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Search Results: 1 - 10 of 4652 matches for " Diem Nguyen Bentzon "
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Clinico-Pathological Characterization of Hereditary, Familial and Sporadic Prostate Cancer  [PDF]
Diem Nguyen Bentzon, Anne Sofie Lynnerup, Michael Borre
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.22008
Abstract: Aim: To characterize familial prostate cancer including hereditary prostate cancer and assess the disease-free survival following radical prostatectomy. Methods: A self-administered written questionnaire was forwarded to 709 prostatectomized patients from the Aarhus Prostate Cancer Study containing questions about cases of prostate cancer (PC), age at diagnosis, vital status, and age at death for all first-degree relatives. Patients were then divided into groups according to their family history: hereditary prostate cancer (HPC), familial prostate cancer (FPC), and sporadic prostate cancer (SPC) groups. The information from a subset of both FPC (n = 17) and SPC (n = 17) groups were validated in the Danish Cancer Register and the Civil Registration System. Between groups, we described the association of age, prostatespecific antigen (PSA), postoperative Gleason score and T Stage. A Kaplan-Meier curve demonstrated postoperative disease-free survival in each group. Results: The response rate was 81% (574/709). About 21% of the patients were categorized in the FPC group, of which 7% were identified as having HPC. The median follow-up time was 63 months for HPC, 65 months for FPC and 88 months for SPC. Overall, there was no significant difference between groups in clinical features and disease-free survival except that patients with HPC were significantly associated with younger age than sporadic cases (p = 0.02). The proportion of self-reported PC diagnoses confirmed in the cancer register was 27.8%. The index persons with SPC reported no PC in first-degree relatives and none was found the cancer register. Conclusion: Overall, we found no difference in clinical characteristics and survival, following radical prostatectomy except that patients with HPC were younger at diagnosis. These results are in line with previously reported data.
Expression Profiling of Hereditary versus Sporadic Prostate Cancer Suggests CYR61, EGR3, KLF6 and SNF1LK as Differentially Expressed Genes  [PDF]
Diem Nguyen Bentzon, Martin M?rck Mortensen, Torben ?rntoft, Lars Dyrskj?t, Michael Borre
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.22010
Abstract: Background: Distinguishing between sub-clinical and aggressive forms of prostate cancer is difficult due to the heterogeneity of the disease. It is, however, important to identify aggressive forms to guide proper treatment. This study compared gene expression profiles in cancer cells from hereditary and sporadic prostate cancer cases and attempted to correlate differentially regulated genes with clinico-pathological characteristics and prognosis. Materials and methods: The study population comprised patients diagnosed with clinically localized prostate cancer undergoing prostatectomy. Patients were divided into hereditary and sporadic cancer cases based on their family history. Fresh frozen biopsies from prostatectomy specimens were laser-dissected for RNA-extraction. Affymetrix HG-U133 Plus GeneChips were used to measure gene expression loaded onto Cluster 3.0 and Ingenuity Pathway Analysis softwares to examine the relationship among genes between groups. Differentially expressed genes were selected for protein expression analysis using immunohistochemistry on histological sections and tissue microarrays. Results: No single genes were signifycantly differentially expressed between hereditary and sporadic cases after adjustment for multiple testing. Using cluster analysis, four transcripts were found to be upregulated in hereditary prostate cancer tissue: CYR61, EGR3, KLF6 and SNF1LK. The intensity of CYR61, EGR2, KLF6 and SNF1LK immunostainings, however, were not significantly different in a separate sample of hereditary and sporadic prostate cancers. Furthermore, no correlations between CYR61, EGR2, KLF6, and SNF1LK staining intensities and the clinico-pathological variables or disease-free survival were detected, except for EGR3 that was significantly associated with T stage (p = 0.04). Conclusion: Overall, no single transcript level was significantly associated with hereditary prostate cancer. Cluster analysis suggested that the expression of CYR61, EGR3, KLF6 and SNF1LK were upregulated in cancer tissue from hereditary cases, but we were not able to confirm this on the protein level, and levels of these proteins were not found to correlate with clinico-pathological characteristics or biochemical recurrence.
