. Using a measure of functional similarity based on the three categories of Gene Ontology (GO) classifications (biological process, molecular function, and cellular component), we quantified the correlation between functional similarity and sequence similarity measured by sequence identity or statistical significance of the alignment and compared such a correlation against randomly chosen protein pairs.Various sequence-function relationships were identified from BLAST versus PSI-BLAST, sequence identity versus Expectation Value, GO indices versus semantic similarity approaches, and within genome versus between genome comparisons, for the three GO categories. Our study provides a benchmark to estimate the confidence in assignment of functions purely based on sequence similarity.Large-scale genome sequencing projects have discovered many new proteins. Of all the proteins whose sequences are known, functions have been experimentally determined for only a small percentage [1]. Annotation of a genome involves assignment of functions to proteins in most cases on the basis of sequence similarity. Protein function assignments based on postulated homology as recognized by sequence identity or significant expectation value of alignment are used routinely in genome analysis. Over the past years, many computational methods [2-11] have been developed to predict function through identifying sequence similarity between a protein of unknown function and one or more proteins with experimentally characterized or computationally predicted functions. However, it is widely recognized that functional annotations should be transferred with caution, as the sequence similarity does not guarantee evolutionary or functional relationship. In addition, if
Involvement of nitric oxide signaling in mammalian Bax-induced terpenoid indole alkaloid production of Catharanthus roseus cells
MaoJun Xu,JuFang Dong
Science China Life Sciences , 2007, DOI: 10.1007/s11427-007-0096-z
Abstract: Bax, a mammalian pro-apoptotic member of the Bcl-2 family, has been demonstrated to be a potential regulatory factor for plant secondary metabolite biosynthesis recently. To investigate the molecular mechanism of Bax-induced secondary metabolite biosynthesis, we determined the contents of nitric oxide (NO) of the transgenic Catharanthus roseus cells overexpressing a mouse Bax protein and checked the effects of NO specific scavenger 2,4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPITO) on Bax-induced terpenoid indole alkaloid (TIA) production of the cells. The data showed that overexpression of the mouse Bax in C. roseus cells triggered NO generation of the cells. Treatment of cPITO not only inhibited the Bax-triggered NO burst but also suppressed the Bax-induced TIA production. The results indicated that the mouse Bax might activate the NO signaling in C. roseus cells and induce TIA production through the NO-dependent signal pathway in the cells. Furthermore, the activities of nitric oxide synthase (NOS) were significantly increased in the transgenic Bax cells as compared to those in the control cells, showing that the mouse Bax may induce NOS of C. roseus cells. Treatment of the transgenic Bax cells with NOS inhibitor PBITU blocked both Bax-induced NO generation and TIA production, which suggested that the mouse Bax might trigger NO generation and TIA production through NOS. However, the NOS-like activities and NO generation in the transgenic Bax cells did not match kinetically and the Bax-induced NOS-like activity was much later and lower than NO production. Moreover, the Bax-induced NO generation and TIA production were only partially inhibited by PBITU. Thus, our results suggested that the Bax-induced NO production and secondary metabolite biosynthesis in C. roseus cells was not entirely dependent on NOS or NOS-like enzymes.
