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Las estrategias docentes al servicio del desarrollo del aprendizaje autorregulado
Estudios pedagógicos (Valdivia) , 2011, DOI: 10.4067/S0718-07052011000200004
Abstract: within a theoretical framework that regards teaching methodology as a theoretical and practical knowledge, this paper presents the preliminary results of an ongoing inquiry based on classroom observation data gathered at a medicine school. it is suggested that the working guidelines used might be applicable in other university contexts.
Las estrategias docentes al servicio del desarrollo del aprendizaje autorregulado As estratégias do ensino para o desenvolvimento da autorregula o da aprendizagem Teaching strategies for self-regulated learning
Florencia Daura
Estudios Pedagógicos (Valdivia) , 2011,
Abstract: El artículo presenta un marco teórico en el que se considera la didáctica como saber de carácter teórico práctico, y describe los resultados preliminares de una investigación en curso, referidos a datos recogidos en observaciones de clase realizadas en la carrera de medicina, trabajo para el cual se utilizó una guía que podría ser aplicada en otros contextos universitarios. Apresenta um marco teórico no qual se considera a Didática como saber de caráter teórico e prático e descreve resultados preliminares de uma investiga o em curso, obtidos por meio de coleta de dados observados em aulas do curso de Medicina. Utilizou-se um guia que poderia ser aplicado em outros contextos universitários. Within a theoretical framework that regards teaching methodology as a theoretical and practical knowledge, this paper presents the preliminary results of an ongoing inquiry based on classroom observation data gathered at a medicine school. It is suggested that the working guidelines used might be applicable in other university contexts.
Assessing the structural conservation of protein pockets to study functional and allosteric sites: implications for drug discovery
Alejandro Panjkovich, Xavier Daura
BMC Structural Biology , 2010, DOI: 10.1186/1472-6807-10-9
Abstract: We performed a large-scale study of protein cavities as potential allosteric and functional sites, by integrating publicly available information on protein sequences, structures and active sites for more than a thousand protein families. By identifying common pockets across different structures of the same protein family we developed a method to measure the pocket's structural conservation. The method was first parameterized using known active sites. We characterized the predicted pockets in terms of sequence and structural conservation, backbone flexibility and electrostatic potential. Although these different measures do not tend to correlate, their combination is useful in selecting functional and regulatory sites, as a detailed analysis of a handful of protein families shows. We finally estimated the numbers of potential allosteric or regulatory pockets that may be present in the data set, finding that pockets with putative functional and effector characteristics are widespread across protein families.Our results show that structurally conserved pockets are a common feature of protein families. The structural conservation of protein pockets, combined with other characteristics, can be exploited in drug discovery procedures, in particular for the selection of the most appropriate target protein and pocket for the design of drugs against entire protein families or subfamilies (e.g. for the development of broad-spectrum antimicrobials) or against a specific protein (e.g. in attempting to reduce side effects).Molecular processes in the living cell are coordinated and executed under tight regulation. Proteins play a fundamental role in almost all biological processes, and their overall activity is regulated at different levels [1]. At a first level, the concentration of a particular protein in the cell is regulated through its synthesis rate (gene expression) and its degradation rate. At another level, mechanisms act on the protein molecule itself through covalent mo
Obarrio Moreno, Juan Alfredo, “Testamentorum sollemnia iuris romani medii aevi memoria” (Madrid, Dykinson, 2009), 402 págs.
Josep Serrano Daura
Revista de estudios histórico-jurídicos , 2012,
Brufau Prats, Jaime - Sánchez-Lauro, Sixto, Domingo de Soto, OP., Relecciones y opúsculos (Salamanca, Editorial San Esteban, 2011), II, 2, 617 págs.
Josep Serrano Daura
Revista de estudios histórico-jurídicos , 2012,
Exploiting protein flexibility to predict the location of allosteric sites
Panjkovich Alejandro,Daura Xavier
BMC Bioinformatics , 2012, DOI: 10.1186/1471-2105-13-273
Abstract: Background Allostery is one of the most powerful and common ways of regulation of protein activity. However, for most allosteric proteins identified to date the mechanistic details of allosteric modulation are not yet well understood. Uncovering common mechanistic patterns underlying allostery would allow not only a better academic understanding of the phenomena, but it would also streamline the design of novel therapeutic solutions. This relatively unexplored therapeutic potential and the putative advantages of allosteric drugs over classical active-site inhibitors fuel the attention allosteric-drug research is receiving at present. A first step to harness the regulatory potential and versatility of allosteric sites, in the context of drug-discovery and design, would be to detect or predict their presence and location. In this article, we describe a simple computational approach, based on the effect allosteric ligands exert on protein flexibility upon binding, to predict the existence and position of allosteric sites on a given protein structure. Results By querying the literature and a recently available database of allosteric sites, we gathered 213 allosteric proteins with structural information that we further filtered into a non-redundant set of 91 proteins. We performed normal-mode analysis and observed significant changes in protein flexibility upon allosteric-ligand binding in 70% of the cases. These results agree with the current view that allosteric mechanisms are in many cases governed by changes in protein dynamics caused by ligand binding. Furthermore, we implemented an approach that achieves 65% positive predictive value in identifying allosteric sites within the set of predicted cavities of a protein (stricter parameters set, 0.22 sensitivity), by combining the current analysis on dynamics with previous results on structural conservation of allosteric sites. We also analyzed four biological examples in detail, revealing that this simple coarse-grained methodology is able to capture the effects triggered by allosteric ligands already described in the literature. Conclusions We introduce a simple computational approach to predict the presence and position of allosteric sites in a protein based on the analysis of changes in protein normal modes upon the binding of a coarse-grained ligand at predicted cavities. Its performance has been demonstrated using a newly curated non-redundant set of 91 proteins with reported allosteric properties. The software developed in this work is available upon request from the authors.
