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Search Results: 1 - 10 of 208659 matches for " Dominick L. Opitz "
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Review of Azithromycin Ophthalmic 1% Solution (AzaSite ) for the Treatment of Ocular Infections
Dominick L. Opitz and Jennifer S. Harthan
Ophthalmology and Eye Diseases , 2012, DOI: 10.4137/OED.S7791
Abstract: AzaSite (azithromomycin 1.0%) ophthalmic solution was approved in 2007 by the US Food and Drug Administration (FDA) as the first commercially available formulation of ophthalmic azithromycin for the treatment of bacterial conjunctivitis. AzaSite utilizes a vehicle delivery system called DuraSite , which stabilizes and sustains the release of azithromycin to the ocular surface, leading to a longer drug residence time, less frequent dosing, and an increase in patient compliance. AzaSite is a broad spectrum antibiotic, effective against Gram-positive, Gram-negative, and atypical bacteria. AzaSite has been studied for the treatment of ocular conditions beyond its clinical indication. A number of clinical studies have evaluated its efficacy and safety in the management of ocular conditions such as bacterial conjunctivitis and blepharitis on both the pediatric and adult populations. This article aims to evaluate the peer-reviewed published literature on the use of azithromycin 1.0% ophthalmic for current and possible future ophthalmic uses.
Review of Azithromycin Ophthalmic 1% Solution (AzaSite ) for the Treatment of Ocular Infections
Dominick L. Opitz,Jennifer S. Harthan
Ophthalmology and Eye Diseases , 2012,
Abstract:
Adjuncts or adversaries to shared decision-making? Applying the Integrative Model of behavior to the role and design of decision support interventions in healthcare interactions
Dominick L Frosch, France Légaré, Martin Fishbein, Glyn Elwyn
Implementation Science , 2009, DOI: 10.1186/1748-5908-4-73
Abstract: Shared decision-making requires not only a cognitive understanding of the medical problem and deliberation about the potential options to address it, but also a number of communicative behaviors that the patient and physician need to engage in to reach the goal of making a shared decision. Theoretical models of behavior can guide both the identification of constructs that will predict the performance or non-performance of specific behaviors relevant to shared decision-making, as well as inform the development of interventions to promote these specific behaviors. We describe how Fishbein's Integrative Model (IM) of behavior can be applied to the development and evaluation of DESIs. There are several ways in which the IM could be used in research on the behavioral effects of DESIs. An investigator could measure the effects of an intervention on the central constructs of the IM - attitudes, normative pressure, self-efficacy, and intentions related to communication behaviors relevant to shared decision-making. However, if one were interested in the determinants of these domains, formative qualitative research would be necessary to elicit the salient beliefs underlying each of the central constructs. Formative research can help identify potential targets for a theory-based intervention to maximize the likelihood that it will influence the behavior of interest or to develop a more fine-grained understanding of intervention effects.Behavioral theory can guide the development and evaluation of DESIs to increase the likelihood that these will prepare patients to play a more active role in the decision-making process. Self-reported behavioral measures can reduce the measurement burden for investigators and create a standardized method for examining and reporting the determinants of communication behaviors necessary for shared decision-making.Over the last several decades, we have witnessed a redefinition of the role of patients in decision-making. This new conceptualization o
Climate Change and Range Expansion of the Asian Tiger Mosquito (Aedes albopictus) in Northeastern USA: Implications for Public Health Practitioners
Ilia Rochlin, Dominick V. Ninivaggi, Michael L. Hutchinson, Ary Farajollahi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060874
Abstract: The Asian tiger mosquito, Aedes albopictus (Skuse), is an invasive species with substantial biting activity, high disease vector potential, and a global distribution that continues to expand. New Jersey, southern New York, and Pennsylvania are currently the northernmost boundary of established Ae. albopictus populations in the eastern United States. Using positive geographic locations from these areas, we modeled the potential future range expansion of Ae. albopictus in northeastern USA under two climate change scenarios. The land area with environmental conditions suitable for Ae. albopictus populations is expected to increase from the current 5% to 16% in the next two decades and to 43%–49% by the end of the century. Presently, about one-third of the total human population of 55 million in northeastern USA reside in urban areas where Ae. albopictus is present. This number is predicted to double to about 60% by the end of the century, encompassing all major urban centers and placing over 30 million people under the threat of dense Ae. albopictus infestations. This mosquito species presents unique challenges to public health agencies and has already strained the resources available to mosquito control programs within its current range. As it continues to expand into areas with fewer resources and limited organized mosquito control, these challenges will be further exacerbated. Anticipating areas of potential establishment, while planning ahead and gathering sufficient resources will be the key for successful public health campaigns. A broad effort in community sanitation and education at all levels of government and the private sector will be required until new control techniques are developed that can be applied efficiently and effectively at reasonable cost to very large areas.
