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Search Results: 1 - 10 of 1880 matches for " Debasish Saha "
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Evaluation of Lercanidipine in Paclitaxel-Induced Neuropathic Pain Model in Rat: A Preliminary Study
Lekha Saha,Debasish Hota,Amitava Chakrabarti
Pain Research and Treatment , 2012, DOI: 10.1155/2012/143579
Abstract: Objective. To demonstrate the antinociceptive effect of lercanidipine in paclitaxel-induced neuropathy model in rat. Materials and Methods. A total of 30 rats were divided into five groups of six rats in each group as follows: Gr I: 0.9% NaCl, Gr II: paclitaxel?+?0.9% NaCl, Gr III: paclitaxel?+?lercanidipine 0.5?μg/kg, Gr IV: paclitaxel?+?lercanidipine 1?μg/kg, and Gr V: paclitaxel?+?lercanidipine 2.5?μg/kg. Paclitaxel-induced neuropathic pain in rat was produced by single intraperitoneal (i.p.) injection of 1?mg/kg of paclitaxel on four alternate days (0, 2, 4, and 6). The tail flick and cold allodynia methods were used for assessing the pain threshold, and the assessments were done on days 0 (before first dose of paclitaxel) and on days 7, 14, 21, and 28. Results. There was a significant decrease ( ) in the tail flick and cold allodynia latency in the paclitaxel-alone group from day 14 onward when compared with day 0. In the lercanidipine groups, the decrease in the tail flick and cold allodynia latency was not observed in 1.0 and 2.5?μg/kg groups and it was statistically significant ( ) when compared with paclitaxel-alone group. 1. Introduction Neuropathic pain is a type of pain which is caused by damage to or dysfunction of the nervous system. [1] Neuropathic pain cannot be explained by a single disease process or a single specific location of damage. It is a disorder in the structure and function of peripheral, motor, sensory, and/or autonomic neurons either partially or completely [2]. Neuropathic pain may be divided into peripheral, central, or mixed (peripheral and central) neuropathic pain. As much as 7% to 8% of the population is affected and in 5%, it may be severe [3]. In order to evaluate the mechanisms of neuropathic pain and to find new therapeutic approaches, different experimental neuropathic pain models have been developed which include chronic constriction injury of sciatic nerve, partial sciatic nerve ligation, and partial transaction of sciatic nerve. Current knowledge regarding the mechanisms of neuropathic pain is incomplete and is biased by a focus on animal models of peripheral nerve injury, and the treatment is often unsatisfactory. It is an area of largely unmet therapeutic need. The current pharmacological mainstays of clinical management are tricyclic antidepressants and certain anticonvulsants, but these only achieve clinically significant (>50%) pain relief in 40–60% of patients and are associated with several side effects. Opioids are generally considered to be less effective in neuropathic pain than in inflammatory pain
A prospective randomised, controlled clinical trial comparing medial and lateral entry pinning with lateral entry pinning for percutaneous fixation of displaced extension type supracondylar fractures of the humerus in children
Abhijan Maity, Debasish Saha, Debasis Roy
Journal of Orthopaedic Surgery and Research , 2012, DOI: 10.1186/1749-799x-7-6
Abstract: The study was a single center, prospective, randomized controlled clinical trial. Between October 2007 and September 2010, 160 patients who satisfy the inclusion and exclusion criterias were enrolled in the study, with 80 patients in each group. All the percutaneous pinning was done according to a uniform standardized technique. The patients were re-evaluated as outpatients at three weeks, six weeks and three months after the surgery. At three months follow-up visit, following informations were recorded as outcome measures: (i) Carrying angle (deg) (ii) passive range of elbow motion (deg) (iii) Flynn's criteria for grading, based on the loss of carrying angle and loss of total range of elbow motion. (iv) Baumann angle (deg) (v) Change in Baumann angle (deg) between the Intraoperative radiographs after the surgery and radiographs at three months follow-up visit (vi) loss of reduction grading, based on the change in the Baumann angle.There were no significant differences between the two groups with regard to base-line characteristics, withdrawals and complication rate. At three months follow-up visit, patients were evaluated by recording the various outcome measures. There were no significant differences between the two groups with regard to the various outcome measures such as carrying angle, passive range of elbow motion, Flynn grading, Baumann angle, change in the Baumann angle and loss of reduction grading.If a uniform standardized operative technique is followed in each method, then the result of both the percutaneous fixation methods will be same in terms of safety and efficacy.Supracondylar fractures of the humerus are the most common fractures about the elbow in children [1,2]. According to Boyd and Altenberg [3], these fractures account for 65.4% of upper extremity fractures in children. Gartland [4] proposed a classification for these fractures: type I, Undisplaced; type II, displaced with the posterior cortex intact; and type III, completely displaced with
