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accounts for less than 3% of all gastrointestinal tract malignancies, and it is
mainly metastatic in origin. In contrast, primary melanoma of the small bowel
is an extremely rare entity. We report the case of a 34-year-old male who was
diagnosed with melanoma involving the ileum most likely secondary in origin.
Histologically, the neoplastic cells involved the entire wall thickness,
showed nuclear pleomorphism, nuclear pseudoinclusions, abundant eosinophilic
cytoplasm, and were immunoreactive for S100, HMB45, and Melan-A. Electron
microscopy showed electron-dense complexes that suggested aggregates of melanin.
The final diagnosis was given based on the clinical, radiologic and
histopathologic correlation. This case demonstrates the need of clinical and histological immunohistochemistry, electron microscopy
and molecular studies together to make a correct diagnosis of spindle cell and
epithelioid tumors of the gastrointestinal tract.