A screen to identify drug resistant variants to target-directed anti-cancer agents
Azam Mohammad,Raz Tal,Nardi Valentina,Opitz Sarah L.
Biological Procedures Online , 2003, DOI: 10.1251/bpo63
Abstract: The discovery of oncogenes and signal transduction pathways important for mitogenesis has triggered the development of target-specific small molecule anti-cancer compounds. As exemplified by imatinib (Gleevec), a specific inhibitor of the Chronic Myeloid Leukemia (CML)-associated Bcr-Abl kinase, these agents promise impressive activity in clinical trials, with low levels of clinical toxicity. However, such therapy is susceptible to the emergence of drug resistance due to amino acid substitutions in the target protein. Defining the spectrum of such mutations is important for patient monitoring and the design of next-generation inhibitors. Using imatinib and BCR/ABL as a paradigm for a drug-target pair, we recently reported a retroviral vector-based screening strategy to identify the spectrum of resistance-conferring mutations. Here we provide a detailed methodology for the screen, which can be generally applied to any drug-target pair.
The community service of the Ghent University Zoology Museum
Dominick Verschelde
University Museums and Collections Journal , 2009,
Abstract: The Ghent University Zoology Museum is not only providing guided exhibitions, but is more and more organizing fun workshops and practical exercises for all members of the community: families, toddlers (kindergarten), students of the primary, secondary, and high schools as well as adults. Our approach is an informal teaching of formal learning; we offer ‘tantalizing teasers to taste Science’. We teach the public to use their senses to observe, and their mental sensibilities to create critical ideas; all this in a fun and passionate way instead of the commonly believed ‘boring scientific way’. We allow high school trainees and apprentices of unemployment offices and the Department of Social Service to work and train in our museum, thus getting a taste of the immense workload surrounding a university collection. But this is not a fairy tale, as it is not without some bitter side effects. Universities and university museums not only have a duty towards a small part of the community, in carrying out research and training students, but need to focus on the entire population in order to get the critical scientific way of thinking into the society as well as improving transparency of an academic environment for laymen. Taking this into consideration, UMAC does not only stand for ‘University Museums and Collections’, but even more so for ‘University Museums and Communities’.
La guerre contre les drogues illicites : Est-ce qu’elle est perdue ? - Has the war against drugs been lost ? - La guerra contro le droghe è persa ?
Dominick M.
Rivista di Criminologia, Vittimologia e Sicurezza , 2009,
Abstract: Le système légal du Mexique est dans un état de ruine à cause des cartels de la drogue soutenus et subventionnés par les états-Unis d'Amerique. En effet, les états-Unis sont le marché principal de la marijuana, de la cocaine et, en moindre quantité, des drogues synthétiques provénantes du Mexique. L’article met en évidence que les régions frontalières du Mexique sont pris en otage entre d’une part, les principaux producteurs mondiaux de coca et d’autre part, les principaux consommateurs (de l’Amerique du Nord et de l’Europe). Pour cela, l’avis de l’autrice et de son collaborateur est que le Mexique ne peut résoudre seul les problèmes liés au narcotrafique. The Mexican legal system is in a state of ruin because of illegal drug cartels supported, sustained and subsidized by the United States of America. It is the U.S. which is the market for marijuana, cocaine and to a lesser extent synthetic drugs trafficked through Mexico. This article evidences that especially the frontier regions of Mexico have been taken hostage between, on the one hand, the principal world producers of cocaine and, on the other hand, the principal consumers (from North America and from Europe). Accordingly, it is the view of the author and her collaborator that Mexico cannot resolve in isolation the problems involved in narco-trafficking.Il sistema legale messicano versa in uno stato disastroso a causa dei cartelli della droga sostenuti e sovvenzionati dagli Stati Uniti d’America. Infatti, gli USA rappresentano il principale mercato della marijuana, della cocaina e delle droghe sintetiche (queste ultime in misura minore) provenienti dal Messico. L’articolo mette in evidenza che le regioni frontaliere del Messico sono prese in ostaggio, da una parte, dai principali produttori modiali di cocaina e, dall’altra, dai principali consumatori (che si trovano nell’America del Nord ed in Europa). Pertanto, secondo l’autrice ed il suo collaboratore, il Messico non può risolvere da solo i suoi problemi derivanti dal narco-traffico.
