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Search Results: 1 - 10 of 178226 matches for " De Staercke Christine "
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The effects of obesity on venous thromboembolism: A review  [PDF]
Genyan Yang, Christine De Staercke, W. Craig Hooper
Open Journal of Preventive Medicine (OJPM) , 2012, DOI: 10.4236/ojpm.2012.24069
Abstract: Obesity has emerged as a global health issue that is associated with wide spectrum of disorders, including coronary artery disease, diabetes mellitus, hypertension, stroke, and venous thromboembolism (VTE). VTE is one of the most common vascular disorders in the United States and Europe and is associated with significant mortality. Although the association between obesity and VTE appears to be moderate, obesity can interact with other environmental or genetic factors and pose a significantly greater risk of VTE among individuals who are obese and who are exposed simultaneously to several other risk factors for VTE. Therefore, identification of potential interactions between obesity and certain VTE risk factors might offer some critical points for VTE interventions and thus minimize VTE morbidity and mortality among patients who are obese. However, current obesity measurements have limitations and can introduce contradictory results in the outcome of obesity. To overcome these limitations, this review proposes several future directions and suggests some avenues for prevention of VTE associated with obesity as well.
The relationship between FV Leiden and pulmonary embolism
W Craig Hooper, Christine De Staercke
Respiratory Research , 2001, DOI: 10.1186/rr180
Abstract: Pulmonary embolism (PE), a potential lethal complication of venous thromboembolism (VTE), is a leading cause of in-hospital death and the prevalence of symptomatic pulmonary embolism has been estimated to be approximately 630,000 cases per year in the United States [1]. It has also been estimated that PE may be directly responsible for up to 100,000 deaths and a contributing cause in another 100,000 [1]. Despite these estimates, it has been commonly agreed that the true magnitude of PE is unknown. The pathogenesis of VTE/PE is multifactorial and frequently reflects the interplay between environmental, clinical and genetic factors. Although it has been long recognized that deficiencies in the anticoagulation proteins protein C, protein S and antithrombin III were often the consequence of underlying genetic defects, there was little interest in defining the genetics of VTE/PE. This view changed, however, when FV Leiden was described and subsequently shown to be associated with 18–20% of all idiopathic VTE cases [2,3].FV Leiden is a consequence of a single G-to-A transition at nucleotide 1691 in the Factor V gene that results in the amino acid substitution of an arginine by glutamine [4,5]. This single nucleotide substitution is the only known mutation responsible for the FV Leiden genotype and a rapid molecular diagnosis can thus be easily made. A phenotypic diagnosis, which is commonly referred to as resistance to activated protein C, can also be made using findings from the clinical hematology laboratory [6]. The phenotypic diagnosis can be directly correlated with FV Leiden in approximately 90–95% of cases [7]. Since the initial description of FV Leiden, several studies have demonstrated that the prevalence of this mutation differs among the populations of the world, ranging from 5–12% of individuals of northern European descent to approximately 1% in those of African descent [7,8,9]. For example, in a case–control study of African-Americans with VTE, a FV Leiden p
The relationship between FV Leiden and pulmonary embolism
Hooper W Craig,De Staercke Christine
Respiratory Research , 2002,
Abstract: Pulmonary embolism (PE) is one of the leading causes of in-patient hospital deaths. As a consequence, the identification of hemostatic variables that could identify those at risk would be important in reducing mortality. It has previously been thought that deep vein thrombosis and PE are a single disease entity and would, therefore, have the same risk factors. This view is changing, however, with the realization that the prevalence of FV Leiden, a recognized genetic risk factor for deep vein thrombosis, may be a 'milder' genetic risk factor for PE. These observations suggest that PE is not only associated with a different set of risk factors, but may be reflective of a different clot structure.
