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Search Results: 1 - 10 of 6533 matches for " Donald Ross "
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Resolution of Chronic Subdural Hematoma after Treatment with Tumor Necrosis Factor Alpha Inhibitor  [PDF]
Donald Ross
Neuroscience & Medicine (NM) , 2011, DOI: 10.4236/nm.2011.24045
Abstract: Background and Importance: Chronic subdural hematomas (cSDH) are a common problem for which solutions remain imperfect. Surgery is effective, but not without risk. Recent data have suggested a role for inflammation in the genesis of cSDH and several reports have documented some benefit to steroid treatment. In this report, a possible role for tumor necrosis factor alpha blockade in the resolution of a multiply recurrent cSDH is described. Clinical Presentation: An 86-year-old man with rheumatoid arthritis treated with infliximab presented with a large, symptomatic, multiloculated cSDH. Infliximab was withheld and craniotomy for evacuation was uncomplicated, but recurrent symptoms were noted and a recurrence was operated upon again several weeks later. Follow up CT showed a second recurrence. The patient requested to go back on his infliximab due to painful arthralgias. After a single dose of 10 mg/kg, follow up CT showed that the cSDH resolved and did not recur. Conclusion: Anti-TNF-alpha treatment with infliximab may have played a role in the resolution of this patient’s cSDH. Further investigation of this possible effect seems warranted.
Review: ‘The Personal Observations of a Man of Intelligence’: Notes on a Tour in North America in 1861, by Sir James Fergusson, edited by Ben Wynne
Ross, Donald
Journal of Historical Biography , 2010,
Radical Resection of Adult Low Grade Oligodendroglioma without Adjuvant Therapy: Results of a Prospective Treatment Protocol—Surgical Treatment of Low-Grade Oligodendroglioma  [PDF]
Donald A. Ross, Lynda Yang, Oren Sagher, Amy M. Ross
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.22030
Abstract: The goal of this work was to demonstrate prospectively that maximal surgical resection of low grade oligodendrogliomas without adjuvant therapy does not reduce life expectancy over that of historical controls. All patients with surgically accessible grade II oligodendrogliomas underwent maximal resection using stereotactic guidance and/or cortical mapping and were followed with serial MRI scans without adjuvant therapy until either progression or spread into brain regions deemed not surgically resectable. Nineteen patients were treated between 1993 and 2006. Ten patients required reoperation an average of 55 months after their first surgery. Nine patients progressed to anaplastic tumors an average of 42 months after their first surgery: six patients died from their tumors an average of 73 months after diagnosis, two are still alive 76 and 18 months after progression, and one was lost to follow up. Ten patients are alive and progression-free an average of 116 months after diagnosis, one of whom was lost to follow up at 106 months from diagnosis. Four patients are alive and event-free an average of 125 months after diagnosis. All are male and three had tumors in the superior frontal gyrus. The event-free survival, progression-free survival, and overall survival of our patients are not worse than those of patients treated with postoperative adjuvant therapy. Withholding adjuvant therapy at diagnosis appears to be safe. It will be important to establish the molecular differences between the patients who did very well and those who progressed so that adjuvant therapy could be offered to the latter.
