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Los prostanoides, una revolución autacoide
Dominguez,Zury;
Anales Venezolanos de Nutrición , 2006,
Abstract: from 1960 to the end of the xx century, efforts from different laboratories were done to understand the regulation of eicosanoids biosynthesis and metabolism. these autacoids are synthesized from 20 c polyunsaturated fatty acids, from where they got the prefix eico, twenty. the physiologic and in certain conditions pathphysiologic actions, requires ≤ mmolar concentrations remaining active for periods of time ranging from seconds to minutes. during this productive period of the xx century it was possible to identify: 1- araquidonic acid as the main eicosanoid?s precursor, 2- the membrane phospholipids compartment as the cellular storage of the precursor fatty acid and 3- the phospholipases as the enzymes required to liberate the precursor fatty acid rending possible its access to the eicosanoids biosynthetic machinery. two main groups of eicosanoids arrive on the scene, classified in function to its molecular structure, one that includes the cyclic or prostanoids, where the prostaglandin h (pgh) is the universal precursor, pgh is a cyclic endoperoxide synthesized by the enzyme prostaglandin endoperóxido synthase, better known by its acronym cox for cycloxygenase, and the other, linear eicosanoids:: leukotrienes, lypoxines, and epoxides which are products synthesized from different enzymatic pathways including the lypoxygenase and cytochrome oxidases. the most relevant findings in the history of the prostanoids are considered in this review.
O Complexo Avícola em Entre Ríos e suas Rela es Internas The Entre Ríos Chicken-raising Complex and its Inward Relations El Complejo Avícola Entrerriano y las Relaciones en su interior
DOMINGUEZ, Nestor
Revista Brasileira de Gest?o de Negócios , 2007,
Abstract: RESUMO O trabalho faz parte dos avan os obtidos no projeto de pesquisa publicado pela Universidad Nacional de Entre Ríos (UNER). “As granjas avícolas integradas de Entre Ríos, mudan a tecnológica e reconvers o”, Faculdade de Ciências Econ micas, UNER, Expte. 4028-2 UNER, período 2004/2007. O trabalho pretende informar sobre as modalidades organizacionais da cadeia avícola de Entre Ríos nos últimos anos, particularmente no período 2001-2006, onde a característica predominante teve como destaque a expans o e o crescimento do setor e seu impacto nas características socio-tecnológicas das granjas, conforme as diferentes regi es produtoras de frangos existentes. Pelo trabalho é possível concluir que, apesar de ter-se incrementado a capacidade de produ o acompanhado de certo avan o tecnológico, sob a ótica das regi es produtoras e os agentes envolvidos ocorrem importantes heterogeneidades, onde a rentabilidade e as condi es nas quais se desenvolve a atividade, continuam sendo pouco favoráveis para alguns produtores, em conseqüência da disparidade dos agentes sociais e de seu poder de negocia o. ABSTRACT The work is part of the advances arrived in the project of investigation credited by the National University of Entre Ríos (UNER). “The integrated chiken-raising farms of Entre Ríos, technology change and re-conversion “ School of Economics Sciences, UNER, file 4028-2 UNER, 2004/2007. The work tries to give account of the organizational modalities of the chiken-raising chain of Entre Ríos, in the lasts years, particularly in period 2001 - 2005, in which the predominant characteristic was marked by the expansion and the growth of the sector, and its impact in the social and technological characteristics of the farms, according to the different existing productive zones of chickens. From the work it can conclude that, although an increase in the capacity of production accompanied by certain technological advance has taken place, from the plane of the producing zones and the involved agents there are many heterogeneities, in where the yield and the conditions in which the activity is carried out, follow not being the most favorable for some farmers because of the disparities of the social agents and it power of negotiation. RESUMEN El trabajo es parte de los avances arribados en el proyecto de investigación acreditado por la Universidad Nacional de Entre Ríos (UNER). “Las granjas avícolas integradas de Entre Ríos, cambio tecnológico y reconversión”, Facultad de Ciencias Económicas, UNER, Expte. 4028-2 UNER, período 2004/2007. El trabajo pretende analizar y exp
National Background is Associated with Disparities in Initiation and Persistence to Statin Treatment in Subjects with Diabetes in Denmark
Helena Dominguez
Frontiers in Pharmacology , 2010, DOI: 10.3389/fphar.2010.00142
Abstract: Background: To investigate the effects of statin use over the last 10 years among diabetic patients who initiated glucose-lowering medications (GLMs) in Denmark. Methods: we identified all Danish citizens 30 years and older who claimed their first GLM between 1997 and 2006, with follow-up until 2007. Use of medications, national background, income, and hospitalizations were obtained by cross-linkage of national registries in Denmark. We analyzed factors related to initiation and interruption of statin treatment. The analyses included country of birth, citizenship and, as proxy for ethnic origin, we constructed variables based on both the subjects and on their parent’s country of birth. Countries were grouped as Denmark, Western countries, Eastern countries, and Africa. Results: the cohort included 143,625 subjects. Compared with persons of Danish origin, the initiation of a statin medication during follow-up was significantly lower among patients of non-Danish origin: Odds ratio for subjects of Eastern origin 0.61 [CI 0.49–0.76] and 0.37 for subjects of African origin, [CI 0.24–0.59], both p < 0.001. The risk of interrupting statin treatment once it had been initiated was also higher in these groups (hazard ratio 2.03, [CI 1.91–2.17] for Eastern subjects and 1.94, [CI 1.63–2.32] for African subjects, both p < 0.0001). Combination of ethnic parameters to refine identification of the cohort led to the same conclusions as the analysis based only on country of birth or citizenship respectively. Conclusion: diabetes patients of African and Eastern origin in Denmark have less chance of being treated with a statin than those of western and Danish origin despite similar access to the Danish health care system.
