oalib

OALib Journal期刊

ISSN: 2333-9721

费用:99美元

投稿

时间不限

2017 ( 11 )

2016 ( 28 )

2015 ( 431 )

2014 ( 607 )

自定义范围…

匹配条件: “Dean Ho” ,找到相关结果约7927条。
列表显示的所有文章,均可免费获取
第1页/共7927条
每页显示
Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents
Erik Pierstorff,Dean Ho
International Journal of Nanomedicine , 2008,
Abstract: Erik Pierstorff1, Dean Ho1,21Departments of Biomedical and Mechanical Engineering, Robert R McCormick School of Engineering and Applied Science; 2Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Evanston, IL, USAAbstract: The release of therapeutic drugs from the surface of implantable devices is instrumental for the reduction of medical costs and toxicity associated with systemic administration. In this study we demonstrate the triblock copolymer-mediated deposition and release of multiple therapeutics from a single thin film at the air-water interface via Langmuir–Blodgett deposition. The dual drug elution of dexamethasone (Dex) and doxorubicin hydrochloride (Dox) from the thin film is measured by response in the RAW 264.7 murine macrophage cell line. The integrated hydrophilic and hydrophobic components of the polymer structure allows for the creation of hybrids of the copolymer and the hydrophobic Dex and the hydrophilic Dox. Confirmation of drug release and functionality was demonstrated via suppression of the interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα) inflammatory cytokines (Dex), as well as TUNEL staining and DNA fragmentation analysis (Dox). The inherent biocompatibility of the copolymeric material is further demonstrated by the lack of inflammation and apoptosis induction in cells grown on the copolymer films. Thus a layer-by-layer anchored deposition of an anti-inflammatory and chemotherapeutic functionalized copolymer film is able to localize drug dosage to the surface of a medical device, all with an innate material thickness of 4 nm per layer.Keywords: co-elution, combinatorial therapy, nanomedicine, drug delivery, chemotherapy, inflammation
Nanodiamond and its application to drug delivery
Eiji Osawa,Dean Ho
Journal of Medical and Allied Sciences , 2012,
Abstract: Quasi-spherical diamond crystals having an average diameter of 3.7±0.6 nm are attracting much attention as an ideal material in carbon nanotechnology. In contrast to the other popular nanocarbons including fullerenes, carbon nanotubes and graphenes, our single-nanodiamond can be produced in uniform shape/size on industrial scale. Thus, the most serious problem in nanocarbon industry that persisted in the past 25 years, namely the technical failure to produce highly crystalline nanocarbons in narrow shape/size range does not exist in our diamond from the beginning. Among potential applications of the single-nanodiamond under development, this review concentrates on its highly promising role as a drug carrier, especially for therapeutic-resistant cancer. An interesting possibility of intercalation is proposed as the mechanism of drug transport through blood, which takes into accounts of the spontaneous formation of nanographene layer on the [111] facets, which is then extensively oxidized during oxidative soot removal process to give nanographene oxide partial surface, capable of intercalating drug molecules to prevent them from leaking and causing undesirable side effects during transportation to target malignant cells. A perspective of quantifying the drug delivery process by anticipating orders of magnitude in the number of administered detonation nanodiamond (DND) particles is suggested.
A Multivariable Index for Grading Exercise Gas Exchange Severity in Patients with Pulmonary Arterial Hypertension and Heart Failure
Chul-Ho Kim,Steve Anderson,Dean MacCarter,Bruce Johnson
Pulmonary Medicine , 2012, DOI: 10.1155/2012/962598
Abstract:
A Multivariable Index for Grading Exercise Gas Exchange Severity in Patients with Pulmonary Arterial Hypertension and Heart Failure
Chul-Ho Kim,Steve Anderson,Dean MacCarter,Bruce Johnson
Pulmonary Medicine , 2012, DOI: 10.1155/2012/962598
