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Search Results: 1 - 10 of 1446 matches for " Domenico; "
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Agro-Biodiversity Spatial Assessment and Genetic Reserve Delineation for the Pollino National Park (Italy)  [PDF]
Giovanni Figliuolo, Domenico Cerbino
Natural Resources (NR) , 2014, DOI: 10.4236/nr.2014.57029
Abstract:

Ancient fruit trees, grape vines, traditional crop and garden cultivars have been inventoried in Pollino National Park by adopting a spatial sampling grid which covers 23 different municipalities (~1500 Km2) and 190 surveyed sites. Each site is a circle with a visible radius of 200 - 250 m. The spatial analysis of the diversity of plant genetic resources has been conducted with pre-fixed landscape units (size: 4 Km × 4 Km). Overall, 49 different woody long cycle (455 ancient cultivars) and 53 short cycle species (102 ancient cultivars) have been scored. Long cycle species exhibit higher cultivar richness than short cycle species. The analysis has recognized that pre-Columbian indigenous cultivars had not been displaced by the American species introduced after the 16th century. In addition, it is confirmed that small-scale poly-production, under conditions of spatial niche variation, is associated to high species and cultivar richness. The mapped realized niche, for both pre- and post-Columbian genetic resources, includes the actual genetic reserve suitable for in situ conservation of plant agro-biodiversity. Agro-biodiversity models, drivers of genetic erosion, and realistic responses to genetic erosion are outlined.

The Open Access Model, Trends and Opportunities in Accounting Research  [PDF]
Simone Domenico Scagnelli
Open Journal of Accounting (OJAcct) , 2014, DOI: 10.4236/ojacct.2014.31001
Abstract: The Open Access Model, Trends and Opportunities in Accounting Research
Neuropathological Changes in Hydrocephalus—A Comprehensive Review  [PDF]
Domenico L. Di Curzio
Open Journal of Modern Neurosurgery (OJMN) , 2018, DOI: 10.4236/ojmn.2018.81001
Abstract: Hydrocephalus is a heterogeneous, neurological condition characterized by altered flow of cerebrospinal fluid (CSF) that can occur at any age. Neuropathological changes associated with hydrocephalus are dependent on the age of onset, rate of ventricular enlargement, and the etiology. Hydrocephalic brain damage is also influenced by contributions from both mechanical forces and metabolic changes, which increases the heterogeneity of the condition. However, as ventriculomegaly progresses, the surrounding brain tissue is compressed within the cranial vault, elevating intracranial pressure and eventually leading to severe brain damage. From this perspective, it makes sense that periventricular brain regions are the initial sites of damage as ventricular dilatation occurs. The following review of neuropathological changes in hydrocephalus will first discuss cellular and region specific damage from the ventricles and outward towards the cortex and brainstem. This will be followed by vascular and hypoxic changes associated with the condition. Both types of brain impairments are dependent on the severity of the condition, and they will be described accordingly.
Animal Models of Hydrocephalus  [PDF]
Domenico L. Di Curzio
Open Journal of Modern Neurosurgery (OJMN) , 2018, DOI: 10.4236/ojmn.2018.81004
Abstract:

Hydrocephalus is a neurological condition characterized by altered cerebrospinal fluid (CSF) flow leading to an accumulation of CSF inside the cranial vault. Neuropathogenesis associated with hydrocephalus has been elucidated by pathological studies of human brains and through experimental and genetic animal models. Experimental animal models have been developed in numerous species using a variety of methods and agents to induce hydrocephalus or through genetic mutations in rodents. Each of these animal models has been described briefly in this review, along with the basic strengths and weaknesses of each model. Although none of these models can fully mimic the human condition, they each provide fundamental knowledge contributing to understanding more about the pathogenesis of hydrocephalus and its underlying causes.