Vortex dynamics in disordered Josephson junction arrays: from plastic flow to flux flow
Daniel Dominguez
Physics , 1996, DOI: 10.1016/0921-4526(96)00208-6
Abstract: We study the dynamics of Josephson junction arrays with positional disorder and driven by an external current. We consider weak magnetic fields, corresponding to a frustration $f=n+1/25$ with $n$ integer. We find that above the critical current $i_c$ there is a plastic flow of vortices, where most of the vortices are pinned and only a few vortices flow through channels. This dynamical regime is characterized by strong fluctuations of the total vorticity. The number of the flow channels grow with increasing bias current. At larger currents there is a dynamical regime characterized by the homogeneous motion of all the vortices, i.e. a flux flow regime. We find a dynamical phase transition between the plastic flow and the flux flow regimes when analyzing voltage-voltage correlation functions.
Velocity dispersion in N-body simulations of CDM models
Alvaro Dominguez
Physics , 2001, DOI: 10.1002/asna.200310165
Abstract: This work reports on a study of the spatially coarse-grained velocity dispersion in cosmological N-body simulations (OCDM and Lambda-CDM models) as a function of time (redshifts z=0-4) and of the coarsening length (0.6-20 Mpc/h). The main result is the discovery of a polytropic relationship I_1 ~ rho^{2-eta} between the velocity-dispersion kinetic energy density of the coarsening cells, I_1, and their mass density, rho. The exponent eta, dependent on time and coarsening scale, is a compact measure of the deviations from the naive virial prediction eta_virial=0. This relationship supports the ``polytropic assumption'' which has been employed in theoretical models for the growth of cosmological structure by gravitational instability.
Study of corrections to the dust model via perturbation theory
Alvaro Dominguez
Physics , 2001, DOI: 10.1046/j.1365-8711.2002.05538.x
Abstract: This work reports on the application of the Eulerian perturbation theory to a recently proposed model of cosmological structure formation by gravitational instability (astro-ph/0009414). Its physical meaning is discussed in detail and put in perspective of previous works. The model incorporates in a systematic fashion corrections to the popular dust model due to multistreaming and, more generally, the small-scale, virialized degrees of freedom. It features a time-dependent length scale L(t) estimated to be L/r0 ~ 0.1 (r0(t) is the nonlinear scale, at which the density variance =1). The model provides a new angle on the dust model and allows to overcome some of its limitations. Thus, the scale L(t) works as a physically meaningful short-distance cutoff for the divergences appearing in the perturbation expansion of the dust model when there is too much initial power on small scales. The model also incorporates the generation of vorticity by tidal forces; according to the perturbational result, the filtered vorticity for standard CDM initial conditions should be significant today only at scales below ~ 1 Mpc/h.
Dynamic transition in vortex flow in strongly disordered Josephson junction arrays and superconducting thin films
Daniel Dominguez
Physics , 1998, DOI: 10.1103/PhysRevLett.82.181
Abstract: We study the dynamics of vortices in strongly disordered $d=2$ Josephson junction arrays and superconducting films driven by a current. We find a dynamic phase transition in vortex flow at a current $I_p>I_c$. Below $I_p$ there is plastic flow characterized by an average-velocity correlation length scale $\xi_v$ in the direction of motion, which diverges when approaching $I_p$. Above $I_p$ we find a moving vortex phase with homogeneous flow and short range smectic order. A finite size analysis shows that this phase becomes asymptotically a liquid for large length scales.
Hydrodynamic approach to the evolution of cosmological structures
Alvaro Dominguez
Physics , 2000, DOI: 10.1103/PhysRevD.62.103501
Abstract: A hydrodynamic formulation of the evolution of large-scale structure in the Universe is presented. It relies on the spatially coarse-grained description of the dynamical evolution of a many-body gravitating system. Because of the assumed irrelevance of short-range (``collisional'') interactions, the way to tackle the hydrodynamic equations is essentially different from the usual case. The main assumption is that the influence of the small scales over the large-scale evolution is weak: this idea is implemented in the form of a large-scale expansion for the coarse-grained equations. This expansion builds a framework in which to derive in a controlled manner the popular ``dust'' model (as the lowest-order term) and the ``adhesion'' model (as the first-order correction). It provides a clear physical interpretation of the assumptions involved in these models and also the possibility to improve over them.
Morphology of the large-scale structure
Alvaro Dominguez
Physics , 2001,
Abstract: The Minkowski functionals are a mathematical tool to quantify morphological features of patterns. Some applications to the matter distribution in galaxy catalogues and N-body simulations are reviewed, with an emphasis on the effects of cosmic variance. The conclusions are that (i) the observed large-scale morphology is sensitive to cosmic variance on scales much larger than the nonlinear length (approx. 8 Mpc/h), and (ii) the large-scale morphology predicted by simulations is thus affected by finite-size effects, but nonetheless a Lambda-CDM model is favored.
Filon-Clenshaw-Curtis rules for a class of highly-oscillatory integrals with logarithmic singularities
Victor Dominguez
Mathematics , 2013,
Abstract: In this work we propose and analyse a numerical method for computing a family of highly oscillatory integrals with logarithmic singularities. For these quadrature rules we derive error estimates in terms of $N$, the number of nodes, $k$ the rate of oscillations and a Sobolev-like regularity of the function. We prove that that the method is not only robust but the error even decreases, for fixed $N$, as $k$ increases. Practical issues about the implementation of the rule are also covered in this paper by: (a) writing down ready-to-implement algorithms; (b) analysing the numerical stability of the computations and (c) estimating the overall computational cost. We finish by showing some numerical experiments which illustrate the theoretical results presented in this paper.
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