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Search Results: 1 - 10 of 18699 matches for " Di Stefano Giuseppina "
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Altered glycosylation profile of purified plasma ACT from Alzheimer’s disease
Ianni Manuela,Manerba Marcella,Di Stefano Giuseppina,Porcellini Elisa
Immunity & Ageing , 2010, DOI: 10.1186/1742-4933-7-s1-s6
Abstract: Background Alzheimer’s disease (AD) is one of the most frequent cause of neurodegenerative disorder in the elderly. Inflammation has been implicated in brain degenerative processes and peripheral markers of brain AD related impairment would be useful. Plasma levels of alpha-1-antichymotrypsin (ACT), an acute phase protein and a secondary component of amyloid plaques, are often increased in AD patients and high blood ACT levels correlate with progressive cognitive deterioration. During inflammatory responses changes in the micro-heterogeneity of ACT sugar chains have been described. Methods N-Glycanase digestion from Flavobacterium meningosepticum (PNGase F) was performed on both native and denatured purified ACT condition and resolved to Western blot with the purpose to revealed the ACT de-glycosylation pattern. Further characterization of the ACT glycan profile was obtained by a glycoarray; each lectin group in the assay specifically recognizes one or two glycans/epitopes. Lectin-bound ACT produced a glyco-fingerprint and mayor differences between AD and controls samples were assessed by a specific algorithms. Results Western blot analysis of purified ACT after PNGase F treatment and analysis of sugar composition of ACT showed significantly difference in “glyco-fingerprints” patterns from controls (CTR) and AD; ACT from AD showing significantly reduced levels of sialic acid. A difference in terminal GlcNac residues appeared to be related with progressive cognitive deterioration. Conclusions Low content of terminal GlcNac and sialic acid in peripheral ACT in AD patients suggests that a different pattern of glycosylation might be a marker of brain inflammation. Moreover ACT glycosylation analysis could be used to predict AD clinical progression and used in clinical trials as surrogate marker of clinical efficacy.
Tango-Therapy: An Alternative Approach in Early Rehabilitation of Multiple Sclerosis  [PDF]
Luca Collebrusco, Giuseppina Di Tocco, Alessandra Bellanti
Open Journal of Therapy and Rehabilitation (OJTR) , 2018, DOI: 10.4236/ojtr.2018.63008
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disorder of central nervous system (CNS), characterized by the presence of multifocal demyelination plaques with characteristic symptoms as fatigue, balance disorder, reduced endurance in gait and decrease in quality of life. The study supposed that the motor treatment through dance could represent useful therapeutic option, together with other treatments already in use such as the pharmacological and physiotherapy one. We included 9 person (6 male and 3 female) affected by relapsing-remitting multiple sclerosis (RRMS) with an expanded disability status scale (EDSS) score less than 3, underwent rehabilitation treatment with Argentine Tango (Riabilitango®method). The study lasted twenty months, considering a sixty-minute session a week. The aim of the study was to verify the real improvement of quality of life, fatigue, balance disorder and gait endurance due to the dance treatment. We collected outcomes data of Short Form 36 (SF-36) in physical function (PF) (45.56 ± 21.42 vs. 69.44 ± 23.64), vitality (VT) (45.00 ± 7.90 vs. 67.77 ± 6.18), social function (SF) (54.00 ± 13.86 vs. 75.11 ± 6.25), general health (GH) (32.22 ± 5.06 vs. 54.11 ± 5.20); Modified fatigue impact test scales (MFSI) (3.56 ± 3.72 vs. 37.22 ± 3.88); Berg balance scale (BBS-it) (33.89 ± 4.12 vs. 45.11 ± 3.51); Six Minute Walk Test (6mWT), in distance (m) (352.89 ± 174.56 vs. 397.22 ± 174.83), oxygen saturation in arterial blood (%SpO2) (87.67 ± 3.35 vs. 91.78 ± 5.92) and beast per minute (bpm) (82.67 ± 13.08 vs. 72.67 ± 10.52). We found statistically significant (p < 0.05) improvements in each evaluation scale. In conclusion, despite the small sample size included, the results confirm
Curiosità russo-pisane Curiosità russo-pisane
Stefano Garzonio,Giuseppina Larocca
Studi Slavistici , 2012,
Abstract:
Nonlinear elliptic equations and Gauss measure
Giuseppina Di Blasio,Filomena Feo
Le Matematiche , 2006,
Abstract: We prove existence and regularity results for weak solutions to nonlinear elliptic equations.
