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Search Results: 1 - 10 of 52995 matches for " David Kavanaugh "
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Two new species of Pterostichus Bonelli subgenus Pseudoferonina Ball (Coleoptera, Carabidae, Pterostichini) from the mountains of central Idaho, U.S.A.
James Bergdahl,David Kavanaugh
ZooKeys , 2011, DOI: 10.3897/zookeys.104.1272
Abstract: Two new species of Pterostichus Bonelli subgenus Pseudoferonina Ball, are described from the mountains of central Idaho: Pterostichus bousqueti Bergdahl [type locality = small tributaries of South Fork of Payette River watershed, ca. 1170 m (3840 ft), 44.0675°/-115.6822°, near Lowman, Salmon River Mountains, Boise County, Idaho, U.S.A.] and Pterostichus lolo Bergdahl [type locality = Cottonwood/Orogrande Creek, ca. 870 m (2850 ft), 46.5528°/-115.5522°, North Fork of Clearwater River watershed, Clearwater Mountains, near Bungalow, Clearwater County, Idaho, U.S.A.]. Males of P. bousqueti and P. lolo are easily distinguished from each other and the seven previously described Pseudoferonina species by the form of the median lobe of the aedeagus, and from most individuals of the other species of Pseudoferonina in Idaho by features of pronotal shape and macrosculpture. Both species appear to be obligate ripicolous hygrophiles, restricted in distribution primarily to the margins of small montane streams in forested areas. Widespread intensive stream surveys for Pseudoferonina over many years indicate the geographic ranges of both species are highly localized, and additional undescribed species may occur in Idaho.
A new species of genus Nippononebria Ueno (Coleoptera, Carabidae, Nebriini) from Changbai Mountain, Jilin Province, China, the first species of the genus confirmed from the Asian mainland
David Kavanaugh,Hongbin Liang
ZooKeys , 2010, DOI: 10.3897/zookeys.46.458
Abstract: The authors describe a new species, Nippononebria changbaiensis sp. n. (type locality: Changbai Mountain, 42.034004°N, 128.055854°E, 2000–2600 m, Jilin Province, PR China), which represents the first confirmed record of the genus from the Asian mainland. They also provide a review of the taxonomic history of the genus and a key for distinguishing adults of subgenus Nippononebria species.
Contribution to knowledge of the genus Chydaeus in Xizang Autonomous Region (Tibet) and Yunnan Province, China (Coleoptera, Carabidae, Harpalini)
Boris M. Kataev,Hongbin Liang,David Kavanaugh
ZooKeys , 2012, DOI: 10.3897/zookeys.171.2306
Abstract: Five new species of the genus Chydaeus Chaudoir, 1854 are described from China: C. fugongensis sp. n. (Shibali, Fugong County, Yunnan Province), C. gutangensis sp. n. (Gutang, Medog County, Xizang Autonomous Region [Tibet]), C. hanmiensis sp. n. (Hanmi, Medog County, Xizang Autonomous Region [Tibet]), C. asetosus sp. n. (NE of Fugong, Yunnan Province), and C. baoshanensis sp. n. (N of Baoshan, Yunnan Province). Taxonomic and faunistic notes on eleven other species occurring in Xizang and Yunnan are also provided. Chydaeus shunichii Ito, 2006 is re-described, based on specimens from Lushui County, Yunnan. Chydaeus kumei Ito, 1992 is treated as a subspecies of C. andrewesi Schauberger, 1932 [NEW STATUS]. The taxonomic status of C. guangxiensis Ito, 2006 is discussed. The following taxa are recorded from China for the first time: C. obtusicollis Schauberger, 1932 (Xizang and Yunnan), C. malaisei Kataev & Schmidt, 2006 (Yunnan), C. semenowi (Tschitschérine, 1899) (Xizang and Yunnan), C. andrewesi andrewesi Schauberger, 1932 (Xizang and Yunnan), C. andrewesi kumei Ito (Yunnan), C. bedeli interjectus Kataev & Schmidt, 2002 (Xizang), and C. bedeli vietnamensis Kataev & Schmidt, 2002 (Yunnan).
