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Search Results: 1 - 10 of 58122 matches for " Dong Gu Lee "
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Analysis of the trans-Cinnamic Acid Content in Cinnamomum spp. and Commercial Cinnamon Powder Using HPLC  [PDF]
Jaemin Lee, Dong Gu Lee, Jun Yeon Park, Sungwook Chae, Sanghyun Lee
Journal of Agricultural Chemistry and Environment (JACEN) , 2015, DOI: 10.4236/jacen.2015.44011
Abstract: The present study aimed to quantify the content of trans-cinnamic acid (CA) in Cinnamomum japonicum, C. loureirii, and C. camphora and the commercial application of CA using high performance liquid chromatography (HPLC). A C18 column was used, with water/methanol as the mobile phase gradient. The highest content of CA was observed in the bark of C. loureirii (16.97 mg/g) and cinnamon powder A (47.60 mg/g). The lowest content of CA was observed in leaf and heartwood of C. japonicum (0.10 and 0.10 mg/g, respectively) and cinnamon powder C (22.87 mg/g). This result could be utilized as a guideline for the analysis of the commercial applications of Cinnamomum.
Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens  [PDF]
Dong Gu Lee, So-Youn Mok, Changsun Choi, Eun Ju Cho, Hyun Young Kim, Sanghyun Lee
Journal of Agricultural Chemistry and Environment (JACEN) , 2012, DOI: 10.4236/jacen.2012.11005
Abstract: To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat lenses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC50 value, 0.11 μg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity (IC50 value, 4.03 μM). The content of apigenin was measured in B. balsamifera (0.47 mg/g) by HPLC/UV analysis. Our result suggests that B. balsamifera could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications.

Logistics Cost Management from the Supply Chain Perspective  [PDF]
Yu Gu, Shaojian Dong
Journal of Service Science and Management (JSSM) , 2016, DOI: 10.4236/jssm.2016.93028
Abstract: With the increasingly fierce market competition, China has more sound market economy system. Competition in the market price on the important position of the company is also increasing. It increases its profit source which can provide third-party logistics services business. Third-party logistics enterprises should put the customer requirements on an important position and meet the requirements of customers with the lowest prices. Our third-party logistics companies should know as soon as possible about the process of supply chain operations, and actively involved, starting from its own characteristics. And our third-party logistics companies control the entire supply chain from the perspective of the total cost of logistics companies. To accelerate the development of cost control and improvement, our third-party logistics companies improve their competitiveness, become a very important sector of our economy and the development of new economic growth point, build closer cooperation between the various companies in the supply chain and achieve long-term development.
High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway
Kyung-Ah Kim, Wan Gu, In-Ah Lee, Eun-Ha Joh, Dong-Hyun Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047713
Abstract: Background & Aims While it is widely accepted that obesity is associated with low-grade systemic inflammation, the molecular origin of the inflammation remains unknown. Here, we investigated the effect of endotoxin-induced inflammation via TLR4 signaling pathway at both systemic and intestinal levels in response to a high-fat diet. Methods C57BL/6J and TLR4-deficient C57BL/10ScNJ mice were maintained on a low-fat (10 kcal % fat) diet (LFD) or a high–fat (60 kcal % fat) diet (HFD) for 8 weeks. Results HFD induced macrophage infiltration and inflammation in the adipose tissue, as well as an increase in the circulating proinflammatory cytokines. HFD increased both plasma and fecal endotoxin levels and resulted in dysregulation of the gut microbiota by increasing the Firmicutes to Bacteriodetes ratio. HFD induced the growth of Enterobecteriaceae and the production of endotoxin in vitro. Furthermore, HFD induced colonic inflammation, including the increased expression of proinflammatory cytokines, the induction of Toll-like receptor 4 (TLR4), iNOS, COX-2, and the activation of NF-κB in the colon. HFD reduced the expression of tight junction-associated proteins claudin-1 and occludin in the colon. HFD mice demonstrated higher levels of Akt and FOXO3 phosphorylation in the colon compared to the LFD mice. While the body weight of HFD-fed mice was significantly increased in both TLR4-deficient and wild type mice, the epididymal fat weight and plasma endotoxin level of HFD-fed TLR4-deficient mice were 69% and 18% of HFD-fed wild type mice, respectively. Furthermore, HFD did not increase the proinflammatory cytokine levels in TLR4-deficient mice. Conclusions HFD induces inflammation by increasing endotoxin levels in the intestinal lumen as well as in the plasma by altering the gut microbiota composition and increasing its intestinal permeability through the induction of TLR4, thereby accelerating obesity.