Neural Modulation of Hemiparetic Shoulder Pain by Repetitive Ultrasound-Guided Suprascapularis Nerve Block  [PDF]
Luigi Di Lorenzo,Santopadre Domenico
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.33030
Abstract: Background: Neural blockade is widely used in clinical practice to alleviate acute or chronic pain, including pain during rehabilitation. To date there is little controlled evidence to confirm the efficacy of nerve blocks in hemiparetic shoulder pain after stroke. Design: This study is a prospective, open label, cohort trial reporting result from a cohort of stroke patients affected by shoulder pain. Aim: As a cohort study report, in which it is often firstly reported the possibility of an association between an observed effect and a specific environmental based on detailed clinical evaluations and histories, we aim to firstly provide clues in identifying Suprascapularis Nerve blockade as further valuable approach for shoulder pain after stroke. Population: We studied a cohort of patients affected by hemiparetic shoulder pain after Stroke. Methods: Our protocol foresees nerve blocks to be performed each 3 out of 4 days (treatment lasting 30 days) in conjunction with a rehabilitation program with the first aim to provide the window of opportunity to proceed with effective rehabilitation. 47 potential study subjects fulfilled the study criteria and were enrolled. Twenty-four subjects were randomised to the study Group to receive SSNB for the pain of their hemiparetic shoulder while 23 subjects randomized to the control Group whose member did not receive SSNB. They received serial blocks each 3 out of 4 days during rehabilitation.Results: Both treatment reported a reduction in the intensity of their shoulder pain, according to data collected from day 1 through day 42 (6 weeks). Study Group patients, receiving SSNBs, reported significant improvement from entry through the whole follow-up period. The efficiency data were higher for SSNB Group after 2 weeks and again for SSNb group at the end of treatment. Conclusion: Excellent pain relief was achieved in SSNB without clinically relevant complications, these patients having a better improvement on pain during rehabilitation, than the control subjects. Great efficacy has been achieved by combining a nerve block and rehabilitation. About Clinical Rehabilitation Impact, we believe that Suprascapularis nerve blocks can help the stroke survivors maintain an ambulatory or outpatient treatment status, maintain participation in a physical therapy or rehabilitation program, decrease the need for analgesics and in some cases lead to a complete pain relief.
Neural Modulation of Hemiparetic Shoulder Pain by Repetitive Ultrasound-Guided Suprascapularis Nerve Block  [PDF]
Luigi Di Lorenzo, Santopadre Domenico
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.33030
Abstract:

Background: Neural blockade is widely used in clinical practice to alleviate acute or chronic pain, including pain during rehabilitation. To date there is little controlled evidence to confirm the efficacy of nerve blocks in hemiparetic shoulder pain after stroke. Design: This study is a prospective, open label, cohort trial reporting result from a cohort of stroke patients affected by shoulder pain. Aim: As a cohort study report, in which it is often firstly reported the possibility of an association between an observed effect and a specific environmental based on detailed clinical evaluations and histories, we aim to firstly provide clues in identifying Suprascapularis Nerve blockade as further valuable approach for shoulder pain after stroke. Population: We studied a cohort of patients affected by hemiparetic shoulder pain after Stroke. Methods: Our protocol foresees nerve blocks to be performed each 3 out of 4 days (treatment lasting 30 days) in conjunction with a rehabilitation program with the first aim to provide the window of opportunity to proceed with effective rehabilitation. 47 potential study subjects fulfilled the study criteria and were enrolled. Twenty-four subjects were randomised to the study Group to receive SSNB for the pain of their hemiparetic shoulder while 23 subjects randomized to the control Group whose member did not receive SSNB. They received serial blocks each 3 out of 4 days during rehabilitation.Results: Both treatment reported a reduction in

