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Search Results: 1 - 10 of 95 matches for " Dimple Notani "
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Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner
Dimple Notani,Kamalvishnu P. Gottimukkala,Ranveer S. Jayani,Amita S. Limaye,Madhujit V. Damle,Sameet Mehta,Prabhat Kumar Purbey,Jomon Joseph,Sanjeev Galande
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1000296
Abstract: In vertebrates, the conserved Wnt signalling cascade promotes the stabilization and nuclear accumulation of β-catenin, which then associates with the lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) to activate target genes. Wnt/β -catenin signalling is essential for T cell development and differentiation. Here we show that special AT-rich binding protein 1 (SATB1), the T lineage-enriched chromatin organizer and global regulator, interacts with β-catenin and recruits it to SATB1's genomic binding sites. Gene expression profiling revealed that the genes repressed by SATB1 are upregulated upon Wnt signalling. Competition between SATB1 and TCF affects the transcription of TCF-regulated genes upon β-catenin signalling. GATA-3 is a T helper type 2 (TH2) specific transcription factor that regulates production of TH2 cytokines and functions as TH2 lineage determinant. SATB1 positively regulated GATA-3 and siRNA-mediated knockdown of SATB1 downregulated GATA-3 expression in differentiating human CD4+ T cells, suggesting that SATB1 influences TH2 lineage commitment by reprogramming gene expression. In the presence of Dickkopf 1 (Dkk1), an inhibitor of Wnt signalling, GATA-3 is downregulated and the expression of signature TH2 cytokines such as IL-4, IL-10, and IL-13 is reduced, indicating that Wnt signalling is essential for TH2 differentiation. Knockdown of β-catenin also produced similar results, confirming the role of Wnt/β-catenin signalling in TH2 differentiation. Furthermore, chromatin immunoprecipitation analysis revealed that SATB1 recruits β-catenin and p300 acetyltransferase on GATA-3 promoter in differentiating TH2 cells in a Wnt-dependent manner. SATB1 coordinates TH2 lineage commitment by reprogramming gene expression. The SATB1:β-catenin complex activates a number of SATB1 regulated genes, and hence this study has potential to find novel Wnt responsive genes. These results demonstrate that SATB1 orchestrates TH2 lineage commitment by mediating Wnt/β-catenin signalling. This report identifies a new global transcription factor involved in β-catenin signalling that may play a major role in dictating the functional outcomes of this signalling pathway during development, differentiation, and tumorigenesis.
Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner
Dimple Notani,Kamalvishnu P. Gottimukkala,Ranveer S. Jayani,Amita S. Limaye,Madhujit V. Damle,Sameet Mehta,Prabhat Kumar Purbey,Jomon Joseph,Sanjeev Galande
PLOS Biology , 2010, DOI: 10.1371/journal.pbio.1000296
Abstract: In vertebrates, the conserved Wnt signalling cascade promotes the stabilization and nuclear accumulation of β-catenin, which then associates with the lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) to activate target genes. Wnt/β -catenin signalling is essential for T cell development and differentiation. Here we show that special AT-rich binding protein 1 (SATB1), the T lineage-enriched chromatin organizer and global regulator, interacts with β-catenin and recruits it to SATB1's genomic binding sites. Gene expression profiling revealed that the genes repressed by SATB1 are upregulated upon Wnt signalling. Competition between SATB1 and TCF affects the transcription of TCF-regulated genes upon β-catenin signalling. GATA-3 is a T helper type 2 (TH2) specific transcription factor that regulates production of TH2 cytokines and functions as TH2 lineage determinant. SATB1 positively regulated GATA-3 and siRNA-mediated knockdown of SATB1 downregulated GATA-3 expression in differentiating human CD4+ T cells, suggesting that SATB1 influences TH2 lineage commitment by reprogramming gene expression. In the presence of Dickkopf 1 (Dkk1), an inhibitor of Wnt signalling, GATA-3 is downregulated and the expression of signature TH2 cytokines such as IL-4, IL-10, and IL-13 is reduced, indicating that Wnt signalling is essential for TH2 differentiation. Knockdown of β-catenin also produced similar results, confirming the role of Wnt/β-catenin signalling in TH2 differentiation. Furthermore, chromatin immunoprecipitation analysis revealed that SATB1 recruits β-catenin and p300 acetyltransferase on GATA-3 promoter in differentiating TH2 cells in a Wnt-dependent manner. SATB1 coordinates TH2 lineage commitment by reprogramming gene expression. The SATB1:β-catenin complex activates a number of SATB1 regulated genes, and hence this study has potential to find novel Wnt responsive genes. These results demonstrate that SATB1 orchestrates TH2 lineage commitment by mediating Wnt/β-catenin signalling. This report identifies a new global transcription factor involved in β-catenin signalling that may play a major role in dictating the functional outcomes of this signalling pathway during development, differentiation, and tumorigenesis.