Lobar Distribution of Low Grade Oligodendroglioma: Distribution, Molecular Characteristics, and Survival Based upon Location  [PDF]
Donald A. Ross, Shao Tao, Sakir Gultekin, Amy M. Ross
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.513126

Grade II oligodendrogliomas are rare and slow growing tumors, making long-term follow up difficult, but necessary for better understanding. In this retrospective study a review of all grade II oligodendrogliomas encountered in the last 20 years at one institution, was undertaken to determine if specific tumor location and immunohistochemical analysis had any impact on recurrence rate, progression free survival, or life expectancy. Eighty-nine grade II oligodendroglioms cases were reviewed (38 females and 51 males; mean age was 40.3 ± 13.8 years). Tumor location was: frontal lobe (44, 49.4%) and superior frontal gyrus (30, 33.7%). 1p19q data were available in 49 patients. Twenty-nine cases were co-deleted (59.2%). There was no significant difference in the incidence of 1p19q co-deletion between superior frontal gyrus tumors vs. other frontal tumors or extra-frontal tumors (p= 0.45). Follow up of at least 3 months after diagnosis was available in 79 patients (mean follow up: 93.2 months). In recurrence analysis, recurrence by 1p19q status and recurrence by location revealed no significant differences. In analysis of progression, progression by 1p19q status and progression by location revealed no significant differences. An analysis of deaths for the sample, deaths by 1p19q status and deaths by location revealed no significant differences. There was a higher death rate among patients >50 years of age, however this, too, was not significant.There did not appear to be any advantage in recurrence rate, progression free survival, or life expectancy for tumors located in the frontal lobe or superior frontal gyrus. 1p19q co-deletion did not appear to confer an advantage as measured by time to recurrence, time to progression, or overall survival. Other than age, eloquent location, Karnofsky status, and overall tumor size as reported by others, tumor location and 1p19q status in low grade oligodendrogliomas are not currently predictive of survival.

Ross Berkowitz,Donald Goldstein
Revista del Hospital Materno Infantil Ramón Sardá , 2009,
Stereotactic Brain Biopsy or Bronchoscopic/Transthoracic Needle Biopsy for Diagnosis of Metastatic Cancer Presenting Simultaneously in Lung and Brain: A Comparison of Safety and Efficacy
Donald A Ross
Cancer and Clinical Oncology , 2012, DOI: 10.5539/cco.v1n2p81
Abstract: Background: When patients present with sim ultaneous lung and brain lesions consistent with metastases, it is often presumed that it is safer and less invasive to biopsy the lung lesion. Objective: To determine whether lung biopsy or stereotactic brain biopsy has a higher diagnostic yield and lower morbidity for tissue diagnosis in patients with simultaneous brain and lung lesions. Methods: Retrospective review of the author’s stereotactic biopsy series and of the literature on brain and lung biopsies for suspected malignancy. Results: The overall diagnostic yield for bronchoscopic lung biopsy ranged from 44% to 88% and the pneumothorax rate from 1.2% to 8%. No deaths were reported. The overall diagnostic yield for transthoracic lung biopsy ranged from 74% to 96% and pneumothorax rate from 2.2% to 8%. No deaths were reported. The overall diagnostic yield for stereotactic brain biopsy ranged from 90.6% to 99.3% when all potential diagnoses are included. Complication rates ranged from 0.6% to 4.8% with mortality from 0% to 1.5%. Several series reported no mortality. Conclusion: Stereotactic brain biopsy has a higher diagnostic yield and a lower complication rate, but a higher mortality. The inclusion of diagnoses other than metastases in the reported series may account for some of the reported mortality. When lung and brain lesions are detected simultaneously, stereotactic biopsy is an excellent option for tissue diagnosis.
