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Search Results: 1 - 10 of 402026 matches for " Dina M. Fouad "
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Synthesis and thermal studies of mixed ligand complexes of Cu(II), Co(II), Ni(II) and Cd(II) with mercaptotriazoles and dehydroacetic acid  [PDF]
Dina M. Fouad, Ahmed Bayoumi, Mohamed A. ElGahami, Said A. Ibrahim, Abbas M. Hammam
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.28103
Abstract: A series of new mixed ligand complexes of cobalt(II), nickel(II), copper(II) and cadmium(II) have been synthesized with 3benzyl1H4[(2 methoxybenzylidine) amino]1, 2, 4triazole5 thione (MBT), 3bezyl1H4[(4chlorobenzylidine) amino]1, 2, 4triazole5thione (CBT), 3benzyl 1H4[(4nitrobenzylidine)amino]1, 2, 4triazole 5thione (NBT) and dehydroacetic acid sodium salt (Nadha). The mixed ligand complexes have been characterized by elemental analysis, spec troscopic spectral measurements (IR, UVVis.), molar conductance, magnetic measurements and thermal studies. The stoichiometry of these com plexes is M:L1:L2 = 1:1:1, 1:2:1 or 1:1:2 where L1 = NBT, CBT and MBT and L2 = Nadha. Tetrahedral structure was proposed for all Cd(II) mixed ligand complexes while the square planar geometry was proposed for Cu(II) mixed ligand complex with NBT. Octahedral structure was proposed for Ni(II), Co(II) mixed ligand complexes and Cu(II) mixed ligand complexes with CBT and MBT ligands. The thermal decomposition study of the prepared complexes was monitored by TG, DTG and DTA analysis in dynamic nitrogen atmosphere. TG, DTG and DTA studies confirmed the chemical formulations of theses complexes. The kinetic parameters were determined from the the thermal decomposition data using the graphical methods of CoatsRedfern and HorwitzMetzger. Thermodynamic parameters were calculated using standard relations.
Paget's disease of the breast in a male with lymphomatoid papulosis: a case report
Dina Fouad
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-43
Abstract: We present the case of a 67-year-old Caucasian man with lymphomatoid papulosis who was diagnosed with Paget's disease of the nipple and who was treated successfully with surgery alone. We discuss the presentation, investigations, management and pathogenesis of Paget's disease of the nipple.The case highlights the need to be vigilant when new skin lesions arise in the context of an underlying chronic skin disorder.Paget's disease is an eczematous skin change of the nipple that is usually associated with an underlying breast malignancy [1]. It may present with erythema, scaling, ulceration, bleeding or a painful nipple [2,3]. Male breast cancer accounts for less than 1% of all breast cancer with Paget's disease remaining very rare. Paget's disease of the nipple may be associated with an underlying invasive cancer, a non-invasive cancer ductal carcinoma in situ or no underlying cancer. Prognosis is dependent upon the status of invasion and treatment is tailored accordingly. Approximately 90% of patients presenting with a palpable mass or who have a visible mass on mammography will have underlying invasive disease. Notably, invasive cancer can occur with Paget's disease in 38% of patients with no underlying mass [3,4].The patient is a 67-year-old Caucasian man who presented to the Breast Clinic in August 2008 with a six-month history of a painful right nipple and one episode of clear nipple discharge. His problem had not resolved with use of a topical ointment prescribed by his general practitioner and he was admitted to the Breast ward of our hospital in September 2008 for further investigations.The patient's past medical history includes 30 years of lymphomatoid papulosis, a chronic papulonodular dermatological condition, which has been controlled with long-term methotrexate treatment and folic acid supplementation. There was no report that the control of this had been particularly poor recently, however the patient had several previous recorded flare ups (1992, 2000,
A Boundary Integral Formulation of the Plane Problem of Magneto-Elasticity for an Infinite Cylinder in a Transverse Magnetic Field  [PDF]
Moustafa Saber Abou-Dina, Ahmed Fouad Ghaleb
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.54052

The objective of this work is to present a boundary integral formulation for the static, linear plane strain problem of uncoupled magneto-elasticity for an infinite magnetizable cylinder in a transverse magnetic field. This formulation allows to obtain analytical solutions in closed form for problems with relatively simple geometries, in addition to being particularly well-adapted to numerical approaches for more complicated cases. As an application, the first fundamental problem of Elasticity for the circular cylinder is investigated.

