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Search Results: 1 - 10 of 71 matches for " Darja Pollpeter "
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Impaired Cellular Responses to Cytosolic DNA or Infection with Listeria monocytogenes and Vaccinia Virus in the Absence of the Murine LGP2 Protein
Darja Pollpeter,Akihiko Komuro,Glen N. Barber,Curt M. Horvath
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018842
Abstract: Innate immune signaling is crucial for detection of and the initial response to microbial pathogens. Evidence is provided indicating that LGP2, a DEXH box domain protein related to the RNA recognition receptors RIG-I and MDA5, participates in the cellular response to cytosolic double-stranded DNA (dsDNA). Analysis of embryonic fibroblasts and macrophages from mice harboring targeted disruption in the LGP2 gene reveals that LGP2 can act as a positive regulator of type I IFN and anti-microbial gene expression in response to transfected dsDNA. Results indicate that infection of LGP2-deficient mice with an intracellular bacterial pathogen, Listeria monocytogenes, leads to reduced levels of type I IFN and IL12, and allows increased bacterial growth in infected animals, resulting in greater colonization of both spleen and liver. Responses to infection with vaccinia virus, a dsDNA virus, are also suppressed in cells lacking LGP2, reinforcing the ability of LGP2 to act as a positive regulator of antiviral signaling. In vitro mechanistic studies indicate that purified LGP2 protein does not bind DNA but instead mediates these responses indirectly. Data suggest that LGP2 may be acting downstream of the intracellular RNA polymerase III pathway to activate anti-microbial signaling. Together, these findings demonstrate a regulatory role for LGP2 in the response to cytosolic DNA, an intracellular bacterial pathogen, and a DNA virus, and provide a plausible mechanistic hypothesis as the basis for this activity.
Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes
Darja Kanduc
Biologics: Targets and Therapy , 2010, DOI: http://dx.doi.org/10.2147/BTT.S12097
Abstract: cribing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes Original Research (4522) Total Article Views Authors: Darja Kanduc Published Date September 2010 Volume 2010:4 Pages 245 - 261 DOI: http://dx.doi.org/10.2147/BTT.S12097 Darja Kanduc Department of Biochemistry and Molecular Biology, University of Bari, Italy Abstract: We searched the primary sequence of influenza A H5N1 polyprotein for hexamer amino acid sequences shared with human proteins using the Protein International Resource database and the exact peptide matching analysis program. We find that the viral polyprotein shares numerous hexapeptides with the human proteome. The human proteins involved in the viral overlap are represented by antigens associated with basic cell functions such as proliferation, development, and differentiation. Of special importance, many human proteins that share peptide sequences with influenza A polyprotein are antigens such as reelin, neurexin I-a, myosin-IXa, Bardet–Biedl syndrome 10 protein, Williams syndrome transcription factor, disrupted in schizophrenia 1 protein, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein, fragile X mental retardation 2 protein, and jouberin. That is, the viral-vs-human overlap involves human proteins that, when altered, have been reported to be potentially associated with multiple neurological disorders that can include autism, epilepsy, obesity, dystonia, ataxia–telangiectasia, amyotrophic lateral sclerosis, sensorineural deafness, sudden infant death syndrome, Charcot-Marie-Tooth disease, and myelination. The present data are discussed as a possible molecular basis for understanding influenza A viral escape from immunosurveillance and for defining anti-influenza immune-therapeutic approaches devoid of collateral adverse events.
Cooperation of a public library with the University for the Third Period of Life
Darja Kramberger
Knji?nica : Revija za Podro?je Bibliotekarstva in Informacijske Znanosti , 1997,
Abstract: The authors present the model of education organized by the Maribor Library for its readers in the third period of life which follows the orientation of the Slovenian University for the Third Period of Life. The program called Literary Cycle with a defined aim takes pla e in the frames of the activities for adults readers. The Library acts as the initiator and organizer of multi-faceted activities, guided by a librarian in charge of the Literary Cycle. There are several forms of participation:participants attend lectures, study on their own or in of study groups, take part in organized visits of cultural institutions etc.; in pursuing their activities, they make use of library materials intensively. With informal forms of eductaion, the Library enhances the quality of life of the elderly and makes an important contribution to the cultural development of its environment.
Research work in the librarianship field in the frame of research work in Slovenia
Darja Vajs
Knji?nica : Revija za Podro?je Bibliotekarstva in Informacijske Znanosti , 2007,
Abstract: The article reflects the significance of research and development work, which is very important in every society as knowledge and creativity are the most important movers of growth and employment. In Slovenia, research is present in various fields (universities, institutions, research organizations, etc.). The article deals with research in the field of library and information science by analyzing in detail 64 researchers which are currently registered in SICRIS database supported and developed by Institute of Information Science, Maribor. The article highlights great investments into research and its monitoring and evaluation. A comparative analysis has shown that regarding the expenditures on research and development Slovenia is ranked in the midst of the European Union countries. Author’s personal opinion and research results are linked and summed up in the final chapter.
Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes
Darja Kanduc
Biologics: Targets and Therapy , 2010,
Abstract: Darja KanducDepartment of Biochemistry and Molecular Biology, University of Bari, ItalyAbstract: We searched the primary sequence of influenza A H5N1 polyprotein for hexamer amino acid sequences shared with human proteins using the Protein International Resource database and the exact peptide matching analysis program. We find that the viral polyprotein shares numerous hexapeptides with the human proteome. The human proteins involved in the viral overlap are represented by antigens associated with basic cell functions such as proliferation, development, and differentiation. Of special importance, many human proteins that share peptide sequences with influenza A polyprotein are antigens such as reelin, neurexin I-a, myosin-IXa, Bardet–Biedl syndrome 10 protein, Williams syndrome transcription factor, disrupted in schizophrenia 1 protein, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein, fragile X mental retardation 2 protein, and jouberin. That is, the viral-vs-human overlap involves human proteins that, when altered, have been reported to be potentially associated with multiple neurological disorders that can include autism, epilepsy, obesity, dystonia, ataxia–telangiectasia, amyotrophic lateral sclerosis, sensorineural deafness, sudden infant death syndrome, Charcot-Marie-Tooth disease, and myelination. The present data are discussed as a possible molecular basis for understanding influenza A viral escape from immunosurveillance and for defining anti-influenza immune-therapeutic approaches devoid of collateral adverse events.Keywords: peptide sharing, neurological disorders, host-pathogen relationships, viral escape from immunosurveillance
Biseksuali asmen patirtys ir biseksualios socialin s tapatyb s formavimasis Lietuvoje
Darja Lyzenko
Culture and Society : Journal of Social Research , 2011,
Abstract: The article focuses on the lives of bisexual men and women in Lithuania. As a consequence of homophobia and heteronormativity in the country, bisexuality is regarded as at least to some extent an unacceptable set of sexual preferences and practices. Therefore, bisexuals as members of a subordinated social group are forced to deal with their negative identity and its consequences.The article analyzes how bisexuals as members of a negatively regarded social group construct their bisexual social identity and what main obstacles they encounter in doing it. The theoretical background of this study is based on Henri Tajfel’s social identity theory and on the integrated LGB (lesbian, Gay, Bisexual) identity formation stage model. Eleven semi-structured interviews with bisexual men and women living in Lithuania were conducted for this article. The study demonstrates that the bisexuals’ relation to the social reality is twofold. On the one hand, the emergence of bisexual social identity is rather slow in Lithuania and in forming their identity bisexuals encounter a number of obstacles including monosexism and social ignorance. On the other hand, the participants of this research almost unanimously claimed that it is much easier to pursue a bisexual lifestyle in Lithuania than a homosexual one. The main reason for it is the ability to switch their identities and to voice, in most cases, only a “part of the truth.” The study draws a paradoxical conclusion: the reasons that are to be blamed for the slow formation of Lithuanian bisexual social identity coincide with the reasons that enable individuals to choose among different social identities that make their lives more bearable.
Job-induced Commuting between Two Residences – Characteristics of a Multilocational Living Arrangement in the Late Modernity
Darja Reuschke
Comparative Population Studies , 2010,
Abstract: Against the background of the ongoing flexibilisation of labour markets and a rising labour force participation of (highly) qualified women, job-related commuting between a main and secondary residence has become more important in Western capitalist countries as is the case in contemporary Germany. The limited number of recent empirical studies on this kind of multilocational living arrangement almost entirely focuses on commuters in couple/family households. The main objective of this article is, firstly, to provide data about the characteristics and formation contexts of job-related multilocational household organisations as a whole, in order to make a contribution to the discussion of the forms and causes of this currently important phenomenon. Secondly, by means of comparison analyses, the multilocational form of living is compared to the group of long-distance movers, in order to provide insights into who prefers commuting to migration with the complete household under which circumstances. The article draws on data of a field research study, which have been obtained from an individual based random sample from official registers of inhabitants of four metropolises in Germany. The sample was restricted to individuals with specific characteristics (in-movers, age 25 to 59). The fully structured postal interviews were complemented by qualitative telephone interviews with selected commuters. The results show that commuters are a heterogeneous group. Living in a partnership and the social connections established thereby play a prominent role for multilocational household organisations. Among male commuters, one can distinguish between those who are young, never married and predominantly childless, on the one hand, and a group of older married commuters with children in the household, on the other. The vast majority of female commuters, however, live childless. As men commute between two residences even if they live with a family, they significantly more often have a job-related secondary residence than women. Late modern characteristics of job-related multilocational living arrangements are dual earner households for male commuters and high occupational positions for female commuters. The commuting between two accommodations is strongly connected to the career entry, on the one hand, and is also important in a later occupational career phase as a partly longer-lasting period, on the other hand. It may be suggested that the rise of fix-term employment will further increase the importance of multilocational living arrangements in Late Modernity.
