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Search Results: 1 - 10 of 30896 matches for " Do Seon Song "
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Durability of viral response after off-treatment in HBeAg positive chronic hepatitis B
Myeong Jun Song,Do Seon Song,Hee Yeon Kim,Sun Hong Yoo
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i43.6277
Abstract: AIM: To evaluate the durability in hepatitis B e antigen (HBeAg) positive chronic hepatitis B patients who discontinued antiviral treatment. METHODS: A total of 48 HBeAg positive chronic hepatitis B patients who were administered nucleoside analogues and maintained virological response for ≥ 6 mo [hepatitis B virus (HBV) DNA < 300 copies/mL and HBeAg seroconversion] before cessation of treatment were enrolled between February 2007 and January 2010. The criteria for the cessation of the antiviral treatment were defined as follows: (1) achievement of virological response; and (2) duration of consolidation therapy (≥ 6 mo). After treatment cessation, the patients were followed up at 3-6 mo intervals. The primary endpoint was serologic and virologic recurrence rates after withdrawal of antiviral treatment. Serologic recurrence was defined as reappearance of HBeAg positivity after HBeAg seroconversion. Virologic recurrence was defined as an increase in HBV-DNA level > 104 copies/mL after HBeAg seroconversion with previously undetectable HBV-DNA level. RESULTS: During the median follow-up period of 18.2 mo (range: 5.1-47.5 mo) after cessation of antiviral treatment, the cumulative serological recurrence rate was 15 % at 12 mo. The median duration between the cessation of antiviral treatment and serologic recurrence was 7.2 mo (range: 1.2-10.9 mo). Of the 48 patients with HBeAg positive chronic hepatitis, 20 (41.6%) showed virological recurrence. The cumulative virologic recurrence rates at 12 mo after discontinuing the antiviral agent were 41%. The median duration between off-treatment and virologic recurrence was 7.6 mo (range: 4.3-27.1 mo). The mean age of the virological recurrence group was older than that of the non-recurrence group (46.7 ± 12.1 years vs 38.8 ± 12.7 years, respectively; P = 0.022). Age (> 40 years) and the duration of consolidation treatment (≥ 15 mo) were significant predictive factors for offtreatment durability in the multivariate analysis [P = 0.049, relative risk (RR) 0.31, 95% CI (0.096-0.998) and P = 0.005, RR 11.29, 95% CI (2.054-65.12), respectively]. Patients with age (≤ 40 years) who received consolidation treatment (≥ 15 mo) significantly showed durability in HBeAg positive chronic hepatitis B patients (P = 0.014). These results suggest that additional treatment for more than 15 mo after HBeAg seroconversion in patients who are ≤ 40 years old may be beneficial in providing a sustained virological response. CONCLUSION: Our data suggest that HBeAg seroconversion is an imperfect end point in antiviral treatment. Long-term consol
A Cosmological Test of Standard Gravity by Weak Lensing
Yong-Seon Song
Physics , 2006,
Abstract: The large scale structure formation in the standard Einstein gravity at later time is uniquely determined by the expansion history H(z) measured by the geometrical factor. A possible departure from the expected standard structure formation is detectable by growth structure test. We design new deviation parameters to test standard gravity at large scales and estimate the expected errors by weak lensing experiment. The effective Newtonian constant G_N at the present time can be constrained around 10% accuracy by measuring the difference curvature perturbations (\Phi-\Psi)/2 within 2% accuracy.
Coherent Combination of Baryon Acoustic Oscillation Statistics and Peculiar Velocity Measurements from Redshift Survey
Yong-Seon Song
Physics , 2010, DOI: 10.1103/PhysRevD.83.103009
Abstract: New statistical method is proposed to coherently combine Baryon Acoustic Oscillation statistics (BAO) and peculiar velocity measurements exploiting decomposed density-density and velocity-velocity spectra in real space from the observed redshift distortions in redshift space, 1) to achieve stronger dark energy constraints, \sigma(w)=0.06 and \sigma(w_a)=0.20, which are enhanced from BAO or velocity measurements alone, and 2) to cross-check consistency of dark energy constraints from two different approaches; BAO as geometrical measurements and peculiar velocity as large scale structure formation observables. In addition to those advantages, as power spectra decomposition procedure is free from uncertainty of galaxy bias, this simultaneous fitting is an optimal method to extract cosmological parameters without any pre-assumption about galaxy bias.
