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Search Results: 1 - 10 of 114111 matches for " Diogo O. Pimentel "
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Impacto da análise do "wavefront" na refratometria de pacientes com ceratocone
Ambrósio Junior, Renato;Caldas, Diogo Leit？o;Silva, Renata Siqueira da;Pimentel, Leonardo Nogueira;Valbon, Bruno de Freitas;
Revista Brasileira de Oftalmologia , 2010, DOI: 10.1590/S0034-72802010000500004
Abstract: objective: to verify if the total ocular aberrometry (wavefront analysis) facilitates manifest refraction and improvement in best spectacle distance corrected visual acuity (bscdva) with sphero-cylindrical lenses, in keratoconus cases with some degree of contact lenses intolerance. methods: retrospective chart review of 46 patients (89 eyes) referred with keratoconus and contact lenses intolerance was performed. ocular aberrometry with ray tracing was followed by manifest refraction. bscdva (logmar) with the previous correction was compared with the one obtained based on the wavefront auto-refraction. the nonparametric test of wilcoxon for paired samples was used to test statistically significant differences in bscdva. results: there was a statistically significant improvement in bscdva with the new manifest refraction (p <0,0001). the average bscdva changed from 0,37 or 20/47 (varying between 1,3 and 0; standard deviation [sd] = 0,25) with previous refraction to 0,23 or 20/34 (varying between 1 and 0,1; sd = 0,21). 52 eyes (58,4%) of 28 patients showed improvement in bscdva with the new refraction. the average improvement was 0,13 logmar (1,3 lines on snellen chart), varying between zero and 0,6 (6 lines), with standard deviation of 0,16. eight patients had significant anisometropia that limited the prescription of glasses. conclusion: aberrometry facilitated the refraction, determining significant improvement in visual acuity with sphero-cylindrical lenses in keratoconus patients intolerant to contact lenses. the anisometropia was a limiting factor in the prescription of glasses.
Impacto da análise do 'wavefront' na refratometria de pacientes com ceratocone
Ambrósio Junior, Renato;Caldas, Diogo Leit？o;Silva, Renata Siqueira da;Pimentel, Leonardo Nogueira;Valbon, Bruno de Freitas;
Revista Brasileira de Oftalmologia , 2011, DOI: 10.1590/S0034-72802011000100004
Abstract: objective: to verify if the total ocular aberrometry (wavefront analysis) facilitates manifest refraction and improvement in best spectacle distance corrected visual acuity (bscdva) with sphero-cylindrical lenses, in keratoconus cases with some degree of contact lenses intolerance. methods: retrospective chart review of 46 patients (89 eyes) referred with keratoconus and contact lenses intolerance was performed. ocular aberrometry with ray tracing was followed by manifest refraction. bscdva (logmar) with the previous correction was compared with the one obtained based on the wavefront autorefraction. the nonparametric test of wilcoxon for paired samples was used to test statistically significant differences in bscdva. results: there was a statistically significant improvement in bscdva with the new manifest refraction (p <0,0001). the average bscdva changed from 0,37 or 20/47 (varying between 1,3 and 0; standard deviation [sd] = 0,25) with previous refraction to 0,23 or 20/34 (varying between 1 and 0,1; sd = 0,21). 52 eyes (58,4%) of 28 patients showed improvement in bscdva with the new refraction. the average improvement was 0,13 logmar (1,3 lines on snellen chart), varying between zero and 0,6 (6 lines), with standard deviation of 0,16. eight patients had significant anisometropia that limited the prescription of glasses. conclusion: aberrometry facilitated the refraction, determining significant improvement in visual acuity with sphero-cylindrical lenses in keratoconus patients intolerant to contact lenses. the anisometropia was a limiting factor in the prescription of glasses.
Ceratoplastia em crian？as: indica？？es e resultados
Pimentel, Leonardo Nogueira;Caldas, Diogo Leit？o;Valbon, Bruno de Freitas;Canedo, Ana Laura Caiado;Ramos, Isaac Carvalho de Oliveira;
Revista Brasileira de Oftalmologia , 2011, DOI: 10.1590/S0034-72802011000200006
Abstract: purpose: to evaluate the indications and results after penetrating keratoplasty in children at altino ventura foundation (fav). methods: a retrospective study was performed in 33 patients (34 eyes), with ages equal or less than 12 years, they underwent a penetrating keratoplasty at fav, from 2000 to 2009. the mean follow up time was 32.5 ± 23.1 months. surgery indication, best corrected visual acuity (bcva) before and after surgery, spherical equivalent (se) pos surgical and complications were analyzed. the qualitative results were expressed by their frequencies and the quantitative by their means and standard deviations. the t-student test was used to verify possible differences between means. the level of significance was 95.0% (p<0.05). results: mean age at surgery was 7.5 ± 3.3 years. twenty seven (79.4%) grafts had optical indication and seven (20.6%) therapeutic or tectonic. among the optical transplants, the most frequent indication was cornea opacity after ocular trauma in 18 (52.9%) eyes. the visual acuity was better in 21 (61.7%) eyes and worse in eight (23.5%). in the optical transplants, rejection was present in four (14.8%) eyes, and four (11.8%) developed glaucoma. conclusion: in fav opacity after ocular trauma was the most common indication for pediatric keratoplasty. this may be the result of the low income and violent society, among the citizens from the studied population. many blind children due to cornea disease may achieve improvement in visual acuity if an appropriate surgical and good postoperative management is performed.