Abstract: Patients with pulmonary arterial hypertension (PAH) and heart failure (HF) display many abnormalities in respiratory gas exchange. These abnormalities are accentuated with exercise and track with disease severity. However, use of gas exchange measures in day-to-day clinical practice is limited by several issues, including the large number of variables available and difficulty in data interpretation. Moreover, maximal exercise testing has limitations in clinical populations due to their complexity, patient anxiety and variability in protocols and cost. Therefore, a multivariable gas exchange index (MVI) that integrates key gas exchange variables obtained during submaximal exercise into a severity score that ranges from normal to severe-very-severe is proposed. To demonstrate the usefulness of this index, we applied this to 2 groups (PAH, and HF, ) as well as to age matched healthy controls ( ). We demonstrate that this score tracks WHO classification and right ventricular systolic pressure in PAH ( and 0.73, ) and NYHA and cardiac index in HF ( and 0.74, ). This index demonstrates a stronger relationship than any single gas exchange variable alone. In conclusion, MVI obtained from light, submaximal exercise gas exchange is a useful approach to simplify data interpretation in PAH and HF populations. 1. Introduction The lungs are linked hemodynamically in series with the heart, share a common surface area, are exposed to similar intrathoracic pressure changes during breathing, compete for intrathoracic space, and receive nearly 100% of the cardiac output. Receptors in the heart influence breathing patterns, while neural pathways in the lungs in turn may influence cardiac function (e.g., heart rate). Small increases in metabolic demand (e.g., exercise) enhance these cardiopulmonary interactions. Thus it is no surprise that diseases that primarily influence the lungs or the heart significantly impact the other organ system [1, 2]. This can be especially observed in patients with pulmonary arterial hypertension (PAH) where right heart failure evolves and in patients with left heart failure (HF) where significant changes occur in lung mechanics, ventilatory control, and ultimately in respiratory gas exchange. In both these patient groups gas exchange abnormalities are often present at rest, but are accentuated with the challenges of exercise. Thus, noninvasive measures of cardiopulmonary gas exchange obtained during exercise have become a relatively common means to assess disease severity, prognosis, and response to therapy. However, despite the large
Goodman’s New Riddle of Induction  [PDF]
Dean Lubin
Open Journal of Philosophy (OJPP) , 2012, DOI: 10.4236/ojpp.2012.21009
Abstract: In this paper, I consider Goodman’s new riddle of induction and how we should best respond to it. Noticing that all the emeralds so far observed are green, we infer (project) that all emeralds are green. However, all emeralds so far observed are also grue, so we could also infer that they are grue. Only one of these inductive inferences or projections could, however, be valid. For the hypothesis that all emeralds are green predicts that the next observed emerald will be green; whereas the hypothesis that they are grue predicts that it will blue. Goodman’s new riddle is the problem of saying why the inductive inference involving “green” is the valid one. Goodman’s own solution appeals to the idea of entrenchment. His idea is that “green” is a more entrenched predicate than “grue” in the sense that it has figured many more times in our past projections than has “grue”. In his view, this explains why “green” is projectible (can be used in valid inductive inferences) whereas “grue” isn’t. I argue that this response doesn’t go far enough and that we additionally need an explanation of why “green” is more entrenched than “grue”—that we are otherwise left with the unsatisfactory view that its superior entrenchment is a mere linguistic accident. I try to supplement Goodman’s solution with an explanation of this kind. I argue that “grue” is not entrenched be- cause past successful inductions involving “green” show that past projections that could have been made using what I call “grue-like” predicates—predicates which are like “grue” except that the times featuring in their definitions are past—would have been unsuccessful.
Modeling Population Growth: Exponential and Hyperbolic Modeling  [PDF]
Dean Hathout
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.42045
Abstract:

A standard part of the calculus curriculum is learning exponential growth models. This paper, designed to serve as a teaching aid, extends the standard modeling by showing that simple exponential models, relying on two points to fit parameters do not do a good job in modeling population data of the distant past. Moreover, they provide a constant doubling time. Therefore, the student is introduced to hyperbolic modeling, and it is demonstrated that with only two population data points, an amazing amount of information can be obtained, such as reasonably accurate doubling times that are a function of t, as well as accurate estimates of such entertaining topics as the total number of people that have ever lived on earth.

Polycrystalline-Diamond MEMS Biosensors Including Neural Microelectrode-Arrays
Michael W. Varney,Dean M. Aslam,Abed Janoudi,Ho-Yin Chan,Donna H. Wang
Biosensors , 2011, DOI: 10.3390/bios1030118
Abstract: Diamond is a material of interest due to its unique combination of properties, including its chemical inertness and biocompatibility. Polycrystalline diamond (poly-C) has been used in experimental biosensors that utilize electrochemical methods and antigen-antibody binding for the detection of biological molecules. Boron-doped poly-C electrodes have been found to be very advantageous for electrochemical applications due to their large potential window, low background current and noise, and low detection limits (as low as 500 fM). The biocompatibility of poly-C is found to be comparable, or superior to, other materials commonly used for implants, such as titanium and 316 stainless steel. We have developed a diamond-based, neural microelectrode-array (MEA), due to the desirability of poly-C as a biosensor. These diamond probes have been used for in vivo electrical recording and in vitro electrochemical detection. Poly-C electrodes have been used for electrical recording of neural activity . In vitro studies indicate that the diamond probe can detect norepinephrine at a 5 nM level. We propose a combination of diamond micro-machining and surface functionalization for manufacturing diamond pathogen-microsensors.
A quantitative PCR method to detect blood microRNAs associated with tumorigenesis in transgenic mice
Alice C Fan, Marianna M Goldrick, Jennifer Ho, Yu Liang, Pavan Bachireddy, Dean W Felsher
Molecular Cancer , 2008, DOI: 10.1186/1476-4598-7-74
Abstract: Distinct miRNA profiles have been described for many cancers including hematologic and solid malignancies [1-12]. Many reports have shown that patterns of miRNA expression differ between normal and cancerous tissues [1-10,12-20]. Gene expression profiling of traditional mRNA targets in whole blood or fractionated leukocytes has also shown correlations with many types of both neoplastic and non-neoplastic human disease, for example renal cancer and Crohn's disease [21-30]. To investigate whether miRNA patterns in blood correlated with tumorigenesis, we measured by qRT-PCR a panel of miRNAs in MYC-induced transgenic models of tumorigenesis.First, we developed a protocol optimized for collection, storage and shipping of whole mouse blood, RNA extraction from a small volume of stored sample, and qRT-PCR assays for mouse blood miRNA profiling. To enable blood to be collected from mice at different time points and stored so that total RNA extraction and miRNA quantitation could be batch analyzed, mouse blood was mixed with an RNA stabilizing reagent (RNAlater? Tissue Collection:RNA Stabilization Solution, Ambion), transported, and stored at -20 deg C. Total RNA extraction was subsequently performed using the Mouse RiboPure? Blood kit (Ambion).Total RNA yields from cardiac puncture samples from 6 mice averaged 114 μg by NanoDrop measurement (Figure 1A). To determine the quality of total RNA extracted, Agilent bioanalyzer scans were performed. RNA was found to be intact as shown by the high RIN values observed in the Agilent traces and the sharp 18S and 28S ribosomal RNA (rRNA) peaks and lack of significant species between those peaks (Figure 1B, C). The bioanalyzer traces also showed a distinct peak that correlates with the recovery of low molecular weight RNA including miRNA. The high yields of RNA from mouse blood suggested that sufficient RNA for analysis might be extracted from lower volume tail vein bleeds that do not require sacrifice of the mouse. Indeed, blood acqu
Amplitude Contrast Imaging in High-Resolution Transmission Electron Microscopy of Ferroelectric Superlattice Film
Jianguo Wen,Dean J. Miller,Nestor J. Zaluzec,Russell E. Cook,Ho Nyung Lee,Xifan Wu
Physics , 2014,
Abstract: To date, high-resolution electron microscopy has largely relied on using the phase of the exit wave function at the exit surface to form a high-resolution electron microscopic image. We have for the first time used chromatic aberration correction to implement a new imaging mode to achieve amplitude contrast imaging in high-resolution electron microscopy, allowing us to obtain directly interpretable high-resolution electron microscopic images with discrimination between light and heavy atomic columns. Using this imaging approach, we have successfully visualized the atomic structure in a BaTiO3/CaTiO3 superlattice with high spatial accuracy and discrimination between Ba and Ca columns, providing direct visualization of the Ca and Ba associated oxygen octahedral tilt that controls ferroelectric behavior in these superlattice structures. Furthermore, this approach offers new opportunities to unravel the structure in a wide range of materials, especially complex oxides with exotic behaviors based on specific structural arrangements.
Highly polar phase stabilized at interface of perovskite superlattice designed by oxygen octahedron rotation reconstruction
Hongwei Wang,Jianguo Wen,Dean J. Miller,Qibin Zhou,Ho Nyung Lee,Karin M. Rabe,Xifan Wu
Physics , 2015,
Abstract: Ferroelectricity (FE) is generally suppressed in Pbnm structured perovskite such as CaTiO3(CTO) [1]. Notably, large FE is favored in perovskite of R3c structure like BiFeO3 [2], which is a metastable phase of CTO. Here, we report the stabilization of the highly-polar R3c-like phase of CTO in the BaTiO3(BTO)/CTO superlattice grown on a SrTiO3 (STO) substrate. Through a combination of amplitude-contrast sub 0.1nm high-resolution transmission electron microscopy (HRTEM) and first-principles calculations of the structure, energetics, and polarization of the superlattice and its constituents, the above is found to be realized by a reconstruction of the oxygen octahedron rotations at the interfaces from the pattern in nonpolar bulk CTO to a different pattern that is characteristic of a metastable R3c phase of CTO. Under this new mechanism, a large number of perovskites with the CTO structure type, which include many magnetic representatives, are now good candidates for novel highly-polar multiferroic materials [3].
第1页/共7927条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.