Direct Determination of Expansion History Using Redshift Distortions
Yong-Seon Song
Physics , 2012, DOI: 10.1103/PhysRevD.87.023005
Abstract: We investigate the direct determination of expansion history using redshift distortions without plugging into detailed cosmological parameters. The observed spectra in redshift space include a mixture of information: fluctuations of density-density and velocity-velocity spectra, and distance measures of perpendicular and parallel components to the line of sight. Unfortunately it is hard to measure all the components simultaneously without any specific prior assumption. Common prior assumptions include a linear/quasi-linear model of redshift distortions or a model for the shape of the power spectra, which eventually breaks down on small scales at later epochs where nonlinear structure formation disturbs coherent growth. The degeneracy breaking, between the effect of cosmic distances and redshift distortions for example, depends on the prior we assume. An alternative approach is to utilize the cosmological principle inscribed in the heart of the Friedmann-Lematre-Robertson-Walker (hereafter FLRW) universe, that is, the specific relation between the angular diameter distance and the Hubble parameter, in this degeneracy breaking. We show that utilizing this FLRW prior early in the step of distinguishing the distance effect from redshift distortions helps us improve the detectability of power spectra and distance measures with no leaning on a combination of other experiments.
Decomposition of Spectra from Redshift Distortion Maps
Yong-Seon Song,Issha Kayo
Physics , 2010, DOI: 10.1111/j.1365-2966.2010.16955.x
Abstract: We develop an optimized technique to extract density--density and velocity--velocity spectra out of observed spectra in redshift space. The measured spectra of the distribution of halos from redshift distorted mock map are binned into 2--dimensional coordinates in Fourier space so as to be decomposed into both spectra using angular projection dependence. With the threshold limit introduced to minimize nonlinear suppression, the decomposed velocity--velocity spectra are reasonably well measured up to scale k=0.07 h/Mpc, and the measured variances using our method are consistent with errors predicted from a Fisher matrix analysis. The detectability is extendable to k\sim 0.1 h/Mpc with more conservative bounds at the cost of weakened constraint.
The Detectability of Departures from the Inflationary Consistency Equation
Yong-Seon Song,Lloyd Knox
Physics , 2003, DOI: 10.1103/PhysRevD.68.043518
Abstract: We study the detectability, given CMB polarization maps, of departures from the inflationary consistency equation, r \equiv T/S \simeq -5 n_T, where T and S are the tensor and scalar contributions to the quadrupole variance, respectively. The consistency equation holds if inflation is driven by a slowly-rolling scalar field. Departures can be caused by: 1) higher-order terms in the expansion in slow-roll parameters, 2) quantum loop corrections or 3) multiple fields. Higher-order corrections in the first two slow-roll parameters are undetectably small. Loop corrections are detectable if they are nearly maximal and r \ga 0.1. Large departures (|\Delta n_T| \ga 0.1) can be seen if r \ga 0.001. High angular resolution can be important for detecting non-zero r+5n_T, even when not important for detecting non-zero r.
A limit on the detectability of the energy scale of inflation
Lloyd Knox,Yong-Seon Song
Physics , 2002, DOI: 10.1103/PhysRevLett.89.011303
Abstract: We show that the polarization of the cosmic microwave background can be used to detect gravity waves from inflation if the energy scale of inflation is above 3.2 times 10^15 GeV. These gravity waves generate polarization patterns with a curl, whereas (to first order in perturbation theory) density perturbations do not. The limiting ``noise'' arises from the second--order generation of curl from density perturbations, or rather residuals from its subtraction. We calculate optimal sky coverage and detectability limits as a function of detector sensitivity and observing time.
UP780, a Chromone-Enriched Aloe Composition, Enhances Adipose Insulin Receptor Signaling and Decreases Liver Lipid Biosynthesis  [PDF]
Julie Tseng-Crank, Seon-Gil Do, Brandon Corneliusen, Carmen Hertel, Jennifer Homan, Mesfin Yimam, Jifu Zhao, Qi Jia
Open Journal of Genetics (OJGen) , 2013, DOI: 10.4236/ojgen.2013.32A2002
Abstract:

Nutrigenomic studies were conducted to uncover the mechanism of action for the hypoglycemic and insulin sensitizing effects of UP780. From high fat diet-induced obesity mouse model for UP780, livers and white adipose tissues (WAT) from groups of lean control, high fat diet (HFD), and HFD treated with UP780 were collected for microarray study. Microarray generated gene expression changes were applied to Ingenuity Pathway Analysis for changes in canonical metabolic and signaling pathways. Microarray was validated by quantitative reverse transcriptase-polymerase chain reaction (QPCR), Western blots, liver triglyceride, liver cholesterol, liver steatosis, and insulin ELISA. UP780 treatment decreased liver gene expressions for multiple enzymes involved in fatty acid biosynthesis and triglyceride production. UP780 treatment increased gene expressions globally for the insulin receptor signaling pathway in WAT. Both liver triglyceride and liver cholesterol levels were significantly reduced by UP780 over HFD. The reduction of liver fat was confirmed by microscopic analysis of liver steatosis. Finally, UP780 significantly decreased fasting plasma insulin level over HFD. The mechanism of action for UP780 indicated a reduction of liver fat accumulation and an enhancement in adipose tissue insulin signaling pathway. This provided mechanistic explanation for the in vivo UP780 effects of enhanced insulin sensitiveity and decreased blood glucose in mouse diabetes and prediabetes models.