Kinetics of the glass transition of fragile soft colloidal suspensions
Debasish Saha,Yogesh M. Joshi,Ranjini Bandyopadhyay
Physics , 2015,
Abstract: Microscopic relaxation timescales are estimated from the autocorrelation functions obtained by dynamic light scattering experiments for Laponite suspensions with different concentrations ($C_{L}$), added salt concentrations ($C_{S}$) and temperatures ($T$). It has been shown in an earlier work [Soft Matter, 10, 3292-3300 (2014)] that the evolutions of relaxation timescales of colloidal glasses can be compared with molecular glass formers by mapping the waiting time ($t_{w}$) of the former with the inverse of thermodynamic temperature ($1/T$) of the latter. In this work, the fragility parameter $D$, which signifies the deviation from Arrhenius behavior, is obtained from fits to the time evolutions of the structural relaxation timescales. For the Laponite suspensions studied in this work, $D$ is seen to be independent of $C_{L}$ and $C_{S}$, but is weakly dependent on $T$. Interestingly, the behavior of $D$ corroborates the behavior of fragility in molecular glass formers with respect to equivalent variables. Furthermore, the stretching exponent $\beta$, which quantifies the width $w$ of the spectrum of structural relaxation timescales is seen to depend on $t_{w}$. A hypothetical Kauzmann time $t_{k}$, analogous to the Kauzmann temperature for molecular glasses, is defined as the timescale at which $w$ diverges. Corresponding to the Vogel temperature defined for molecular glasses, a hypothetical Vogel time $t^{\infty}_{\alpha}$ is also defined as the time at which the structural relaxation time diverges. Interestingly, a correlation is observed between $t_{k}$ and $t^{\infty}_{\alpha}$, which is remarkably similar to that known for fragile molecular glass formers. A coupling model that accounts for the $t_{w}$-dependence of the stretching exponent is used to analyse and explain the observed correlation between $t_{k}$ and $t^{\infty}_{\alpha}$.
Investigation of the dynamical slowing down process in soft glassy colloidal suspensions: comparisons with supercooled liquids
Debasish Saha,Yogesh M. Joshi,Ranjini Bandyopadhyay
Physics , 2013,
Abstract: The primary and secondary relaxation timescales of aging colloidal suspensions of Laponite are estimated from intensity autocorrelation functions obtained in dynamic light scattering (DLS) experiments. The dynamical slowing down of these relaxation processes are compared with observations in fragile supercooled liquids by establishing a one-to-one mapping between the waiting time since filtration of a Laponite suspension and the inverse of the temperature of a supercooled liquid that is rapidly quenched towards its glass transition temperature. New timescales, such as the Vogel time and the Kauzmann time, are extracted to describe the phenomenon of dynamical arrest in Laponite suspensions. In results that are strongly reminiscent of those extracted from supercooled liquids approaching their glass transitions, it is demonstrated that the Vogel time calculated for each Laponite concentration is approximately equal to the Kauzmann time, and that a strong coupling exists between the primary and secondary relaxation processes of aging Laponite suspensions. Furthermore, the experimental data presented here clearly demonstrates the self-similar nature of the aging dynamics of Laponite suspensions within a range of sample concentrations.
Characteristics of the secondary relaxation process in soft colloidal suspensions
Debasish Saha,Yogesh M Joshi,Ranjini Bandyopadhyay
Physics , 2015,
Abstract: A universal secondary relaxation process, known as the Johari-Goldstein (JG) $\beta$-relaxation process, appears in glass formers. It involves all parts of the molecule and is particularly important in glassy systems because of its very close relationship with the $\alpha$-relaxation process. However, the absence of a J-G $\beta$-relaxation mode in colloidal glasses raises questions regarding its universality. In the present work, we study the microscopic relaxation processes in Laponite suspensions, a model soft glassy material, by dynamic light scattering (DLS) experiments. $\alpha$ and $\beta$-relaxation timescales are estimated from the autocorrelation functions obtained by DLS measurements for Laponite suspensions with different concentrations, salt concentrations and temperatures. Our experimental results suggest that the $\beta$-relaxation process in Laponite suspensions involves all parts of the constituent Laponite particle. The ergodicity breaking time is also seen to be correlated with the characteristic time of the $\beta$-relaxation process for all Laponite concentrations, salt concentrations and temperatures. The width of the primary relaxation process is observed to be correlated with the secondary relaxation time. The secondary relaxation time is also very sensitive to the concentration of Laponite. We measure primitive relaxation timescales from the $\alpha$-relaxation time and the stretching exponent ($\beta$) by applying the coupling model for highly correlated systems. The order of magnitude of the primitive relaxation time is very close to the secondary relaxation time. These observations indicate the presence of a J-G $\beta$-relaxation mode for soft colloidal suspensions of Laponite.
