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Search Results: 1 - 10 of 4363 matches for " Denis Soulières "
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Vaccines in Non-Small Cell Lung Cancer  [PDF]
Luis Corrales-Rodriguez, Normand Blais, Denis Soulières
World Journal of Vaccines (WJV) , 2013, DOI: 10.4236/wjv.2013.31004
Abstract:

Immunotherapy as an option of treatment in cancer has experienced an important development with the inclusion of vaccines. In lung cancer this type of treatment has emerged and vaccines can be classified in three groups: antigen-specific vaccines, tumor cell vaccines, and dendritic cell vaccines. Emepepimut (L-BLP25) and MAGE-A3 have been the vaccines most widely studied. Their promising results with benefit in survival and limited toxicity in preclinical and clinical trials have led to phase III trials with results eagerly awaited. Other vaccines have been investigated, but results were not favorable or are still pending. Hopefully, vaccines could be an additional instrument for the treatment of lung cancer in the adjuvant or metastatic setting as time will unveil the results of current and future trials.

Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes
Eric Bissada,Olivier Abboud,Zahi Abou Chacra,Louis Guertin,Xiaoduan Weng,Phuc Félix Nguyen-Tan,Jean-Claude Tabet,ève Thibaudeau,Louise Lambert,Marie-Lise Audet,Bernard Fortin,Denis Soulières
International Journal of Otolaryngology , 2013, DOI: 10.1155/2013/848021
Abstract: Background. RAS gene mutations have an impact on treatment response and overall prognosis for certain types of cancer. Objectives. To determine the prevalence and impact of K-RAS codons 12 and 13 mutations in patients with locally advanced HNSCC treated with primary or adjuvant chemo-radiation. Methods. 428 consecutive patients were treated with chemo-radiation therapy and followed for a median of 37 months. From these, 199 paraffin embedded biopsy or surgical specimens were retrieved. DNA was isolated and analyzed for K-RAS mutational status. Results. DNA extraction was successful in 197 samples. Of the 197 specimens, 3.5% presented K-RAS codon 12 mutations. For mutated cases and non-mutated cases, complete initial response to chemoradiation therapy was 71 and 73% ( ). LRC was respectively 32 and 83% ( ), DFS was 27 and 68% ( ), distant metastasis-free survival was 100 and 81% ( ) and OS was 57 and 65% ( ) at three years. K-Ras codon 13 analysis revealed no mutation. Conclusion. K-RAS codon 12 mutational status, although not associated with a difference in response rate, may influence the failure pattern and the type of therapy offered to patients with HNSCC. Our study did not reveal any mutation of K-RAS codon 13. 1. Introduction Head and neck squamous cell carcinoma (HNSCC) accounts for 47?000 new malignancies diagnosed each year in the USA and is the sixth most common human neoplasm, representing about 3% of all cancers [1]. Despite efforts to improve conventional treatment, survival rates for these cancers have not changed significantly over the past decade. Initial evaluation of patients includes clinical assessment, study of tumor histological characteristics and tumor grading, as well as local-regional and distant metastasis status. Traditional clinical, radiological, and histopathological characteristics are however limited in their ability to accurately predict response to treatment. This has motivated many researchers to identify molecular characteristics that may influence overall prognosis. A recent interest in molecular biology and genetics is motivated by the belief that understanding the origins of cancer can lead to more logical means of treating malignancies [2]. Identification of molecular events that lead to HNSCC may represent a key to predicting biological behaviour and may consequently lead to new treatment modalities that could lead to increases in survival rates. [3, 4]. Despite the recent progress in the field of molecular biology, clinicians need more tools to predict response to therapy or to identify patients at high risk of
The Level and Nature of Autistic Intelligence II: What about Asperger Syndrome?
Isabelle Soulières,Michelle Dawson,Morton Ann Gernsbacher,Laurent Mottron
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0025372
Abstract: A distinctively uneven profile of intelligence is a feature of the autistic spectrum. Within the spectrum, Asperger individuals differ from autistics in their early speech development and in being less likely to be characterized by visuospatial peaks. While different specific strengths characterize different autistic spectrum subgroups, all such peaks of ability have been interpreted as deficits: isolated, aberrant, and irreconcilable with real human intelligence. This view has recently been challenged by findings of autistic strengths in performance on Raven's Progressive Matrices (RPM), an important marker of general and fluid intelligence. We investigated whether these findings extend to Asperger syndrome, an autistic spectrum subgroup characterized by verbal peaks of ability, and whether the cognitive mechanisms underlying autistic and Asperger RPM performance differ. Thirty-two Asperger adults displayed a significant advantage on RPM over Wechsler Full-Scale and Performance scores relative to their typical controls, while in 25 Asperger children an RPM advantage was found over Wechsler Performance scores only. As previously found with autistics, Asperger children and adults achieved RPM scores at a level reflecting their Wechsler peaks of ability. Therefore, strengths in RPM performance span the autistic spectrum and imply a common mechanism advantageously applied to different facets of cognition. Autistic spectrum intelligence is atypical, but also genuine, general, and underestimated.