Enhancement of Lipid Extraction from Marine Microalga, Scenedesmus Associated with High-Pressure Homogenization Process
Seok-Cheol Cho,Woon-Yong Choi,Sung-Ho Oh,Choon-Geun Lee,Yong-Chang Seo,Ji-Seon Kim,Chi-Ho Song,Ga-Vin Kim,Shin-Young Lee,Do-Hyung Kang,Hyeon-Yong Lee
Journal of Biomedicine and Biotechnology , 2012, DOI: 10.1155/2012/359432
Abstract: Marine microalga, Scenedesmus sp., which is known to be suitable for biodiesel production because of its high lipid content, was subjected to the conventional Folch method of lipid extraction combined with high-pressure homogenization pretreatment process at 1200 psi and 35°C. Algal lipid yield was about 24.9% through this process, whereas only 19.8% lipid can be obtained by following a conventional lipid extraction procedure using the solvent, chloroform : methanol (2 : 1, v/v). Present approach requires 30 min process time and a moderate working temperature of 35°C as compared to the conventional extraction method which usually requires >5 hrs and 65°C temperature. It was found that this combined extraction process followed second-order reaction kinetics, which means most of the cellular lipids were extracted during initial periods of extraction, mostly within 30 min. In contrast, during the conventional extraction process, the cellular lipids were slowly and continuously extracted for >5 hrs by following first-order kinetics. Confocal and scanning electron microscopy revealed altered texture of algal biomass pretreated with high-pressure homogenization. These results clearly demonstrate that the Folch method coupled with high-pressure homogenization pretreatment can easily destruct the rigid cell walls of microalgae and release the intact lipids, with minimized extraction time and temperature, both of which are essential for maintaining good quality of the lipids for biodiesel production.
Effect of Autologus Platelet-Rich Plasma on IL-6, MMP-3 and MCP-1 Expression in Synoviocytes from Osteoarthritic Patients Knees  [PDF]
Chang Ich Hur, Cheol Park, Hanlou Li, Jong Keun Seon, Hyun Keun Kim, Taek Rim Yoon, Eun-Kyoo Song
Open Journal of Regenerative Medicine (OJRM) , 2014, DOI: 10.4236/ojrm.2014.33008
Abstract: Nowadays, some studies reported promising results of platelet-rich plasma (PRP) for the treatment of osteoarthritis (OA). However, the effects of PRP on prevention of osteoarthritis in knee joints have been debated. The present study investigated the effects of PRP on osteoarthritis related inflammatory cytokines expressed in fibroblast-like synoviocytes (FLS) from osteoarthritic knees. The synovial tissues were harvested from eight osteoarthritic patients who had undertaken total knee arthroplasties (TKAs) and cultured in DMEM containing 10% FBS. Platelet-rich plasma releasate (PRPr) was made by clotting or activation of PRP by citrate. The levels of PDGF-AA and VEGF in PRPr and whole blood were measured with ELISA method. The FLS were isolated and cultured from osteoarthritic knees. The IL-1β stimulated FLS were cultivated with three different conditions (none, 1% and 10% of PRP). To determine the expression of IL-6, MMP-3, and MCP-1, we used reverse transcriptase polymerase chain reaction (RT-PCR). The concentrations of platelet count in PRP were about 7 to 9 times higher than those of whole blood. The levels of PDGF-AA in PRPr were approximately 3 to 4 times higher than those of whole blood. The levels of VEGF in PRPr were also significantly 7 to 18 times higher than those of whole blood. Without induction of the FLS with IL-1β, 1% or 10% PRPr did not reduce expressions of inflammatory proteins (MMP-3, MCP-1), except for IL-6. However, with induction of the FLS with IL-1β, both concentrations (1% and 10%) of PRPr reduced significantly all inflammatory protein expressions (IL-6, MMP-3, MCP-1). PRPr diminished inflammatory IL-1β-mediated effects on human osteoarthritic fibroblast-like synoviocytes. These results suggest that platelet-rich plasma can be a good therapeutic option for the treatment of osteoarthritis.
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