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Preparation and in vitro characterization of the transdermal drug delivery system containing tamoxifen citrate for breast cancer
Adhyapak Anjana,Desai B
Asian Journal of Pharmaceutics , 2011,
Abstract: A matrix-type transdermal drug delivery system of tamoxifen citrate was developed by using a different ratio of eudragit-RL100, hydroxypropyl methyl cellulose (HPMC-K15), and ethyl cellulose (EC), by the solvent evaporation technique. The effect of the binary mixture of polymers with a penetration enhancer on the physical chemical parameters including, thickness, folding endurance, uniformity of drug content, moisture content, moisture uptake, tensile strength, and in vitro drug permeation were evaluated. The in vitro drug permeation studies were conducted by using modified Keshary-Chein diffusion cells through female Sprague Dawley rat skin using pH 7.4 phosphate buffer saline (PBS). The selected formulation′s stability studies were conducted as per the International Conference on Harmonization (ICH) guidelines, and did not show any degradation of the drug.
DESIGN AND EVALUATION OF FAST DISSOLVING FILM OF DOMPERIDONE
Desai P,Basu B
International Research Journal of Pharmacy , 2012,
Abstract: The objective of present research work was formulation and development fast dissolving film of domperidone. Domperidone is a specific blocker of dopamine receptors Solvent casting method was used for preparation of fast dissolving film. Various film forming polymers were evaluated for selection of suitable polymer. Different polymers like maltodextrin, polyvinyl alcohol and different grades of hydroxypropyl methylcellulose like HPMC E5 LV, HPMC E15 LV and HPMC E3 LV were used in study for selection of polymers. Amongst them HPMC E3 LV, HPMC E5 LV was selected as film forming polymer and propylene glycol was used as plasticizer. For solubility enhancement inclusion complex from β-cyclodextine was prepared by kneading method. Films were evaluated for physical and mechanical properties, drug content, disintegration time, in vitro dissolution and stability study. Prepared films showed satisfactory physical and mechanical properties. Drug-excepients interaction study (IR spectroscopy), Differential scanning calorimetry (DSC), Drug content, disintegration time and in vitro dissolution were also acceptable. 32 factorial design were used for optimization of film formulation. Batch F4 was found to be optimized film formulation which has 35.33 second disintegration time, tensile strength 2.180 N/cm2, drug release 75.26% after 15 min. Acelerated stability studies on the promising formulations indicated that there were no significant changes in drug content, in vitro disintegration time, tensile strength, in vitro dissolution and surface pH.
Rabeprazole.
Desai C,Samant B
Journal of Postgraduate Medicine , 2002,
Abstract:
Fabrication and Investigation of Damping Properties of Nano Particulate Composites  [PDF]
K. S. Umashankar, K. V. Gangadharan, Vijay Desai, B. Shivamurthy
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2010, DOI: 10.4236/jmmce.2010.99059
Abstract: Nano particulate composites with Al-Si alloys (LM6 and LM25) as matrix and Multiwall Carbon Nanotube (MWNT) as reinforcement (0.25, 0.5, 0.75, 1.0 and 1.5 weight percentage) have been fabricated by powder metallurgy process. Damping specimens were prepared according to ASTM E 756-05 standard and the specimens were subjected to free vibration test to investigate the damping ratio and natural frequency. It is observed from the free vibration test data; both alloys (LM6 and LM25) have shown significant improvement in damping ratio, natural frequency and modulus when reinforced with 0.5 weight percentage of MWNT. Increase in weight percentage of MWNT beyond 0.5 leads to deterioration in damping ratio, natural frequency and modulus. This is due to agglomeration of reinforcement phase. The same has been observed in the morphological study using transmission electron microscopy (TEM). In this work an attempt has been made to also investigate the mechanical properties of the fabricated composites.
Radio Frequency Modelling for Future Wireless Sensor Network on Surface of the Moon  [PDF]
Jayesh P. Pabari, Yashwant B. Acharya, Uday B. Desai, Shabbir N. Merchant, Barla Gopala Krishna
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2010, DOI: 10.4236/ijcns.2010.34050
Abstract: In order to study lunar regolith properties, wireless sensor network is planned to be deployed on surface of the Moon. This network can be deployed having few wireless sensor nodes capable of measuring soil properties and communicating results, as and when ready. Communication scenario on lunar surface is quite different as compared to that on the Earth, as there is no atmosphere and also there are lots of craters as well as various terrain topologies. Since the deployment of sensors on the Moon is a challenging and difficult task, it is advisable to predict the behaviour of communication channel on lunar surface. However, communication models like Irregular Terrain Model used for terrestrial communication networks are not directly applicable for Unattended Ground Sensor type sensor networks and need modifications according to lunar surface conditions and lunar environment. Efforts have been put to devise a model of radio frequency environment on the Moon using basic equations governing various physical phenomena occurring during radio propagation. The model uses Digital Elevation Model of four sites of the Moon, measured by Terrain Mapping Camera on board Chandrayan-1, a recent Indian mission to the Moon. Results presented in this paper can provide understanding of percentage area coverage for given minimum received signal strength, potential sites for sensor deployment assuring wireless communication, decision whether a given sensor node can work and can provide suggestion for possible path of rover with cluster head to remain in contact with the nodes. Digital Elevation Model based results presented here can provide more insight in to the communication scenario on the Moon and can be very useful to mission planners.
