oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 38 )

2018 ( 364 )

2017 ( 378 )

2016 ( 414 )

Custom range...

Search Results: 1 - 10 of 208287 matches for " DeLacerda L. "
All listed articles are free for downloading (OA Articles)
Page 1 /208287
Display every page Item
Adrenocortical tumors in children
Ribeiro R.C.,Michalkiewicz E.L.,Figueiredo B.C.,DeLacerda L.
Brazilian Journal of Medical and Biological Research , 2000,
Abstract: Childhood adrenocortical tumors (ACT) are rare. In the USA, only about 25 new cases occur each year. In Southern Brazil, however, approximately 10 times that many cases are diagnosed each year. Most cases occur in the contiguous states of S o Paulo and Paraná. The cause of this higher rate has not been identified. Familial genetic predisposition to cancer (p53 mutations) and selected genetic syndromes (Beckwith-Wiedemann syndrome) have been associated with childhood ACT in general but not with the Brazilian counterpart. Most of the affected children are young girls with classic endocrine syndromes (virilizing and/or Cushing). Levels of urinary 17-ketosteroids and plasma dehydroepiandrosterone sulfate (DHEA-S), which are abnormal in approximately 90% of the cases, provide the pivotal clue to a diagnosis of ACT. Typical imaging findings of pediatric ACT consist of a large, well-defined suprarenal tumor containing calcifications with a thin capsule and central necrosis or hemorrhage. The pathologic classification of pediatric ACT is troublesome. Even an experienced pathologist can find it difficult to differentiate carcinoma from adenoma. Surgery is the single most important procedure in the successful treatment of ACT. The role of chemotherapy in the management of childhood ACT has not been established although occasional tumors are responsive to mitotane or cisplatin-containing regimens. Because of the heterogeneity and rarity of the disease, prognostic factors have been difficult to establish in pediatric ACT. Patients with incomplete tumor resection or with metastatic disease at diagnosis have a dismal prognosis. In patients with localized and completely resected tumors, the size of the tumor has predictive value. Patients with large tumors have a much higher relapse rate than those with small tumors.
Adrenocortical tumors in children
Ribeiro, R.C.;Michalkiewicz, E.L.;Figueiredo, B.C.;DeLacerda, L.;Sandrini, F.;Pianovsky, M.D.;Sampaio, G.;Sandrini, R.;
Brazilian Journal of Medical and Biological Research , 2000, DOI: 10.1590/S0100-879X2000001000013
Abstract: childhood adrenocortical tumors (act) are rare. in the usa, only about 25 new cases occur each year. in southern brazil, however, approximately 10 times that many cases are diagnosed each year. most cases occur in the contiguous states of s?o paulo and paraná. the cause of this higher rate has not been identified. familial genetic predisposition to cancer (p53 mutations) and selected genetic syndromes (beckwith-wiedemann syndrome) have been associated with childhood act in general but not with the brazilian counterpart. most of the affected children are young girls with classic endocrine syndromes (virilizing and/or cushing). levels of urinary 17-ketosteroids and plasma dehydroepiandrosterone sulfate (dhea-s), which are abnormal in approximately 90% of the cases, provide the pivotal clue to a diagnosis of act. typical imaging findings of pediatric act consist of a large, well-defined suprarenal tumor containing calcifications with a thin capsule and central necrosis or hemorrhage. the pathologic classification of pediatric act is troublesome. even an experienced pathologist can find it difficult to differentiate carcinoma from adenoma. surgery is the single most important procedure in the successful treatment of act. the role of chemotherapy in the management of childhood act has not been established although occasional tumors are responsive to mitotane or cisplatin-containing regimens. because of the heterogeneity and rarity of the disease, prognostic factors have been difficult to establish in pediatric act. patients with incomplete tumor resection or with metastatic disease at diagnosis have a dismal prognosis. in patients with localized and completely resected tumors, the size of the tumor has predictive value. patients with large tumors have a much higher relapse rate than those with small tumors.
Amplification of 9q34 in childhood adrenocortical tumors: a specific feature unrelated to ethnic origin or living conditions
Figueiredo, B.C.;Ribeiro, R.C.;Zambetti, G.;Haddad, B.;Pianovsky, M.D.;Pereira, R.M.;DeLacerda, L.;Sandrini, R.;
Brazilian Journal of Medical and Biological Research , 2000, DOI: 10.1590/S0100-879X2000001000012
Abstract: adrenocortical tumors (act) in children under 15 years of age exhibit some clinical and biological features distinct from act in adults. cell proliferation, hypertrophy and cell death in adrenal cortex during the last months of gestation and the immediate postnatal period seem to be critical for the origin of act in children. studies with large numbers of patients with childhood act have indicated a median age at diagnosis of about 4 years. in our institution, the median age was 3 years and 5 months, while the median age for first signs and symptoms was 2 years and 5 months (n = 72). using the comparative genomic hybridization technique, we have reported a high frequency of 9q34 amplification in adenomas and carcinomas. this finding has been confirmed more recently by investigators in england. the lower socioeconomic status, the distinctive ethnic groups and all the regional differences in southern brazil in relation to patients in england indicate that these differences are not important to determine 9q34 amplification. candidate amplified genes mapped to this locus are currently being investigated and southern blot results obtained so far have discarded amplification of the abl oncogene. amplification of 9q34 has not been found to be related to tumor size, staging, or malignant histopathological features, nor does it seem to be responsible for the higher incidence of act observed in southern brazil, but could be related to an act from embryonic origin.