A new species of Amara (Coleoptera, Carabidae, Zabrini) from Sichuan Province, China, with additional records for other Amara species from the region
Fritz Hieke,David Kavanaugh,Hongbin Liang
ZooKeys , 2012, DOI: 10.3897/zookeys.254.4223
Abstract: A new species, Amara (Bradytulus) shalulishanica Hieke & Kavanaugh, sp. n. (type locality: Haizishan Yakou, 29.47366°N, 100.21921°E, 4623 m, Shalulishan, Dishan Township, Litang County, Sichuan Province, China) is described and diagnosed. Additional records are provided for 16 other Amara species, each of which represents one of five different geographical distribution types, which are discussed.
A key to species of subgenus Lithochlaenius (Coleoptera, Carabidae, Chlaeniini, Chlaenius), with descriptions of three new species
Ye Liu,David Kavanaugh,Hongliang Shi,Hongbin Liang
ZooKeys , 2011, DOI: 10.3897/zookeys.128.1804
Abstract: Three new species of genus Chlaenius Bonelli subgenus Lithochlaenius Kryzhanovskij are described from China: Chlaenius chuanqianensis Liu & Liang, sp. n. (type locality: Xishui, Guizhou Province), C. linwensini Liu & Liang, sp. n. (type locality: Fujian Province), and Chlaenius propeagilis Liu & Kavanaugh, sp. n. (type locality: Gaoligongshan, Yunnan Province). Seven species of the subgenus are redescribed: C. agiloides Jedli ka, C. formosensis Lorenz, C. agilis Chaudoir, C. leishanensis Kirschenhofer, C. noguchii Bates, C. rambouseki Lutshnik, and C. wrasei Kirschenhofer. Additional taxonomic changes include the following: Chlaenius formosanus Jedli ka is treated as a junior synonym of C. rambouseki Lutshnik and C. anchomenoides Bates, syn. n. and C. nuristanus Jedli ka as junior synonyms of C. agilis Chaudoir, syn. n. Chlaenius latro LaFerté-Sénectère is considered a nomen nudum stat. n. and unavailable, leaving C. agilis Chaudoir as the next available name. Chlaenius nuristanus aberration rubridipes Jedli ka is also an unavailable name. Chlaenius formosensis Lorenz (=C. formosanus Habu) is returned to species status stat. n. A key to adults of the 10 known species of subgenus Lithochlaenius is provided.
A re-consideration of the taxonomic status of Nebria lacustris Casey (Coleoptera, Carabidae, Nebriini) based on multiple datasets – a single species or a species complex?
David Kavanaugh,Sophie L. Archambeault,Peter D. Roopnarine,Joel Ledford
ZooKeys , 2011, DOI: 10.3897/zookeys.147.2082
Abstract: This study gathered evidence from principal component analysis (PCA) of morphometric data and molecular analyses of nucleotide sequence data for four nuclear genes (28S, TpI, CAD1, and Wg) and two mitochondrial genes (COI and 16S), using parsimony, maximum likelihood, and Bayesian methods. This evidence was combined with morphological and chorological data to re-evaluate the taxonomic status of Nebria lacustris Casey sensu lato. PCA demonstrated that both body size and one conspicuous aspect of pronotal shape vary simultaneously with elevation, latitude, and longitude and served to distinguish populations from the southern Appalachian highlands, south of the French Broad, from all other populations. Molecular analyses revealed surprisingly low overall genetic diversity within N. lacustris sensu lato, with only 0.39% of 4605 bp varied in the concatenated dataset. Evaluation of patterns observed in morphological and genetic variation and distribution led to the following taxonomic conclusions: (1) Nebria lacustris Casey and Nebria bellorum Kavanaugh should be considered distinct species, which is a NEW STATUS for N. bellorum. (2) No other distinct taxonomic subunits could be distinguished with the evidence at hand, but samples from northeastern Iowa, in part of the region known as the “Driftless Zone”, have unique genetic markers for two genes that hint at descent from a local population surviving at least the last glacial advance. (3) No morphometric or molecular evidence supports taxonomic distinction between lowland populations on the shores of Lake Champlain and upland populations in the adjacent Green Mountains of Vermont, despite evident size and pronotal shape differences between many of their members.
