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Preparation and in vitro characterization of paclitaxel-loaded injectable microspheres
Hiremath Jagadeesh,Devi V
Asian Journal of Pharmaceutics , 2010,
Abstract: The main objective of this study was to develop paclitaxel loaded poly (caprolactone) injectable microspheres prepared by solvent evaporation method. Mircoparticles were characterized in terms of particle size and size distribution, surface morphology, drug physical state, and crystalline nature by using master size analyzer, scanning electron microscope, differential scanning calorimetry, and X-ray diffraction. Paclitaxel loading over different concentrations was analyzed by high-performance liquid chromatography. In vitro drug release studies were performed in phosphate buffer saline. Best formulation was selected for in vitro cytotoxic studies by using MCF-7 breast cancer cell lines.
Preparation and in vitro characterization of poly (epsilon-caprolactone)-based tamoxifen citrate-loaded cylindrical subdermal implant for breast cancer
Hiremath Jagadeesh,Devi V
Asian Journal of Pharmaceutics , 2011,
Abstract: In the present study cylindrical poly(epsilon-caprolactone) (PCL)-based biodegradable polymeric tamoxifen citrate-loaded subdermal implants were prepared by laboratory-based modified melt extrusion technique. The prepared implants were evaluated for their physicochemical parameters. Drug content in implants by high-performance liquid chromatographic (HPLC) method, differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscope (SEM) studies of tamoxifen citrate-loaded implants. Determination of in vitro hydrolytic degradation of polymeric and tamoxifen citrate-loaded implants and in vitro drug release was carried out by using indigenously developed dissolution apparatus. DSC and XRD studies proved that the drug is entrapped in the implant. The highest rate of hydrolytic degradation (weight loss) was observed in blank implants when compared to tamoxifen citrate-loaded implants. The studies proved that the developed method have potential in terms of industrial feasibility.
GC-MS ANALYSIS OF ETHANOL EXTRACT OF ENTADA PURSAETHA DC SEED
Kalpana Devi V
Bioscience Discovery , 2012,
Abstract: The investigation was carried out to determine the possible bioactive components of seed of Entada pursaetha using GC-MS. Entada pursaetha known to the Kanikkars as “Parandaikodi” is an important medicinal plant. The Kanikkar tribe, inhabitants of Agasthiarmalai Biosphere Reserve, Western Ghats, Tamil Nadu use this plant to relief from rheumatic pain. The chemical compositions of the ethanol extract of seed of Entada pursaetha were investigated using Perkin-Elmer Gas Chromatography-Mass Spectrometry, while the Mass spectra of the compounds found in the extract was matched with the National Institute of Standard and Technology (NIST) library. Fourteen compounds were identified; 1,2, Benzenedicarboxylic acid, diisooctyl ester (69.52%) was found to be major component followed by Benzeneacetic acid, 2,5-dihydroxy- (syn: Homogentisic acid) (8.12%), n-Hexadecanoic acid (4.48%) Oleic acid (4.39%) Azulene, 1,4-dimethyl 1-7- (1-methylethyl)- (3.86%) and undecanoic acid (2.46%).
Ramelteon: A melatonin receptor agonist for the treatment of insomnia
Devi V,Shankar P
Journal of Postgraduate Medicine , 2008,
Abstract: Ramelteon is a novel MT1 and MT2 melatonin receptor selective agonist recently approved for the treatment of insomnia characterized by difficulty in sleep onset. It is a nonscheduled drug since it lacks the potential for abuse and does not interact with neurotransmitter receptors most associated with these phenomena. Although the effects of ramelteon use> 5 weeks are unknown, the available data confirms its safety and efficacy for short-term use. Clinical use and future research should uncover more information about ramelteon′s properties.
Issues and Concerns of Higher Education in Universities and Colleges
V. Selvaraj,K. Marammal Devi
International Business Management , 2012,
Abstract: The research component and higher education programs at universities have been challenged due to perceived neglect of undergraduate education. Higher education, relevant research and community partnerships, have become the battle cry of many critics of higher education. Undergraduate education and research should interface. Integrating faculty research into the classroom experience creates a direct flow between discovery and dissemination, exposing students to the full range of knowledge. Faculty and students, working side-by-side on issues and problems, cultivate a spirit of collaboration, which will better prepare students for team oriented work. If the established measure of excellence is in federally funded research and doctoral programs, research and doctoral granting universities have little incentive to broaden their priorities. Conflict exists because the value system and reward structure that currently guide faculty are out of sync with the priorities of the public. These results in a disgruntled public that does not feel well served and institutions that feel misunderstood and unappreciated.