ELISA for Determination of Human Growth Hormone: Recognition of Helix 4 Epitopes
Moura Juliana F.,DeLacerda Luiz,Sandrini Romolo,Borba Fernanda M.
Journal of Biomedicine and Biotechnology , 2004,
Abstract: Human growth hormone (hGH) signal transduction initiates with a receptor dimerization in which one molecule binds to the receptor through sites 1 and 2. A sandwich enzyme-linked immunosorbent assay was developed for quantifying hGH molecules that present helix 4 from binding site 1. For this, horse anti-rhGH antibodies were eluted by an immunoaffinity column constituted by sepharose-rhGH. These antibodies were purified through a second column with synthetic peptide correspondent to hGH helix 4, immobilized to sepharose, and used as capture antibodies. Those that did not recognize synthetic peptide were used as a marker antibody. The working range was of 1.95 to 31.25 ng/mL of hGH. The intra-assay coefficient of variation (CV) was between 4.53% and 6.33%, while the interassay CV was between 6.00% and 8.27%. The recovery range was between 96.0% to 103.8%. There was no cross-reactivity with human prolactin. These features show that our assay is an efficient method for the determination of hGH.
Childhood Adrenocortical Tumours: a Review
Rosana Marques-Pereira, Luiz DeLacerda, Hadriano M Lacerda, Edson Michalkiewicz, Fabiano Sandrini, Romolo Sandrini
Hereditary Cancer in Clinical Practice , 2006, DOI: 10.1186/1897-4287-4-2-81
Abstract: Adrenocortical tumours (ACT) occur at all ages and have a bimodal distribution with peaks of incidence at around 5 years of age and in the 4th and 5th decades of life [1,2]. Childhood ACTs are rare, with the annual worldwide incidence around 0.34 per million children below the age of 15 [1,3]. In the United States, Surveillance Epidemiology and End Results (SEER) data from the National Cancer Institute show that only about 0.2% of all childhood malignancies are ACTs [4].In southern Brazil (State of Paraná), the ACT incidence is 4.2 per million in the age range of 0 - 15 years [5] with higher prevalence in 0 - 4-year-old girls (Fig. 1). Over the last 40 years, more than 137 ACT patients under 19 years of age have been admitted for treatment in the Pediatric Endocrinology Unit of the Department of Pediatrics in the Clinical Hospital of the Federal University of Paraná, in Curitiba, Brazil. This hospital is a tertiary referral centre for a population of approximately 16 million people, 5 million of whom are less than 15 years of age. It should be noted that at least 5 other hospitals in our state are referral centres for childhood malignancies. In the neighbouring State of S?o Paulo, Marigo et al. observed that childhood ACTs accounted for 2.9% of solid tumours registered at Santa Casa de Misericordia of S?o Paulo over a period of 15 years, whereas in the London Hospital for Sick Children, ACTs comprised only 0.8% [6]. Later on, other groups in the State of S?o Paulo also reported a large series of ACTs in children and adolescents [7-10].The population in these two Brazilian states are descendants of migrants from Portugal, Italy, Spain, Germany, Poland, Ukraine, Japan and Africa - countries where the incidence of ACTs is not increased - and a minority of the native population. The sporadic occurrence, absence of any clinical characteristics consistent with genetic disorders (i.e. Beckwith-Wiedemann and MEN1 syndromes, hemihypertrophy, congenital adrenal hyperplasia an
ELISA for Determination of Human Growth Hormone: Recognition of Helix 4 Epitopes
Juliana F. Moura,Luiz DeLacerda,Romolo Sandrini,Fernanda M. Borba,Denise N. Castelo,Elis R. Sade,Sandra Sella,Jo o C. Minozzo,Luis G. Callefe,Bonald C. Figueiredo
Journal of Biomedicine and Biotechnology , 2004, DOI: 10.1155/s1110724304308090
Abstract: Human growth hormone (hGH) signal transduction initiates with a receptor dimerization in which one molecule binds to the receptor through sites 1 and 2. A sandwich enzyme-linked immunosorbent assay was developed for quantifying hGH molecules that present helix 4 from binding site 1. For this, horse anti-rhGH antibodies were eluted by an immunoaffinity column constituted by sepharose-rhGH. These antibodies were purified through a second column with synthetic peptide correspondent to hGH helix 4, immobilized to sepharose, and used as capture antibodies. Those that did not recognize synthetic peptide were used as a marker antibody. The working range was of 1.95 to 31.25 ng/mL of hGH. The intra-assay coefficient of variation (CV) was between 4.53% and 6.33%, while the interassay CV was between 6.00% and 8.27%. The recovery range was between 96.0% to 103.8%. There was no cross-reactivity with human prolactin. These features show that our assay is an efficient method for the determination of hGH.
Computing Reachable Sets as Capture-Viability Kernels in Reverse Time  [PDF]
No?l Bonneuil
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.311219
Abstract: The set SF(x0;T) of states y reachable from a given state x0 at time T under a set-valued dynamic x’(t)∈F(x (t)) and under constraints x(t)∈K where K is a closed set, is also the capture-viability kernel of x0 at T in reverse time of the target {x0} while remaining in K. In dimension up to three, Saint-Pierre’s viability algorithm is well-adapted; for higher dimensions, Bonneuil’s viability algorithm is better suited. It is used on a large-dimensional example.
Three Dimensional Evolution of SN 1987A in a Self-Gravitating Disk  [PDF]
L. Zaninetti
International Journal of Astronomy and Astrophysics (IJAA) , 2013, DOI: 10.4236/ijaa.2013.32010
Abstract:

The introduction of an exponential or power law gradient in the interstellar medium (ISM) allows to produce an asymmetric evolution of the supernova remnant (SNR) when the framework of the thin layer approximation is adopted. Unfortunately both the exponential and power law gradients for the ISM do not have a well defined physical meaning. The physics conversely is well represented by an isothermal self-gravitating disk of particles whose velocity is everywhere Maxwellian. We derived a law of motion in the framework of the thin layer approximation with a control parameter of the swept mass. The photon’s losses, which are often neglected in the thin layer approximation, are modeled trough velocity dependence. The developed framework is applied to SNR 1987A and the three observed rings are simulated.

The Luminosity Function of Galaxies as Modeled by a Left Truncated Beta Distribution  [PDF]
L. Zaninetti
International Journal of Astronomy and Astrophysics (IJAA) , 2014, DOI: 10.4236/ijaa.2014.41013
Abstract: A first new luminosity function of galaxies can be built starting from a left truncated beta probability density function, which is characterized by four parameters. In the astrophysical conversion, the number of parameters increases by one, due to the addition of the overall density of galaxies. A second new galaxy luminosity function is built starting from a left truncated beta probability for the mass of galaxies once a simple nonlinear relationship between mass and luminosity is assumed; in this case the number of parameters is six because the overall density of galaxies and a parameter that regulates mass and luminosity are added. The two new galaxy luminosity functions with finite boundaries were tested on the Sloan Digital Sky Survey (SDSS) in five different bands; the results produce a better fit than the Schechter luminosity function in two of the five bands considered. A modified Schechter luminosity function with four parameters has been also analyzed.
On the Dark Matter’s Halo Theoretical Description  [PDF]
L. M. L. M. Chechin
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.35052
Abstract: We argued that the standard field scalar potential couldn’t be widely used for getting the adequate galaxies’ curve lines and determining the profiles of dark matter their halo. For discovering the global properties of scalar fields that can describe the observable characteristics of dark matter on the cosmological space and time scales, we propose the simplest form of central symmetric potential celestial-mechanical type, i.e. U(φ) = –μ/φ. It was shown that this potential allows get rather satisfactorily dark matter profiles and rotational curves lines for dwarf galaxies. The good agreement with some previous results, based on the N-body simulation method, was pointed out. A new possibility of dwarf galaxies’ masses estimation was given, also.
Page 1 /208287
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.