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Search Results: 1 - 10 of 215 matches for " Denny Borsboom "
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Letting the daylight in: Reviewing the reviewers and other ways to maximize transparency in science
Jelte M. Wicherts,Rogier A. Kievit,Marjan Bakker,Denny Borsboom
Frontiers in Computational Neuroscience , 2012, DOI: 10.3389/fncom.2012.00020
Abstract: With the emergence of online publishing, opportunities to maximize transparency of scientific research have grown considerably. However, these possibilities are still only marginally used. We argue for the implementation of (1) peer-reviewed peer review, (2) transparent editorial hierarchies, and (3) online data publication. First, peer-reviewed peer review entails a community-wide review system in which reviews are published online and rated by peers. This ensures accountability of reviewers, thereby increasing academic quality of reviews. Second, reviewers who write many highly regarded reviews may move to higher editorial positions. Third, online publication of data ensures the possibility of independent verification of inferential claims in published papers. This counters statistical errors and overly positive reporting of statistical results. We illustrate the benefits of these strategies by discussing an example in which the classical publication system has gone awry, namely controversial IQ research. We argue that this case would have likely been avoided using more transparent publication practices. We argue that the proposed system leads to better reviews, meritocratic editorial hierarchies, and a higher degree of replicability of statistical analyses.
The Small World of Psychopathology
Denny Borsboom, Angélique O. J. Cramer, Verena D. Schmittmann, Sacha Epskamp, Lourens J. Waldorp
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027407
Abstract: Background Mental disorders are highly comorbid: people having one disorder are likely to have another as well. We explain empirical comorbidity patterns based on a network model of psychiatric symptoms, derived from an analysis of symptom overlap in the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV). Principal Findings We show that a) half of the symptoms in the DSM-IV network are connected, b) the architecture of these connections conforms to a small world structure, featuring a high degree of clustering but a short average path length, and c) distances between disorders in this structure predict empirical comorbidity rates. Network simulations of Major Depressive Episode and Generalized Anxiety Disorder show that the model faithfully reproduces empirical population statistics for these disorders. Conclusions In the network model, mental disorders are inherently complex. This explains the limited successes of genetic, neuroscientific, and etiological approaches to unravel their causes. We outline a psychosystems approach to investigate the structure and dynamics of mental disorders.
A Network Approach to Psychopathology: New Insights into Clinical Longitudinal Data
Laura F. Bringmann, Nathalie Vissers, Marieke Wichers, Nicole Geschwind, Peter Kuppens, Frenk Peeters, Denny Borsboom, Francis Tuerlinckx
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060188
Abstract: In the network approach to psychopathology, disorders are conceptualized as networks of mutually interacting symptoms (e.g., depressed mood) and transdiagnostic factors (e.g., rumination). This suggests that it is necessary to study how symptoms dynamically interact over time in a network architecture. In the present paper, we show how such an architecture can be constructed on the basis of time-series data obtained through Experience Sampling Methodology (ESM). The proposed methodology determines the parameters for the interaction between nodes in the network by estimating a multilevel vector autoregression (VAR) model on the data. The methodology allows combining between-subject and within-subject information in a multilevel framework. The resulting network architecture can subsequently be analyzed through network analysis techniques. In the present study, we apply the method to a set of items that assess mood-related factors. We show that the analysis generates a plausible and replicable network architecture, the structure of which is related to variables such as neuroticism; that is, for subjects who score high on neuroticism, worrying plays a more central role in the network. Implications and extensions of the methodology are discussed.
