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Search Results: 1 - 10 of 236 matches for " Deep Aakash "
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New oxadiazole derivatives of isonicotinohydrazide in the search for antimicrobial agents: Synthesis and in vitro evaluation
Malhotra Manav,Sanduja Mohit,Samad Abdul,Deep Aakash
Journal of the Serbian Chemical Society , 2012, DOI: 10.2298/jsc110123155m
Abstract: Structural modification of the front line antitubercular drug isoniazid provide a lipophilic adaptations of the drug in which hydrazide moiety of isoniazid is replaced by 1,3,4-oxadiazole heterocycles to eliminate in-vivo acetylation by arylamine N-acetyltransferase which results to form inactive acetylated drug. In the present study a series of sixteen oxadiazole derivatives were synthesized and characterized by (IR, 1H NMR, 13C NMR and Mass spectral) studies. All the synthesized compounds were evaluated for their antimicrobial activity by broth dilution method against two Gram positive strains (Bacillus subtilis and Staphylococcus aureus), two Gram negative strains (Pseudomonas aeruginosa and Escherichia coli) and fungal strain (Candida albicans and Aspergillus niger). The minimum inhibitory concentration of the compounds was in the range of 1.56-50 μg ml-1 against bacterial and fungal strain. The results revealed that all synthesized compounds have a significant biological activity against the tested microorganisms. Among the synthesized derivatives 4g, 4h, 4m and 4p were found to be most effective antimicrobial compounds.
Assisted Reproductive Technology
JP Deep
Journal of Chitwan Medical College , 2014, DOI: 10.3126/jcmc.v4i1.10840
Abstract: All the treatment or procedure that includes the handling of both human sperm and oocytes or embryos in vitro for the purpose of establishing a pregnancy in order to bypass some pathological obstacles in human reproduction is known as Assisted Reproductive Technology (ART). Now we must be approaching 1.5 million Assisted Reproductive Technology birth since the birth of the world’s first in vitro fertilization baby, Louise Brown, in the United Kingdom. The infertility is caused by various reason and factors from either or both partners. Infertility affects worldwide by 8-15 percent of couples in general and defined as a disease of the reproductive system by the failure to achieve a clinical pregnancy after one year or more of regular unprotected sexual intercourse. DOI: http://dx.doi.org/10.3126/jcmc.v4i1.10840 Journal of Chitwan Medical College 2014; 4(1): 1-10
Modeling protein synthesis from a physicist's perspective: a toy model
Aakash Basu,Debashish Chowdhury
Physics , 2007, DOI: 10.1119/1.2757628
Abstract: Proteins are polymers of amino acids. These macromolecules are synthesized by intracellular machines called ribosomes. Although the experimental investigation of protein synthesis has been a traditional area of research in molecular cell biology, important quantitative models of protein synthesis have been reported in research journals devoted to statistical physics and related interdisciplinary topics. From the perspective of a physicist, protein synthesis is the classical transport of interacting ribosomes on a messenger RNA (mRNA) template that dictates the sequence of the amino acids on the protein. We discuss appropriate simplification of the models and methods. In particular, we develop and analyze a simple toy model using some elementary techniques of non-equilibrium statistical mechanics and predict the average rate of protein synthesis and the spatial organization of the ribosomes in the steady state.
Traffic of interacting ribosomes: effects of single-machine mechano-chemistry on protein synthesis
Aakash Basu,Debashish Chowdhury
Physics , 2006, DOI: 10.1103/PhysRevE.75.021902
Abstract: Many ribosomes simultaneously move on the same messenger RNA (mRNA), each separately synthesizing the protein coded by the mRNA. Earlier models of ribosome traffic represent each ribosome by a ``self-propelled particle'' and capture the dynamics by an extension of the totally asymmetric simple exclusion process (TASEP). In contrast, here we develope a theoretical model that not only incorporates the mutual exclusions of the interacting ribosomes, but also describes explicitly the mechano-chemistry of each of these individual cyclic machines during protein synthesis. Using analytical and numerical techniques of non-equilibrium statistical mechanics, we analyze this model and illustrate its power by making experimentally testable predictions on the rate of protein synthesis in real time and the density profile of the ribosomes on some mRNAs in E-Coli.
Motion of the Plasma Critical Layer During Relativistic-electron Laser Interaction with Immobile and Comoving Ion Plasma for Ion Acceleration
Aakash A. Sahai
Physics , 2014, DOI: 10.1063/1.4876616
Abstract: We analyze the motion of the plasma critical layer by two different processes in the relativistic-electron laser-plasma interaction regime ($a_0>1$). The differences are highlighted when the critical layer ions are stationary in contrast to when they move with it. Controlling the speed of the plasma critical layer in this regime is essential for creating low-$\beta$ traveling acceleration structures of sufficient laser-excited potential for laser ion accelerators (LIA). In Relativistically Induced Transparency Acceleration (RITA) scheme the heavy plasma-ions are fixed and only trace-density light-ions are accelerated. The relativistic critical layer and the acceleration structure move longitudinally forward by laser inducing transparency through apparent relativistic increase in electron mass. In the Radiation Pressure Acceleration (RPA) scheme the whole plasma is longitudinally pushed forward under the action of the laser radiation pressure, possible only when plasma ions co-propagate with the laser front. In RPA the acceleration structure velocity critically depends upon plasma-ion mass in addition to the laser intensity and plasma density. In RITA, mass of the heavy immobile plasma-ions does not affect the speed of the critical layer. Inertia of the bared immobile ions in RITA excites the charge separation potential whereas RPA is not possible when ions are stationary.
