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Search Results: 1 - 10 of 5817 matches for " Dona Sara Kurian "
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BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF PIRFENIDONE BY RPHPLC METHOD AND ITS APPLICATION TO THE DETERMINATION OF DRUG FOOD INTERACTION STUDY IN WISTER RATS
N. Tamilselvi,Dona Sara Kurian
International Journal of Pharmaceutical and Biological Research , 2012,
Abstract: A simple precise, accurate RP-HPLC method has been developed and validated for bioavailability study of pirfenidone in wister rat plasma. The separation and quantization of pirfenidone was achieved on a C18 reversed phase column using the mobile phase in gradient mode constituting of eluant A HPLC grade water (adjusted to pH 3.5) and eluant B 20% acetonitrile and 15% of methanol in the ratio of 60: 40 at a flow rate 1 mlmin-1. Eluted components were detected at 324 nm. The method showed good linearity for Pirfenidone in the range of 50–250ng mL-1, Y=54.97x - 349.5and correlation coefficient R2 is 0.998 respectively. The limit of quantitation (LOQ) and limit of detection (LOD) were found to be 12 and 20 ng mL-1respectively.Thedeveloped method shows good accuracy and precision. . Accuracy ranges from 98.49% to 99.37% with the precision 6.43% to 7.67% in inter-day method. Intra-day method the accuracy ranges from 98.64% to 99.33%with the precision 5.64% to 6.93 %. For bioanalytical study, parameters like Cmax, Tmax, AUC0-t,AUC 0-∞,Keli and T1/2 are compared by statistical analysis. The maximum concentration (Cmax) obtained for pirfenidone before and after food was found to be 1020.76 ng mL-1 and 836.5ng mL-1 respectively. The half life (T1/2) of pirfenidonebefore and after food were calculated and found to be 2.732158 h and 4.009485 h respectively. Area under the curve t AUC.0 of pirfenidone before food was calculated as 3060.95nghr mL-1 and 0 AUC was found to be 3053.07ng mL-1. Area under the curve t AUC.0 of pirfenidone after food was calculated as 2534.16nghr mL-1 and 0 AUC was found to be 2510.64ng mL-1. Elimination rate constant for Pirfenidone was found to be 0.004228 h-1and 0.002881 h-1 respectively. This method was successfully applied to the bioavailability study of pirfenidone.
Listeria monocytogenes
Dona Benadof
Revista chilena de infectología , 2008,
Abstract:
A solution to Ahmed's Integral(II)
Dona Ghosh
Mathematics , 2014,
Abstract: In the year 2000, Ahmed proposed a family of integrals in the American Mathematical Monthly which invoked a considerable response then. Here I would like to present another solution to this family of integrals. I propose to call this as Ahmed's Integral (II) in the light of the well known Ahmed's Integral.