La recherche partenariale : point de vue de praticiens au Québec
Denis Bussières,Jean-Marc Fontan
SociologieS , 2011,
Abstract: Au cours des deux dernières décennies, la recherche partenariale conna t un essor important. Un essor associé à plusieurs facteurs dont le nouvel engouement manifesté par des chercheurs pour cette stratégie de recherche, le fait que nous observons une augmentation des demandes pour des activités de recherche provenant des milieux de la pratique ou encore en raison de l’importance que lui accordent les organismes subventionnaires. Dans le cadre de cet article, nous allons examiner ce mode de recherche à partir du point de vue des praticiens qui ont participé à des recherches partenariales au sein du Réseau québécois de recherche partenariale en économie sociale (RQRP-éS). L’analyse des entrevues réalisées auprès de praticiens nous révèlera les raisons de leur participation, les activités auxquelles ils ont pris part et les conditions identifiées par les praticiens pour assurer le bon déroulement d’une recherche partenariale. Partnership research: practitioners’ point of view in QuébecIn the last two decades, partnership research has been rediscovered. The renewal of this interest is directly linked to a positive change of attitudes of researchers, in response to an increase of requests from practitioners for University conducted research and a change of priority in organizations providing research funds. In this article, we will examine this research model in the light of work done in the Réseau québécois de recherche partenariale en économie sociale (RQRP-éS). We recently have done an inquiry with practitioners who where partners in research done in the RQRP-éS. We present here the results from those interviews in terms of their motivations to work in the context of an academic process of producing new knowledge, the kind of participation they were involved in the research process and finally the conditions of success in conducting that kind of research. La investigación en colaboración: el punto de vista de los investigadores en QuébecEn el transcurso de las dos últimas décadas, la investigación en colaboración ha experimentado un importante auge. Auge asociado a numerosos factores entre los cuales el nuevo interés masivo de los investigadores por esta estrategia de investigación. Observamos un aumento de la demanda por actividades de investigación que provienen de medios en contacto con la realidad social y también por el aumento de subvenciones por parte de diversos organismos. En el marco de este artículo examinamos este tipo de investigación desde el punto de vista de los que intervienen en estas investigaciones colaborativas en el seno del Réseau
L’expérience de recherche de l’Alliance de recherche universités-communautés en économie sociale
Denis Bussières,Jean-Marc Fontan
Interventions économiques , 2005,
Abstract: L’article qui suit présente le cadre de réalisation des travaux de l’ARUC-éS. Cette section rappelle la genèse du programme de recherche, ses objectifs, le partenariat qu’il implique et la fa on dont les travaux sont conduits. Nous concluons cette section en présentant les principales le ons qui se dégagent de notre expérience et les défis qui sont toujours à relever. Au nombre de ces défis, nous retrouvons la question liée à l’éternel débat sur la finalité de l’économie sociale et la place et la fonction qu’elle occupe eu égard à la transformation d’ensemble du système socioéconomique de la société québécoise. Nous développerons quelques éléments de réflexion sur cette question, ce qui nous permettra de présenter les trois éléments clés qui structureront les travaux de l’ARUC-éS au cours des cinq prochaines années.
Révolution, conversion et disparition. La littérature de fiction dans la presse d’information générale.
Denis Saint-Jacques,Marie-José des Rivières
COnTEXTES : Revue de Sociologie de la Littérature , 2012, DOI: 10.4000/contextes.5365
Abstract: Cet article développe une historicisation de la fracture entre littératures légitime et populaire, fracture bien connue, mais beaucoup plus problématique qu’on ne le croit souvent. D’une part, les auteurs tentent de comprendre les choses du point de vue de ceux et celles pour qui la littérature populaire s’est écrite plut t qu’à l’aune de l’incompréhension, pour ne pas dire du scandale, des littéraires dont ils font eux-mêmes partie. De l’autre, au delà de ce même scandale, ils cherchent à co...