Camptocormia in Parkinson's Disease
Kazuo Abe,Yutaka Uchida,Masaru Notani
Parkinson's Disease , 2010, DOI: 10.4061/2010/267640
Abstract: Objectives. Abnormalities of posture represent one of the main features of Parkinson's disease (PD). Among them, camptocormia has been considered as rare in PD. We investigated frequency and clinical features of camptocormia in PD patients. Methods. 153 PD patients (mean 6 8 . 5 ± 1 0 . 7 years old, duration 5 . 9 ± 2 . 4 years) outpatiently recruited. After neurologic examination, patients were rated on the Unified PD Rating Scale motor scale (UPDRS Part III), minimental state examination (MMSE). Also we evaluated patients with camptocormia by MRI. Of the 153 PD patients, 27 had camptocormia (mean age, 6 7 . 9 ± 7 . 9 years old; disease duration, 6 . 1 ± 3 . 9 years). For further evaluation, we recruited age- and sex-matched 27 PD patients without camptocormia (11 men and 16 women; mean age ± S D , 6 9 . 2 ± 1 0 . 1 years, duration 6 . 0 ± 2 . 7 years) These selected 54 patients completed several self-assessments. Lumbar and thoracic paraspinal muscles were studied by EMG. Results. There were no significant differences in age, duration, severity, and drug dose between patients with and without camptocormia. Analysis of NMSS subitems indicated that PD patients tended to show lower scores for sleep/fatigue, attention/memory, and miscellaneous items. Conclusions. We found significant differences concerning nonmotor signs and symptoms evaluated by FAB, PDQ-8, FSQ, VAS-F, and NMSS between patients with and without camptocormia. Our findings indicate that camptocormia is a relatively common sign in PD and that patients with camptocormia scores on the PDQ-8 compared with PD patients without camptocormia. This suggests that improvements in camptocormia of PD patients may improve their QOL. 1. Introduction Parkinson’s disease (PD) may involve skeletal abnormalities including extreme neck flexion (“dropped head") and truncal flexion (camptocormia) [1]. Camptocormia in PD is defined by marked anteroflexion of the trunk, which abates in the recumbent position, with no or minimal response to levodopa [1–4]. The condition is exacerbated by walking and is relieved by sitting, lying in the supine position or by volitionally extending the trunk when the patient leans against a wall or a table. Although early reports often attributed camptocormia to a conversion disorder, it is now accepted as an axial feature of Parkinson’s disease [5–7]. However, previous studies found no differences between the parkinsonian clinical signs of PD patients with and without camptocormia, but Bloch et al. and Tiple et al. reported that there were differences in terms of disease duration
Agent Based Preventive Measure for UDP Flood Attack in DDoS Attacks
AARTI SINGH,,DIMPLE JUNEJA
International Journal of Engineering Science and Technology , 2010,
Abstract: Distributed Denial-of-Service (DDoS) attack is an attack which makes victim resources and services unavailable to its intended users. In particular, User Datagram Protocol (UDP) flood attack in DDoS attacks is a method causing host based denial of service. It occurs when attacker sends UDP packets to a random port on the victim system,causing responses to be sent to forged IP address. The basic thrust of this paper is agent based solution for UDP lood attack because software agent technology seems to be a strong candidate for defending DDoS attacks and very few researchers have thought of deploying agents towards providing solution for UDP attack earlier.
