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匹配条件: “Dinesh V. Thakkar” ,找到相关结果约131121条。
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DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF METOPROLOL SUCCINATE AND ATORVASTATIN CALCIUM IN A PHARMACEUTICAL DOSAGE FORM
Ginoya Charmi G.,Dinesh V. Thakkar
International Research Journal of Pharmacy , 2013,
Abstract: A new, simple, precise, accurate and selective high performance thin-layer chromatographic (HPTLC) method has been developed and validated for the simultaneous determination of Metoprolol succinate and Atorvastatin calcium in a marketed formulation. Chromatographic separation was carried out on Merck TLC aluminium sheets of silica gel 60F254 using Acetonitrile: Methanol: Ethyl acetate: Glacial acetic acid (2: 4: 4: 0.06 % v/v/v/v) as mobile phase followed by densitometric analysis at 223 nm. This system was found to give compact spots for Metoprolol succinate (Rf value of 0.32 ± 0.005) and Atorvastatin calcium (Rf value of 0.77 ± 0.004). The method was validated in terms of linearity, accuracy, precision, limit of detection, limit of quantification and specificity in accordance with International Conference on Harmonization (ICH) guidelines. The calibration curve was found to be linear between 500 to 3000 and 200 to 1200 ng/spot for Metoprolol succinate and Atorvastatin calcium, respectively with significantly high value of correlation coefficient (r2 > 0.99). The limits of detection and quantitation were found to be 0.8432 and 2.5553 ng/spot, respectively for Metoprolol succinate and 27.8428 and 84.3662 ng/spot, respectively for Atorvastatin calcium. The proposed method was found to be accurate, precise, reproducible, specific and sensitive and can be applicable for the simultaneous determination of Metoprolol succinate and Atorvastatin calcium in marketed formulation.
QSAR Study on a Series of Protein Tyrosine Phosphatase 1B Inhibitors
Rajendra S. Mehta,Hetal R. Prajapati,Dinesh V. Thakkar,Pathik S. Brahmkshatriya
International Journal of Biomedical Science , 2008,
Abstract: As a therapeutic target, protein tyrosine phosphatase 1B (PTP1B) has received considerable attention for the treatment of diabetes mellitus. A QSAR study using substituted monocyclic and polycyclic thiophene derivatives, recently reported as potent PTP1B inhibitors, was carried out. More than 60 physicochemical descriptors were calculated which underwent rational selection before their use in derivation of QSAR models. Statistically significant equations were generated using multiple linear regression analysis. External validation of the derived models with test set compounds proved good predictability of the models. Interpretation of the results revealed lipophilicity as a key regulatory feature which affects PTP1B inhibition along with several electronic and steric parameters. The study provides an important platform upon which novel rationally designed molecules can be synthesized with cautious optimism.
Efficacy of Isovolumic Acceleration in Assessing Right Ventricular Function in Pulmonary Hypertension  [PDF]
V. S. Bharathi, Adikesava Naidu Otikunta, Y. V. Subbareddy, K. Laxman Rao, Syed Imamuddin, Ashok Thakkar
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.512093
Abstract:

Objective: The aim of the study was to determine usefulness of isovolumic acceleration to assess right ventricular function in patients with pulmonary hypertension. Background: Right ventricular dysfunction is a powerful predictor of adverse outcomes in patients with pulmonary hypertension. Although isovolumic acceleration is a sensitive and relatively load-independent parameter for ventricular contractile function, it has not been widely used. So, the aim of the study was to determine the usefulness of isovolumic acceleration in assessing right ventricular function in patients with pulmonary hypertension. Methods: A single center, prospective observational case-control study has been carried out for the period of one year at Osmania general hospital (Hyderabad). A total of 32 consecutive patients with pulmonary hypertension and 32 age matched healthy controls were recruited in the study as per the inclusion and exclusion criteria of the study. Receiver operator characteristic curves were used to study sensitivity, specificity, positive predictive value, negative predictive values as well as pearson’s correlation coefficients. Results: The results of the study showed

A comparative study of DNA damage in patients suffering from diabetes and thyroid dysfunction and complications
Nima V Thakkar, Sunita M Jain
Clinical Pharmacology: Advances and Applications , 2010, DOI: http://dx.doi.org/10.2147/CPAA.S11366
Abstract: comparative study of DNA damage in patients suffering from diabetes and thyroid dysfunction and complications Original Research (3534) Total Article Views Authors: Nima V Thakkar, Sunita M Jain Published Date September 2010 Volume 2010:2 Pages 199 - 205 DOI: http://dx.doi.org/10.2147/CPAA.S11366 Nima V Thakkar, Sunita M Jain Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad, Gujarat, India Objective: The apoptotic DNA levels in blood leukocytes of patients with type 2 diabetes (T2D) and thyroid dysfunction were evaluated. Materials and methods: Single-cell gel electrophoresis (comet assay) detects migration of DNA from individual cell nuclei following alkaline treatment. Comet assay pattern was studied in individuals with T2D, hypothyroid (HT), hyperthyroid (HeT), and patients suffering from both diabetes mellitus and HT (HT + DM). Results were compared with the normal subjects (n = 9 in each group). The percentage apoptotic cells were calculated from the tail length. Results: T2D patients showed 92.24% of cell damage compared to HT or HeT patients (51.04% or 54.64%, respectively). Further, increase in cell damage was also observed in HT + DM subjects (P < 0.05). Pharmacologic therapy significantly influenced cell damage. However, age and duration of disease did not show any definite influence on apoptosis. Conclusion: Dependence of disease seems to be the major contributor of the cell damage. However, thyroid dysfunction did not show any deleterious effects on individual cells under the study.
Accelerated Atherosclerosis in a Young Female with Familial Hypercholesterolemia  [PDF]
Adikesava Naidu Otikunta, Praneeth Polamuri, Subba Reddy Y V, Ravi Srinivas, Ashok Thakkar, Arohi Sarang
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.510074
Abstract:

Familial hypercholesterolemia is an autosomal dominant genetic disease due to mutation in low-density lipoprotein-cholesterol receptor gene. It is characterized by elevated plasma low-density lipoprotein-cholesterol and the consequence of which leads to premature cardiovascular disease. The mainstay in the management of familial hypercholesterolemia patient is the treatment with high potency statin. However, current research shows influence of the type of low-density lipoprotein-cholesterol receptor mutations on severity of the cardiovascular disease, lipid profile, and response to statin treatment. We are here presenting a case of young Indian female patient who was diagnosed with familial hypercholesterolemia and treated with percutaneous transluminal coronary angioplasty in view of double vessel disease in the third decade of her life. She was prescribed with statin therapy for elevated low-density lipoprotein cholesterol. After 3 years, she presented once again with a triple vessel disease along with patent stented segments and abnormal lipid profile.

Characterization of Dispersive Soils  [PDF]
T. S. Umesh, S. V. Dinesh, Puvvadi V. Sivapullaiah
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.26085
Abstract: Dispersive soils which occur in many parts of the world are easily erodible and segregate in water pose serious problems of stability of earth and earth retaining structures. The mechanism of dispersivity of soils is reasonably well understood. However there is simple method to identify the dispersivity of the soils and even more difficult to quantify the dispersivity. Visual classification, Atterberg’s limits and particle size analysis do not provide sufficient basis to differentiate between dispersive clays and ordinary erosion resistant clays. Pinhole test and double hydrometer test are the only two tests that are in vogue to identify the dispersive soils. This paper explores the possibility of using other standard tests such as shrinkage limit and unconfined compressive strength tests to quantify the dispersivity of the soils. The rationale of using the methods and correlation between the dispersivity determined by various methods has been explained. It has been concluded that dispersivity ascertained from strength tests is more reliable.
Greedy Segmented Channel Router
Dinesh Bhatia,V. Shankar
VLSI Design , 1996, DOI: 10.1155/1996/53512
Abstract:
A Novel Packet Switch Node Architecture for Contention Resolution in Synchronous Optical Packet Switched Networks  [PDF]
Virendra Singh SHEKHAWAT, Dinesh Kumar TYAGI, V. K. CHAUBEY
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2009, DOI: 10.4236/ijcns.2009.26062
Abstract: Packet contention is a key issue in optical packet switch (OPS) networks and finds a viable solution by including optical buffering techniques incorporating fiber delay lines (FDLs) in the switch architecture. The present paper proposes a novel switch architecture for packet contention resolution in synchronous OPS network employing the packet circulation in FDLs in a synchronized manner. A mathematical model for the proposed switch architecture is developed employing packet queuing control to estimate the blocking probability for the incoming traffic. The switch performance is analyzed with a suitable contention resolution al-gorithm through the computer simulation. The simulation results substantiate the proposed model for the switch architecture.
EFFECT OF TEMPERATURE ON REPRODUCTIVE AND EGG LAYING BEHAVIOR OF SILK MOTH BOMBYX MORI L.
Dinesh Wanule,J V Balkhande
Bioscience Discovery , 2013,
Abstract: In present investigation a study was conducted to determine the effect of changes in temperature on reproductive behavior, fecundity, site selection for egg laying and longevity of adult Bombyx mori L. crossbreed of PM X CSR2.The present investigation showed that adult of B. mori were died when kept at 40+ 5 o C and unable to lay eggs, at 30+ 1 o C they lay least number of eggs i.e. 2494 and died within 72 hours. At 10 + 1 o C they exhibit diapauses mechanism and delayed in egg laying showed higher number of egg laying i.e. 2619 and found live on the day15th of termination of experiment. No change in temperature cause normal reproduction behavior and laid highest number of eggs i.e.2922 and died after seven days. Silk worm prefer egg lying at the bottom of the beaker than upper side of beaker.
Bayesian and hierarchical Bayesian analysis of response - time data with concomitant variables  [PDF]
Dinesh Kumar
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.37095
Abstract: This paper considers the Bayes and hierarchical Bayes approaches for analyzing clinical data on response times with available values for one or more concomitant variables. Response times are assumed to follow simple exponential distributions, with a different parameter for each patient. The analyses are carried out in case of progressive censoring assuming squared error loss function and gamma distribution as priors and hyperpriors. The possibilities of using the methodology in more general situations like dose- response modeling have also been explored. Bayesian estimators derived in this paper are applied to lung cancer data set with concomitant variables.
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