Traffic of interacting ribosomes on mRNA during protein synthesis: effects of chemo-mechanics of individual ribosomes
Aakash Basu,Debashish Chowdhury
Physics , 2006, DOI: 10.1103/PhysRevE.75.021902
Abstract: Many {\it ribosomes} simultaneously move on the same messenger RNA (mRNA), each synthesizing separately a copy of the same protein. In contrast to the earlier models, here {\it we develop a ``unified'' theoretical model} that not only incorporates the {\it mutual exclusions} of the interacting ribosomes, but also describes explicitly the mechano-chemistry of each of these macromolecular machines during protein synthesis. Using analytical and numerical techniques of non-equilibrium statistical mechanics, we analyze the rates of protein synthesis and the spatio-temporal organization of the ribosomes in this model. We also predict how these properties would change with the changes in the rates of the various chemo-mechanical processes in each ribosome. Finally, we illustrate the power of this model by making experimentally testable predictions on the rates of protein synthesis and the density profiles of the ribosomes on some mRNAs in {\it E-coli}.
The Endplate Morphology Changes with Change in Biomechanical Environment Following Discectomy  [PDF]
Aakash Agarwal, Anand K. Agarwal, Vijay K. Goel
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.47A1002
Abstract: Bone is a dynamic structure and is known to respond to changes in the load over time, in accordance with Wolff’s law. It states that the bone changes its shape and internal architecture in response to stresses acting on it [1]. Therefore, any structural changes in the spine may lead to bone remodeling due to changes in the optimal stress pattern. The changes in apparent density and thickness of the endplates following discectomy of varying amounts were analyzed. The study design coupled a bone remodeling algorithm based on strain energy density theory of adaptive remodeling with an experimentally validated 3D ligamentous finite element model of the spine. The apparent density and thickness of the index level endplates decreased above and below the region of discectomy. On the other hand, these parameters showed increases at the remaining regions of the endplate. There were no correlations between the amount of nucleus removed and the average percentage changes in apparent density and thickness of endplate above and below the discectomy region. However, the average percentage changes in apparent density and thickness at endplate in the other region increased with increase in amount of nucleus removed. These predictions are in agreement with the clinical observations [2-6].
Laser Raman Spectroscopic Studies on Hemeproteins in Epileptic Children  [PDF]
Sanjeev Kumar, Vinod Kumar, Deep Chand Jain
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.31018
Abstract:

Laser Raman spectroscopic studies were carried out on hemoproteins with special reference to epilepsy and compared the data with those of controls. Some of the bands were found approximately at 368.45 cm-1, 424.90 cm-1, 625.27 cm-1 and 807.38 cm-1 in case of normal children and at 1749.00 cm-1, 1795 cm-1 and 2000 cm-1 in epileptic children cases. A clear cut picture of the hemoproteins has already given in the literature and very interesting bands were found in the range from 300 cm-1 to 1800 cm-1. Our Raman lines are very effective and peculiar. We did not say anything about the detailing of these bands at this juncture.

Checking of XRF Observations with Matrix Terms Involved in Sample Analysis  [PDF]
Meenakshi Bansal, Kanan Deep, Raj Mittal
Open Journal of Microphysics (OJM) , 2013, DOI: 10.4236/ojm.2013.32005
Abstract: In X-Ray Fluorescence (XRF) studies of samples, the relative absorption terms for an analyte in a sample with respect to its standard (the analyte itself or its compound) have been empirically related to analyte amount as well as to next enhanced element amount in the sample. The terms along with these empirical relations have been used to cross check the XRF observations for the analysis work. One such an attempt has been made in the present work for bulk measurements on rice saplings and a disparity in observations has been caught.
A Study Of Consumer Behavior Towards Life Insurance In Kolhapur City
Deep K. Thakkar
Golden Research Thoughts , 2012, DOI: 10.9780/22315063
Abstract: Life insurance is a tool against protection of life of individuals. Basically it is protection against unforeseen death of an individual. So his/her family is financially protected against such risk. The purpose of life insurance for every individual may be different. There are large number of insurance companies having wide range of insurance products. On the other hand, consumers are so much confused as to which policy and of which company to be purchased. So marketers are interested to know the buying behavior of life insurance consumers in order to form their marketing strategies.
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