Trans-Human and Post-Human: A Challenge for the Human and Philosophical Sciences  [PDF]
Marta Toraldo, Domenico Maurizio Toraldo
Open Journal of Philosophy (OJPP) , 2019, DOI: 10.4236/ojpp.2019.91005
Abstract: This paper describes the concept of scientific knowledge in both modern and post-modern society. It presents a brief analysis of how the value of scientific knowledge is changing in contemporary society and describes future developments linked to the new concept of trans-humanism. The term “post-human” refers to a progressive alteration of human characteristics by means of genetic and electronic manipulation that results in an anthropological mutation, which is a prelude to the advent of a new, and post-human species. The term “trans-human” means more than human, beyond human, transcending the limits of the human condition and aspiring to an almost divine superior meaning. This new modified condition of human beings is defined as post-human and the process of change is described within the cultural framework of humanism. Trans-humanism as a term refers to a philosophical doctrine belonging to the family of contemporary progressive ideologies in which trans-humanist intellectuals analyse and promote technologies aimed at overcoming the limits of human nature. Analyzing the trends, the anthropological implications and the cultural impact of such technologies, this new philosophical/scientific doctrine tends to emphasise the positive aspects of scientific development, but without underestimating the potential dangers arising from the misuse of technology. The open ethical challenge of trans-humanism is twofold: 1) the physical improvement of human beings with reference to the new trans-human concept of human nature; 2) the development of a trans-human being that can fulfil humanity’s dream of escaping the bonds of its condition, acquiring a “cybernetic nature” free from pain and suffering.
Therapeutic Use of Botulinum Toxin in Neurorehabilitation
Domenico Intiso
Journal of Toxicology , 2012, DOI: 10.1155/2012/802893
Abstract: The botulinum toxins (BTX), type A and type B by blocking vesicle acetylcholine release at neuro-muscular and neuro-secretory junctions can result efficacious therapeutic agents for the treatment of numerous disorders in patients requiring neuro-rehabilitative intervention. Its use for the reduction of focal spasticity following stroke, brain injury, and cerebral palsy is provided. Although the reduction of spasticity is widely demonstrated with BTX type A injection, its impact on the improvement of dexterity and functional outcome remains controversial. The use of BTX for the rehabilitation of children with obstetrical brachial plexus palsy and in treating sialorrhea which can complicate the course of some severe neurological diseases such as amyotrophic lateral sclerosis and Parkinson's disease is also addressed. Adverse events and neutralizing antibodies formation after repeated BTX injections can occur. Since impaired neurological persons can have complex disabling feature, BTX treatment should be viewed as adjunct measure to other rehabilitative strategies that are based on the individual's residual ability and competence and targeted to achieve the best functional recovery. BTX therapy has high cost and transient effect, but its benefits outweigh these disadvantages. Future studies must clarify if this agent alone or adjunctive to other rehabilitative procedures works best on functional outcome. 1. Introduction Botulinum toxins are some of the most potent poisons present in nature produced by the anaerobic bacterium Clostridium Botulinum. Historically, these toxins were predominantly associated with a food-borne toxicosis producing a neurological life-threatening disease called “botulism”, characterized by a severe generalized muscular paralysis and cholinergic autonomic blockade. Currently, botulinum toxins have become established as efficacious therapeutic agents for the treatment of numerous medical disorders. Seven types of toxins have been harvested from clostridium, designated A through G, but only type A (BTX-A) and B (BTX-B) are commercially available and used in clinical practice. In 1989, the Food and Drug Administration approved BTX-A for the treatment of strabismus; since then, the growing use of this drug in several neurological disturbances has made it one of the most important advancements in the therapeutics of movement disorders such as muscular dystonia and dyskinesia. At the same time, botulinum toxin (BTX) either alone or adjunct to other measures has emerged as a new important therapeutic strategy for clinicians, treating a
Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs
Domenico Fuoco
Antibiotics , 2012, DOI: 10.3390/antibiotics1010001
Abstract: By studying the literature about tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are well known, especially against bacteria, while against other targets, they are virtually unknown. In other diverse fields of research—such as neurology, oncology and virology—the utility and activity of the tetracyclines are being discovered and are also emerging as new technological fronts. The first aim of this paper is to classify the compounds already used in therapy and prepare the schematic structure that includes the next generation of TCs. The second aim of this work is to introduce a new framework for the classification of old and new TCs, using a medicinal chemistry approach to the structure of those drugs. A fully documented Structure-Activity-Relationship (SAR) is presented with the analysis data of antibacterial and nonantibacterial (antifungal, antiviral and anticancer) tetracyclines. The lipophilicity and the conformational interchangeability of the functional groups are employed to develop the rules for TC biological activity.
The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis
Domenico Ribatti
Pharmaceuticals , 2010, DOI: 10.3390/ph3030482
Abstract: Antiangiogenesis, e.g., inhibition of blood vessel growth, is being investigated as a way to prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological inhibition interferes with the angiogenic cascade or the immature neovasculature with synthetic or semi-synthetic substances, endogenous inhibitors or biological antagonists.The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane, which serves as a gas exchange surface and its function is supported by a dense capillary network. Because its extensive vascularization and easy accessibility, CAM has been used to study morphofunctional aspects of the angiogenesis process in vivo and to study the efficacy and mechanism of action of pro- and anti-angiogenic molecules. The fields of application of CAM in the study of antiangiogenesis, including our personal experience, are illustrated in this review article.
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