First report of evaluation of K-M media: A new corneal preservation medium
Desai Beena,Khamar B,Ghodadra B
Indian Journal of Ophthalmology , 2007,
Abstract: Purpose: To analyze the outcome of keratoplasty performed using Kalevar-Majumdar (K-M) media, a new synthetic viscous medium for preservation of the cornea. Materials and Methods: The K-M media-preserved donor eye balls were kept in a bottle in a refrigerator at 4° C till the corneas were used. Forty-eight consecutive keratoplasty cases of pseudophakic bullous keratopathy with vision less than counting fingers at one meter and operated by a single surgeon have been analyzed. Corneal donor button of 7.5 mm was used on the 7.0 mm recipient bed in all cases. Surgery was done with a standard technique. All the cases were examined daily for the first week and at the end of one month for graft clarity, epithelial defect and stromal edema. Results: The K-M media-preserved corneal grafts remained clear at the end of the first week in 95.8% (46 of 48) cases and at the end of one month in 93.7% (45 of 48) cases. Donor epithelial haze cleared in 24h in all cases. The stromal edema got cleared in the majority (91.7%, 44 of 48) within 24h. Epithelial defect was seen in only 10.4% (five cases). There was no primary graft failure. Conclusion: K-M medium, a new viscous, synthetic corneal preservation medium, is a safe (no primary donor failure) alternative to conventional liquid corneal preservation media. K-M media-preserved eyes appear to have better preserved corneal epithelium with faster achievement of graft clarity postoperatively.
A Blended Module for the Emergency Medicine Resident: An Introduction to Vital Signs and Emergency Stabilization  [PDF]
Bobby Desai
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.63035
Abstract: Beginning a residency in Emergency Medicine is a daunting task, and the new physician must be aware of what abnormal vital signs are and understand when to initiate emergency therapy. This module was created to teach the new physician about the vital sign of temperature. The module is blended to incorporate online learning via both direct and asynchronous methods, as well as face-to-face interactions using high fidelity simulation.
Overview of international teledermatology
B Desai, K McKoy, C Kovarik
Pan African Medical Journal , 2010,
Abstract: Teledermatology is essentially “dermatology at a distance”, using one of many communication technologies to expand the reach of a dermatologist to those in need of their specialized knowledge. Most international teledermatology is store-and-forward in nature, a method in which images are stored on a computer and then transmitted electronically to a consulting dermatologist. This system is more convenient and less costly than realtime teledermatology. This review will focus on several of the store-and-forward teledermatology systems being developed and utilized successfully internationally. This discussion of “who” is practicing teledermatology is not comprehensive, but attempts to show some of the breadth of teledermatology practice around the world, including government national health plans, commercial endeavors, and charitable work by individuals and institutions. The goal in many instances is to provide better health outcomes through increased access, efficiency, and/or costeffectiveness. More studies ultimately need to be conducted to develop a more comprehensive and sustainable model for teledermatology.
Certain subclasses of univalent functions and an application of the fractional calculus
B. A. Uralegaddi,A. R. Desai
Tamkang Journal of Mathematics , 2001, DOI: 10.5556/j.tkjm.32.2001.11-116
Abstract: The object of this paper is to obtain some distortion theorems for hte fractional calculus for certain subclasses of analytic and univalent functions. Certain special cases of the results obtained here are also mentioned.
Synthesis of Some New Thiazolidinones Derived from 1-p-Tolylethanone and Their Antibacterial and Antifungal Activities
Jitesh B. Patel,Vikas A. Desai
International Journal of Industrial Chemistry , 2011,
Abstract: Some new 3-(substitutedphenyl)-2-methyl-2-p-tolylthiazolidin-4-ones (3a-t) were prepared by refluxing the 1-p-tolylethanone (1) with different aromatic amines (2a-t) in presence of thioglycolic acid in benzene (one pot synthesis). The title compounds have been characterized on the basis of elemental analysis, IR, 1H-NMR and 13C-NMR spectral data. All the synthesized compounds have been screened against four different bacterial strains S. aureus, S. paratyphi-A, E. coli and B. subtilis and fungal strain F. molaniforme and A. niger. Some of them showed good antibacterial and antifungal activity compared to reference drugs used in the study.
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