Replication of Prostate Cancer Risk Variants in a Danish Case-Control Association Study  [PDF]
Diem Nguyen Bentzon, Mette Nyegaard, Anders B?rglum, Torben ?rntoft, Michael Borre, Karina Dalsgaard S?rensen
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.22009
Abstract: Background: Prostate cancer is one of the main causes for cancer morbidity and mortality in Western countries. Recently, several single nucleotide polymorphisms (SNPs) associated with prostate cancer have been identified in genome-wide association studies and multiple variant models have been developed to predict prostate cancer risk. The association between genetic markers and clinico-pathological tumor variables has, however, been inconsistent. Methods and Materials: A total of 32 previously identified prostate cancer-associated risk SNPs were genotyped in 648 prostate cancer cases and 526 age-matched controls. Family history was obtained by questionnaire. Age at diagnosis, clinical tumor variables including pre- and postoperative PSA, Gleason score, and T stage were obtained from prospectively collected clinical data (Aarhus Prostate Cancer Study). The SNPs were genotyped using Sequenom and Taqman assays and associations between SNPs, prostate cancer risk, and clinico-pathological variables were assessed. Results: Seventeen SNPs were successfully replicated in our case-control study and the association estimates were consistent with previous reports. Four markers were excluded from further analysis due to linkage disequilibrium. The cumulative effect of having the disease-associated genotype at five SNPs (rs4430796, rs6983267, rs1859962, rs1447295 and rs16901979) increased the prostate cancer risk with odds ratio 6.02 (95% CI: 2.21 - 16.38; P = 1.0 × 10–4) in patients with any combination of ≥4 markers compared with patients without any of the five SNPs (P for trend = 1.0 × 10–4). Six markers were significantly associated with clinico-pathological variables: SNP rs2735839 (GG) at locus 19q13, which is in the KLK3 gene encoding PSA, was associated with high preoperative PSA (P = 0.04), low Gleason score (P = 0.01) and low T stage (P = 0.02). Variants rs5759167 (GG/GT) (22q13) and rs7679673 (CC/CA) (4q24) were correlated with low risk for biochemical relapse (P = 0.015 and P = 0.009, respectively), whereas rs6983267 (GG) (8q24) was significantly associated with biochemical recurrence (P = 0.045). In addition, variants rs6983267 (GG) and rs5759167 (GG/GT) were significantly associated with negative family history (P = 0.04 and P = 0.02, respectively). Conclusion: We replicated 17 previously identified prostate cancer-associated risk SNPs in a Danish case-control study and found a cumulative and significant association between five SNPs and prostate cancer. Overall, we
Case Report: Acute Fatty Liver of Pregnancy  [PDF]
Huynh Nguyen Khanh Trang, Hoang Thi Diem Tuyet
Open Journal of Obstetrics and Gynecology (OJOG) , 2017, DOI: 10.4236/ojog.2017.710102
Abstract: Acute fatty liver of pregnancy (AFLP) is a rare disease in Vietnam. Diagnosis by recorded literature is often difficult to distinguish from viral hepatitis, paraplegia, or bile duct disease, so AFLP diagnosis is often delayed. The prevalence of hepatitis B in Vietnam in pregnant women is estimated at 10% REF _Ref494526757 \r \h [1], preeclampsia is estimated at 0.2% REF _Ref494526760 \r \h [2]. A case pregnant woman has 35.5-week gestational age with AFLP, who was safely delivered both mother and infant at Hung Vuong hospital, Vietnam. A careful history and physical examination, in conjunction with compatible laboratory and ultrasound imaging results, are often sufficient to make the diagnosis, and liver biopsy is rarely indicated. Intensive adjuvant therapy and rapid birth control are essential for maternal and fetal outcomes.
Studying on Tyrosinase Inhibition Activity of Some Vietnamese Folk Plants Aims to Use in Skin-Whitening Cosmetics  [PDF]
Nguyen Thi My Hanh, Nguyen Kim Phi Phung, Quach Ngo Diem Phuong
American Journal of Plant Sciences (AJPS) , 2017, DOI: 10.4236/ajps.2017.86088
Abstract: White mulberry Morus alba and jackfruit Artocarpus heterophyllus are two of seven chosen Vietnamese folk plants which showed the highest tyrosinase inhibition activity. Besides, both of them showed antioxidant and antibacterial activities. Especially, the Sulforhodamine B (SRB) assay test result of the root core extract of M. alba figured out its non-toxicity on foreskin fibroblasts.