Nitric oxide mediates the fungal elicitor-induced taxol biosynthesis of Taxus chinensis suspension cells through the reactive oxygen species-dependent and -independent signal pathways
Maojun Xu,Jufang Dong
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-006-2081-5
Abstract: Nitric oxide and reactive oxygen species are two important signal molecules that play key roles in plant defense responses. Nitric oxide generation and oxidative burst and accumulation of reactive oxygen species are the early reactions of Taxus chinensis suspension cells to fungal elicitor prepared from the cell walls of Penicillium citrinum. In order to investigate the relationship and/or interactions of nitric oxide and reactive oxygen species in the elicitor-induced Taxol biosynthesis of T. chinensis suspension cells, we treated the cells with nitric oxide specific scavenger 2-4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPITO), nitric oxide synthase inhibitor S,S′-1,3-phenylene-bis(1,2-ethanediyl)-bis-isothiourea (PBITU), membrane NAD(P) H oxidase inhibitor diphenylene iodonium (DPI), superoxide dismutases (SOD) and catalase. The results show that pretreatment of T. chinensis cells with cPITO and DPI inhibited not only the elicitor-induced nitric oxide biosynthesis and oxidative burst, but also the elicitor-induced Taxol production, suggesting that both nitric oxide and reactive oxygen species are involved in elicitor-induced Taxol biosynthesis. Furthermore, pretreatment of the cells with cPITO and PBITU suppressed the elicitor-induced oxidative burst, indicating that the oxidative burst might be dependent on NO. Application of nitric oxide via its donor sodium nitroprusside (SNP) triggered Taxol biosynthesis of T. chinensis cells. The nitric oxide-induced Taxol production was suppressed by DPI, showing that the oxidative burst is involved in NO-triggered Taxol biosynthesis. However, nitric oxide and the fungal elicitor induced Taxol biosynthesis even though the accumulation of reactive oxygen species wass completely abolished in T. chinensis cells. Our data show that nitric oxide may mediate the elicitor-induced Taxol biosynthesis of T. chinensis suspension cells through both reactive oxygen species-dependent and-independent signal pathways. Moreover, the results of our work show that the elicitor-and nitric oxide-induced Taxol biosynthesis is inhibited by catalase, indicating that H2O2 from the oxidative burst might be the signal molecule involved in induced Taxol production of T. chinensis cells.
Enhancing terpenoid indole alkaloid production by inducible expression of mammalian Bax in Catharanthus roseus cells
MaoJun Xu,JuFang Dong
Science China Life Sciences , 2007, DOI: 10.1007/s11427-007-0030-4
Abstract: Bax, a mammalian pro-apoptotic member of the Bcl-2 family, triggers hypersensitive reactions when expressed in plants. To investigate the effects of Bax on the biosynthesis of clinically important natural products in plant cells, we generate transgenic Catharanthus roseus cells overexpressing a mouse Bax protein under the β-estradiol-inducible promoter. The expression of Bax in transgenic Catharanthus roseus cells is highly dependent on β-estradiol concentrations applied. Contents of catharanthine and total terpenoid indole alkaloid of the transgenic cells treated with 30 μmol/L β-estradiol are 5.0-and 5.5-fold of the control cells. Northern and Western blotting results show that expression of mammalian Bax induces transcriptional activation of Tdc and Str, two key genes in terpenoid indole alkaloid biosynthetic pathway of Catharanthus roseus cells, and stimulates the accumulation of defense-related protein PR1 in the cells, showing that the mouse Bax triggers the defense responses of Catharanthus roseus cells and activates the terpenoid indole alkaloid biosynthetic pathway. Thus, our data suggest that the mammalian Bax might be a potential regulatory factor for secondary metabolite biosynthesis in plant cells and imply a new secondary metabolic engineering strategy for enhancing the metabolic flux to natural products by activating the whole biosynthetic pathway rather than by engineering the single structural genes within the pathways.
Enzymatic Process for The Wool Fabric Anti-felting Finishing
Li Dong,Lei Xu
Modern Applied Science , 2009, DOI: 10.5539/mas.v2n3p91
Abstract: Recently washable wool is strongly requested in order to avoid dry cleaning with chlorinated solvents such as perchlomethyiene. In this paper, a new enzymatic process direction is described for obtaining machine washable wool with acceptable quality. The principle of enzymatic process is introduced. To get a good result, proper pre-treatment process and proper enzyme is discussed. The conclusion gives advice to improve the quality of enzymatic wool fabrics.
Pay attention to follow-up and monitoring of patients with gastric epithelial dysplasia associated with chronic atrophic gastritis
Xu-dong Tang
Zhong Xi Yi Jie He Xue Bao , 2011,
Abstract: : Because of the close relationship with stomach cancer and higher rates of carcinoma, gastric epithelial dysplasia associated with chronic atrophic gastritis is considered the most important precancerous lesion of stomach cancer. Due to the absence of recognized treatment methods, periodical follow-up and monitoring were considered an effective method to prevent the occurrence of gastric cancer. Currently, there are numerous areas requiring attention; the authors provide some suggestions on the recognition and key technologies for follow-up and re-examination.
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