Gills scanning images of the seawater fish Eugerres brasilianus (Gerreidae)
Eiras-Stofella, Daura Regina;Charvet-Almeida, Patricia;
Brazilian Archives of Biology and Technology , 2000, DOI: 10.1590/S1516-89132000000400011
Abstract: the gills of the adult fish, eugerres brasilianus (gerreidae) were analyzed in a scanning electron microscope. the stratified epithelium was uniform on all parts of the branchial arch. concentric microridges were present on cells that form this epithelium and were mainly observed in the primary lamellae and pharyngeal region where mucous cells were also abundant. the ultrastructural features of e. brasilianus gills indicated that this was not a filtering species, and that the feeding habit included mainly the intake of small organisms. the results presently obtained agreed with other literature data which determined the feeding habit of this species by means of stomach content analysis and other aspects.
Ultrastructure (SEM) of the gills of Prochilodus Scrofa Steindachner (Pisces, Teleostei)
Eiras-Stofella, Daura Regina;Charvet-Almeida, Patricia;
Revista Brasileira de Zoologia , 1998, DOI: 10.1590/S0101-81751998000200001
Abstract: gills arches of the freshwater fish prochilodus scrofa steindachner, 1881 (lt= 8.0-12.4cm) were removed to be analyzed in a scanning electron microscope. the morphology of the superficial structures of the gill filaments and pharyngeal region of the gills arches was discussed and related to their functional aspects. a great quantity of mucous secretory cells and of microridges, along with the pavement cell surface of the primary lamellae and branchial pharyngeal region, indicate the existence of a protection strategy of the respiratory lamellae. the chloride cells are abundant, specially on the distal portion of the primary lamellae, and bring out the osmo regulatory capacity of this species. this fish seems not to be a filtering one according to: its short and simple gill rakers; presence of several taste buds turned towards the mouth opening; evidence of spines on the external side of the arches and an abundant secretion of mucous in the pharyngeal region. this species probably selects the food to be swallowed through its chemical receptors and retains it with the help of spines and mucous secretion this way protecting the gills filaments against the rubbing of particles over them.
The ultrastructure of the mullet Mugil curema Valenciennes (Teleostei, Mugilidae) spermatozoa
Eiras-Stofella, Daura Regina;Gremski, Waldemiro;Kuligowski, Sandra Maria;
Revista Brasileira de Zoologia , 1993, DOI: 10.1590/S0101-81751993000400007
Abstract: the structure of the spermatozoon of mugil curema valenciennes, 1836 was studied using scanning and transmission electron microscopy. the spermatic head is rounded and formed by the nucleus containing granular chromatin, firmly packed resulting in a mass extremely electron dense. the acrossome is absent. the midpiece is characterized by the presence of two centrioles, a plasmatic canal, very few vesicles, and several mitochondria (9-10) with aproximately 0.50μm in diameter. the head and the midpiece are aproximately 1.56μm in diameter. the flagellum conforms to the 9 + 0 flagellar pattern near the transition region in its midpiece and is 9 + 2 from there on up to the distal region of the axoneme. the electron density in the a tubules 1, 2, 5 and 6 shows the asymetry of this spermatozoa. its spermatic cell differs ultrastructuraly from those of other mugilidae species mainly because it has the highest number of mitochondria.
Assessment of post-harvest challenges of small scale farm holders of tomotoes, bell and hot pepper in some local government areas of Kano State, Nigeria
FF Olayemi, JA Adegbola, EI Bamishaiye, AM Daura
Bayero Journal of Pure and Applied Sciences , 2010,
Abstract: The survey assessed the post harvest challenges of small scale farm holder of three different vegetables, tomatoes (Solanium lycorpesicum), bell pepper (Capsicum annuum) and hot pepper (Capsicum chinense) in four (4) Local Government Areas namely Danbatta, Bunkure, Kura and Dawakin Tofa of Kano State. The primary data used for the investigation were obtained through the use of questionnaire. One hundred and twenty (120) farmers were randomly sampled and selected for the study; the farming experience of respondent, stage and time of harvest of produce, percentage loss of produce during harvesting and transportation, on-farm storage facilities utilized by respondents and mode of transportation and packaging materials utilized by the respondents were looked into. Investigative Survey Research Approach (ISRA) and descriptive statistics were employed in the analysis of the data. The results obtained revealed that most of the tomatoes, ball and hot pepper farmers experience losses of 10-30% during harvesting and transportation stages. The farmer harvest mostly when they have buyer, harvest at fully ripe stage (90%) and most still use the traditional basket and sacks as their packaging material in conveying produce resulting into massive post harvest losses (62.5%). Theses practices by the farmers often result in reduction of profit and in-availability of these products all through the seasons. Based on these findings, it was concluded that farmers in these areas require proper and extensive training on how to reduce their losses especially through proper pre-harvesting, harvesting and post-harvesting practices like primary processing in times of glut and the introduction of some important easy-to-use technologies that will reduce if not eliminate fruits and vegetables wastages in the areas. Key word: Tomatoes, postharvest, pepper, losses, assessment.
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