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Search Results: 1 - 10 of 463216 matches for " Demajo Miroslav A. "
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TGF-beta1 in breast cancer-estrogen regulation
Todorovi?-Rakovi? Nata?a,Ivanovi? Vesna,Demajo Miroslav A.,Ne?kovi? Borka
Archive of Oncology , 2002, DOI: 10.2298/aoo0203164t
Abstract: TGF-beta1 is a pluripotent cytokine with diverse effects in the normal development of mammary glands, and in the development of malignant tumors of the breast. The aim of the study was to determine the levels of TGF-beta1 in the group of advanced breast cancer, in which increased TGF-beta1 levels were most likely to be expected. TGF-beta1 levels were also compared with estradiol levels. Our results suggested that TGF-beta1 synthesis may be regulated by estrogen or anti-estrogen through ER. Finding of increased TGF-beta1 levels, due to its possible role in predicting invasive phenotype in later phases of tumor progression, may indicate the tendency of tumor tissue towards autonomy.
Elevated plasma levels of TGF-beta1 in patients with locally advanced breast cancer related to other clinical stages
Todorovi?-Rakovi? Nata?a,Ivanovi? Vesna,Demajo Miroslav A.,Ne?kovi?-Konstantinovi? Zora
Archive of Oncology , 2003, DOI: 10.2298/aoo0303131t
Abstract: Background: The application of plasma tumor markers is mainly during the follow-up of cancer patients and especially in monitoring of advanced disease. These biomarkers do not require surgical intervention and provide relatively simple monitoring at any time during the disease course. TGF-beta1 is a pluripotent cytokine, with diverse effects in normal physiology and a role in both normal mammary gland development and progression of breast cancer. In early stages of breast carcinomas TGF-beta1 acts as tumor suppressor, while in later stages, when tumor cells become resistant to growth inhibition by TGF-beta1, it acts as tumor promoter. For that reason, the aim of this study was to assess the stage-related TGF-beta1 elevation in circulation of breast cancer patients, during disease progression. Methods: We analyzed 52 breast cancer patients of different stages (I/II, III, IV) and 36 healthy donors. TGF-beta1 levels were determined by enzyme-linked immunosorbent assay (ELISA, R&D). Results Although there was no increase in plasma TGF-beta1 in stage I/II patients (n =10, median value = 0.89 ng/ml), statistically significant elevation of plasma TGF-beta1 was found in locally advanced breast cancer (stage III, n = 9, median value = 2.30 ng/ml) and also in metastatic breast cancer (stage IV, n = 33, median value = 2.46 ng/ml) in relation to healthy donors and stage I/II. Conclusion: This elevation of plasma TGF-beta1 in locally advanced breast cancer is probably the result of increased tumor mass and tumor-stromal interactions in this stage, as well as a possible cause of greater metastatic potential of tumor cells which lead to metastatic breast cancer. Prognostic role of TGF-beta1 is not fully understood, but from these results we could say that it could be a marker for monitoring patients disease course, as well as for understating the biology of breast cancer.
Gated communities in Latin American cities Barrios cerrados en ciudades latinoamericanas
Lucía Demajo Meseguer
URBS : Revista de Estudios Urbanos y Ciencias Sociales , 2011,
Abstract: Urban space in many Latin American cities is proliferating these last decades in a gated community form, being defined as enclosed housing developments, with controlled access and security devices. The search for security, the contact with nature and exclusivity are some common features of these urbanizations. These features are usually presented by advertising agencies as vital needs for this modern society. Development of gated communities entails consequences associated with urban space fragmentation, privatization of public space, social segregation and lack of a community belonging sense; hence the need to question these types of developments and to intervene to modify them. Interventions, both aimed to redirect the emerging urban model and to carry out specific actions in the already existing gated communities, should bet on following traditional neighborhood models. This article pretends to analyze the gated communities’ phenomenon occurring in Latin America, detecting it consequences and proposing possible intervention measures. El espacio urbano de algunas ciudades latinoamericanas está proliferando, en las últimas décadas, en forma de barrios cerrados; entendidos como áreas de viviendas cerradas, con acceso controlado y dispositivos de seguridad. La búsqueda de la seguridad, el contacto con la naturaleza y la exclusividad son algunos rasgos comunes de estos barrios que, en muchos casos, la publicidad trata de convertir en necesidades vitales para la sociedad. Los barrios cerrados llevan consigo consecuencias relacionadas con la fragmentación del espacio urbano, la privatización del espacio público, la segregación social y el sentimiento de comunidad; de ahí, la necesidad de cuestionarse este tipo de emprendimientos y de intervenir sobre ellos. Las intervenciones, ya sean dirigidas a redireccionar el modelo urbano emergente, como actuaciones puntuales en BC ya existentes, deberían apostar por seguir modelos de barrio tradicional. Este artículo pretende analizar el fenómeno de los barrios cerrados latinoamericanos, detectando sus consecuencias y proponiendo posibles medidas de intervención.
