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Search Results: 1 - 10 of 53162 matches for " David McCracken "
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Raymond Carver and the Ethos of Drinking  [PDF]
David McCracken
Advances in Literary Study (ALS) , 2013, DOI: 10.4236/als.2013.12004
Abstract: In Raymond Carver’s “Careful”, “Gazebo”, and “Chef’s House”, characters depend on the process of drinking as a paradigm to understand their lives. In these three stories, the characters rely upon alcohol as a solution to problems paradoxically caused by their addiction to alcohol.
Trach tubes designed to maximize safety may increase risk to ventilated patients
John McCracken, David Leasa
Critical Care , 2010, DOI: 10.1186/cc9306
Abstract: Guidelines have endorsed the position that a tracheostomy tube with an inner cannula and a low-pressure cuff is inherently safer than a single cannula tube with a low-volume cuff [1,2]. For patients who undergo tracheostomy for failure to wean from mechanical ventilation, however, design features intended to make tracheostomy tubes safer may complicate subsequent efforts to liberate them from the ventilator. Since prolonged mechanical ventilation also increases risk [3], it is uncertain that tubes of the first type afford these patients an overall safety advantage in an intensive care setting.A dual-cannulae tracheostomy tube, such as the Shiley LPC (Covidien-Nellcor, Boulder, CO, USA), occupies a relatively large amount of space within the trachea when the cuff is deflated during ventilator weaning. Because of resistance to flow around this type of tube, patients so equipped often cannot tolerate having the tube capped with either a speaking valve or a solid cap. Early spontaneous breathing trials must then be conducted while the patient breathes through an open tube. An open tube short-circuits speech, and impairs the natural airway defenses of coughing [4] and swallowing [5]. Moreover, bypassing the upper airway may diminish the patient's ability to sustain spontaneous breathing, leading caregivers to overestimate ventilator dependence. Exchanging to a smaller or cuffless tube can remedy this problem, but is delayed until caregivers are confident the stomal tract is stable and the patient can either breathe spontaneously or be adequately ventilated through the new tube.With an aim to facilitate more timely rehabilitation of ventilated patients, London Ontario's University Hospital has been percutaneously inserting the Bivona TTS tube (Smtih Medical, St Paul, MN, USA). Because of this tube's single lumen design and cuffless profile, even a size 8 tube (outer diameter 11 mm) can usually be capped during spontaneous breathing trials, thereby allowing caregivers to a
Cultura e consumo: uma explica??o teórica da estrutura e do movimento do significado cultural dos bens de consumo
McCracken, Grant;
Revista de Administra??o de Empresas , 2007, DOI: 10.1590/S0034-75902007000100014
Abstract: cultural meaning in a consumer society moves ceaselessly from one location to another. in the usual trajectory, cultural meaning moves first from the culturally constituted world to consumer goods and then from these goods to the individual consumer. several instruments are responsible for this movement: advertising, the fashion system, and four consumption rituals. this article analyses the movement of cultural meaning theoretically, showing both where cultural meaning is resident in the contemporary north american consumer system and the means by which this meaning is transferred from one location in this system to another.
Emission line galaxies at 9200 A, including a multi-component galaxy system at z =6.43
Simon Lilly,Kim-Vy Tran,Mark Brodwin,David Crampton,Stephanie Juneau,Henry McCracken
Physics , 2003,
Abstract: This paper has been temporarily withdrawn by the authors. Subsequent observations with the VLT have shown that the high equivalent width line emission from the candidate z=6.4 galaxy most likely is associated with an unusually strong lined low redshift galaxy to the north west. The paper will be revised accordingly and resubmitted.
Polarization observables in the longitudinal basis for pseudo-scalar meson photoproduction using a density matrix approach
Biplab Dey,Michael E. McCracken,David G. Ireland,Curtis A. Meyer
Physics , 2010, DOI: 10.1103/PhysRevC.83.055208
Abstract: The complete expression for the intensity in pseudo-scalar meson photoproduction with a polarized beam, target, and recoil baryon is derived using a density matrix approach that offers great economy of notation. A Cartesian basis with spins for all particles quantized along a single direction, the longitudinal beam direction, is used for consistency and clarity in interpretation. A single spin-quantization axis for all particles enables the amplitudes to be written in a manifestly covariant fashion with simple relations to those of the well-known CGLN formalism. Possible sign discrepancies between theoretical amplitude-level expressions and experimentally measurable intensity profiles are dealt with carefully. Our motivation is to provide a coherent framework for coupled-channel partial-wave analysis of several meson photoproduction reactions, incorporating recently published and forthcoming polarization data from Jefferson Lab.
Promoting accountability with a new generation of logic models
McCracken, Ann L.;
Ensaio: Avalia??o e Políticas Públicas em Educa??o , 2006, DOI: 10.1590/S0104-40362006000400005
Abstract: to better facilitate their work, program evaluators have developed a series of tools. one tool, the logic model, consists of inputs, activities, outputs, and outcomes. this article debates the adequacy of this commonly accepted logic model in evaluating the implementation of evidence-based practices in organizations. the author proposes a different logic model format which connects evidence and practice.
