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Search Results: 1 - 10 of 4005 matches for " Dereure Jacques "
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Risk Zones of Human Leishmaniases in the Western Mediterranean Basin: Correlations between Vector Sand Flies, Bioclimatology and Phytosociology
Rispail, Philippe;Dereure, Jacques;Jarry, Daniel;
Memórias do Instituto Oswaldo Cruz , 2002, DOI: 10.1590/S0074-02762002000400004
Abstract: correspondence analysis was applied to sand fly sampling in 865 stations from the western mediterranean basin. the position of each of 24 species was determined with respect to the bioclimatic belts. thus, the multidimensional analyses manifest clear correlations between bioclimatic belts and their expression in the area, the phytosociological groupings, and vector species of visceral and cutaneous leishmaniases. the transfer of these data to usual maps allows to delimit the geographical distribution of these diseases in the western mediterranean basin and contributes to the determination, in a rational manner, of the high risk zones.
Risk Zones of Human Leishmaniases in the Western Mediterranean Basin: Correlations between Vector Sand Flies, Bioclimatology and Phytosociology
Rispail Philippe,Dereure Jacques,Jarry Daniel
Memórias do Instituto Oswaldo Cruz , 2002,
Abstract: Correspondence analysis was applied to sand fly sampling in 865 stations from the Western Mediterranean basin. The position of each of 24 species was determined with respect to the bioclimatic belts. Thus, the multidimensional analyses manifest clear correlations between bioclimatic belts and their expression in the area, the phytosociological groupings, and vector species of visceral and cutaneous leishmaniases. The transfer of these data to usual maps allows to delimit the geographical distribution of these diseases in the Western Mediterranean basin and contributes to the determination, in a rational manner, of the high risk zones.
Multifaceted Population Structure and Reproductive Strategy in Leishmania donovani Complex in One Sudanese Village
Virginie Rougeron equal contributor ,Thierry De Mee?s equal contributor,Mallorie Hide,Georges Le Falher,Bruno Bucheton,Jacques Dereure,Sayda H. El-Safi,Alain Dessein,Anne-Laure Ba?uls
PLOS Neglected Tropical Diseases , 2011, DOI: 10.1371/journal.pntd.0001448
Abstract: Leishmania species of the subgenus Leishmania and especially L. donovani are responsible for a large proportion of visceral leishmaniasis cases. The debate on the mode of reproduction and population structure of Leishmania parasites remains opened. It has been suggested that Leishmania parasites could alternate different modes of reproduction, more particularly clonality and frequent recombinations either between related individuals (endogamy) or between unrelated individuals (outcrossing) within strongly isolated subpopulations. To determine whether this assumption is generalized to other species, a population genetics analysis within Leishmania donovani complex strains was conducted within a single village. The results suggest that a mixed-mating reproduction system exists, an important heterogeneity of subsamples and the coexistence of several genetic entities in Sudanese L. donovani. Indeed, results showed significant genetic differentiation between the three taxa (L. donovani, L. infantum and L. archibaldi) and between the human or canine strains of such taxa, suggesting that there may be different imbricated transmission cycles involving either dogs or humans. Results also are in agreement with an almost strict specificity of L. donovani stricto sensu to human hosts. This empirical study demonstrates the complexity of population structure in the genus Leishmania and the need to pursue such kind of analyses at the smallest possible spatio-temporal and ecological scales.
Dark Energy as a Property of Dark Matter  [PDF]
Jacques Leibovitz
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.212181
Abstract: A novel model of dark matter (DM), elastically compressible, can contribute to the acceleration of our Universe expansion. While each galaxy compresses its own DM within its gravitation field, the DM bordering neighboring galaxies, far from their centers, is pulled apart. It is shown that, although the DM pressure tends to zero at such locations, the DM compressibility tends to infinity. This allows the DM to expand between galaxies without gravitation hindrance. The model is consistent with the coupled distributions of baryonic and dark matters, with black hole formation at the centers of large galaxies, with galactic flat rotation curves, with a Tully-Fisher relation, and with Milgrom’s MOND relation. Results are discussed.
Mechanism and evolution of multidomain aminoacyl-tRNA synthetases revealed by their inhibition by analogues of a reaction intermediate, and by properties of truncated forms  [PDF]
Jacques Lapointe
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.610115
Abstract: Many enzymes which catalyze the conversion of large substrates are made of several structural domains belonging to the same polypeptide chain. Transfer RNA (tRNA), one of the substrates of the multidomain aminoacyl-tRNA synthetases (aaRS), is an L-shaped molecule whose size in one dimension is similar to that of its cognate aaRS. Crystallographic structures of aaRS/tRNA complexes show that these enzymes use several of their structural domains to interact with their cognate tRNA. This mini review discusses first some aspects of the evolution and of the flexibility of the pentadomain bacterial glutamyl-tRNA synthetase (GluRS) revealed by kinetic and interaction studies of complementary truncated forms, and then illustrates how stable analogues of aminoacyl-AMP intermediates have been used to probe conformational changes in the active sites of Escherichia coli GluRS and of the nondiscriminating aspartyl-tRNA synthetase (ND-AspRS) of Pseudomonas aeruginosa.
A Review on Tectonic Record of Strain Buildup and Stress Release across the Andean Forearc along the Gulf of Guayaquil-Tumbes Basin (GGTB) near Ecuador-Peru Border  [PDF]
Jacques Bourgois
International Journal of Geosciences (IJG) , 2013, DOI: 10.4236/ijg.2013.43057
Abstract:

Gravimetric and geologic data show that the reactivation of the Neogene Interandean depression and/or the ~75 - 65 Ma ophiolite suture into the modern dynamic of the Andes controlled the Gulf of Guayaquil Tumbes basin (GGTB) location and evolution during the past 1.8 - 1.6 Myr at least. Depending on whether the remobilization occurred along the interandean depression or the ophiolite suture, the GGTB evolved trough pure or simple shear mechanisms, respectively. Because the GGTB exhibits an along strike tectonic asymmetry associated with a pervasive seismic gap, the simple shear solution is more likely. Tectonic inversion occurred along a mid-crust detachment (the Mid-Crust detachment hereafter) matching the ophiolite suture that accommodates the North Andean Block (NAB) northward drift. The so-called Decoupling Strip located at the shelf slope break accommodated the tensional stress rotation from N-S along the shelf area i.e. NAB-drift induced to E-W along the continental margin i.e. subduction-erosion-induced. The landward dipping Woollard detachment system located at the Upper-Lower slope boundary connects the subduction channel at depth, allowing the Upper slope to evolve independently from the Lower slope wedge. The long-term recurrence interval between earthquakes, the strong interplate coupling, and the aseismic creeping deformation acting along the main low-angle detachments i.e. the Woollard and the Mid-Crust detachments may account for the pervasive seismic gap at the GGTB area. Because the subduction channel exhibits no record of significant seismic activity, no evidence exists to establish a link between the GGTB sustained subsidence and a basin-centered asperity. Because the

New Expansion Dynamics Applied to the Planar Structures of Satellite Galaxies and Space Structuration  [PDF]
Jacques Fleuret
Journal of Modern Physics (JMP) , 2016, DOI: 10.4236/jmp.2016.716204
Abstract:

Recent observations of Dwarf Satellite Galaxies (DSG) show that they have a clear tendency to stay in particular planes. Explanations with standard physics remain controversial. Recently, I proposed a new explanation of the galactic flat rotation curves, introducing a new cosmic acceleration due to expansion. In this paper, I apply this new acceleration to the dynamics of DSG’s (without dark matter). I show that this new acceleration implies planar structures for the DSG trajectories. More generally, it is shown that this acceleration produces a space structuration around any massive center. It remains a candidate to explain several cosmic observations without dark matter.

Studying Differential Invariants in Developmental Variations  [PDF]
Jacques Juhel
Psychology (PSYCH) , 2018, DOI: 10.4236/psych.2018.94041
Abstract: The differential study of intraindividual variability and change is currently reaping the benefits of important methodological advances in longitudinal data modeling. Two major research strategies for detecting invariants in individual differences in developmental change are considered. The most common approach involves operating at a population level to study differences of behavior throughout development. Though rarely used, another approach is the differential study of developmental change based on an individual modeling of the dynamics of intraindividual variability. The potential of these two approaches for improving our understanding of the development of human beings is illustrated.
Mind-Language, the Expanding Heart of Cognition  [PDF]
Jacques Coulardeau
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.66004
Abstract:
On the basis of already published research on the phylogeny of language during the emergence of Homo Sapiens starting around 300,000 years ago, and on still-to-be-published research in its final phase on the psychogenesis of language starting in the 24th week of gestation, I will present my work on the central role of two virtual human constructs of man’s nervous system and brain confronted to their real environment, both natural and social. These two constructs, the mind and language, are the results of the development of the general pattern-capturing potential of the brain’s architecture. The mind and language develop simultaneously, reciprocally and in close coordination transforming the pattern-capturing potential of the brain into the mental and linguistic conceptualizing power of men and women. This long process of development can be captured in six stages: to sense; to perceive; to discriminate (or recognize) patterns; to experiment; to speculate, and to conceptualize spatial items and temporal processes. In psychogenetics, these six stages are essential for education. Lev Vygotsky, among others, has proposed the best approach to this conceptualizing competence in children and young adults, and expanding in our whole life.
Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains
C. Mary,F. Faraut,M. Deniau,J. Dereure,K. Aoun,S. Ranque,R. Piarroux
International Journal of Microbiology , 2010, DOI: 10.1155/2010/819060
Abstract: Experimental studies about Leishmania resistance to metal and antifolates have pointed out that gene amplification is one of the main mechanisms of drug detoxification. Amplified genes code for adenosine triphosphate-dependent transporters (multidrug resistance and P-glycoproteins P), enzymes involved in trypanothione pathway, particularly gamma glutamyl cysteine synthase, and others involved in folates metabolism, such as dihydrofolate reductase and pterine reductase. The aim of this study was to detect and quantify the amplification of these genes in clinical strains of visceral leishmaniasis agents: Leishmania infantum, L. donovani, and L. archibaldi. Relative quantification experiments by means of real-time polymerase chain reaction showed that multidrug resistance gene amplification is the more frequent event. For P-glycoproteins P and dihydrofolate reductase genes, level of amplification was comparable to the level observed after in vitro selection of resistant clones. Gene amplification is therefore a common phenomenon in wild strains concurring to Leishmania genomic plasticity. This finding, which corroborates results of experimental studies, supports a better understanding of metal resistance selection and spreading in endemic areas.
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