Thyroid Hormones in Rats with Hyperluteinized Ovaries
M. Demajo,P. Plamenac,A. Karakasevic,V. Pantic
Journal of Medical Sciences , 2001,
Abstract: The findings of research work showed that animals with hyperluteinized ovaries (HL) obtained after mechanical lesions in the posterior hypothalamus, the circulatory patterns of pituitary and ovarian steroid hormones were disturbed. In these animals the pre-ovulatory surge of luteinizing hormone (LH) was lower and prolactin (Prl) was higher, while in early proestrus estradiol was higher, and progesterone in late proestrus was lower when compared to the intact controls. It is recognized that there is a close relationship between ovarian function and thyroid hormones, measured the serum content of total tri-iodothyronine (T3) and thyroxine (T4) in animals with hyperluteinized ovaries obtained after mechanical lesions in the posterior hypothalamus. There were no a significant differences in the circulatory concentrations of these hormones between rats with HL and intact controls. Histological analysis also showed that there were no significant differences in structure of thyroids between the two groups of animals, although the weights of the thyroid glands in the lesioned animals were significantly heavier than in intact controls. These results showed that lesions in the posterior hypothalamus, which result in a disturbance of the hypothalamo-pituitary-ovarian axis inducing HL, did not bring about changes in the hypothalamo-pituitary-thyroid axis.
Historie der Grundgrubenkarten im Kohlentagebau
Miroslav Klvaňa
Acta Montanistica Slovaca , 2007,
Abstract: Der Artikel besch ftigt sich mit der vierzigj hrigen Historie der Grundgrubenkarten im Nordb hmischen Braunkohlenrevier. Er zeigt die diesbezüglichen Legislativnormen der Staatsbergverwaltung, die sind in den Jahren 1966 und 1987 herausgegeben worden. Er beachtet die kartographische Gründe der Grubenkarten und ihren nderungen, besonders ihre Bestimmung in der ersten markscheiderischen Vorschrift für die Kohlentagebaue von dem Jahr 1966. Der Artikel führt weiter die festgesetzen Gebühren der Kartensektionen und ihre Zeichnungart nach dem Verzeichnis der vereinbarten Kennzeichen ein. Die Proben vom Betrieb Doly Nástup Tu imice darstellen die wirklichen Gestalten der Grundgrubenkarten.
Sub-tenon anesthesia in the operation of cataract using phacoemulsification technique
Avramovi? Sini?a,Vukosavljevi? Miroslav
Srpski Arhiv za Celokupno Lekarstvo , 2008, DOI: 10.2298/sarh0802012a
Abstract: INTRODUCTION Already in 1884, Knapp reported a successful cataract operation using 5% of cocaine in eyedrops. Today, different methods of local anesthesia in the operation of cataract are used, such as retrobulbary, peribulbary, subconjunctival, sub-tenon, topical and intracameral anesthesia. Phacoemulsification is a modern approach to the operation of cataract that is increasingly applied in our country. Aiming to eliminate the risk of severe complications caused by retrobulbary anesthesia, in our patients undergoing surgery to treat cataract we applied sub-tenon anesthesia. OBJECTIVE The aim of this work was to establish the efficacy and the safety of subtenal anesthesia in the operation of cataract using phacoemulsification technique. METHOD We examined 85 patients who were operated for cataract under sub-tenon anesthesia. The operation was performed using phacoemulsification technique. The surgeon injected about 2 ml of the mixture of lidocaine (2%) and bupivacaine (0.5%) in equal proportions into the bottom of the fornix at 11 o’clock or 1 o’clock position into one of the two upper eye quadrants. After phacoemulsification and the placement of intraocular lenses, the patients were asked to reply to the questions according to a standardized protocol. Priory, the patients were informed about the test and the pain scale ranging from 1 to 10, with 1 indicating the absence of pain and 10 unbearable pain. RESULTS Eighty-five patients underwent surgery for cataract using phacoemulsification technique and in whom posterior chamber intraocular lenses were placed under sub-tenon anesthesia. During the application of anesthesia, subjective pain experience was at the level of mild discomfort or non-existent in 3/4 of the patients. In relation to pain experience during surgery, it ranged from mild inconvenience to pain absence in 4/5 of the patients. The most frequent complication during surgery was eye rolling occurring in every 10th patient. In 4/5 patients the overall surgical course was assessed by the surgeon as excellent or outstanding. CONCLUSION Sub-tenon anesthesia applied at one point of the upper quadrant using during modern approach in the surgery of cataract, namely the phacoemulsification technique, offers good comfort to the patient during anesthesia introduction, as well as during surgery, with a relatively low complication rate occurring during the operation, and also offering good comfort to the surgeon.