Spore production in Paecilomyces lilacinus (Thom.) samson strains on agro-industrial residues
Robl, Diogo;Sung, Letizia B.;Novakovich, Jo？o Henrique;Marangoni, Paulo R. D.;Zawadneak, Maria Aparecida C.;Dalzoto, Patricia R.;Gabardo, Juarez;Pimentel, Ida Chapaval;
Brazilian Journal of Microbiology , 2009, DOI: 10.1590/S1517-83822009000200016
Abstract: paecilomyces lilacinus has potential for pests control. we aimed to analyze mycelial growth and spore production in p. lilacinus strains in several agro-industrial residues and commercial media. this study suggests alternative nutrient sources for fungi production and that the biotechnological potential of agro-industrial refuses could be employed in byproducts development.
Local regularity for mean-field games in the whole space
Diogo Aguiar Gomes,Edgard Almeida Pimentel
Mathematics , 2014,
Abstract: In this paper, we investigate the Sobolev regularity for mean-field games in the whole space $\Rr^d$. This is achieved by combining integrability for the solutions of the Fokker-Planck equation with estimates for the Hamilton-Jacobi equation in Sobolev spaces. To avoid the mathematical challenges posed due to the lack of compactness, we prove an entropy dissipation estimate for the adjoint variable. This, together with the non-linear adjoint method, yields uniform estimates for solutions of the Hamilton-Jacobi equation in $W^{1,p}_{loc}(\Rr^d)$.
Time dependent mean-field games with logarithmic nonlinearities
Diogo Aguiar Gomes,Edgard Almeida Pimentel
Mathematics , 2014,
Abstract: In this paper, we prove the existence of classical solutions for time dependent mean-field games with a logarithmic nonlinearity and subquadratic Hamiltonians. Because the logarithm is unbounded from below, this nonlinearity poses substantial mathematical challenges that have not been addressed in the literature. Our result is proven by recurring to a delicate argument, which combines Lipschitz regularity for the Hamilton-Jacobi equation with estimates for the nonlinearity in suitable Lebesgue spaces. Lipschitz estimates follow from an application of the nonlinear adjoint method. These are then combined with a priori bounds for solutions of the Fokker-Planck equation and a concavity argument for the nonlinearity.
Role of the Proteasome in Excitotoxicity-Induced Cleavage of Glutamic Acid Decarboxylase in Cultured Hippocampal Neurons
Márcio S. Baptista,Carlos V. Melo,Mário Armel？o,Dennis Herrmann,Diogo O. Pimentel,Graciano Leal,Margarida V. Caldeira,Ben A. Bahr,Mário Bengtson,Ramiro D. Almeida,Carlos B. Duarte
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010139
Abstract: Glutamic acid decarboxylase is responsible for synthesizing GABA, the major inhibitory neurotransmitter, and exists in two isoforms—GAD65 and GAD67. The enzyme is cleaved under excitotoxic conditions, but the mechanisms involved and the functional consequences are not fully elucidated. We found that excitotoxic stimulation of cultured hippocampal neurons with glutamate leads to a time-dependent cleavage of GAD65 and GAD67 in the N-terminal region of the proteins, and decrease the corresponding mRNAs. The cleavage of GAD67 was sensitive to the proteasome inhibitors MG132, YU102 and lactacystin, and was also abrogated by the E1 ubiquitin ligase inhibitor UBEI-41. In contrast, MG132 and UBEI-41 were the only inhibitors tested that showed an effect on GAD65 cleavage. Excitotoxic stimulation with glutamate also increased the amount of GAD captured in experiments where ubiquitinated proteins and their binding partners were isolated. However, no evidences were found for direct GADs ubiquitination in cultured hippocampal neurons, and recombinant GAD65 was not cleaved by purified 20S or 26S proteasome preparations. Since calpains, a group of calcium activated proteases, play a key role in GAD65/67 cleavage under excitotoxic conditions the results suggest that GADs are cleaved after ubiquitination and degradation of an unknown binding partner by the proteasome. The characteristic punctate distribution of GAD65 along neurites of differentiated cultured hippocampal neurons was significantly reduced after excitotoxic injury, and the total GAD activity measured in extracts from the cerebellum or cerebral cortex at 24h postmortem (when there is a partial cleavage of GADs) was also decreased. The results show a role of the UPS in the cleavage of GAD65/67 and point out the deregulation of GADs under excitotoxic conditions, which is likely to affect GABAergic neurotransmission. This is the first time that the UPS has been implicated in the events triggered during excitotoxicity and the first molecular target of the UPS affected in this cell death process.
