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Search Results: 1 - 10 of 179 matches for " Demetrios Hassiakos "
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Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries
Ariadne Malamitsi-Puchner,Nikolaos Vrachnis,Evi Samoli,Stavroula Baka,George Alexandrakis,Karl-Philipp Puchner,Zoe Iliodromiti,Demetrios Hassiakos
Mediators of Inflammation , 2006, DOI: 10.1155/mi/2006/94381
Abstract: Aims. Our aim is to investigate, in 13 cases (delivering preterm) and 21 matched (for age, parity, and gestational age) controls (delivering at term), whether midtrimester amniotic fluid concentrations of elastase, secretory leukocyte proteinase inhibitor (SLPI), soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule predict asymptomatic intra-amniotic inflammation/infection and preterm labor. Results. Concentrations of all substances were not statistically different among mothers, delivering preterm or at term. SLPI concentrations significantly increased in women, going into labor without ruptured membranes, irrespective of pre- or term delivery (P<.007, P<.001, resp) and correlated with elastase (r=0.508, P<.002). Conclusions. Midtrimester amniotic fluid SLPI concentrations significantly decrease when membrane rupture precedes pre- or full-term labor. However, none of the investigated substances predict preterm delivery.
Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction
Theodora Boutsikou,George Mastorakos,Marialena Kyriakakou,Alexandra Margeli,Demetrios Hassiakos,Ioannis Papassotiriou,Christina Kanaka-Gantenbein,Ariadne Malamitsi-Puchner
Mediators of Inflammation , 2010, DOI: 10.1155/2010/790605
Abstract: We aimed to investigate possible alterations in circulating levels of the perinatal stress markers high sensitivity (hs)-CRP, PAI-1, and S100B—probably reflecting brain and adipose tissue inflammation—in intrauterine growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) pregnancies, given that these groups differ in fat mass and metabolic mechanisms involving aseptic inflammation. Serum hs-CRP, PAI-1, and S100B levels were measured in 40 mothers, and their 20 AGA and 20 IUGR full-term fetuses and neonates on postnatal days 1 and 4. hs-CRP, PAI-1, and S100B levels did not differ at all time points between AGA and IUGR groups. We conclude that the lack of difference in hs-CRP, PAI-1 and S100B levels, between IUGR and AGA fetuses/neonates—despite the lower birth weight, reflecting reduced fat mass in the former—might indicate more intense adipose tissue and nervous system inflammation in IUGRs. However, implication of other inflammation-related mechanisms, common in the IUGR state (e.g. preeclampsia), cannot be excluded. 1. Introduction Intrauterine growth restriction (IUGR), a major cause of infant mortality and morbidity [1, 2], is strongly related to the later development of the metabolic syndrome in adult life [3–5]. The metabolic syndrome represents a cluster of cardiovascular risk factors, such as visceral obesity, lipid and glucose metabolism abnormalities, leading to type 2 diabetes mellitus and arterial hypertension [6]. Insulin resistance has been proposed to be the underlying pathogenic link between metabolic syndrome and cardiovascular disease [7–9] and is associated with a state of low-grade aseptic inflammation that precedes the onset of metabolic syndrome [10, 11]. Data suggest that, compared with appropriate for gestational age (AGA) newborns, those with low birth weight may have relatively increased visceral fat stores [12, 13], as well as elevated levels of adipocytokines, such as leptin [14–16] and visfatin [17], which link the adipose depot to insulin resistance and sensitivity, respectively, as well as to aseptic inflammation [18]. C-reactive protein (CRP) is considered the major acute-phase reactant in humans. It is an important first-line host defence molecule, which recognises pathogens and damaged cells and promotes their elimination by activating the complement system and mediating their phagocytic clearance [19, 20]. Moreover, using high-sensitivity assays for CRP (hs-CRP), several studies have shown elevated CRP levels in obesity, since adiposity resembles a low grade systemic inflammatory state and hs-CRP is
Cord Blood Ischemia-Modified Albumin Levels in Normal and Intrauterine Growth Restricted Pregnancies
Nicoletta Iacovidou,Despina D. Briana,Maria Boutsikou,Sophia Liosi,Stavroula Baka,Theodora Boutsikou,Demetrios Hassiakos,Ariadne Malamitsi-Puchner
Mediators of Inflammation , 2008, DOI: 10.1155/2008/523081
Abstract: Ischemia-modified albumin (IMA) is a sensitive biomarker of cardiac ischemia. Intrauterine growth restriction (IUGR) may imply fetal hypoxia, resulting in blood flow centralization in favour of vital organs (brain, heart, adrenals—‘‘brain sparing effect’’). Based on the latter, we hypothesized that cord blood IMA levels should not differ between IUGR and appropriate-for-gestational-age (AGA) full-term pregnancies. IMA was measured in blood samples from doubly-clamped umbilical cords of 110 AGA and 57 asymmetric IUGR pregnancies. No significant differences in IMA levels were documented between AGA and IUGR groups. IMA levels were elevated in cases of elective cesarean section (P = .035), and offspring of multigravidas (P = .021). In conclusion, ‘‘brain sparing effect’’ is possibly responsible for the lack of differences in cord blood IMA levels at term, between IUGR and AGA groups. Furthermore, higher oxidative stress could account for the elevated IMA levels in cases of elective cesarean section, and offspring of multigravidas.
Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies
Nicoletta Iacovidou,Maria Boutsikou,Demetrios Gourgiotis,Despina D. Briana,Stavroula Baka,Venetia-Maria Vraila,Louiza Kontara,Demetrios Hassiakos,Ariadne Malamitsi-Puchner
Mediators of Inflammation , 2007, DOI: 10.1155/2007/53921
Abstract: Intrauterine growth restriction (IUGR) implies fetal hypoxia, resulting in blood flow redistribution and sparing of vital organs (brain, heart). Serum cardiac Troponin-I (cTnI), a well-established marker of myocardial ischaemia, was measured in 40 mothers prior to delivery, the doubly clamped umbilical cords (representing fetal state), and their 20 IUGR and 20 appropriate-for-gestational-age (AGA) neonates on day 1 and 4 postpartum. At all time points, no differences in cTnI levels were observed between the AGA and IUGR groups. Strong positive correlations were documented between maternal and fetal/neonatal values (r≥.498, P≤.025 in all cases in the AGA and r≥.615, P≤.009 in all cases in the IUGR group). These results may indicate (a) normal heart function, due to heart sparing, in the IUGR group (b) potential crossing of the placental barrier by cTnI in both groups
Time and Frequency Activities at the U.S. Naval Observatory
Demetrios Matsakis
International Journal of Navigation and Observation , 2008, DOI: 10.1155/2008/387418
Abstract: The US Naval Observatory (USNO) has provided timing for the navy since 1830 and, in cooperation with other institutions, has also provided timing for the United States and the international community. Its Master Clock (MC) is the source of UTC(USNO), the USNO's realization of Coordinated Universal Time (UTC), which has stayed within 5 nanoseconds RMS of UTC since 1999. The data used to generate UTC(USNO) are based upon 73 cesium and 21 hydrogen maser frequency standards in three buildings at two sites. The USNO disseminates time via voice, telephone modem, LORAN, Network Time Protocol (NTP), GPS, and two-way satellite time transfer (TWSTT). This paper describes some of the changes being made to meet the future needs for precision, accuracy, and robustness.
El servicio público en encrucijada: El significado y la importancia de la profesionalización en el servicio público
Argyriades, Demetrios;
Convergencia , 2012,
Abstract: the triumph of technical and instrumental reason, which the road of the new public management and neoliberal thinking followed, deeply affected the course of the public discussion of the ethics. on the positive side, it seemed as though professional public service and ethics would have arisen again and, as a matter of fact, an honorable place would have been given to them in the discourse of what constitutes a "good government", as well as responsible management. on the negative side, however, soon it became evident that, in the new public management, the topic of ethics and professionalism in public administration mainly worked for decorative purposes. here we propose the need for ethics and professionalization of public service to be placed again in the center of debate on democratic governance. "doing" and "not doing" of our trade as professionals of public service cannot be subjected to search short term advantages or even to the mere search for efficiency and efficacy, mainly when the highest values and principles are at stake. what globalization brings about is the global scope of these principles, the universality of values.
Interview with Prof. Ravindra Nanda.
Demetrios Mavreas
Hellenic Orthodontic Review , 2006,
Los valores del sector público y la supuesta supremacía administrativa del sector privado
Demetrios Argyriades
Revista Venezolana de Gerencia , 2003,
Abstract: El trabajo tiene como propósito discutir la validez de los modelos de gerencia privada impuestos en la administración pública durante las dos últimas décadas del siglo XX, bajo la denominación de Nueva Gerencia Pública. Los resultados dan cuenta que la crisis desencadenada por el ataque del 11 de septiembre y la implosión de Enron Corporation y Arthur Andersen conducen al cuestionamiento del sector privado y llaman la atención sobre el sector público. En este sentido se discuten las diferencias entre la gerencia privada y la pública, el costo del traslado de los modelos gerenciales privados, la necesidad de profesionalismo y determinados valores en el servicio público y la falsa representación de los ciudadanos como clientes consumidores. Se concluye argumentando la necesidad de regulación y defensa del interés general.
Psychoacoustically-Driven Multichannel Audio Coding
Demetrios Cantzos
Journal of Computations & Modelling , 2013,
Abstract: Multichannel audio rendering allows for the immersion of a listener into a rich acoustic scene, as compared to traditional stereophonic methods. Nevertheless, the excessive transmission and storage requirements of multichannel audio pose a considerable obstacle towards its widespread usage. A novel method is presented here with which a single channel of a multichannel signal is conventionally transmitted and stored while the remaining channels are resynthesized based on statistical conversion of the same, single channel-signal. The size of the parameters required for the resynthesis process is much smaller than the size of the original channel-signal for the same resulting audio quality.
Ciencia e ideología en la administración pública: una perspectiva de las Naciones Unidas
Demetrios Argyriade
Contaduría y administración , 2004,
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