Humanising Language Learning: Blending Learning in SLA
D. Ravikumar,V. Anitha Devi
Humanising Language Teaching , 2012, DOI: 17559715
Abstract:
ANTISENSE TECHNIQUE TO TREAT BREAST CANCER – A REVIEW
Vijayalakshmi S,Devi Rajeswari V
International Research Journal of Pharmacy , 2011,
Abstract: There are many genes which are responsible for developing breast cancer especially, BRCA2 (Breast Cancer 2) and HER2 are extensively involved in developing breast cancer and hence it is the centre of attractions for all the researchers. Nano-particles conjugated with the anti-HER2 monoclonal antibodies are called as “Trastazumab” which directly target the HER2 gene. The major advantage of this technology is that the cells can be prevented before they evolve in to mature stages i.e. metastases production. The BRCA2 gene belongs to the family of tumor suppressor genes and its protein product is responsible for the error free repair mechanisms of DNA. This BRCA2 gene interacts with RAD51 gene to fix the DNA breaks. Mutation in BRCA2 gene such as insertion and deletion leads to breast cancer. More than 800 mutations are found in this gene that lead to increased risk of the breast cancer. Furthermore, BRCA2 gene is also associated with various cancers like prostate, ovarian, fallopian, male breast cancer. Researchers believe that altered products produced due to defects in this gene are unable to interact with the gene RAD51 and cannot repair the DNA. Antisense RNA is the tool which can used to block any RNA or DNA to synthesize its product. In this review we focus in using Antisense RNA against the sense RNA of an altered BRCA2 gene to block the altered affectivity of that gene on the DNA repair mechanism. However, Antisense RNA technique may not help in treating breast cancer, it can better manage the breast cancer to occur.
STANDARDIZATION OF SIDDHA DRUG ‘SANGU PARPAM’ USING INFRARED SPECTRUM
V.N. Meena devi *
International Journal of Pharmacy and Technology , 2010,
Abstract: The traditional medicine is widely used for various human ailments in which plant products are largely used for drug preparation. In Indian medicine till now there is not a single method for the standardization of drug. In the Siddha medicine Sangu parpam is widely used for the treatment of indigestion, acidity, hyperacidity, ulcer, carminative and piles. It is used externally for various skin diseases, pimples and skin crack. Sangu parpam is a product is taken in this present study for standardization by using IR spectrum.
Rationale and Role of High Loading Dose Clopidogrel in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention  [PDF]
Sam T. Mathew, Gayathri Devi S, Prasanth V. V, Vinod B
Pharmacology & Pharmacy (PP) , 2012, DOI: 10.4236/pp.2012.34066
Abstract: Antiplatelet therapy, which reduces platelet activation and aggregation, is the corner stone of treatment for patients undergoing percutaneous coronary intervention (PCI). Clopidogrel is an established oral antiplatelet medication of thienopyridine class, which inhibits blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Many studies have revealed that high loading dose clopidogrel in patients undergoing PCI. This review article investigates the rationale and role of high loading dose clopidogrel in patients undergoing PCI.
Spectrophotometric Determination of Iron(II) and Cobalt(II) by Direct, Derivative, and Simultaneous Methods Using 2-Hydroxy-1-Naphthaldehyde-p-Hydroxybenzoichydrazone
V. S. Anusuya Devi,V. Krishna Reddy
International Journal of Analytical Chemistry , 2012, DOI: 10.1155/2012/981758
Abstract: Optimized and validated spectrophotometric methods have been proposed for the determination of iron and cobalt individually and simultaneously. 2-hydroxy-1-naphthaldehyde-p-hydroxybenzoichydrazone (HNAHBH) reacts with iron(II) and cobalt(II) to form reddish-brown and yellow-coloured [Fe(II)-HNAHBH] and [Co(II)-HNAHBH] complexes, respectively. The maximum absorbance of these complexes was found at 405?nm and 425?nm, respectively. For [Fe(II)-HNAHBH], Beer’s law is obeyed over the concentration range of 0.055–1.373?μg?mL?1 with a detection limit of 0.095?μg?mL?1 and molar absorptivity ?, 5.6 × 104?L mol?1 cm?1. [Co(II)-HNAHBH] complex obeys Beer’s law in 0.118–3.534?μg?mL?1 range with a detection limit of 0.04?μg?mL?1 and molar absorptivity, ? of 2.3 × 104?L mol?1 cm?1. Highly sensitive and selective first-, second- and third-order derivative methods are described for the determination of iron and cobalt. A simultaneous second-order derivative spectrophotometric method is proposed for the determination of these metals. All the proposed methods are successfully employed in the analysis of various biological, water, and alloy samples for the determination of iron and cobalt content. 1. Introduction Iron and cobalt salts are widely used in industrial materials [1, 2], paint products [3], fertilizers, feeds, and disinfectants. They are important building components in biological systems [4]. Special cobalt-chromium-molybdenum alloys are used for prosthetic parts such as hip and knee replacements [5]. Iron-cobalt alloys are used for dental prosthetics [6]. There has been growing concern about the role of iron and cobalt in biochemical and environmental systems. Normally small amounts of iron and cobalt are essential for oxygen transport and enzymatic activation, respectively, in all mammals. But excessive intake of iron causes siderosis and damage to organs [7]. A high dosage of cobalt is very toxic to plants and moderately toxic to mammals when injected intravenously. Hence, quantification of various biological samples for iron and cobalt is very important to know their influence on these systems. A good number of reviews have been made on the use of large number of chromogenic reagents for the spectrophotometric determination of iron and cobalt. Some of the recently proposed spectrophotometric methods for the determination of iron [8–15] and cobalt [16–22] are less sensitive and less selective. We are now proposing simple, sensitive and selective direct and derivative spectrophotometric methods for the determination of iron(II) and cobalt(II) in various
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