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Search Results: 1 - 10 of 120067 matches for " Dansong Wang "
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Granulocytic sarcoma of the pancreas: A case report and review of the literatures
Yefei Rong, Dansong Wang, Wenhui Lou, Tiantao Kuang, Dayong Jin
BMC Gastroenterology , 2010, DOI: 10.1186/1471-230x-10-80
Abstract: We reported a 40-year-old male patient who had jaundice, highly elevated bilirubin, and a mass highly suspicious of pancreatic head carcinoma. We performed surgery and the pathology and immunohistochemistry suggested GS; however the blood test and the bone marrow infiltration showed no evidence of AML. In our review of the published reports of GS, we only found six reports of the GS in the pancreas, and we suggested that immunohistochemical staining should be used to accurately differentiate GS from other pancreatic cancer and other types of leukemia.The accurate diagnosis of GS is necessary for determining prognosis and deciding appropriate therapy.Granulocytic sarcoma (GS), also called extramedulary myeloblastoma or chloroma, is a rare solid tumor composed of immature myeloid cells [1]. The tumor may precede or occur concurrently with acute or chronic myeloid leukaemia or less often with polycythemia vera and primary myelofibrosis. Granulocytic sarcomas usually occurred in skin, soft tissue, lymph nodes, and bones [2]. Only few cases of GS of the pancreas had been reported in literatures [3,4]. We hereby reported a case of GS in the pancreas, in a patient without AML.The patient was a 40-year-old man. He had no significant past medical history. He initially went to the outside hospital on Jan 20, 2009, with the symptom of jaundice and weight loss of 5 Kg in one month. He described that his skin and sclera got yellow and gradually got worse in one month. He denied fever, chills, nausea, or vomiting. His physical examination at the time was only yellow skin and sclera. His routine laboratory test only showed the elevated total bilirubin and direct bilirubin. MRCP of the other hospital showed the malignant tumor in the distal common bile duct.He was referred to our department for surgical treatment on Jan 24, 2009. At this time, his symptoms and physical examination results remained unchanged. Hemoglobin: 118g/L, white blood cell count: 3,600/mm3, platelets: 142 × 10
Primary small cell carcinoma of the pancreas: rare type of pancreatic cancer and review of the literatures
Dansong Wang, Yefei Rong, Wenchuan Wu, Dayong Jin
World Journal of Surgical Oncology , 2012, DOI: 10.1186/1477-7819-10-32
Abstract: We present the case of a 62-year-old man with a half-month history of upper abdominal discomfort who was diagnosed with SCC of the pancreatic tail. A Chest X-ray showed no evidence of primary lung tumor. The diagnosis of a SCCP was confirmed by post-surgery pathology and immunohistology. In our review of the published reports of SCCP, we only found a few cases reported in the literatures. The diagnosis of SCCP needs the post-surgery pathology and immunohistology and the prognosis of SCCP is extremely poor. There was a significant increase in median survival, from 1 to 6 months, in treated patients compared to patients treated only by symptomatic management. Chemotherapy was the most common treatment and the combination of cisplatin/etoposide was most frequently prescribed.The accurate diagnosis of (SCCP) is necessary for determining prognosis and deciding appropriate therapy.Small cell carcinomas (SCCs) is an aggressive tumor, which account for 18-20% of all primary lung cancers, but they are also described in the urinary bladder, prostate, salivary glands, pharynx, larynx, esophagus, stomach, pancreas, colon, rectum, skin, and cervix [1-3]. Similar to SCC of the lung, SCC of the pancreas (SCCP) is a lethal disease and its prognosis is extremely poor. If untreated, it progresses rapidly with fatal course. We hereby reported a case of SCCP and reviewed the articles associated with the SCCP.The patient was a 62-year-old man. Except hypertension, he had no significant past medical history. He went to our hospital on July 21, 2011, with the symptom of upper abdominal discomfort. The local hospital CT scan revealed a low-density mass at the pancreatic tail (Figure 1). Laboratory examination: Hemoglobin: 149 g/L; white blood cell count: 4.7 × 109/L; platelets: 78 × 109/L; AST: 21 U/L; ALT: 14 U/L; total bilirubin: 14.2 μmol/L; direct bilirubin: 6.6 μmol/L; serum creatinine: 75 μmol/L;AFP:2.2 ng/mL (normal < 20 ng/ml); CA19-9:122.7 U/mL (normal < 37 U/mL); CEA: 2.82 ng/ml
Proteomics analysis of serum protein profiling in pancreatic cancer patients by DIGE: up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2
Yefei Rong, Dayong Jin, Chenrui Hou, Jianwen Hu, Wenchuan Wu, Xiaolin Ni, Dansong Wang, Wenhui Lou
BMC Gastroenterology , 2010, DOI: 10.1186/1471-230x-10-68
Abstract: Serum samples from five individuals with pancreatic cancer and five individuals without cancer were compared. Highly abundant serum proteins were depleted by immuno-affinity column. Differential protein analysis was performed using 2-dimensional differential in-gel electrophoresis (2D-DIGE).Among these protein spots, we found that 16 protein spots were differently expressed between the two mixtures; 8 of these were up-regulated and 8 were down-regulated in cancer. Mass spectrometry and database searching allowed the identification of the proteins corresponding to the gel spots. Up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2, which have not previously been implicated in pancreatic cancer, were observed. In an independent series of serum samples from 16 patients with pancreatic cancer and 16 non-cancer-bearing controls, increased levels of mannose-binding lectin 2 and myosin light chain kinase 2 were confirmed by western blot.These results suggest that affinity column enrichment and DIGE can be used to identify proteins differentially expressed in serum from pancreatic cancer patients. These two proteins 'mannose-binding lectin 2 and myosin light chain kinase 2' might be potential biomarkers for the diagnosis of the pancreatic cancer.Pancreatic ductal adenocarcinoma is the most common malignancy of the pancreas that arises from the ductal epithelium of the pancreas. Despite many efforts, conventional treatment approaches, including surgery, radiation, chemotherapy, or combinations of these, have had little impact on the outcome of this lethal disease. The overall prognosis for the disease is dismal: after resection, the median survival does not exceed 2 years with a 5-year survival rate less than 20% [1-3]. One major reason for this poor outcome is the late diagnosis of the disease and only about 10-20% of patients are eligible for resection [4,5]. The overall 5-year survival rate of patients with curative resection of pancreatic cancer is 2
Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?