Influência da dan aterapia na mobilidade funcional de crian as com paralisia cerebral hemiparética espástica Influence of dance therapy on the functional mobility of children with spastic hemiparetic cerebral palsy
Diogo Costa Gar？？o
Motricidade , 2011, DOI: 10.6063/motricidade.7(3).95
Abstract: O objetivo deste estudo foi investigar a influência da dan aterapia na mobilidade funcional de crian as com paralisia cerebral hemiparética espástica. Participaram 10 crian as de sexo feminino, com idade média de 7.2 anos (± 1.2 anos) e diagnóstico de paralisia cerebral. Para avaliar a mobilidade funcional, utilizaram-se as dimens es D (em pé) e E (andar, correr e pular) da escala GMFM. Foram realizadas duas etapas, a primeira composta por seis semanas, em que as pacientes n o eram submetidas a interven o motora (etapa controle), e a segunda composta por 18 sess es de dan aterapia. As crian as foram avaliadas três vezes durante a pesquisa, sendo a primeira (I) antes da etapa controle; a segunda (II) após a fase controle; e a terceira (III) ao término da aplica o da dan aterapia. Os dados das dimens es D e E nas três avalia es foram analisados por meio do teste Kruskal-Wallis (p < .05), seguido do teste Dunn (p < .05). Nas duas dimens es, constatou-se que n o houve mudan a dos desempenhos entre a avalia o I e II (p = 1.00), permanecendo os participantes com itens similares. Entretanto, na avalia o III observou-se um aumento significativo em rela o aos desempenhos das avalia es I e II para a dimens o D (p < .01) e E (p < .01). Os resultados demonstram que a dan aterapia propicia estímulos que influenciam a mobilidade funcional. The aim of this study was to investigate the influence of dance therapy on the functional mobility of children with spastic hemiparetic cerebral palsy. Ten female children (mean age 7.2 ± 1.2 years) diagnosed with cerebral palsy were included. In order to evaluate their functional mobility, standing (D) and walking, running and jumping (E) dimensions from GMFM were applied, and measurements were carried out in two phases: 1) control, six weeks without any motor intervention, and 2) activity, 18 sessions of dancing. Children were assessed three times: first, before the control phase, second, after the control phase, and third, at the end of the dancing phase. Kruskal-Wallis (p < .05) and Dunn tests (p < .05) were used. There were no changes in performance between the two first phases of evaluation (p = 1.00), however, at the end of the dancing phase a significant increase was measured in relation to D (p < .01) and E dimensions (p < .01). Results showed that dance therapy influences children's functional mobility.
Importa o de Técnicas de Recursos Humanos: problema ou solu o?
Alexandre Santos,Rafael Diogo Pereira,Daniel Calbino,Thiago Duarte Pimentel
Revista de Ciências da Administra？？o : RCA , 2010,
Abstract: Partindo da premissa que a literatura brasileira de uma forma geral, mas principalmente na área de Recursos Humanos, é baseada em autores estrangeiros, o objetivo deste ensaio teórico é incitar uma reflex o sobre a eficiência da utiliza o de técnicas importadas de gest o de pessoas no Brasil. As indaga es giram em torno da diferen a entre contextos socioculturais e as implica es da ado o da base estrangeira (estereótipo de seu ber o) no contexto brasileiro, onde o jeitinho brasileiro é considerado único e exclusivo. Esse ambiente acontece com o “patrimonialismo” como palco. Recorre-se também a possibilidade da tropicaliza o destes modelos pela vertente do isomorfismo. Contudo, conclui-se que as diferen as contextuais e socioculturais levam as técnicas de importa o de gest o a serem pouco efetivas no Brasil.
Nephrotic syndrome in plasma cell leukaemia - A rare presentation
Diogo M,Faustino C,Pimentel T,Amorim J
Indian Journal of Cancer , 2011,
Abstract:
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