25-hydroxyvitamin D concentration is inversely associated with serum MMP-9 in a cross-sectional study of African American ESRD patients
Haimanot Wasse, Francesca Cardarelli, Christine De Staercke, Craig Hooper, Emir Veledar, Idris Guessous
BMC Nephrology , 2011, DOI: 10.1186/1471-2369-12-24
Abstract: We conducted a cross-sectional study among ESRD patients receiving maintenance hemodialysis within Emory University-affiliated outpatient hemodialysis units. Demographic, clinical and dialysis treatment data were collected via direct patient interview and review of patients records at the time of enrollment, and each patient gave blood samples. Associations between 25(OH)D and biomarker concentrations were estimated in univariate analyses using Pearson's correlation coefficients and in multivariate analyses using linear regression models. 25(OH) D concentration was entered in multivariate linear regression models as a continuous variable and binary variable (<15 ng/ml and ≥15 ng/ml). Adjusted estimate concentrations of biomarkers were compared between 25(OH) D groups using analysis of variance (ANOVA). Finally, results were stratified by vascular access type.Among 91 patients, mean (standard deviation) 25(OH)D concentration was 18.8 (9.6) ng/ml, and was low (<15 ng/ml) in 43% of patients. In univariate analyses, low 25(OH) D was associated with lower serum calcium, higher serum phosphorus, and higher LDL concentrations. 25(OH) D concentration was inversely correlated with MMP-9 concentration (r = -0.29, p = 0.004). In multivariate analyses, MMP-9 concentration remained negatively associated with 25(OH) D concentration (P = 0.03) and anti-inflammatory IL-10 concentration positively correlated with 25(OH) D concentration (P = 0.04).Plasma MMP-9 and circulating 25(OH) D concentrations are significantly and inversely associated among ESRD patients. This finding may suggest a potential mechanism by which low circulating 25(OH) D functions as a cardiovascular risk factor.The chronic pro-inflammatory state of end-stage renal disease (ESRD) is associated with increased risk for cardiovascular disease and death [1-3]. Observational studies suggest an inverse association between circulating 25-hydroxyvitamin D [25(OH) D] concentration and serum inflammatory biomarkers. Low 25
O curso de enfermagem da Universidade Estadual de Londrina na constru??o de uma nova proposta pedagógica
Godoy, Christine Baccarat de;
Revista Latino-Americana de Enfermagem , 2002, DOI: 10.1590/S0104-11692002000400018
Abstract: this study aimed at outlining the history of the nursing curriculum of the state university of londrina from its beginning in 1972 to the elaboration of the present curriculum, which was implemented in january 2000. the study was based on a literature review and the results enabled us to outline the whole process of curricular changes in view of the the professors' disquiet and the demands from the work. by substantiating all the curricular changes, the study has contributed to a better understanding of the new educational proposal, which is based on the critical and social conception founded on the problem-based pedagogy applied in the current integrated nursing curriculum of the state university of londrina.
O curso de enfermagem da Universidade Estadual de Londrina na constru o de uma nova proposta pedagógica
Godoy Christine Baccarat de
Revista Latino-Americana de Enfermagem , 2002,
Abstract: O artigo teve como objetivo levantar a história do Currículo de Enfermagem da Universidade Estadual de Londrina, desde a implanta o do Curso, em 1972, até o currículo atual, implantado em janeiro de 2000. O estudo constituiu-se em pesquisa bibliográfica e o resultado possibilitou delinear todo o processo de mudan a curricular frente à inquieta o dos docentes e às exigências do mercado de trabalho. O estudo, ao fundamentar todas as mudan as curriculares, contribui para melhor compreendermos a nova proposta pedagógica, baseada na concep o crítico-social e respaldada na pedagogia problematizadora, aplicada no atual Currículo Integrado do Curso de Enfermagem, da Universidade Estadual de Londrina.