Phytochemical Constituents and Determination of Resveratrol from the Roots of Arachis hypogea L.  [PDF]
Tuyen Pham Nguyen Kim, Nga Vo Thi, Phuong Tran Van, Phuong Quach Ngo Diem, Duong Ngo Thi Thuy, Quang Ton That, Phung Nguyen Kim Phi
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.412291

Two triterpenoid saponins, 6, 7, together with five known compounds were isolated from the roots of Arachis hypogea L. collected in Vietnam. Their structures were established by spectroscopic analysis (1D, 2D NMR and HRMS) as well as by comparison with those reported in the literature. Furthermore, the high content of resveratrol in the roots opens a new potential resource for pharmaceutical companies to prepare medicines from the wasted peanut roots.

On a shock problem involving a nonlinear viscoelastic bar
Long Nguyen Thanh,Dinh Alain Pham Ngoc,Diem Tran Ngoc
Boundary Value Problems , 2005,
Abstract: We treat an initial boundary value problem for a nonlinear wave equation in the domain , . The boundary condition at the boundary point of the domain for a solution involves a time convolution term of the boundary value of at , whereas the boundary condition at the other boundary point is of the form with and given nonnegative constants. We prove existence of a unique solution of such a problem in classical Sobolev spaces. The proof is based on a Galerkin-type approximation, various energy estimates, and compactness arguments. In the case of , the regularity of solutions is studied also. Finally, we obtain an asymptotic expansion of the solution of this problem up to order in two small parameters , .
On a shock problem involving a nonlinear viscoelastic bar
Nguyen Thanh Long,Alain Pham Ngoc Dinh,Tran Ngoc Diem
Boundary Value Problems , 2005, DOI: 10.1155/bvp.2005.337
Abstract: We treat an initial boundary value problem for a nonlinear wave equation utt ¢ ’uxx+K|u| ±u+ |ut| 2ut=f(x,t) in the domain 0 Keywords
Influence of Chitosan Binder on the Adhesion of Silver Nanoparticles on Cotton Fabric and Evaluation of Antibacterial Activity  [PDF]
Nguyen Quoc Hien, Dang Van Phu, Nguyen Ngoc Duy, Le Anh Quoc, Nguyen T. Kim Lan, Hoang T. Dong Quy, Huynh T. Hong Van, Phan Ha Nu Diem, Tran Thai Hoa
Advances in Nanoparticles (ANP) , 2015, DOI: 10.4236/anp.2015.44011
Abstract: Colloidal silver nanoparticles (AgNPs) with particle size less than 10 nm and concentration of 2 mM/L (~200 mg/L) were synthesized by gamma Co-60 ray irradiation of Ag+/chitosan solutions with different chitosan concentration of 0.5%, 1% and 2% (w/v). Incorporation of AgNPs onto cotton fabric was carried out by padding method with 100% wet pick-up. The content of AgNPs deposited on cotton fabric and released from cotton fabric after repeated washing was determined by inductively couple plasma-atomic emission spectroscopy (ICP-AES). The results indicated that cotton/AgNPs fabric made from padding into AgNPs solution with 0.5% - 1% chitosan was the best one of AgNPs adhesion ability on cotton fabric. Results on antibacterial activity against S. aureus showed that cotton/AgNPs fabric with AgNPs content more than 100 mg/kg exhibited highly antibacterial activity (η > 98%). The mechanical property (tensile strength and elongation) of cotton/AgNPs fabrics was almost unchanged in comparison with untreated cotton fabric. Thus, the resultant cotton/AgNPs fabric with highly antibacterial activity can be potentially used as bed drapes and/or patient uniforms in hospitals, etc.
Co-Infection of Parvovirus B19, CMV and BK Virus after Renal Transplantation  [PDF]
Hoang Thi Diem Thuy
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.911068
Abstract: Background: Parvovirus B19 is the agent causing a regenerative anemia in organ transplant recipients, due to their immunodepressive status. The diagnosis is usually confirmed by the presence of virus in the blood and bone marrow via the PCR technique. There is a potential co-infection with other opportunistic viruses in the transplanted patients. However, this population is not routinely screened for Parvovirus B19 infection. Case Report: A 14-year-old male patient who received living-donor kidney transplantation developed a severely progressive and aregenerative anemia four weeks later. PCR of Parvovirus B19 was positive from bone marrow aspiration. There were concomittant CMV and BK virus co-infection. The treatment included a reduction of immunosuppressants, intravenous gamma globulin. Valganciclovir has been prescribed for three months that could negativate the CMV blood load. At the end, there was an eradication of parvovirus in the bone marrow. Conclusion: This first reported case in Viet Nam which informed that infection with Parvovirus B19 should be investigated in the transplanted population when a regenerative anemia is present. Otherwise, a screening strategy for Parvovirus B19 should also be considered.
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