The savage in european social thought; A prelude to the conceptualization of the divergent peoples and cultures of Australia and Oceania
Ad. Borsboom
Bijdragen tot de Taal-, Land- en Volkenkunde , 1988,
Abstract:
Mouse placental gene expression
Paul Denny
Genome Biology , 2000, DOI: 10.1186/gb-2000-1-3-reports0069
Abstract: Just over 52,000 mouse expressed sequence tags (ESTs), mainly from pre- and peri-implantation embryos were clustered into a minimally redundant set of 15,000 clones which were then used to construct a cDNA microarray. The number of genes found to be highly expressed in or specific to the placenta in this study was fivefold greater than in previous studies. One of the placenta-specific genes encoded a novel member of the placental growth-related hormone family.Details of the National Institute of Aging mouse cDNA project, the ESTs used in construction of the 15K array, and all hybridization data can be found through the NIA/NIH mouse genomics homepage.The arrayed cDNAs will be invaluable in studying early murine development, and will also find application in analysis of reactivation of embryonic genes during the process of aging.This study has produced one of the first large collections of non-redundant, sequence-validated mouse cDNAs suitable for microarray construction and has demonstrated the power of expression profiling to identify novel, placenta-specific genes.Proceedings of the National Academy of Sciences of the United States of AmericaNIA/NIH mouse genomics
Mouse chromosomal deletions
Paul Denny
Genome Biology , 2000, DOI: 10.1186/gb-2000-1-1-reports027
Abstract: Su and colleagues generated a set of deletions anchored around the X-linked Hprt gene. Deletions were of varying sizes, with the largest estimated to be 1 centiMorgan in size by comparison with the genetic map. About 20% of the ES cell lines tested carried a deletion. A further deletion cluster was produced on mouse chromosome 11 and was used to construct a map of the targeted region, which was then compared with a physical map based on bacterial artificial chromosomes (BACs). Deletions of up to 8 Mb were identified in this second region.The method described by Su et al. for producing mouse chromosomes carrying deletions has three stages. The initial steps introduce two different vectors into the genome of ES cells deficient for Hprt, which enables cells to grow in a medium containing hypoxanthine, aminopterin and thymidine (HAT). The first vector is a targeting vector carrying the 5` half of the Hprt gene, a suitable genomic fragment, a loxP site and a neomycin-resistance gene, and is introduced by homologous recombination. The second vector carries the 3` half of the Hprt gene, a loxP site and a puromycin-resistance gene, and this is introduced into the ES cells by retroviral infection, in a relatively random fashion. Recombination between these two inserted sequences, mediated by a specific recombinase (Cre), excises sequences between the loxP sites. Where the relative orientation of inserted random and specific vectors is appropriate, this leaves a functional Hprt gene and removes the drug-resistance genes. This means that cells carrying potential deleted chromosomes can be selected on the basis of sensitivity to puromycin and neomycin and ability to grow in HAT.One of the genome regions used to demonstrate the effectiveness of the method is on mouse chromosome 11 and is being physically mapped by some of the same authors. Information can be found on the Mouse genome project pages.A novel combination of existing techniques is used to produce nested sets of delet
Cláusulas relativas em Gavi?o de Rond?nia
Moore, Denny;
Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas , 2006, DOI: 10.1590/S1981-81222006000100010
Abstract: the language of the gavi?o of rond?nia constructs relative clauses by syntactic nominalization, using either of two particles, mát 'concrete nominalization' or méne 'abstract nominalization', which are derived diachronically from discourse pronouns. the resulting nominal clause may or may not have an internal head, which, if it occurs, is not marked, leading to a certain degree of ambiguity. the nominalized clause can modify a following noun stem, which serves as an external head. relative clauses and complement clauses are not distinct constructions in this language. the typological significance of these constructions is discussed.
The burden of disease associated with infection with human papillomavirus
L Denny
African Journal of Urology , 2009,
Abstract:
Cervical cancer in South Africa: An overview of current status and prevention strategies
L Denny
Continuing Medical Education , 2010,
Abstract: Current estimates are that 493 243 women are diagnosed with cervical cancer per year and 273 505 die from the disease.1 Globally it is the second most common cancer in women and the most common in developing countries. In Africa, which has a population of 267.9 million women aged 15 years or greater, it is estimated that 78 897 women are diagnosed with cervical cancer annually and 61 671 (78%) will die from the disease, which is a significantly higher incidence to mortality ratio than found in developed countries (http://www.who.int/hpvcentre). There is some regional variation in age-standardised incidence rates (ASIR) of cervical cancer in Africa, with ASIRs of 42.7/100 000 reported in eastern Africa, 28/100 000 in middle Africa, 12.1/100 000 in northern Africa, 38.2/100 000 in southern Africa and 29.3/100 000 in western Africa.
Managing Construction Logistics
Denny McGeorge
Australasian Journal of Construction Economics and Building , 2010,
Abstract: Book Review Managing Construction Logistics Gary Sullivan; Stephen Barthorpe and Stephen Robbins Publishers : Wiley-Blackwell 2010, 304 pages, ISBN 978-1-4051-5124-5 (paperback), GBP 49.99, EUR 60.00, AUD 99.95, NZD 115.00.
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