The Occupiers and the Occupied: A Nexus of Memories
Christine de Matos
New Voices : A Journal for Emerging Scholars of Japanese Studies in Australia and New Zealand , 2006,
Medically Unexplained Symptoms (MUS): What Do Current Trainee Psychologists, Neurologists and Psychiatrists Believe?  [PDF]
Steven Kemp, Catherine Spilling, Christine Hughes, Karel de Pauw
Open Journal of Medical Psychology (OJMP) , 2013, DOI: 10.4236/ojmp.2013.21003

Objectives: Medically unexplained symptoms (MUS) are common in all medical settings. These conditions remain controversial, aetiology remains poorly understood and treatments have been slow to develop. This study aimed to examine the beliefs held by psychologists and other professionals about MUS, which may impact upon clinical practice. Design: 375 clinical psychology trainees from 23UKtraining courses, 12 neurologists and 19 psychiatrists in training completed a weblink survey designed to elicit a range of beliefs about MUS cause and treatment. Results: All three groups viewed MUS as a common clinical problem. Use of terminology differed between groups. All three groups held a view that sexual abuse was a medium to high risk factor for developing MUS. Only a minority of psychologists and psychiatrists doubted that the human mind is capable of massive repression for past distressing events; and few psychologists, and no psychiatrists, doubted the traditional psychodynamic causal model of MUS. Neurologists were generally more skeptical. Only a minority of all three groups disagreed that hypnosis was a helpful way to uncover memories that people can not access. Around one third of each group believed that traumatic memories recovered in therapy were reliable. Dualistic thinking was prevalent among all three groups, but more so among psychiatrists. Conclusions: The data show that many professsionals hold beliefs about MUS for which, empirical support is lacking. These beliefs may impact on clinical practice. Whether such beliefs are deemed to be correct or incorrect, they should be acknowledged.

Louisiana Story, entre nature et cultures
Louveau de la Guigneraye, Christine;
Horizontes Antropológicos , 2001, DOI: 10.1590/S0104-71832001000200009
Abstract: dans louisiana story, robert flaherty a choisi l'opulente nature louisianaise comme lieu de rencontre entre deux cultures: une culture industrielle anglophone et une culture rurale francophone. ce film, qui est commandé et financé par la compagnie pétrolière standard oil devait à l'origine montrer les difficultés et les dangers de l'extraction pétrolière pour ses équipes tout en les mettant en scène dans une réalisation destinée au grand public. le problème posé à flaherty était que de telles man?uvres étaient souterraines, qu'elles échappaient à l'objectif de la caméra. après avoir parcouru des milliers de kilomètres aux etats-unis à la recherche de l'inspiration, son choix se porta sur le pays des acadiens de louisiane où il fut marqué par l'image d'une plate-forme se dépla?ant par voie d'eau sur l'un des multiples bayous de cette région. ce lieu lui permettait de mêler et de confronter dans la même image la modernité des derricks et une nature sauvage, une population étrange par ses traditions et son langage à une population ouvrière plus typiquement américaine. louisiana story reste un film étrange et ambigu. les hommes y apparaissent secondaires dominés par le gigantisme des équipements pétroliers et la grandeur de la nature. il semble que lors du tournage flaherty ait été fasciné par la faune et la flore au détriment du scénario qui était la rencontre entre deux cultures à travers les découvertes et les liens d'amitié d'un petit gar?on cajun.
Acidentes na infancia e adolescência: uma revis?o bibliográfica
Martins, Christine Baccarat de Godoy;
Revista Brasileira de Enfermagem , 2006, DOI: 10.1590/S0034-71672006000300017
Abstract: this study aims at reviewing the literature on accidents among young under the age of 15. throughout brazil, lesions and poisonings are responsible for 5 to 6 percent of total internments by the national health system (sus), generating 8 percent of the total hospital internment expenses. sweden and italy are the countries that have the lowest mortality rates related to external causes among youngsters under the age of 15. the rates of denmark, germany and japan are regarded as intermediate. france, belgium, austria and canada are regarded as countries with high mortality rates related to external causes among youngsters under the age of 15. brazil together with the united states, portugal, mexico and korea are considered countries with very high mortality rates related to childhood accidents, needing preventive actions. furthermore, studies reinforce the importance of recognizing the nature and reality of childhood accidents in order to form a diagnosis that helps elaborate and accomplish specific prevention policies.
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