Efficacy of desonide 0.05% cream and lotion in steroid-responsive dermatoses in Indian patients: A post-marketing surveillance study
Bhankharia Dimple,Sanjana Percy
Indian Journal of Dermatology, Venereology and Leprology , 2004,
Abstract: BACKGROUND: Desonide, a non-halogenated, low-potency topical steroid, is indicated in the treatment of steroid-responsive dermatoses. AIMS: A post-marketing surveillance study was conducted to evaluate the efficacy and safety of DesowenTM (Desonide 0.05%) cream and lotion in Indian patients for the treatment of steroid-responsive dermatoses of mild to moderate severity. METHODS: A 3-week, multicenter, open-label, non-comparative Phase IV trial involving 1789 patients from 229 centers across India was conducted between January and August 2003. RESULTS: Of the 1789 patients, 1483 patients completed the treatment as per protocol. At the end of the therapy, 98.5% of the patients showed an improvement in their dermatitis from baseline. More than half of the patients showed a greater than 75% improvement in their signs and symptoms. No adverse effects were noted in any of the patients. Both the lotion and cream were found to be equally effective. CONCLUSIONS: Desonide 0.05% is a safe and effective low-potency corticosteroid for the treatment of mild to moderate dermatoses in Indian patients. No clinically apparent side-effects were observed in infants less than 1 year of age.
Herpes zoster with ulnar nerve paresis
Chopra Adarsh,Mamta,Dimple
Indian Journal of Dermatology, Venereology and Leprology , 1995,
Abstract:
Hyalinosis cutis et mucosae with rare ocular involvement
Mittal R,Dimple
Indian Journal of Dermatology, Venereology and Leprology , 1996,
Abstract:
An Ant Based Framework for Preventing DDoS Attack in Wireless Sensor Networks
Dimple Juneja,Neha Arora
International Journal of Advancements in Technology , 2010,
Abstract: Security and Privacy are two important parameters that need to be considered when dealing with wireless sensor networks as WSN operate in an unattended environment and carry sensitive information critical to the application. However, applying security techniques that consume minimum resources is still a challenge and this paper makes an attempt to address the same. One of the major attacks in sensor network is denial of service attack that not only diminishes the network capacity but also affects the reliability of information being transmitted. This work is an extension of our previous work which could successfully detect DDoS using ants. However, no emphasis was made towards the prevention mechanism. In this paper an ant-based framework that exploits the significance of stateless and stateful signatures and hence preserving the legtimate packets only, thereby discarding the contaminated packets has been proposed.
Collective Intelligence based Framework for Load Balancing of Web Servers
Atul Garg,Dimple Juneja
International Journal of Advancements in Technology , 2012,
Abstract: The paper exploits the collective intelligence referred to as ant intelligence in World Wide Web with the aim to improve the performance of online web servers by balancing the load. The central concept of this idea is that a collection of agents can individually perform relatively simple, self-centered actions, such as the selection or rejection of hyperlinks in a web page for navigation, computing the load of server and aggregate these individual actions into a common substrate. The common substrate can then be evaluated to find the best available server to perform the task. This work aims to address the challenge of distributing intelligence to World Wide Web by contributing a unique ant-based intelligent load balancing framework which is able to integrate and synthesize knowledge on a scale far beyond the capabilities of individual humans.
Survey on Parameters of Fingerprint Classification Methods Based On Algorithmic Flow
Dimple Parekh,Rekha Vig
International Journal of Computer Science and Engineering Survey , 2011,
Abstract: Classification refers to assigning a given fingerprint to one of the existing classes already recognized inthe literature. A search over all the records in the database takes a long time, so the goal is to reduce thesize of the search space by choosing an appropriate subset of database for search. Classifying afingerprint images is a very difficult pattern recognition problem, due to the minimal interclassvariability and maximal intraclass variability. This paper presents a sequence flow diagram which willhelp in developing the clarity on designing algorithm for classification based on various parametersextracted from the fingerprint image. It discusses in brief the ways in which the parameters are extractedfrom the image. Existing fingerprint classification approaches are based on these parameters as inputfor classifying the image. Parameters like orientation map, singular points, spurious singular points,ridge flow, transforms and hybrid feature are discussed in the paper.
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