Comparative Study of the Photocatalytic Activity of Semiconductor Nanostructures and Their Hybrid Metal Nanocomposites on the Photodegradation of Malathion
Dina Mamdouh Fouad,Mona Bakr Mohamed
Journal of Nanomaterials , 2012, DOI: 10.1155/2012/524123
Abstract: This work is devoted to synthesize different semiconductor nanoparticles and their metal-hybrid nanocomposites such as TiO2, Au/TiO2, ZnO, and Au/ZnO. The morphology and crystal structure of the prepared nanomaterials are characterized by the TEM and XRD, respectively. These materials are used as catalysts for the photodegradation of Malathion which is one of the most commonly used pesticides in the developing countries. The degradation of 10 ppm Malathion under ultraviolet (UV) and visible light in the presence of the different synthesized nanocomposites was analyzed with high-performance liquid chromatography (HPLC) and UV-Visible Spectra. A comprehensive study is carried out for the catalytic efficiency of the prepared nanoparticles. Different factors influencing the catalytic photodegradation are investigated, as different light source, surface coverage, and nature of the organic contaminants. The results indicate that hybrid nanocomposite of the semiconductor-metal hybrid serves as a better catalytic system compared with semiconductor nanoparticles themselves.
Photodegradation of Chloridazon Using Coreshell Magnetic Nanocompsites
Dina Mamdouh Fouad,Mona Bakr Mohamed
Journal of Nanotechnology , 2011, DOI: 10.1155/2011/416060
Abstract: A new synthesized magnetic nanoparticle of Fe3O4 and coreshell Fe3O4@Au is prepared chemically. A comparative study between the photocatalytic activity between Fe3O4 and core shell Au-Fe3O4 nanoparticles has been studied on the effect of UV and sun light on the photodegradation of chloridazon. The particle has been prepared using chemical methods and the particle size and shape have been examined via transmission electron microscopy (TEM). Analysis of the degradation of 20?ppm chloridazon under ultraviolet (UV) and visible light was analyzed with high-performance liquid chromatography (HPLC) and UV-Visible Spectra. Influence of different parameters on the activity photodegradation rate has been studied. The results indicate that the Fe3O4@Au nanoparticles are much more active catalyst in presence of sun light than pure Fe3O4 nanomaterials which have maximum absorption at 560?nm. 1. Introduction Magnetic nanoparticles (NPs) have attracted significant interest, due to their numerous attributes such as their low toxicity and biocompatibility; the increasing attention in these materials as well as other composites is determined by the novel magnetic, electronic, optical, and chemical properties, which are different to those of the bulk materials because of the extreme small sizes and the large specific surface areas, and magnetic properties that enable them to be directed by an external magnetic field, in addition to their possibility to separate them from a reaction mixture [1–7]. Iron oxide nanoparticles could be easily oxidized by oxygen present in air and also can react between its self-forming aggregates. Many trials have been carried out to modify the surface during the synthesis or coating process [8–10]. A special class of particular interest of nanocomposite materials is nanoshell particles or core/shell nanocomposites. These core/shell nanocomposites are highly functional materials consisting of thin coatings (1–20?nm) of one particular material deposited on core particles of another different material utilizing certain procedures [11, 12]. Nanocomposites core/shell has attracted a lot of attention owing to their novel-tailored properties which are different from the single-component counterparts (the single core or shell). Now it is possible to synthesize these nanocomposites in desired size and shape and with controlled improved properties such as increased stability, surface area, magnetic, optical, and catalytic properties [13]. Gold surface allows the attachment of molecules with a relative ease using a variety of thiol linkers [14–16]; gold