Inventory, Geographical Distribution of Caryedon Species in Burkina Faso, and Evaluation of Their Impact on Stored Groundnut  [PDF]
Issoufou Ouedraogo, Mbacke Sembene, Dona Dakouo
Advances in Entomology (AE) , 2017, DOI: 10.4236/ae.2017.52005
Abstract: To understand the mechanism of infestation of stored groundnut in farming areas, studies on the inventory and geographical distribution of Caryedon species were carried out in the tree savannah and in producers’ storage structures. The incidence of C. serratus in stored groundnut was evaluated. Inventory and geographical distribution of insects belonging to Caryedon genus was achieved through a sampling in the savannah and producers’ granaries. The inventory and geographical distribution of insects was made throughout Burkina Faso whereas the evaluation of the perforations of groundnut pods was made in the western zone of the country. The results of the inventory showed the presence of two species belonging to Caryedon genus which are C. serratus and C. crampelii. These species are found on the agro-ecological zones of the country. The survival and maintenance of Caryedon species genus are ensured by the presence of plants belonging to various families such as Caesalpiniceae and Mimosaceae. The evaluation of the losses caused by C. serratus in producer’s stored groundnut revealed that the pods perforation rate varied according to the locality. In?Toussiana, the rate of perforated pods ranged from 53.72% to 100% in five months while in?Karangasso Sembla, for the same conservation time, the rate was in the range from 2.8% to 35%. However it is C. serratus which is responsible for the losses observed in the stored groundnut. Indeed, in the western area of Burkina Faso where more than 25% of the production is realized, 70% of
Fusarium especie
Dona Benadof F
Revista chilena de infectología , 2010,
Abstract:
Neisseria sicca
Dona Benadof F
Revista chilena de infectología , 2009,
Abstract:
Incidence of the African Rice Gall Midge (AfRGM), Orseolia oryzivora H. & G. in Relation with Period of Rice Transplanting in the Kou Valley, Burkina Faso  [PDF]
Karim Sama, Souleymane Nacro, Cheikh Thiaw, Dona Dakouo
Advances in Entomology (AE) , 2016, DOI: 10.4236/ae.2016.42011
Abstract: The African Rice Gall Midge, Orseolia oryzivora H. & G., is an important insect pest recorded in 20 countries in Sub-Sahara Africa. In Burkina Faso, the insect pest particularly prevails in Western and South-Western of the country where both biotic and abiotic conditions favor its development. The insect pest can damage up to 60% of rice tillers in Western Burkina Faso. A study was conducted during the 2011 wet season in the Kou Valley, located 25 km North-West of Bobo-Dioulas- so, Western Burkina Faso. Its objective was to evaluate the damage of this insect pest in farmers’ fields in relation with rice transplanting periods. The Kou Valley rice scheme, 1200 ha, was divided into two zones within which 48 farmers’ fields were randomly selected in relation with rice transplanting periods: P1: 1st period; P2: 2nd period and P3: 3rd period; that is 16 fields per period. Both agronomic and entomological evaluations were performed each week starting from the 21th day after transplanting (DAT) up to 84 DAT. Results showed that the highest average damage level (16% of galls) was recorded in the 3rd transplanting period. The highest larval and pupal parasitism was recorded in P3 at 84 DAT. Pupal parasitism due to Aprostocetus procerae Risbec was higher than larval parasitism due to Platygaster diplosisae Risbec. Lastly, the lowest yield (4.78 t/ha) was recorded in P3. These results can be used in the implementation of an integrated pest management strategy for this insect pest in the Kou Valley.
Influence of Host Plants on the Development of Caryedon serratus Olivier (Coleoptera: Chrysomelidae, Bruchinae), Insect Pest of Groundnut Stocks in Burkina Faso  [PDF]
Issoufou Ouedraogo, Sacamba Aimé Omer Hema, Wendgoundi Guenda, Dona Dakouo
Advances in Entomology (AE) , 2016, DOI: 10.4236/ae.2016.45029
Abstract:
The beetle Caryedon serratusOlivier is a major insect pest responsible for the infesta-tion and damage on groundnut during storage. To understand the infestation mecha-nism of groundnut stocks, studies have been carried out on this insect biology under laboratory conditions in relation with its host plants. The results have demonstrated that the pre-oviposition on groundnut lasts on average 1.28 days. The oviposition pe-riod is 12.04 days, during which 80.42 eggs on average are laid. From hatching to adult stage, C. serratus larvae development goes through four stages with variable durations according to the stage. Three families of host plants (Papilionaceae; Caesalpiniaceae and Mimosaceae) were selected for females C. serratusto lay on their seeds. The re-sults showed that more eggs were laid on the seeds of Papilionaceae (98.75% of in-fested seeds) followed by Caesalpiniaceae (28.59% of infested seeds). Studies were carried out on the laying behavior of C. serratus under laboratory conditions and have revealed that whatever the conditions, C. serratus?females lay on all the plant species seeds exposed. Insects’ development duration has varied according to the plant species seeds used.