Isoperimetric estimates for the first Neumann eigenvalue of Hermite differential equations
Francesco Chiacchio,Giuseppina di Blasio
Mathematics , 2011,
Abstract: We provide isoperimetric Szeg\"{o}-Weinberger type inequalities for the first nontrivial Neumann eigenvalue $\mu_{1}(\Omega)$ in Gauss space, where $\Omega$ is a possibly unbounded domain of $\mathbb{R}^{N}$. Our main result consists in showing that among all sets of $\mathbb{R}^{N}$ symmetric about the origin, having prescribed Gaussian measure, $\mu_{1}(\Omega)$ is maximum if and only if $\Omega$ is the euclidean ball centered at the origin.
Comparison and regularity results for the fractional Laplacian via symmetrization methods
Giuseppina Di Blasio,Bruno Volzone
Mathematics , 2011,
Abstract: In this paper we establish a comparison result through symmetrization for solutions to some boundary value problems involving the fractional Laplacian. This allows to get sharp estimates for the solutions, obtained by comparing them with solutions of suitable radial problems. Furthermore, we use such result to prove a priori estimates for solutions in terms of the data, providing several regularity results which extend the well known ones for the classical Laplacian.
Acupuncture for the treatment of severe acute pain in Herpes Zoster: results of a nested, open-label, randomized trial in the VZV Pain Study
Tamara Ursini, Monica Tontodonati, Lamberto Manzoli, Ennio Polilli, Cristina Rebuzzi, Gabriele Congedo, Sonia Di Profio, Patrizia Toro, Augusta Consorte, Giuseppina Placido, Stefano Laganà, Claudio D'Amario, Carla Granchelli, Giustino Parruti, Lucio Pippa, the VZV Pain Study Group
BMC Complementary and Alternative Medicine , 2011, DOI: 10.1186/1472-6882-11-46
Abstract: Within the VZV Pescara study, pain was assessed in HZ patients on a Visual Analogue Scale (VAS) and by the McGill Pain Questionnaire (MPQ) both at the beginning and at the end of treatment. Response rates, mean changes in pain intensity, differences in total pain burden with an area-under-the-curve (AUC) method over a 1-year follow-up and differences in the incidence of Post-Herpetic Neuralgia (PHN) were evaluated.One hundred and two patients were randomized to receive either AC (n = 52) or ST (n = 50) for 4 weeks. Groups were comparable regarding age, sex, pain intensity at presentation and missed antiviral prescription. Both interventions were largely effective. No significant differences were observed in response rates (81.6% vs 89.2%, p = 0.8), mean reduction of VAS (4.1 +/- 2.3 vs 4.9 +/- 1.9, p = 0.12) and MPQ scores (1.3 +/- 0.9 vs 1.3 +/- 0.9, p = 0.9), incidence of PHN after 3 months (48.4% vs 46.8%, p = 0.5), and mean AUC during follow-up (199 +/- 136 vs 173 +/- 141, p = 0.4). No serious treatment-related adverse event was observed in both groups.This controlled and randomized trial provides the first evidence of a potential role of AC for the treatment of acute herpetic pain.ChiCTR-TRC-10001146.A significant proportion (18% to 41%) of patients suffering with Herpes Zoster (HZ) experience intense or very intense pain at presentation, frequently persisting after the healing of rash [1-4]. Both pain in the acute phase and chronic pain in post-herpetic neuralgia (PHN) may severely impact on quality of life and health care costs, interfering with physical, emotional and social functioning of affected patients [5-7]. Therefore, several investigations were carried out to identify effective strategies to control Zoster-related pain [8-11].Current therapeutic options include the repeated administration of paracetamol and/or other NSAIDs for the immediate relief of pain [9,10], antiviral drugs, which accelerate the resolution of acute pain and may reduce the incide
Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
Negri, Giuseppina;di Santi, Daniel;Tabach, Ricardo;
Revista Brasileira de Farmacognosia , 2010, DOI: 10.1590/S0102-695X2010005000051
Abstract: humulus lupulus l., cannabaceae, is commonly used as light sedative and anxiolytics in folk medicine. hplc-dad-esi-msn represents a powerful tool for the analysis of natural products, since it can simultaneously provide a uv chromatogram and significant structural information about compounds in complex mixture. the aim of this work was characterize the constituents present in hydroethanolic extract. compounds 1-9 were tentatively characterized on the basis of uv, ms/ms, after reversed phase separation, retention time and literature data. the main phenolic compounds (based on peak area) were characterized as hulupinic acid (9), cohulupone (8), two oxidized hop alfa-bitter acids (principal constituents), one being a oxidized cohumulinone (5) and the other an oxidized humulinone (7) derivatives, together with a procyanidin dimer b (3), flavonoids rutin (4) and kaempferol-7-o-rutinoside (6). this plant known, due to anxiolytic property and beer flavoring, showed oxidized hop bitter acids, as principal constituents, in its hydroethanolic extract.
Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic
Giuseppina Negri,Daniel di Santi,Ricardo Tabach
Revista Brasileira de Farmacognosia , 2010,
Abstract: Humulus lupulus L., Cannabaceae, is commonly used as light sedative and anxiolytics in folk medicine. HPLC-DAD-ESI-MSn represents a powerful tool for the analysis of natural products, since it can simultaneously provide a UV chromatogram and significant structural information about compounds in complex mixture. The aim of this work was characterize the constituents present in hydroethanolic extract. Compounds 1-9 were tentatively characterized on the basis of UV, MS/MS, after reversed phase separation, retention time and literature data. The main phenolic compounds (based on peak area) were characterized as hulupinic acid (9), cohulupone (8), two oxidized hop alfa-bitter acids (principal constituents), one being a oxidized cohumulinone (5) and the other an oxidized humulinone (7) derivatives, together with a procyanidin dimer B (3), flavonoids rutin (4) and kaempferol-7-O-rutinoside (6). This plant known, due to anxiolytic property and beer flavoring, showed oxidized hop bitter acids, as principal constituents, in its hydroethanolic extract. Humulus lupulus L., Cannabaceae, é usada como sedativo e ansiolítico na medicina popular. O método de HPLC-DAD-ESI-MSn representa uma ferramenta poderosa para a análise de produtos naturais, desde que ela fornece o espectro de UV e informa es estruturais sobre os constituintes da mistura. O objetivo deste trabalho foi o de caracterizar os constituintes encontrados no extrato hidroalcoólico. Os constituintes 1-9 foram tentativamente caracterizados através do UV/DAD e ioniza o por electrospray (MS/MS) depois da separa o usando fase reversa, tempo de reten o e dados da literatura. Os principais compostos fenólicos (baseados na área dos picos) foram caracterizados como ácido hulupínico (9), coulupona (8), dois alfa-ácidos amargos oxidados (principais constituintes), um deles sendo um derivado da coumulinona oxidada (5) e o outro um derivado da humulinona oxidada (7), junto com uma procianidina B (3) e os flavonoides rutina (4) e o canferol-7-O-rutinosídeo (6). Esta planta conhecida devido às suas propriedades ansiolíticas e por ser um componente da cerveja, mostrou derivados oxidados de alfa-ácidos, como principais constituintes do extrato hidroalcoólico.
Blow-up solutions for some nonlinear elliptic equations involving a Finsler-Laplacian
Francesco Della Pietra,Giuseppina di Blasio
Mathematics , 2015,
Abstract: In this paper we prove existence results and asymptotic behavior for strong solutions $u\in W^{2,2}_{\textrm{loc}}(\Omega)$ of the nonlinear elliptic problem \begin{equation} \tag{P} \label{abstr} \left\{ \begin{array}{ll} -\Delta_{H}u+H(\nabla u)^{q}+\lambda u=f&\text{in }\Omega,\\ u\rightarrow +\infty &\text{on }\partial\Omega, \end{array} \right. \end{equation} where $H$ is a suitable norm of $\mathbb R^{n}$, $\Omega$ is a bounded domain, $\Delta_{H}$ is the Finsler Laplacian, $10$ and $f$ is a suitable function in $L^{\infty}_{\textrm{loc}}$. Furthermore, we are interested in the behavior of the solutions when $\lambda\rightarrow 0^{+}$, studying the so-called ergodic problem associated to \eqref{abstr}. A key role in order to study the ergodic problem will be played by local gradient estimates for \eqref{abstr}.
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