Prognostic Features of BCR-ABL Genetic Variations in Acute Lymphoblastic Leukemia  [PDF]
Dina Adel Fouad, Hasnaa A. Abo_Elwafa, Shereen Philip Aziz, Ahmed A. Allam, Nesma Mokhtar
Open Journal of Blood Diseases (OJBD) , 2018, DOI: 10.4236/ojbd.2018.84010
Abstract: Background: Acute lymphoblastic leukemia (ALL) is a hematologic malignancy which results from accumulation of lymphoid progenitor cells in the bone marrow and/or extramedullary sites. Philadelphia chromosome (Ph1) positive ALL, a high-risk cytogenetic subset, accounts for 25% - 30% of adult ALL cases but occurs in less than 5% of children. We aimed with this study to detect BCR-ABL genes fusion, amplification and deletion in ALL patients, using extrasignal-fluorescence in situ hybridization (ES-FISH), and to assess their relation with other standard prognostic factors and therapeutic response. Patients and Methods: This study was carried out on 39 newly diagnosed ALL patients. All patients were subjected to: history, clinical examination and laboratory investigations, which included complete blood count (CBC), peripheral blood (PB), bone marrow (BM) examination, immunophenotyping and fluorescence in situ hybridization using extra-signal probe to detect BCR-ABL genes fusion. Results: This study showed statistical analysis of patients’ t(9; 22) with other factors revealed, significant association (p < 0.05) of t(9; 22) with patients outcome, age > 35 years, hepatosplenomegaly, absence of lymphadenopathy, TLC ≥ 50 × 109/L, absolute PB blasts ≥ 4.4 × 109/L, immunophenotyping and other aberrations. Conclusion: BCR/ABL fusion gene analysis by ES-FISH may serve as a prognostic marker in adulthood ALL. The age, TLC and t(9; 22) represent the significant standard prognostic factors in relation to patients’ outcome.
Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling
Mohamed T Abdel aziz, Mohamed F El Asmar, Hazem M Atta, Soheir Mahfouz, Hanan H Fouad, Nagwa K Roshdy, Laila A Rashed, Dina Sabry, Amira A Hassouna, Fatma M Taha
Journal of Experimental & Clinical Cancer Research , 2011, DOI: 10.1186/1756-9966-30-49
Abstract: Ninety rats were included in the study and were divided equally into: Control group, rats which received MSCs only, rats which received MSCs vehicle only, HCC group induced by diethylnitroseamine (DENA) and CCl4, rats which received MSCs after HCC induction, rats which received MSCs before HCC induction. Histopathological examination and gene expression of Wnt signaling target genes by real time, reverse transcription-polymerase chain reaction (RT-PCR) in rat liver tissue, in addition to serum levels of ALT, AST and alpha fetoprotein were performed in all groups.Histopathological examination of liver tissue from animals which received DENA-CCl4 only, revealed the presence of anaplastic carcinoma cells and macro-regenerative nodules type II with foci of large and small cell dysplasia. Administration of MSCs into rats after induction of experimental HCC improved the histopathological picture which showed minimal liver cell damage, reversible changes, areas of cell drop out filled with stem cells. Gene expression in rat liver tissue demonstrated that MSCs downregulated β-catenin, proliferating cell nuclear antigen (PCNA), cyclin D and survivin genes expression in liver tissues after HCC induction. Amelioration of the liver status after administration of MSCs has been inferred by the significant decrease of ALT, AST and Alpha fetoprotein serum levels. Administration of MSCs before HCC induction did not show any tumor suppressive or protective effect.Administration of MSCs in chemically induced HCC has tumor suppressive effects as evidenced by down regulation of Wnt signaling target genes concerned with antiapoptosis, mitogenesis, cell proliferation and cell cycle regulation, with subsequent amelioration of liver histopathological picture and liver function.Hepatocellular carcinoma (HCC) is a highly prevalent, treatment-resistant malignancy with a multifaceted molecular pathogenesis[1]. It is a significant worldwide health problem with as many as 500,000 new cases diagno