Specificity and Actions of an Arylaspartate Inhibitor of Glutamate Transport at the Schaffer Collateral-CA1 Pyramidal Cell Synapse
Weinan Sun, Katie M. Hoffman, David C. Holley, Michael P. Kavanaugh
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023765
Abstract: In this study we characterized the pharmacological selectivity and physiological actions of a new arylaspartate glutamate transporter blocker, L-threo-?-benzylaspartate (L-TBA). At concentrations up to 100 μM, L-TBA did not act as an AMPA receptor (AMPAR) or NMDA receptor (NMDAR) agonist or antagonist when applied to outside-out patches from mouse hippocampal CA1 pyramidal neurons. L-TBA had no effect on the amplitude of field excitatory postsynaptic potentials (fEPSPs) recorded at the Schaffer collateral-CA1 pyramidal cell synapse. Excitatory postsynaptic currents (EPSCs) in CA1 pyramidal neurons were unaffected by L-TBA in the presence of physiological extracellular Mg2+ concentrations, but in Mg2+-free solution, EPSCs were significantly prolonged as a consequence of increased NMDAR activity. Although L-TBA exhibited approximately four-fold selectivity for neuronal EAAT3 over glial EAAT1/EAAT2 transporter subtypes expressed in Xenopus oocytes, the L-TBA concentration-dependence of the EPSC charge transfer increase in the absence of Mg2+ was the same in hippocampal slices from EAAT3 +/+ and EAAT3 ?/? mice, suggesting that TBA effects were primarily due to block of glial transporters. Consistent with this, L-TBA blocked synaptically evoked transporter currents in CA1 astrocytes with a potency in accord with its block of heterologously expressed glial transporters. Extracellular recording in the presence of physiological Mg2+ revealed that L-TBA prolonged fEPSPs in a frequency-dependent manner by selectively increasing the NMDAR-mediated component of the fEPSP during short bursts of activity. The data indicate that glial glutamate transporters play a dominant role in limiting extrasynaptic transmitter diffusion and binding to NMDARs. Furthermore, NMDAR signaling is primarily limited by voltage-dependent Mg2+ block during low-frequency activity, while the relative contribution of transport increases during short bursts of higher frequency signaling.
Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab
Sanna Rosengren, Nathan Wei, Kenneth C Kalunian, Nathan J Zvaifler, Arthur Kavanaugh, David L Boyle
Arthritis Research & Therapy , 2008, DOI: 10.1186/ar2497
Abstract: Autoantibodies as well as total IgM and IgG were quantified by enzyme-linked immunosorbent assay in extracts of synovial tissues and matched serum from patients with RA or osteoarthritis (OA). Synovial biopsies and serum were obtained at baseline and 8 weeks following rituximab therapy in 14 RA patients. A synovial/serum index (SSI) was calculated as the ratio of synovial to serum antibody/albumin, with values above 1 representing synovial enrichment. Lymphoid aggregates were evaluated histologically.Anti-CCP IgG, but not RF-IgM, was significantly enriched in RA synovia compared with serum. Total IgM and IgG were also enriched in RA, but not in OA. SSI correlated significantly with mRNA content for both IgM and IgG, demonstrating that it reflected synovial immunoglobulin production. RA synovia with lymphocyte aggregates contained significantly elevated RF-IgM and anti-CCP IgG compared with tissues with diffuse lymphoid infiltration. Rituximab treatment did not affect synovial autoantibody or total immunoglobulin SSI overall. However, in aggregate-containing tissues, rituximab significantly reduced total IgM and IgG SSI as well as IgM and IgG1 mRNA. Surprisingly, RF-IgM and anti-CCP IgG SSIs were unchanged by rituximab in aggregate-containing synovia.Combined with earlier observations that synovial lymphoid aggregates are unaltered by rituximab treatment, these data suggest that lymphoid aggregates may provide a protective niche for autoantibody-producing cells.The ARISE trial is registered at ClinicalTrials.gov as number NCT00147966.Rheumatoid arthritis (RA) is associated with the presence of certain circulating autoantibodies, such as rheumatoid factors (RFs) and anti-cyclic citrullinated peptide (anti-CCP) [1]. The latter has received recent attention because elevated levels can precede development of joint symptoms and because it acts synergistically with the shared HLA-DR epitope to enhance the risk of developing RA [2]. A contribution of B cells and their produ
