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Search Results: 1 - 10 of 53400 matches for " David McKay "
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A Simple Proof That the Curl Defined as Circulation Density Is a Vector-Valued Function, and an Alternative Approach to Proving Stoke’s Theorem  [PDF]
David McKay
Advances in Pure Mathematics (APM) , 2012, DOI: 10.4236/apm.2012.21007
Abstract: This article offers a simple but rigorous proof that the curl defined as a limit of circulation density is a vector-valued function with the standard Cartesian expression.
Decomposing replicable functions
John McKay,David Sevilla
Mathematics , 2008,
Abstract: We describe an algorithm to decompose rational functions from which we determine the poset of groups fixing these functions.
Aplicacion de la descomposicion racional univariada a monstrous moonshine (in Spanish)
John McKay,David Sevilla
Computer Science , 2008,
Abstract: This paper shows how to use Computational Algebra techniques, namely the decomposition of rational functions in one variable, to explore a certain set of modular functions, called replicable functions, that arise in Monstrous Moonshine. In particular, we have computed all the rational relations with coefficients in Z between pairs of replicable functions. ----- En este articulo mostramos como usar tecnicas de Algebra Computacional, concretamente la descomposcion de funciones racionales univariadas, para estudiar un cierto conjunto de funciones modulares, llamadas funciones replicables, que aparecen en Monstrous Moonshine. En concreto, hemos calculado todas las relaciones racionales con coeficientes en Z entre pares de funciones replicables.
Principal moduli and class fields
David Cox,John McKay,Peter Stevenhagen
Mathematics , 2003,
Abstract: We study the values taken by Gamma_0(n) modular functions at elliptic points of order 2 for the Fricke extension that lie outside Gamma_0(n). In the case of a principal modulus (`Hauptmodul') for Gamma_0(n) or its Fricke extension, we determine the class fields generated by these values.
Slow Thermalization Between a Lattice and Free Bose Gas
David C. McKay,Carolyn Meldgin,David Chen,Brian DeMarco
Physics , 2012, DOI: 10.1103/PhysRevLett.111.063002
Abstract: Using a 3D spin-dependent optical lattice, we study thermalization and energy exchange between two ultracold Bose gases, one of which is bound to the lattice and another that is free from the lattice potential. Disruption of inter-species thermalization is revealed through measurements of condensate fraction after the lattice is superimposed on the parabolic confining potential. By selectively heating the lattice-bound species and measuring the rate of heat transfer to the free state, suppression of energy exchange is observed. Comparison with a Fermi's golden rule prediction confirms that this effect is caused by a dispersion mismatch that reduces the phase space available for elastic collisions. This result has critical implications for methods proposed to cool strongly correlated lattice gases.
Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe
Ragunath Singaravelu, David R Blais, Craig S McKay, John Pezacki
Proteome Science , 2010, DOI: 10.1186/1477-5956-8-5
Abstract: The PS4≡ probe successfully targeted 19 active proteins in nine distinct protein families, some that were predominantly labeled in situ compared to the in vitro labeled cell homogenate. Nine proteins revealed altered activity levels during HCV replication. Some candidates identified, such as heat shock 70 kDa protein 8 (or HSP70 cognate), have been shown to influence viral release and abundance of cellular lipid droplets. Other differentially active PS4≡ targets, such as electron transfer flavoprotein alpha, protein disulfide isomerase A5, and nuclear distribution gene C homolog, constitute novel proteins that potentially mediate HCV propagation.These findings demonstrate the practicality and versatility of non-directed activity-based protein profiling (ABPP) to complement directed methods and accelerate the discovery of altered protein activities associated with pathological states such as HCV replication. Collectively, these results highlight the ability of in situ ABPP approaches to facilitate the identification of enzymes that are either predominantly or exclusively labeled in living cells. Several of these differentially active enzymes represent possible HCV-host interactions that could be targeted for diagnostic or therapeutic purposes.The hepatitis C virus (HCV) is the major causative agent of hepatitis that affects over three percent of the global population [1]. With no vaccines yet available and clinical treatments that have only limited success, many HCV-infected individuals develop chronic hepatitis which eventually progresses into liver steatosis, cirrhosis and hepatocellular carcinoma. HCV is the leading cause of liver disease and transplantation [2]. As the HCV genome is a single-stranded RNA molecule of only ~9.6 kb (Figure 1A) that encodes for ten mature viral proteins, HCV relies heavily on host factors for its propagation. During cell entry, HCV E1 and E2 viral proteins interact with four known host receptors CD81, claudin-1, SRB1, and occludin [3
