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Search Results: 1 - 10 of 185 matches for " Dipti Khopkar "
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Functional Recovery in Chronic Stage of Spinal Cord Injury by Neurorestorative Approach: A Case Report
Alok Sharma,Hemangi Sane,Dipti Khopkar,Nandini Gokulchandran,V. C. Jacob,Joji Joseph,Prerna Badhe
Case Reports in Surgery , 2014, DOI: 10.1155/2014/404207
Abstract: Spinal cord injury (SCI) at an early age can be debilitating for the child’s growth. Current treatments show a level of stagnancy, after which the recovery is minimal. Cellular therapy is an emerging area of research and has been found to possess many benefits in the previous studies. Transplantation of autologous bone marrow mononuclear cells (BMMNCs) has demonstrated therapeutic potential for many neurological conditions, including spinal cord injury. Here we report a case of 6-year-old girl with traumatic SCI at the level of C7-D1 4 years back, who underwent 2 doses of cell transplantation with autologous BMMNCs with an interval of 6 months along with standard rehabilitation. The patient did not have any major or minor side effects. The patient showed clinical improvements throughout the 6 months after transplantation, which was assessed using Functional Independence Measure (before: 82, after: 101 out of 126). There were patchy areas of sensory gain in bilateral feet recorded, with improvements in the bladder sensation and control. Improved gait was seen as a result of better strength in abdominals and back extensors. The fact that there was functional improvement in the chronic plateau phase indicates the potential of cell therapy in chronic SCI. Further clinical studies are warranted. 1. Introduction Spinal cord injury (SCI) at an early age is very debilitating for the child in every aspect of life, since it hinders their physical, emotional, and social growth [1]. The major cause of this event is road traffic accidents. Other causes include falls, sports injuries, or violence [2]. Spinal cord injuries are complex, as the central nervous system has a limited capability of regeneration [3]. In spinal cord injury, there is a partial or total disruption of the ascending and descending tracts, which carry information to and from the brain. This poses a great challenge for the health professionals involved in the rehabilitation team, as regeneration needs to happen in between the nerve fibers of the two stumps of the cord [2]. The levels of spinal cord injury may vary, with cervical spine injury leading to quadriplegia; and thoracic and lumbar injuries leads to paraplegia [2]. One of the recent and developing options in improving the condition of patients with neurologically compromised conditions, including spinal cord injury, is cellular therapy. Autologous bone marrow cells have been deemed to be relatively safe option for treating this group of patients. Their effects have been seen in many of the ongoing clinical studies. They are free from any
Autologous Bone Marrow Mononuclear Cells Intrathecal Transplantation in Chronic Stroke
Alok Sharma,Hemangi Sane,Nandini Gokulchandran,Dipti Khopkar,Amruta Paranjape,Jyothi Sundaram,Sushant Gandhi,Prerna Badhe
Stroke Research and Treatment , 2014, DOI: 10.1155/2014/234095
Abstract: Cell therapy is being widely explored in the management of stroke and has demonstrated great potential. It has been shown to assist in the remodeling of the central nervous system by inducing neurorestorative effect through the process of angiogenesis, neurogenesis, and reduction of glial scar formation. In this study, the effect of intrathecal administration of autologous bone marrow mononuclear cells (BMMNCs) is analyzed on the recovery process of patients with chronic stroke. 24 patients diagnosed with chronic stroke were administered cell therapy, followed by multidisciplinary neurorehabilitation. They were assessed on functional independence measure (FIM) objectively, along with assessment of standing and walking balance, ambulation, and hand functions. Out of 24 patients, 12 improved in ambulation, 10 in hand functions, 6 in standing balance, and 9 in walking balance. Further factor analysis was done. Patients of the younger groups showed higher percentage of improvement in all the areas. Patients who underwent cell therapy within 2 years after the stroke showed better changes. Ischemic type of stroke had better recovery than the hemorrhagic stroke. This study demonstrates the potential of autologous BMMNCs intrathecal transplantation in improving the prognosis of functional recovery in chronic stage of stroke. Further clinical trials are recommended. This trial is registered with NCT02065778. 1. Introduction Recovery after stroke is quite heterogeneous, as it is determined by the site and extent of lesion. The process of recovery occurs through a combination of spontaneous and learning-dependent processes. These include restitution (restoring the functional status of the injured neural tissue), substitution (reorganization of the spared pathways in order to relearn the lost functions), and compensation (reducing the disparity between the impaired function of the patient and the environmental demands on the patient) [1]. The process by which the above events occur includes angiogenesis, neurogenesis, and synaptic plasticity [2]. The overall outcome of these patients improves with rapid diagnosis, early preventive treatment, early recognition of complications, and mobilization [3]. After a central nervous system (CNS) insult like stroke, the quiescent stem cells present in the bone marrow show increased mobilization and migration from their resident bone marrow into the blood circulation as a result of cytokine production from the CNS. Thus the recruitment of bone marrow cells in the injured area of the brain is amplified. This process is the
On the Theory of Topological Computation in the Lowest Landau Level of QHE  [PDF]
Dipti Banerjee
Journal of Quantum Information Science (JQIS) , 2011, DOI: 10.4236/jqis.2011.13017
Abstract: We have studied the formation of Hall-qubit in lowest Landau level of (LLL) Quantum Hall effect due to the Aharonov-Bhom oscillation of quasiparticles.The spin echo method plays the key role in the topological entanglement of qubits. The proper ratio of fluxes for maximally entangling qubits has also been pointed out. The generation of higher Quantum Hall state may be possible with the help of quantum teleportation.
Exploring the Efficacy & Suitability of Flipped Classroom Instruction at School Level in India: A Pilot Study  [PDF]
Atasi Mohanty, Dipti Parida
Creative Education (CE) , 2016, DOI: 10.4236/ce.2016.75079
Abstract: The objective of this study was to compare the impact of flipped mode and traditional mode of instruction, on the learning outcomes of Grade VIII school children in History and Science; 90 primary school children from Odisha (India) were randomly assigned to either of control (traditional instruction) or experimental (flipped instruction) group. Pre-test scores of both the groups were compared through “t” test; the obtained “t” values of -0.019 and 1.931 were found to be insignificant (p > 0.05) which revealed no significant difference between these groups at the beginning. Thus, both the groups were assumed to have equal variance and after 01 month their post-test scores in History and Science were again compared to examine the impact of different instructional intervention/s. The obtained “t” values of both the groups’ post-test scores comparisons were -5.592, -3.260, found to be significant at p < 0.01 level, and confirmed the difference between control and experimental groups. Mean scores of flipped and traditional instructional groups further strengthened the positive impact of flipped mode of instruction on children’s learning outcomes in History and Science. The study recommends for future work on flipped instruction with larger sample for educational implications.
IJDVL gets into the Science Citation Index Expanded!
Khopkar Uday
Indian Journal of Dermatology, Venereology and Leprology , 2008,
IJDVL at the crossroads
Khopkar U
Indian Journal of Dermatology, Venereology and Leprology , 2003,
2006: Another fruitful year for IJDVL
Khopkar Uday
Indian Journal of Dermatology, Venereology and Leprology , 2007,
Reporting of drug eruptions: The national pharmacovigilance program
Khopkar Uday
Indian Journal of Dermatology, Venereology and Leprology , 2005,
IJDVL: Looking back at the year 2004-2005
Khopkar Uday
Indian Journal of Dermatology, Venereology and Leprology , 2005,
IJDVL is now indexed with PubMed
Khopkar Uday
Indian Journal of Dermatology, Venereology and Leprology , 2006,
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