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Search Results: 1 - 10 of 171 matches for " Despina Papamichail "
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Severe Asthma: Definitions, risk factors and phenotype characterization
Penny Moraitaki,Despina Papamichail,Niki Georgatou
Pneumon , 2010,
Abstract: SUMMARY. The correct diagnosis of asthma is usually made easily and most patients with asthma respond to therapy. Approximately 5-10% of patients with asthma, however, have disease that is difficult to control despite administration of maximal doses of inhaled medications. It appears that asthma is a heterogeneous disorder which presents not as a single disease but rather as a complex of multiple, separate syndromes that overlap. Although the various different phenotypes of asthma have been long recognized, they are still poorly characterized. Improved phenotypical characterization and understanding of the underlying pathobiology are necessary for linkage of specific genotypes with clinical disease manifestations, for possible development of biomarkers and for devising advanced, phenotype-targeted asthma treatment. This review reports on the asthma phenotypes that have been best described and analyses the methods used to define them. Pneumon 2010, 23(3):260-292.
Improved Algorithms for Approximate String Matching (Extended Abstract)
Dimitris Papamichail,Georgios Papamichail
Computer Science , 2008,
Abstract: The problem of approximate string matching is important in many different areas such as computational biology, text processing and pattern recognition. A great effort has been made to design efficient algorithms addressing several variants of the problem, including comparison of two strings, approximate pattern identification in a string or calculation of the longest common subsequence that two strings share. We designed an output sensitive algorithm solving the edit distance problem between two strings of lengths n and m respectively in time O((s-|n-m|)min(m,n,s)+m+n) and linear space, where s is the edit distance between the two strings. This worst-case time bound sets the quadratic factor of the algorithm independent of the longest string length and improves existing theoretical bounds for this problem. The implementation of our algorithm excels also in practice, especially in cases where the two strings compared differ significantly in length. Source code of our algorithm is available at http://www.cs.miami.edu/\~dimitris/edit_distance
Optimal Performance in Means-Ends Activities: On the Emergence of Self-Other/World Differentiation in Infancy  [PDF]
Despina Stamatopoulou
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.312157
Abstract: We know little about the role of background positive affectivity and flow experiences in early development concerning means-ends activities and their possible contribution regarding symbolic functioning and the consolidation of the self as agent. The theoretical argument presented here is that a deeper appreciation of the benefits and challenges of optimal experience may help built a more unified account of optimal functioning in development. That is, the paradox of control in flow, and its relational/mirroring structure, wherein the demands of the structure (means) are entities in themselves (ends), mark possibilities for the temporal organization of experience when fine motor tuning and gross motor intention overlap. When means-focused action/temporal regulation (I) and ends-focused action (Me) become synchronized in an integrated embodied system, the system shifts experience to the experiential gear. Means-ends dynamics, then, via mirroring processes organized in turn-taking flow structures between formative action (means) and production, push the child’s primary reactive space to be converted into the child’s interactive experiential space and in turn mapped on and gradually transformed to the “secondary,” communicative/expressive space, which also controls its manifestation, initiating in line conscious control and self-referential intentionality.
The Level Ancestor Problem in Practice
Dimitris Papamichail,Thomas Caputi,Georgios Papamichail
Computer Science , 2014,
Abstract: Given a rooted tree T, the level ancestor problem is the problem of answering queries of the form LA(v, d), which identify the level d ancestor of a node v in the tree. Several algorithms of varied complexity have been proposed in the literature, including optimal solutions that preprocess T in linear bounded time and proceed to answer queries in constant bounded time. Despite its significance and numerous applications, to date there have been no comparative studies of the performance of these algorithms and no implementations are widely available. In our experimental study we have implemented and compared several solutions for the level ancestor problem, including two optimal algorithms, and examine their space requirements and time performance.
An Investigation of the Dimensional Changes of Polymer Mixture Tablets Containing a Soluble Drug, Using an Image Analysis Method. Influence of These Characteristics on Drug Release and Its Mechanism  [PDF]
Manuel Efentakis, Despina Tavoulari
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.32026
Abstract: The properties and characteristics of the polymer used for the preparation of matrix drug delivery systems considerably influence their performance and the extent of drug release and its mechanism. The objective of this research was to examine the dimensional changes, and gel evolution of polymer matrices consisting of three different polymers Polyox, sodium alginate (hydrophilic) and Ethocel (hydrophobic), using an image analysis method. Furthermore to explore how these changes influence the release rate of a soluble drug namely, venlafaxine. All tablets displayed marked dimensional expansion and gel growth particularly those consisting of two hydrophilic polymers Polyox/sodium alginate (POL/SA/V) compared to those consisting of the hydrophilic/hydrophobic Polyox/Ethocel (POL/ET/V). Similarly the thickness of the gel layer in POL/SA/V matrices increased considerably with time up to 8 hours. In general our findings show that the POL/SA/V matrices, due to their thicker gel layer produced a more effective barrier which results in a more pronounced sustained release delivery. This accounts for the slower and smaller overall drug release observed with the POL/SA/V matrices compared to those containing POL/ET/V and indicates that the formation of a thick and durable gel barrier is a characteristic necessary for the preparation of sustained drug release systems. Moreover the solubility of venlafaxine in combination with the polymer’s properties appears to play an important role on the extent of drug release and the release mechanism. Overall the polymer mixtures examined comprise a useful and promising combination of materials for the development and manufacture of sustained release preparations based on these polymers.