HPV Prevalence and Prognostic Value in a Prospective Cohort of 255 Patients with Locally Advanced HNSCC: A Single-Centre Experience
E. Thibaudeau,B. Fortin,F. Coutlée,P. Nguyen-Tan,X. Weng,M.-L. Audet,O. Abboud,L. Guertin,A. Christopoulos,J. Tabet,D. Soulières
International Journal of Otolaryngology , 2013, DOI: 10.1155/2013/437815
Abstract: Background. HPV is a positive prognostic factor in HNSCC. We studied the prevalence and prognostic impact of HPV on survival parameters and treatment toxicity in patients with locally advanced HNSCC treated with concomitant chemoradiation therapy. Methods. Data on efficacy and toxicity were available for 560 patients. HPV was detected by PCR. Analysis was performed using Kaplan-Meier survival curves, Fisher’s test for categorical data, and log-rank statistics for failure times. Results. Median follow-up was 4.7 years. DNA extraction was successful in 255 cases. HPV prevalence was 68.6%, and 53.3% for HPV 16. For HPV+ and HPV?, median LRC was 8.9 and 2.2 years ( ), median DFS was 8.9 and 2.1 years ( ), and median OS was 8.9 and 3.1 years ( ). Survival was different based on HPV genotype, stage, treatment period, and chemotherapy regimen. COX adjusted analysis for T, N, age, and treatment remained significant ( ). Conclusions. Oropharyngeal cancer is increasingly linked to HPV. This study confirms that HPV status is associated with improved prognosis among H&N cancer patients receiving CRT and should be a stratification factor for clinical trials including H&N cases. Toxicity of CRT is not modified for the HPV population. 1. Introduction Tobacco and alcohol consumption has long been known as the major risk factor for HNSCC. However, HPV has recently been recognised to play a role in the pathogenesis of a subset of clinically and molecularly distinct HNSCC, most often located in the oropharynx and associated with wild-type p53 and downregulation of cyclin D and retinoblastoma protein pRb [1–5], and in which viral oncoproteins E6 and E7 play a crucial part [6]. HPV prevalence in HNSCC has been increasing significantly in the past few decades [5, 7]; it is estimated at 25% in HNSCC [8], but reaches up to 70% or more in tonsillar SCCs [9–11]. Unlike the HPV-negative oropharyngeal cancers, the HPV-positive subset is not associated with tobacco or alcohol use, but with certain types of sexual behaviours [12, 13]. The HPV 16 subtype is present in up to 90% of HPV-related oropharyngeal cancers, while HPVs 18, 31, and 33 have been identified in the remainder [14, 15]. HPV has recently been recognised as a good prognostic factor in head and neck (H&N) cancer [5, 16–26], which has been attributed to several mechanisms, including absence of field cancerisation and increased sensitivity to chemoradiation therapy [5, 16, 20, 22–24, 26]. Most of the available data is derived from small randomised trials with different treatment options or small heterogeneous cohorts;
Design of a Computer Code “HPFCODE” To Evaluate the Influence of the Harmonics in the Electrical Networks
A. Souli,A. Hellal
International Journal of Electrical and Computer Engineering , 2012, DOI: 10.11591/ijece.v2i5.1465
Abstract: This paper aims to present the design of a computer code (HPFCODE) of the power flow and losses in power systems under the influence of harmonics, using the GUI in MATLAB. After described the program was run for two networks IEEE 6 nodes and IEEE 14 nodes. The power flow by Newton-Raphson method was calculated as the losses of active and reactive power in the lines, respectively, where the loads are linear and nonlinear (Static Var Compensator(SVC), Thyristor controlled Reactor(TCR), and Unified Power Flow Controller (UPFC).
Environmental Sounds Spectrogram Classification using Log-Gabor Filters and Multiclass Support Vector Machines
Sameh Souli,Zied Lachiri
International Journal of Computer Science Issues , 2012,
Abstract: This paper presents novel approaches for efficient feature extraction using environmental sound magnitude spectrogram. We propose approach based on the visual domain. This approach included three methods. The first method is based on extraction for each spectrogram a single log-Gabor filter followed by mutual information procedure. In the second method, the spectrogram is passed by the same steps of the first method but with an averaged bank of 12 log-Gabor filter. The third method consists of spectrogram segmentation into three patches, and after that for each spectrogram patch we applied the second method. The classification results prove that the second method is the most efficient in our environmental sound classification system. These methods were tested on a large database containing 10 environmental sound classes. The best performance was obtained by using the multiclass support vector machines (SVMs), producing an average classification accuracy of 89.62 %.
Environmental Sounds Spectrogram Classification using Log-Gabor Filters and Multiclass Support Vector Machines
Sameh Souli,Zied Lachiri
Computer Science , 2012,
Abstract: This paper presents novel approaches for efficient feature extraction using environmental sound magnitude spectrogram. We propose approach based on the visual domain. This approach included three methods. The first method is based on extraction for each spectrogram a single log-Gabor filter followed by mutual information procedure. In the second method, the spectrogram is passed by the same steps of the first method but with an averaged bank of 12 log-Gabor filter. The third method consists of spectrogram segmentation into three patches, and after that for each spectrogram patch we applied the second method. The classification results prove that the second method is the most efficient in our environmental sound classification system.
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