Berufsbedingtes Pendeln zwischen zwei Wohnsitzen – Merkmale einer multilokalen Lebensform in der Sp tmoderne
Darja Reuschke
Comparative Population Studies , 2010,
Abstract: Vor dem Hintergrund der andauernden Flexibilisierung der Arbeitsm rkte und einer steigenden (hoch-)qualifizierten Frauenerwerbst tigkeit hat das beruflich bedingte Pendeln zwischen einem Haupt- und Zweitwohnsitz in westlichen Industriel ndern wie Deutschland an Bedeutung gewonnen. Die wenigen Studien über diese Art multilokaler Lebensführung beziehen sich nahezu vollst ndig auf Pendler/innen ( Shuttles“) in Paar- bzw. Familienhaushalten. Der Artikel verfolgt das Ziel, erstens, Merkmale und Entstehungskontexte von berufsbedingten multilokalen Haushaltsorganisationen im Allgemeinen zu untersuchen und damit einen Beitrag zur aktuellen Diskussion über die Auspr gungen und Ursachen dieses gegenw rtig bedeutenden Ph nomens zu leisten. Zweitens wird die multilokale Lebensform mit traditionellen“ Fernwandernden verglichen, um Erkenntnisse darüber zu gewinnen, wer und unter welchen Umst nden das berufliche Pendeln zwischen zwei Wohnsitzen einem Umzug mit dem gesamten Haushalt vorzieht. Der Beitrag bezieht sich auf Daten einer Prim rerhebung, in der eine Zufallsstichprobe von Personen aus dem Einwohnermelderegister von vier deutschen Metropolen gezogen wurde. Die Grundgesamtheit ist auf Individuen mit spezifischen Merkmalen (Zuwandernde zwischen 25 bis 59 Jahren) begrenzt. Die Ergebnisse der standardisierten postalischen Befragung wurden durch qualitative Telefoninterviews mit ausgew hlten Shuttles vertieft. Die Ergebnisse zeigen, dass es sich bei Shuttles um eine heterogene Gruppe handelt. Das Leben in einer Partnerschaft und die damit verbundenen sozialen Bindungen spielen für multilokale Haushaltsorganisationen eine entscheidende Rolle. Unter den m nnlichen Pendlern kann eine Gruppe junger, lediger und meist kinderloser M nner und eine Gruppe lterer, verheirateter Pendler mit Kindern im Haushalt identifiziert werden. Die gro e Mehrheit der weiblichen Shuttles lebt dagegen kinderlos. Weil M nner auch in einer Lebensgemeinschaft mit Kind zwischen zwei Wohnsitzen pendeln, haben sie signifikant fter als Frauen einen berufsbedingten Zweitwohnsitz. Sp tmoderne Auspr gungen beruflich bedingter multilokaler Lebensmuster sind doppelerwerbst tige Haushalte für m nnliche Pendler und hohe berufliche Stellungen für Pendlerinnen. Das Pendeln zwischen zwei Wohnsitzen ist einerseits mit dem Berufseinstieg eng verbunden und spielt andererseits auch in einer sp teren Berufsphase für eine zum Teil l nger andauernde Periode eine bedeutende Rolle. Es ist anzunehmen, dass die Bedeutungszunahme befristeter Besch ftigung zu einem Anstieg multilokaler Lebensformen in der Sp tmodern
On Implicitly Discovered OLAP Schema-Specific Preferences in Reporting Tool
Natalija Kozmina, Darja Solodovnikova
Scientific Journal of Riga Technical University. Computer Sciences , 2011, DOI: 10.2478/v10143-011-0005-6
Abstract: We propose content-based methods for construction of recommendations for reports in the OLAP reporting tool. Recommendations are generated based on preference information in user profile, which is updated implicitly by collecting and analyzing user activity in the reporting tool. Taking advantage of data about user preferences for data warehouse schema elements, existing reports that potentially may be interesting to the user are distinguished and recommended. The approach used for recommending reports is composed of two methods - cold-start and hot-start.
Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins
Rosalia Ricco, Darja Kanduc
Biologics: Targets and Therapy , 2010, DOI: http://dx.doi.org/10.2147/BTT.S8890
Abstract: titis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins Original Research (4699) Total Article Views Authors: Rosalia Ricco, Darja Kanduc Published Date April 2010 Volume 2010:4 Pages 75 - 81 DOI: http://dx.doi.org/10.2147/BTT.S8890 Rosalia Ricco1, Darja Kanduc2 1Department of Pathological Anatomy, 2Department of Biochemistry and Molecular Biology, University of Bari, Bari, Italy Abstract: The primary amino acid sequence of the hepatitis B virus (HBV) proteome was searched for identity spots in the human proteome by using the Protein Information Resource database. We find that the HBV polyprotein shares sixty-five heptapeptides, one octapeptide, and one nonapeptide with the human proteins. The viral matches are disseminated among fundamental human proteins such as adhesion molecules, leukocyte differentiation antigens, enzymes, proteins associated with spermatogenesis, and transcription factors. As a datum of special interest, a number of peptide motifs are shared between the virus- and brain-specific antigens involved in neuronal protection. This study may help to evaluate the potential cross reactions and side effects of HBV antigen-based vaccines.
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