The Impact of Neural Stem Cell Biology on CNS Carcinogenesis and Tumor Types
K. M. Kurian
Pathology Research International , 2011, DOI: 10.4061/2011/685271
Abstract: The incidence of gliomas is on the increase, according to epidemiological data. This increase is a conundrum because the brain is in a privileged protected site behind the blood-brain barrier, and therefore partially buffered from environmental factors. In addition the brain also has a very low proliferative potential compared with other parts of the body. Recent advances in neural stem cell biology have impacted on our understanding of CNS carcinogenesis and tumor types. This article considers the cancer stem cell theory with regard to CNS cancers, whether CNS tumors arise from human neural stem cells and whether glioma stem cells can be reprogrammed. 1. Introduction Epidemiological data suggests that the incidence of gliomas—the most common form of intrinsic brain tumour—is rising [1–3]. This is surprising, because the brain is partially protected from the environment factors by the blood-brain barrier and has a low proliferative potential compared with other organs. Recent advances from the stem-cell biology field have impacted on our understanding of CNS carcinogenesis and tumor types [4–7]. This paper considers the evidence for the cancer stem cell theory, whether CNS tumours arise from human neural stem cells and whether glioma stem cells can be reprogrammed. 2. Cancer Stem-Cell Theory Normal human neural stem cells are thought to reside within the brain mostly in the subventricular zone (SVZ) lining the lateral ventricles and within the dentate gyrus of the hippocampus [8, 9]. These stem cells persist throughout adulthood into old age and may divide symmetrically for self-renewal and asymmetrically to produce neurons, astrocytes, and oligodendrocytes [10]. By comparison, brain cancer or glioma stem cells are a population within a glioma that can divide infinitely, have the capacity to show neuronal, astrocytic, and oligodendroglial differentiation and can recapitulate the whole tumour when transplanted into the brain of a nude mouse [11–13]. Whether brain cancer stem cells actually develop from preexisting human neural stem cells or represent cells which reacquire a stem-like state as a by product of tumorigenesis or in vitro culture conditions remains controversial [11–13]. Brain cancer/glioma stem cells are of great interest, because they may represent the population of cells within a tumour that may be resistant to therapy and responsible for tumour relapse. Cancer stem cells, were originally described in acute myeloid leukaemia and in haematological malignancies and subsequently in many solid tumours [4, 6, 7]. Brain cancer stem cells, also
Abhishiktananda: A Christian advaitin
Celia Kourie,Alex Kurian
HTS Theological Studies/Teologiese Studies , 2011, DOI: 10.4102/hts.v67i3.1054
Abstract: In our pluralistic society, the diverse religious traditions offer an opportunity for interreligious dialogue which has as its aim an appreciation of, and respect for, the integrity of individual traditions. Swami Abhishiktananda is a clear example of one who offered an alternative to Christian exclusiveness in his willingness to engage in an inter-spiritual lifestyle in which Eastern and Western mystical traditions are seen to be mutually enriching. By opting to make his own life a crucible to test his beliefs and convictions Abhishiktananda endured lifelong trials and tribulations. His life can broadly be divided into four phases, namely the ‘fulfilment’ phase, with its typical Western triumphalist missionary mentality, followed by the crisis phase thanks to his encounter with Hindu spirituality. This led him to the third phase in which he dared to relativise all conceptualisations as concretisations of the inexpressible Mystery. During the final two years of his life he entered the fourth and the last phase of liberation or ‘explosion’ of all previous concepts. Abhishiktananda spoke of an experience, which he called ati-Advaita, or Advaitatita which is an experience of Unity and Trinity. He claimed that the sages of India were correct to say neither one nor many, but just to say, not-two, advaita, and not-one, an-eka. How to cite this article: Kourie, C. & Kurian, A., 2011, ‘Abhishiktananda: A Christian advaitin’, HTS Teologiese Studies/Theological Studies 67(3), Art. #1054, 8 pages. http://dx.doi.org/10.4102/hts.v67i3.1054
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