Evaluation of Lead Hepatotoxicity; Histological, Histochemical and Ultrastructural Study  [PDF]
Ahmed M. S. Hegazy, Usama A. Fouad
Forensic Medicine and Anatomy Research (FMAR) , 2014, DOI: 10.4236/fmar.2014.23013
Abstract: Lead is one of the most well-known naturally occurring environmental heavy metals. This experimental study was designed to evaluate lead induced toxic effects on hepatocytes and lobular architecture as judged microscopically. Material and Methods: This study was conducted in anatomy department, Benha faculty of medicine, Benha University, Egypt from May to October 2013 on 30 normal adult albino rats divided into 3 groups; one control and 2 experimental groups. The experimental groups were given 0.13% lead acetate solution in drinking water for 4 and 8 weeks, respectively. Animals were scarified and livers were removed and used to identify microscopic changes. Specimens were stained with Hematoxylin and eosin, with Masson trichrome stain for study of fibrous tissue and with periodic acid shiff's (PAS) to study the glycogen content. Other specimens were prepared for ultrastructural study. Results: Mild lymphocytic infiltration, vacuolar degeneration and mild increase of periportal fibrosis with mild depletion of glycogen content and partial disappearance of glycogen vacuoles were reported in animals received contaminated water for 4 weeks. Animals maintained for 8 weeks on contaminated water showed hepatic changes in the form of abundant lymphocytic infiltration, increased cellular polymorphism, pyknotic nuclei and areas of cell necrosis with evident moderate periportal fibrosis and marked vacuolar degeneration associated with marked depletion of glycogen content. Ultrastructural study revealed mitochondrial edema, appearance of interstitial inflammatory cells, and appearance of scattered variable sized lead electron-dense inclusion bodies. Conclusion: It could be concluded that chronic exposure to lead imposes a potent toxic effect on liver cells manifested as glycogen depletion, cellular infiltration and liver architecture in the form of initiation of periportal fibrosis that may progress to liver cirrhosis.
Uniform Kadec-Klee Property in Banach lattices
Fouad Chaatit,M. Khamsi
Mathematics , 1994,
Abstract: We prove that a Banach lattice $X$ which does not contain the $l^n_{\infty}$-uniformly has an equivalent norm which is uniformly Kadec-Klee for a natural topology $\tau$ on $X$. In case the Banach lattice is purely atomic, the topology $\tau$ is the coordinatewise convergence topology.
Predictors of Complete Early Virological Response to Pegylated Interferon and Ribavirin in Egyptian Patients with Chronic Hepatitis C Genotype 4  [PDF]
Gamal El Din Esmat Gamil, Maissa El Said El Raziky, Rabab Maamoun Salama, Wafaa Ahmed El Akel, Waleed Fouad Fathalah, Dina Ismail Attia
Advances in Infectious Diseases (AID) , 2013, DOI: 10.4236/aid.2013.32012

We aim to determine the baseline factors associated with partial and cEVR by analyzing the data of 1861 Egyptian patients treated for 12 weeks with a course of Peg-IFN plus RBV. Base line data of 1861 Egyptian patients with chronic hepatitis C coming at Cairo-Fatemic Hospital for HCV treatment were studied including full clinical, Ultrasonographic examination, laboratory evaluation and liver biopsy. The most significant variables in relation to complete early virological response were low Hb level (<13 gm/dl) with p < 0.01, the stage of fibrosis p value < 0.05 and the grades of inflammation p value < 0.05 were associated with less achievement of c EVR. We conclude that identifying the most significant predictors of response such as Hb, stage of fibrosis F, at baseline before initiating treatment is mandatory to predict which patient will be more expected to achieve a cEVR and thus reducing the side-effects and healthcare costs associated with interferon therapies.

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