The developmental cycle of domestic groups and Amazonian deforestation
Moran, Emilio;McCracken, Stephen;
Ambiente & Sociedade , 2004, DOI: 10.1590/S1414-753X2004000200003
Abstract: it has been common to attribute tropical deforestation to population growth and/or migration. this paper finds that this is true only at large and aggregated spatial and temporal scales. when one examines regional-scaled processes, there are numberous mediating factors and more complex demographic processes that account for differences in rates of deforestation. based upon three years of research in the altamira region, xingu basin, brazilian amazon, we differenttiate between period and cohort effects in trajectories of deforestation. we find that every cohort of migrants follows the same overall trajectory of deforestation but that the magnitude of deforestation along a 20 year trajectory is dependent on period effects (such as hyperinflation, credit policy, land policy changes). moreover, we find that the 20-year trajectory does indeed follow the constraints posed by the development cycle of the domestic group-refleting as it does the changing supply of labor.
Metabolism of ciclesonide in the upper and lower airways: review of available data
Ruediger Nave, Nigel McCracken
Journal of Asthma and Allergy , 2008, DOI: http://dx.doi.org/10.2147/JAA.S4051
Abstract: abolism of ciclesonide in the upper and lower airways: review of available data Review (5068) Total Article Views Authors: Ruediger Nave, Nigel McCracken Published Date September 2008 Volume 2008:1 Pages 11 - 18 DOI: http://dx.doi.org/10.2147/JAA.S4051 Ruediger Nave, Nigel McCracken Nycomed GmbH, Konstanz, Germany Abstract: Ciclesonide is a novel corticosteroid (CS) for the treatment of asthma and allergic rhinitis. After administration, the parent compound ciclesonide is converted by intracellular airway esterases to its pharmacologically active metabolite desisobutyryl-ciclesonide (des-CIC). We investigated the in vitro activation of ciclesonide and further esterification of des-CIC to (mainly) des-CIC oleate in several human target organ test systems. Human precision-cut lung slices, alveolar type II epithelial cells (A549), normal bronchial epithelial cells (NHBE), and nasal epithelial cells (HNEC) were incubated with ciclesonide. Enzymes characterization and the determination of the reversibility of fatty acid esterifi cation was investigated in HNEC and NHBE. Ciclesonide was taken up and converted to des-CIC in all cellular test systems. Intracellular concentrations of des-CIC were maintained for up to 24 h. Formation of des-CIC oleate increased over time in HNEC, A549 cells, and lung slices. The formed des-CIC fatty acid conjugates were reconverted to des-CIC. Increasing concentrations of carboxylesterase and cholinesterase inhibitors progressively reduced the formation of metabolites. The results derived from these studies demonstrate the activation of ciclesonide to des-CIC in the upper and lower airways. The reversible formation of des-CIC fatty acid conjugates may prolong the anti-inflammatory activity of des-CIC and may allow for once-daily dosing.
Robert Plant (1818–1858): A Victorian plant hunter in Natal, Zululand, Mauritius and the Seychelles
Donal P. McCracken
South African Journal of Science , 2011, DOI: 10.4102/sajs.v107i3/4.359
Abstract: In the 1850s Robert William Plant collected plants and other natural specimens in what is now KwaZulu-Natal. This one-time Englishman compiled a dictionary for gardeners before emigrating to Natal in 1850. There he worked as the agent for Samuel Stevens, the London dealer in ‘curiosities of natural history’. Though Plant collected mainly plants, he also sent consignments of beetles, butterflies, bird skins and shells back to Britain. He published the first scientific paper on Zululand and was requested by the Royal Botanic Gardens at Kew to write the first Flora natalensis. It was while collecting for this never-to-be-completed treatise that Plant contracted malaria in Maputaland. He died in St Lucia in 1858 and in doing so became South Africa’s martyr to botany. What emerges from this study is a picture of the difficulties faced by plant hunters in mid-19th-century South Africa, the sort of plants they collected and the necessity for them sometimes to diversify into other natural history products to survive.
Metabolism of ciclesonide in the upper and lower airways: review of available data
Ruediger Nave,Nigel McCracken
Journal of Asthma and Allergy , 2008,
Abstract: Ruediger Nave, Nigel McCrackenNycomed GmbH, Konstanz, GermanyAbstract: Ciclesonide is a novel corticosteroid (CS) for the treatment of asthma and allergic rhinitis. After administration, the parent compound ciclesonide is converted by intracellular airway esterases to its pharmacologically active metabolite desisobutyryl-ciclesonide (des-CIC). We investigated the in vitro activation of ciclesonide and further esterification of des-CIC to (mainly) des-CIC oleate in several human target organ test systems. Human precision-cut lung slices, alveolar type II epithelial cells (A549), normal bronchial epithelial cells (NHBE), and nasal epithelial cells (HNEC) were incubated with ciclesonide. Enzymes characterization and the determination of the reversibility of fatty acid esterifi cation was investigated in HNEC and NHBE. Ciclesonide was taken up and converted to des-CIC in all cellular test systems. Intracellular concentrations of des-CIC were maintained for up to 24 h. Formation of des-CIC oleate increased over time in HNEC, A549 cells, and lung slices. The formed des-CIC fatty acid conjugates were reconverted to des-CIC. Increasing concentrations of carboxylesterase and cholinesterase inhibitors progressively reduced the formation of metabolites. The results derived from these studies demonstrate the activation of ciclesonide to des-CIC in the upper and lower airways. The reversible formation of des-CIC fatty acid conjugates may prolong the anti-inflammatory activity of des-CIC and may allow for once-daily dosing.Keywords: ciclesonide, des-CIC, metabolism, human, lung, nasal tissue
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