Quantitative biomarker analysis of synovial gene expression by real-time PCR
David L Boyle, Sanna Rosengren, William Bugbee, Arthur Kavanaugh, Gary S Firestein
Arthritis Research & Therapy , 2003, DOI: 10.1186/ar1004
Abstract: The need to validate therapeutic agents in clinical trials is a key challenge in drug development for arthritis [1]. Advances in preclinical discovery technology have identified a large portfolio of targets that can potentially be tested in patients with inflammatory arthritis. However, trials that are dependent on clinical endpoints require relatively large numbers of patients due to heterogeneity of disease and placebo responses. In addition to the substantial expense, competition for patient enrollment among the various agents also complicates the process. Alternative methods to evaluate the drug effect, to predict clinical responses, and to prioritize targets are needed.One potential solution to this problem is the use of short-term clinical trials that focus on biomarker-based analysis [2]. This approach has been employed in rheumatoid arthritis (RA), although studies often rely on synovial fluid and peripheral blood samples [3,4] or on semiquantitative assessments of synovial tissue protein expression [5] and mRNA expression [6]. Synovial tissue analysis using immunohistochemistry (IHC) has more recently utilized precise image analysis techniques [7] to determine the relative expression of protein, although the lack of normalizing and external standards can potentially limit the power of this method. Analysis of tissue RNA transcripts, such as in situ hybridization, is less well established and is subject to additional constraints.To develop a reproducible and accurate method of gene expression analysis on synovial biopsies, we evaluated and validated real-time quantitative PCR (Q-PCR) on very small synovial tissue samples using a novel cell-based standard curve technique. This method is ideally suited for small proof-of-concept clinical trials designed to determine a biomarker endpoint in arthritis. In combination with IHC or tissue extract-based protein expression measurements [8], these techniques could help prioritize drug candidates so that resources can
A randomized trial comparing digital and live lecture formats [ISRCTN40455708
David J Solomon, Gary S Ferenchick, Heather S Laird-Fick, Kevin Kavanaugh
BMC Medical Education , 2004, DOI: 10.1186/1472-6920-4-27
Abstract: Students were randomized to either attend a lecture series at our main campus or view digital versions of the same lectures at community-based teaching sites. Both groups completed the same examination based on the lectures, and the group viewing the digital lectures completed a feedback form on the digital format.There were no differences in performance as measured by means or average rank. Despite technical problems, the students who viewed the digital lectures overwhelmingly felt the digital lectures could replace live lectures.This study provides preliminary evidence digital lectures can be a viable alternative to live lectures as a means of delivering didactic presentations in a community-based setting.Medical education is increasingly being conducted in community-based teaching sites outside of the traditional academic medical setting [1], At the same time, the economics of health care are requiring academic physicians to be more productive[2]. These trends in academic medicine are making it more difficult to provide students and residents with consistent, high quality instruction.Our institution has a community integrated structure where medical students spend the clinical portion of their training in one of six community campuses spread throughout the State of Michigan. Although this structure has many advantages, it is difficult to provide a consistent educational experience for the students. To help address this challenge, we implemented an all-day lecture series held at one of the community campuses two weeks before the end of the internal medicine clerkship.The students and faculty presenters from other campuses traveled from their home campus to the campus hosting the lecture series. End-of-clerkship feedback from the students has indicated the lecture series is both valuable and well received. Traveling to the host community, however, was inconvenient and time consuming for both students and faculty presenters. In addition, it is not practical for stud
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