Outer membrane protein genes and their small non-coding RNA regulator genes in Photorhabdus luminescens
Dimitris Papamichail, Nicholas Delihas
Biology Direct , 2006, DOI: 10.1186/1745-6150-1-12
Abstract: By bioinformatics analysis of conserved genetic loci, mRNA 5'UTR sequences, RNA secondary structure motifs, upstream promoter regions and protein sequence homologies, an ompF -like porin gene in P. luminescens as well as a duplication of this gene have been predicted. Gene loci for micF RNA, as well as OmpC protein and its associated regulatory micC RNA, were not found. Significantly, a sequence bearing the appropriate signatures of the E. coli micA RNA was located. The ompA homolog was previously annotated in P. luminescens.Presence of an ompF-like porin in P. luminescens is in keeping with the necessity to allow for passage of small molecules into the cell. The apparent lack of ompC, micC and micF suggests that these genes are not essential to P. luminescens and ompC and micF in particular may have been lost when the organism entered its defined life cycle and partially protected habitat. Control of porin gene expression by RNA may be more prevalent in free- living cells where survival is dependent on the ability to make rapid adjustments in response to environmental stress. Regulation of ompA by micA may have been retained due to a necessity for ompA control during one or both stages of the P. luminescens life cycle.This article was reviewed by Tal Dagan (nominated by Dan Graur), Mikhail Gelfand and Anna Gerasimova (nominated by Mikhail Gelfand) and J Peter Gogarten.Reviewed by Tal Dagan (nominated by Dan Graur), Mikhail Gelfand and Anna Gerasimova (nominated by Mikhail Gelfand) and J Peter Gogarten. For the full reviews, please go to the Reviewers' comments section.Outer membrane porin proteins allow for the passive diffusion of small solutes into the bacterial cell. Passage of molecules through the cell envelope and control of this process are crucial to cell survival when nutrients are scarce or when the cell is exposure to toxins or other adverse conditions. In E. coli and related gamma-proteobacteria, the major outer membrane porin proteins are OmpF and OmpC
Evaluation of pan coefficient equations in a semi-arid Mediterranean environment using the ASCE-standardized Penman-Monteith method  [PDF]
Vassilis G. Aschonitis, Vassilis Z. Antonopoulos, Dimitris M. Papamichail
Agricultural Sciences (AS) , 2012, DOI: 10.4236/as.2012.31008
Abstract: Reference crop evapotranspiration (ETo) is essential for irrigation, water resources management and environmental assessment. The indirect estimation of ETo is based a) on energy budget approach using meteorological data and b) pan evaporation measurements (Epan) multiplied by pan coefficients (kp) adapted to the surrounding environmental conditions. Significant interest is shown for the kp equations, which have to be tested before their use. The purpose of this study is to evaluate six different kp equations, such as those of Cuenca, Allen and Puitt, Snyder, Pereira et al., Orang, Raghuwanshi and Wallender for the summer growing season (April to October) of Thessaloniki plain in Greece, which is characterized by a semi-arid Mediterranean environment. The evaluation of the kp equations is performed by two years Epan measurements, using as reference the daily ETo values estimated by the ASCE-standardized Penman-Monteith equation (ASCE-PM) in hourly time step. The results of this study showed that Cuenca’s equation provided more accurate daily estimations. Additional analysis is performed in other methods such as those of FAO-56 and Hargreaves based on the calculation time step (hourly or daily) and their correspondence to the ASCE-PM.
Despina Nazou
Tourismos : an International Multidisciplinary Journal of Tourism , 2009,
Abstract: The purpose of this paper is to present the family tourist trips and holidays as a complex process, defined by a series of socio-cultural factors such as the sense of locality, the family ties, the professional status. There will be the attempt to show the tourist perceptions and practices of a group of entrepreneurs from Mykonos (place of origin), an overly-developed Greek tourist island. While they themselves are producers of tourism services, by going on pleasure trips to Thailand they become tourists, even forming a tourist identity related to perceptions about the sense of belonging and the family.
Entrepreneurship and Relational Capital in a Levantine Context: Bartolomew Edward Abbott, the "Father of the Levant Company" in Thessaloniki (Eighteenth-Nineteenth Centuries)
Despina Vlami
Historical Review , 2010,
Abstract: No abstract
The identification of some Fusarium species in Trifolium pratense L. cultures in Transilvania
Despina MUSAT
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 1968,
Abstract: Three Fusarium species (F. redolens Wr., F. solani (Mart) App. et Wr., F. moniliforme Sheld.) are identified for the first time in Romania, the symptoms being described on Trifolium pratense L.
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