Reduced Surface Expression of Epithelial E-Cadherin Evoked by Interferon-Gamma Is Fyn Kinase-Dependent
David Smyth, Gabriella Leung, Maria Fernando, Derek M. McKay
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038441
Abstract: Interferon gamma (IFNγ) is an important regulatory cytokine that can exert a pro-inflammatory effect in the gut, where it has been shown to increase epithelial permeability via disruption of the tight junctions. Here we investigated the potential for IFNγ to regulate the adherens junction protein E-cadherin, an important mediator of normal epithelial tissue function, using the model T84 human colonic epithelial cell line. IFNγ (10 ng/ml) stimulated increased internalization of E-cadherin as assessed by immunofluorescence microscopy; internalization was reversed when cells were treated with PP1 (125 nM), a Src kinase-selective inhibitor. Immunoprecipitation studies demonstrated loss of E-cadherin from membrane fractions following IFNγ treatment and a corresponding increase in cytosolic E-cadherin and its binding partners, p120-catenin and beta-catenin: effects that were Src-kinase dependent. E-cadherin and p120-catenin phosphorylation was increased by IFNγ treatment and siRNA studies showed this was dependent upon the Src-kinase isoform Fyn. E-cadherin ubiquitinylation and subsequent proteasomal degradation stimulated by IFNγ was found to be dependent upon Fyn and the E-cadherin-selective ubiquitin ligase, Hakai. Use of Fyn and Hakai siRNA inhibited the internalization of E-cadherin as shown by immunoblotting and confocal fluorescence microscopy. Finally, IFNγ treatment resulted in a more fragile T84 cell monolayer with increased cell detachment in response to physical stress, which was prevented by PP1 and siRNA targeting Fyn or Hakai. Collectively, these results demonstrate a Fyn kinase-dependent mechanism through which IFNγ regulates E-cadherin stability and suggest a novel mechanism of disruption of epithelial cell contact, which could contribute to perturbed epithelial barrier function.
Signal Characteristics from Electromagnetic Cascades in Ice
Soebur Razzaque,Surujhdeo Seunarine,David Z. Besson,Douglas W. McKay
Physics , 2001, DOI: 10.1063/1.1398167
Abstract: We investigate the development of electromagnetic cascades in ice using a GEANT Monte Carlo simulation. We examine the Cherenkov pulse that is generated by the charge excess that develops and propagates with the shower. This study is important for the RICE experiment at the South Pole, as well as any test beam experiment which seeks to measure coherent Cherenkov radiation from an electromagnetic shower.
Large Dimensional Analysis of Robust M-Estimators of Covariance with Outliers
David Morales-Jimenez,Romain Couillet,Matthew R. McKay
Statistics , 2015, DOI: 10.1109/TSP.2015.2460225
Abstract: A large dimensional characterization of robust M-estimators of covariance (or scatter) is provided under the assumption that the dataset comprises independent (essentially Gaussian) legitimate samples as well as arbitrary deterministic samples, referred to as outliers. Building upon recent random matrix advances in the area of robust statistics, we specifically show that the so-called Maronna M-estimator of scatter asymptotically behaves similar to well-known random matrices when the population and sample sizes grow together to infinity. The introduction of outliers leads the robust estimator to behave asymptotically as the weighted sum of the sample outer products, with a constant weight for all legitimate samples and different weights for the outliers. A fine analysis of this structure reveals importantly that the propensity of the M-estimator to attenuate (or enhance) the impact of outliers is mostly dictated by the alignment of the outliers with the inverse population covariance matrix of the legitimate samples. Thus, robust M-estimators can bring substantial benefits over more simplistic estimators such as the per-sample normalized version of the sample covariance matrix, which is not capable of differentiating the outlying samples. The analysis shows that, within the class of Maronna's estimators of scatter, the Huber estimator is most favorable for rejecting outliers. On the contrary, estimators more similar to Tyler's scale invariant estimator (often preferred in the literature) run the risk of inadvertently enhancing some outliers.
Managing Exercise Induced Anaphylaxis in Labour  [PDF]
Mazhar Chaudry, Ciara Mckay
Open Journal of Obstetrics and Gynecology (OJOG) , 2016, DOI: 10.4236/ojog.2016.66044
Abstract: Exercise induced anaphylaxis is an uncommon condition first reported by Sheffer and Austen in 1980. In this condition there is an exercise-induced lowering of the mast cell degranulation threshold, causing release of histamine and other mediators leading to the progression of symptoms of anaphylaxis. These can range from mild cutaneous pruritis and urticaria to severe systemic manifestations such as hypotension, cardiovascular collapse, syncope and even death. In Pregnancy and Labour, this can result in a number of complications and challenges. We will describe a case we were involved with.
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