A study of cluster behavioral abnormalities in down syndrome
Bhattacharyya Ranjan,Sanyal Debasish,Roy Krishna,Saha Sanjay
Indian Journal of Medical Sciences , 2009,
Abstract: Background :The behavioral phenotype in Down syndrome follows a characteristic pattern. Aims: To find the incidence of behavioral abnormalities in Down syndrome, to compare these findings with other causes of intellectual disability and normal population and to cluster these abnormalities. Settings :One hundred forty mentally challenged people attending at tertiary care set up and from various non-governmental organizations were included in the study. Patients from both rural and urban set up participated in the study. The age-matched group from normal population was also studied for comparison. Design :The study design is a cross-sectional survey done independently by four observers. Materials and Methods :A semi-structured proforma for demographic profile has been used. The behavioral abnormalities are assessed by using DASH II (Diagnostic Assessment for the Severely Handicapped second modified version) scale. Statistical Analysis :Demographic comparison has been done by analysis of variance. Correlation matrix has been run to identify correlation between individual items. Principal component analysis has been used for grouping the behavioral pattern. Results :Behavioral abnormalities as expected are more common in people having intellectual disability than the normal population. The Down syndrome group unlike other causes of intellectual disability shows higher scores in Stereotypy. Impulse control and Mania subscales. Factor analysis yields five characteristic factor structures, namely, hyperactive-impulsive, biological functions, affective, neurotic and organic-pervasive developmental disorder clusters. Conclusions :Contrary to the conventional belief of docile-fun and music loving prototype, individuals diagnosed with Down syndrome show clusters of behavioral abnormalities and management can vary depending on these target symptoms.
Electrical transport in deformed nanostrips: electrical signature of reversible mechanical failure
Soumendu Datta,Debasish Chaudhuri,Tanusri Saha-Dasgupta,Surajit Sengupta
Physics , 2005, DOI: 10.1209/epl/i2005-10448-8
Abstract: We calculate the electrical conductivity of a thin crystalline strip of atoms confined within a quasi one dimensional channel of fixed width. The conductivity shows anomalous behavior as the strip is deformed under tensile loading. Beyond a critical strain, the solid fails by the nucleation of alternating bands of solid and {\em smectic} like phases accompanied by a jump in the conductivity. Since the failure of the strip in this system is known to be reversible, the onductivity anomaly may have practical use as a sensitive strain transducer.
Astrophysical Constraints on the Scale of Left-Right Symmetry in Inverse Seesaw Models  [PDF]
Debasish Borah
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.329144
Abstract: We revisit the recently studied supersymmetric gauged inverse seesaw model [1] to incorporate astrophysical constraints on lightest supersymmetric particle (LSP) lifetime such that LSP constitutes the dark matter of the Universe. The authors in [1] considered light sneutrino LSP that can play the role of inelastic dark matter (iDM) such that desired iDM mass splitting and tiny Majorana masses of neutrinos can have a common origin. Here we consider a generalized version of this model without any additional discrete symmetry. We point out that due to spontaneous R-parity(Rp=(-1)3(B-L)+2s) breaking in such generic supersymmetric gauged inverse seesaw models, LSP can not be perfectly stable but decays to standard model particles after non-renormalizable operators allowed by the gauge symmetry are introduced. We show that strong astrophysical constraints on LSP lifetime makes sneutrino dark matter more natural than standard neutralino dark matter. We also show that long-livedness of sneutrino dark matter constrains the left right symmetry breaking scale MR<104 GeV.
Value-at-Risk Based on Time-Varying Risk Tolerance Level  [PDF]
Debasish Majumder
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.81007
Abstract: The conventional judgement-based method for fixing the risk tolerance level in the Value-at-Risk (VaR) model might be a suboptimal method, because the procedure induces the possibility of bias in risk measurement. Conversely, a superior risk management practice might be one, where input parameters are determined by a quantitative process which is non-subjective to the risk modeller’s preferences. Based on this insight, we have improved on the VaR model. Our model allows time variation of the risk tolerance level and so is suitable for scenario-wise risk analysis.
Possible Involvement of Nuclear Factor Kappa B in Rapid Disease Progression in ART Naive HIV-1 Infected Remunerated Blood Donors with History of Oral Iron Intake  [PDF]
Debasish Chattopadhya
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.67006
Abstract: A retrospective analysis on the assessment of the level of p65 component of the transcription factor Nuclear Factor Kappa B (NF-kB p65) in the nuclear extract of lipopolysaccharide stimulated peripheral blood mon-onuclear cells (PBMCs) of remunerated blood donors with HIV-1 infection revealed NF-kB p65 to be significantly higher in the subgroup with history of oral iron intake compared to the HIV-1 infected subgroup without such history. The level of NF-kB p65 in iron consuming subgroup of HIV-1 positive donors showed positive correlation with the serum ferritin level and with the rate of increase in viral load. The NF-kB p65 level also showed positive correlation with the level of superoxide produced by cultured Monocyte derived macrophages (MDMs) as well as with the levels of the immune activation markers viz. Tumour necrosis factor alpha (TNF-α) and two of its soluble markers i.e. Tumour necrosis factor receptor types one and two (TNFRI and TNFRII) reported in earlier studies in the same subgroup. The opposing roles of NF-kB in situation of iron overload in HIV-1 infection i.e. disease enhancement on one hand and facilitation of effective antiretroviral therapy through activation of HIV-1 in the latently infected cells on other hand suggest the need for further research to weigh benefits and risks of iron therapy in situations where iron deficiency in HIV-1 infection may be a serious consideration.
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