The future impact of population growth and aging on coronary heart disease in China: projections from the Coronary Heart Disease Policy Model-China
Andrew Moran, Dong Zhao, Dongfeng Gu, Pamela Coxson, Chung-Shiuan Chen, Jun Cheng, Jing Liu, Jiang He, Lee Goldman
BMC Public Health , 2008, DOI: 10.1186/1471-2458-8-394
Abstract: The CHD Policy Model is a validated state-transition, computer simulation of CHD on a national scale. China-specific CHD risk factor, incidence, case-fatality, and prevalence data were incorporated, and a CHD prediction model was generated from a Chinese cohort study and calibrated to age-specific Chinese mortality rates. Disability-adjusted life years (DALYs) due to CHD were calculated using standard methods. The projected population of China aged 35–84 years was entered, and CHD events, deaths, and DALYs were simulated over 2000–2029. CHD risk factors other than age and case-fatality were held at year 2000 levels. Sensitivity analyses tested uncertainty regarding CHD mortality coding, the proportion of total deaths attributable to CHD, and case-fatality.We predicted 7.8 million excess CHD events (a 69% increase) and 3.4 million excess CHD deaths (a 64% increase) in the decade 2020–2029 compared with 2000–2009. For 2030, we predicted 71% of almost one million annual CHD deaths will occur in persons ≥65 years old, while 67% of the growing annual burden of CHD death and disability will weigh on adults <65 years old. Substituting alternate CHD mortality assumptions led to 17–20% more predicted CHD deaths over 2000–2029, though the pattern of increases in CHD events and deaths over time remained.We forecast that absolute numbers of CHD events and deaths will increase dramatically in China over 2010–2029, due to a growing and aging population alone. Recent data suggest CHD risk factor levels are increasing, so our projections may underestimate the extent of the potential CHD epidemic in China.China, the most populous of nations, will have a growing and aging population in coming decades. China's population was 1.27 billion in 2000, with seven percent of the population ≥ 65 years old; by 2030 the population is predicted to be 1.46 billion, and 16% percent of Chinese citizens will be ≥ 65 (Figure 1).[1,2] The aging of the population is due both to a boom in births in Chin
Measurement of Blood Pressure Using an Arterial Pulsimeter Equipped with a Hall Device
Sang-Suk Lee,Dong-Hyun Nam,You-Sik Hong,Woo-Beom Lee,Il-Ho Son,Keun-Ho Kim,Jong-Gu Choi
Sensors , 2011, DOI: 10.3390/s110201784
Abstract: To measure precise blood pressure (BP) and pulse rate without using a cuff, we have developed an arterial pulsimeter consisting of a small, portable apparatus incorporating a Hall device. Regression analysis of the pulse wave measured during testing of the arterial pulsimeter was conducted using two equations of the BP algorithm. The estimated values of BP obtained by the cuffless arterial pulsimeter over 5 s were compared with values obtained using electronic or liquid mercury BP meters. The standard deviation between the estimated values and the measured values for systolic and diastolic BP were 8.3 and 4.9, respectively, which are close to the range of values of the BP International Standard. Detailed analysis of the pulse wave measured by the cuffless radial artery pulsimeter by detecting changes in the magnetic field can be used to develop a new diagnostic algorithm for BP, which can be applied to new medical apparatus such as the radial artery pulsimeter.
Decreased expression of extracellular matrix proteins and trophic factors in the amygdala complex of depressed mice after chronic immobilization stress
Soonwoong Jung, Younghyurk Lee, Gyeongwha Kim, Hyeonwi Son, Dong Hoon Lee, Gu Seob Roh, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Hyun Joon Kim
BMC Neuroscience , 2012, DOI: 10.1186/1471-2202-13-58
Abstract: Eight genes were decreased in the amygdala of CIS mice, including genes for neurotrophic factors and extracellular matrix proteins. Among these, osteoglycin, fibromodulin, insulin-like growth factor 2 (Igf2), and insulin-like growth factor binding protein 2 (Igfbp2) were further analyzed for histological expression changes. The expression of osteoglycin and fibromodulin simultaneously decreased in the medial, basolateral, and central amygdala regions. However, Igf2 and Igfbp2 decreased specifically in the central nucleus of the amygdala. Interestingly, this decrease was found only in the amygdala of mice showing higher immobility, but not in mice displaying lower immobility, although the CIS regimen was the same for both groups.These results suggest that the responsiveness of the amygdala may play a role in the sensitivity of CIS-induced behavioral changes in mice.