Classification, Natural History, and Evolution of Tarsosteninae (Coleoptera: Cleridae)—Part I: Generic Composition of the Subfamily and Key and Phylogeny of Genera
Weston Opitz
Psyche , 2012, DOI: 10.1155/2012/752402
Abstract: Four new genera and one new species of the subfamily Tarsosteninae (Coleoptera: Cleridae) are described. The new genera are: Agapetilus Opitz, gen. nov., Fallopylus Opitz, gen., nov, Globoclava Opitz, gen. nov., and Pseudopylus Opitz, gen. nov. The new species involves Agapetilus vietus Opitz. sp. nov. Liostylus Fairmaire is synonymized with Rhophaloclerus Fairmaire. New combinations, Fallopylus pallipes (MacLeay, 1872), comb. nov., Globoclava quadrimaculata (Chevrolat, 1876), comb. nov., Parapylus sedlaceki (Kolibáč, 2003), comb. nov., Pseudopylus okei (Elston, 1929), comb. nov., and Rhophaloclerus pictus (Fairmaire, 1902), comb. nov., are established. A key and phylogeny of the genera of Tarsosteninae is provided.
Widerstreitende Temporalit ten: Recht in Zeiten des Risikos
Sven Opitz
Behemoth : a Journal on Civilisation , 2011,
Abstract: Drawing on Niklas Luhmann’s systems theory, this article approaches the legal exception throughan analysis of conflicting temporalities. According to Luhmann, each subsystem of society possessesa specific mode of relating to past and future events. Law has a specific temporality that is characterizedby its orientation to the past: it deals with deeds done in light of laws already set in place. Luhmannsuggests that considerations of future risks are at odds with the temporality of law. Followingthis idea, it will be argued that future orientated measures such as preventive detention and the doctrineof preemptive warfare introduce the legal exception into law itself. Both cases exhibit differentrationalities of relating to an uncertain, potentially threatening futures that collide with law’s propertemporality. Whereas preventive detention relies on the 19th century idea of the probable crime asincorporated into a ‘dangerous individual’, the preemptive strike thrives on the post-probabilisticanticipation of the unexpected. Both measures indicate the erosion of law’s capacity to sustain anindifferent attitude towards the future. Consequently, both measures thwart law’s retroactivity, albeitin different ways. They articulate a counter-legal temporality within law – and thereby disruptthe legal system.
Sinnlichkeit und Macht Sensuality and Power
Claudia Opitz
querelles-net , 2002,
Abstract: Der Band ist aus einer gleichnamigen Tagung hervorgegangen und versammelt 10 Beitr ge zu h chst unterschiedlichen Themen. Als übergreifendes Interesse formulieren die Herausgeberinnen das Anliegen, Sinneslust und Sinneswandel“ historisch zu begreifen und politisch-emanzipatorische Aspekte dieser historischen Entwicklung zu verstehen und weiterzuführen. Zwar ist die historisch-kulturelle Dimension in den Beitr gen weniger deutlich ausgepr gt, als es eine solche Programmatik erwarten l t. Das Interesse für den Zusammenhang von politischer Macht und Sinnlichkeit dagegen ist in praktisch allen Beitr gen deutlich herausgearbeitet und erscheint insgesamt als lohnender Zugang zu dem derzeit boomenden Feld der Sinnlichkeits- und Emotionenforschung. This reader features the proceedings of a conference on “Sensuality and Changes of Heart” The ten articles featured in the reader aim to render understandable the history of sensuality and its political-emancipatory aspects. Contrary to what one might expect the historical approach only scarcely manifests itself in these articles, as most authors tend to draw on philosophical approaches. Nonetheless, the overarching interest in the relationship between political power and sensuality becomes visible in all of the articles, making this book a worthwhile read for anyone interested in the currently booming field of research on sensuality and emotions.
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