Complications of Minimally Invasive, Tubular Access Surgery for Cervical, Thoracic, and Lumbar Surgery
Donald A. Ross
Minimally Invasive Surgery , 2014, DOI: 10.1155/2014/451637
Abstract: The object of the study was to review the author’s large series of minimally invasive spine surgeries for complication rates. The author reviewed a personal operative database for minimally access spine surgeries done through nonexpandable tubular retractors for extradural, nonfusion procedures. Consecutive cases ( ) were reviewed for complications. There were no wound infections. Durotomy occurred in 33 cases (2.7% overall or 3.4% of lumbar cases). There were no external or symptomatic internal cerebrospinal fluid leaks or pseudomeningoceles requiring additional treatment. The only motor injuries were 3 C5 root palsies, 2 of which resolved. Minimally invasive spine surgery performed through tubular retractors can result in a low wound infection rate when compared to open surgery. Durotomy is no more common than open procedures and does not often result in the need for secondary procedures. New neurologic deficits are uncommon, with most observed at the C5 root. Minimally invasive spine surgery, even without benefits such as less pain or shorter hospital stays, can result in considerably lower complication rates than open surgery. 1. Introduction Minimal access spinal surgery is a rapidly developing set of techniques, which have compared favorably with open surgeries in the recent literature (see review in Wong et al., 2012) [1–4]. In addition to reduced blood loss, shorter operative time, reduced postoperative pain, earlier discharge, rapid return to normal activities, and other reported advantages of minimally invasive surgery, [5] a decreased complication rate associated with these surgeries has also been noted, particularly with respect to wound infections [6]. The author reports experience on management of a large series of minimally invasive spine procedures. 2. Methods 2.1. Patient Population The author began using the Metrx Tubular Retraction System (Medtronic, Minneapolis) in 2001. This report constitutes a retrospective review of all consecutive spine cases done using this system from that time to the present. Information was obtained from the author’s personal surgeries database. This report does not include intentionally intradural procedures or fusion procedures. This series does not include the use of expandable tubes or other minimal access retractor systems other than a tubular system. Procedures reported here were for laminectomy and/or foraminotomy for spondylotic diseases such as discectomy or stenosis, for epidural masses such as metastases, abscesses, or synovial cysts, or for spinal cord stimulator paddle electrode implantation.
Boundary Conditions and Dualities: Vector Fields in AdS/CFT
Donald Marolf,Simon Ross
Physics , 2006, DOI: 10.1088/1126-6708/2006/11/085
Abstract: In AdS, scalar fields with masses slightly above the Breitenlohner-Freedman bound admit a variety of possible boundary conditions which are reflected in the Lagrangian of the dual field theory. Generic small changes in the AdS boundary conditions correspond to deformations of the dual field theory by multi-trace operators. Here we extend this discussion to the case of vector gauge fields in the bulk spacetime using the results of Ishibashi and Wald [hep-th/0402184]. As in the context of scalar fields, general boundary conditions for vector fields involve multi-trace deformations which lead to renormalization-group flows. Such flows originate in ultra-violet CFTs which give new gauge/gravity dualities. At least for AdS4/CFT3, the dual of the bulk photon appears to be a propagating gauge field instead of the usual R-charge current. Applying similar reasoning to tensor fields suggests the existence of a duality between string theory on AdS4 and a quantum gravity theory in three dimensions.
Plane Waves: To infinity and beyond!
Donald Marolf,Simon F. Ross
Physics , 2002,
Abstract: We describe the asymptotic boundary of the general homogeneous plane wave spacetime, using a construction of the `points at infinity' from the causal structure of the spacetime as introduced by Geroch, Kronheimer and Penrose. We show that this construction agrees with the conformal boundary obtained by Berenstein and Nastase for the maximally supersymmetric ten-dimensional plane wave. We see in detail how the possibility to go beyond (or around) infinity arises from the structure of light cones. We also discuss the extension of the construction to time-dependent plane wave solutions, focusing on the examples obtained from the Penrose limit of Dp-branes.
A new recipe for causal completions
Donald Marolf,Simon F. Ross
Physics , 2003, DOI: 10.1088/0264-9381/20/18/314
Abstract: We discuss the asymptotic structure of spacetimes, presenting a new construction of ideal points at infinity and introducing useful topologies on the completed space. Our construction is based on structures introduced by Geroch, Kronheimer, and Penrose and has much in common with the modifications introduced by Budic and Sachs as well as those introduced by Szabados. However, these earlier constructions defined ideal points as equivalence classes of certain past and future sets, effectively defining the completed space as a quotient. Our approach is fundamentally different as it identifies ideal points directly as appropriate pairs consisting of a (perhaps empty) future set and a (perhaps empty) past set. These future and past sets are just the future and past of the ideal point within the original spacetime. This provides our construction with useful causal properties and leads to more satisfactory results in a number of examples. We are also able to endow the completion with a topology. In fact, we introduce two topologies, which illustrate different features of the causal approach. In both topologies, the completion is the original spacetime together with endpoints for all timelike curves. We explore this procedure in several examples, and in particular for plane wave solutions, with satisfactory results.
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