Molecular and Clinical Characterization of the Variable Phenotype in Korean Families with Hearing Loss Associated with the Mitochondrial A1555G Mutation
Jae Woong Bae, Dong-Bin Kim, Jae Young Choi, Hong-Joon Park, Jong Dae Lee, Dong Gu Hur, Seung-Hyun Bae, Da Jung Jung, Sang Heun Lee, Un-Kyung Kim, Kyu Yup Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042463
Abstract: Hearing loss, which is genetically heterogeneous, can be caused by mutations in the mitochondrial DNA (mtDNA). The A1555G mutation of the 12S ribosomal RNA (rRNA) gene in the mtDNA has been associated with both aminoglycoside-induced and non-syndromic hearing loss in many ethnic populations. Here, we report for the first time the clinical and genetic characterization of nine Korean pedigrees with aminoglycoside-induced and non-syndromic hearing loss. These Korean families carry in the A1555G mutation of 12S rRNA gene and exhibit variable penetrance and expressivity of hearing loss. Specifically, the penetrance of hearing loss in these families ranged between 28.6% and 75%, with an average of 60.8%. These results were higher than the 29.8% penetrance that was previously reported in a Chinese population but similar to the 65.4% and 54.1% penetrance observed in a large Arab-Israeli population and nineteen Spanish pedigrees, respectively. The mutational analysis of the complete mtDNA genome in these families showed that the haplogroups of the Korean population, which belongs to the eastern Asian population, were similar to those of the Chinese population but different from the Spanish population, which belongs to the European-Caucasian population. The mtDNA variants that may act as modifier factors were also found to be similar to the Chinese population. Although the mtDNA haplogroups and variants were similar to the eastern Asian population, we did find some differing phenotypes, although some subjects had the same variants. This result suggests that both the ethnic background and environmental factors lead to a variable phenotype of the A1555G mutation.
Continued Fraction Method for Approximation of Heat Conduction Dynamics in a Semi-Infinite Slab  [PDF]
Jietae Lee, Dong Hyun Kim
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.57100

Heat conduction dynamics are described by partial differential equations. Their approximations with a set of finite number of ordinary differential equations are often required for simpler computations and analyses. Rational approximations of the Laplace solutions such as the Pade approximation can be used for this purpose. For some heat conduction problems appearing in a semi-infinite slab, however, such rational approximations are not easy to obtain because the Laplace solutions are not analytic at the origin. In this article, a continued fraction method has been proposed to obtain rational approximations of such heat conduction dynamics in a semi-infinite slab.

Survivin expression and its clinical significance in pancreatic cancer
Myung Ah Lee, Gyeong-sin Park, Hee-Jung Lee, Ji-Han Jung, Jin-Hyoung Kang, Young Seon Hong, Kyung Shik Lee, Dong-gu Kim, Seung-Nam Kim
BMC Cancer , 2005, DOI: 10.1186/1471-2407-5-127
Abstract: We performed immunohistochemical staining for survivin, p53, and Bax in formalin-fixed, paraffin-embedded block from forty-nine pancreatic tissues. To determine the association with clinical course, we reviewed the patients' clinical record.Of the 49 cases of pancreatic cancer, 46 cases (93.9%) were positive for survivin expression. There was no significant association between survivin expression and p53 or bax. For clinicopathological parameters, perineural invasion was more common in survivin positive and venous invasion was more common in survivin negative (p = 0.041 and 0.040, respectively). Responsiveness to chemotherapy appeared to be slightly better in patients with low survivin expression.Survivin expression may be associated with venous or perineural invasion, indicating metastatic route, and seems to have a potential as a predictive marker for chemotherapy. Further study of large scale is required to determine the clinical significance of survivin expression in pancreatic cancer.Survivin has recently been identified as a novel inhibitor of apoptosis (IAP). It blocks common downstream elements of both the mitochondrial pathway and the death receptor pathway, by directly inhibiting terminal effector caspase-3, caspase-7, and caspase-9 activity[1,2]. Thus, it inhibits apoptosis pathway differently from bcl-2, which blocks mitochondrial cytochrome c release into the cytosol, resulting in the inhibition of mitochondrial apoptotic pathway. Survivin is expressed during embryonic and fetal development but is undetectable in terminally differentiated normal adult tissue. However, it is re-expressed in transformed cell lines and several human cancer cells at a frequency of 34–100 % [3,4]. As a prognostic factor, survivin expression is significantly associated with poor clinical outcome in cancers, such as neuroblastoma, colorectal cancer, breast cancer, lung cancer and esophageal cancer [5-10].Survivin expression in pancreatic cancer has not been widely studied. Sat
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