The influence of shine duration on glare in pseudophakic persons
Avramovi? Sini?a,Vukosavljevi? Miroslav
Srpski Arhiv za Celokupno Lekarstvo , 2007, DOI: 10.2298/sarh0712635a
Abstract: Introduction Glare can be defined as unpleasant sensation caused by a relatively strong source of light, which results in unpleasantness, discomfort and the lowering of optimal vision characteristics. It has been demonstrated that different factors influence the glare in pseudophakic subjects: opacity in vision media, the brightness of the pupil and the design of intraocular lenses. Objective The aim was to examine the influence of shine duration on glare in pseudophakic persons. Method We studied 152 eyes of 98 pseudophakic persons, aged from 50 to 70 years, with good vision acuity (0.8 and more) after final correction for far and near vision. The examination was conducted on the device Niktomat (Rodenstock Instrumente GMBH, Munchen-Hamburg) under the conditions of short and long shine. The source of light of 0.35 lux intensity, under the angle of 3 degrees, lightened the pupil for ten seconds in the first test, and continually in the second test. Results In the observed group, during a direct short tensecond shine, the sign on the screen with the contrast of 30% was seen by 140 eyes (92.1%), and in the control group the sign was seen by 88 eyes (97.8%). Under the direct continuous shine, normal findings were confirmed in 40 eyes (26.3%) of the observed group, and in 83 eyes (92.2%) of the control group. Conclusion In the observed pseudophakic persons, the duration of shine was found to be in correlation with glare.
Influence of age, corneal astigmatism and some characteristics of intraocular lens on glare in pseudophakic persons
Avramovi? Sini?a,Vukosavljevi? Miroslav
Vojnosanitetski Pregled , 2007, DOI: 10.2298/vsp0712823a
Abstract: Background/Aim. Although an extraordinary visual acuity is achieved following the extracapsular cataract extraction with the implantation of intraocular lens, all the problems of vision are not solved in so doing and many of them should be considered. The aim of this study was to establish the influence of age, dioptric power of intraocular lens, corneal astigmatism and optic diameter of intraocular lens on glare in pseudophakic subjects. Methods. We examined 152 patients who underwent final correction at least two weeks after the suture removing what was performed if the astigmatism more than 2.0 D was measured by the use of a Javal keratometer. Examination was performed by a Rodenstock Adaptometer Nyctomat. According to the recommendation of the manufacturer, healthy persons should notice 50% of contrast under the constant glare and in the given time. Statistical data processing was performed by χ2 test. Results. In the group of patients with the findings lower than normal at constant glare there were 112 of eyes (73.68%) as follows: 22 eyes (14.47%) at the age from 50-55 years; 15 eyes (9.87%) were at the age from 56-60 years; 18 eyes (11.84%) were at the age from 61-65 years, and 57 eyes (37.50%) were at the age from 66-70 years. Dioptric power of lenses up to 20.0 D had 37 eyes (24.3%), from 20.5-22.0 D 85 eyes (56.9%) and more than 22.5 D, 27 eyes (17.8%). Regarding the results of discomfort caused by glare and corneal astigmatism, measured by a Javal keratometer, in the observed group normal results were found in 112 eyes (73.68%), and out of that number 95 (62.50%) were with corneal astigmatism less than 20.0 D, and 17 (11.18%) had astigmatism of 20.0 D and more. Out of 112 eyes there were 58 of them (38.16%) with findings lower than normal in relation to the constant glare and with the lens diameter of 5.5 mm, 48 (31.58%) with the lens diameter of 6.0mm, and 6 of them (3.95%) with lens diameter of 6.5mm. Conclusion. The study determined a significant statistical correlation between the dioptric power of lenses and the glare. The obtained results did not find out a significant increase in glare in relation to the age of subjects, optic diameter and corneal astigmatism.
Miroslav Ba?a,Kornelije Rabuzin
Journal of Information and Organizational Sciences , 2006,
Abstract: Minutiae classification and fingerprint classification in fingerprint evaluating process are very important. Fingerprint image contains about 150 minutiae’s. When we compare two fingerprint images, we compare latent and non latent fingerprint and we try to find 12 minutiae’s placed on the same position on latent and non latent fingerprint images. After fingerprint image pre-processing we can perform classification or we can try to find minutiae. In this paper we describe the process of minutiae classification for comparison purposes. For that purpose we use Walsh function and Walsh transforms. Paper describes minutiae classification which is relatively new in recognition systems and gives contribution for development of practical fingerprint recognition systems. Paper also gives contribution in the theoretical part due to the fact that Walsh functions were not implemented in fingerprint pre-processing systems so far. The new symbolic database model for fingerprint storage gives multifunctional foundations for future research.
The Blow up Rate Estimates for a Reaction Diffusion System with Gradient Terms
Maan A. Rasheed,Miroslav Chlebik
Mathematics , 2012,
Abstract: We concider, the blow-up solutions for a coupled reaction diffusion system with gradient terms. The main purpose is to understand whether the gradient terms effect the blow-up properties. We derive the upper and lower blow-up rate estimates under certain assumptions.
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