Wenchuan Wu,Xiuzhong Yao,Chao Lin,Dayong Jin,Dansong Wang,Wenhui Lou,Xinyu Qin
Gastroenterology Research and Practice , 2014, DOI: 10.1155/2014/253471
Abstract: To explore whether steroid therapy should be needed for autoimmune pancreatitis patients after operation, eight AIP patients receiving operation were enrolled in this study from January 2007 to July 2013. All patients underwent liver function, CA19-9, and contrast-enhanced CT and/or MRI. Tests of IgG and IgG4 were performed in some patients. Tests of serum TB/DB, γ-GT, and γ-globulin were undergone during the perioperative period. Six cases receiving resection were pathologically confirmed as AIP patients and two were confirmed by intraoperative biopsy. For seven patients, TB/DB level was transiently elevated 1 day or 4 days after operation but dropped below preoperative levels or to normal levels 7 days after operation, and serum γ-GT level presented a downward trend. Serum γ-globulin level exhibited a downward trend among six AIP patients after resection, while an upward trend was found in another two AIP patients receiving internal drainage. Steroid therapy was not given to all six AIP patients until two of them showed new lines of evidence of residual or extrapancreatic AIP lesion after operation, while another two cases without resection received steroid medication. Steroid therapy might not be recommended unless there are new lines of evidence of residual extrapancreatic AIP lesions after resection. 1. Introduction Patients with autoimmune pancreatitis (AIP) often receive unnecessary operation due to misdiagnosis for malignances, although they can be cured by steroid therapy without surgery [1, 2]. About 2.5% of patients receiving pancreaticoduodenectomy reported in the literature were pathologically confirmed as AIP [3–5]. Autoantibodies against pancreatic antigen are induced during the pathogenesis of autoimmune pancreatitis (AIP), which causes extensive infiltration of lymphocytes and plasma cells within pancreatic tissue around the pancreatic duct and diffuse enlargement of the pancreas. Similar manifestations may appear in the extrapancreatic organs due to the presence of common antigens. Actually, mechanism for antigens and antibodies of AIP has not been clearly elucidated. The diagnosis and disease severity of AIP are mainly dependent on a comprehensive assessment with serology, morphology, imaging, and therapeutics [6]. Similar to IgG, IgG4 is only the representative of the responsive level of antigen-specific antibody in the serum, although it is a key indicator among the diagnostic criteria for AIP [7, 8]. IgG4 is also related to the degree of AIP but does not directly represent the extent of lymphoplasmacytic infiltration into the
Multi-object Segmentation Based on Improved Pulse Coupled Neural Network
Dansong Cheng,Xianglong Tang,Jiafeng Liu,Xiaofang Liu
Computer and Information Science , 2009, DOI: 10.5539/cis.v1n4p91
Abstract: This paper introduces an approach for image segmentation by using pulse coupled neural network (PCNN), based on the phenomena of synchronous pulse bursts in the animal visual cortexes. The synchronous bursts of neurons with different input were generated in the proposed PCNN model to realize the multi-object segmentation. The criterion to automatically choose the dominant parameter (the linking strength ?), which determines the synchronous-burst stimulus range, was described in order to stimulate its application in automatic image segmentation. Segmentations on several types of image are implemented with the proposed method and the experimental results demonstrate its validity.
Software Industry Cluster be Disagreement on Theory and Practice  [PDF]
Yang Wang, Luqian Wang
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.210069
Abstract: In the view of traditional industry cluster theory, it is easy to copy the software industry cluster pattern, or it is easy to copy another Silicon Valley, due to low reliability of the resources and the guidance factors of locations in software industry. But it is much more difficult to copy a Silicon Valley mode practically than imaginatively and the difficulties of bringing up and supporting high-tech initiatives is more than theoretic anticipation. In China, the software companies have just gathered together geographically and therefore no initiative center can be formed. All these above signify that software industry cluster is distinct from the traditional industry clusters, but the cognition of the reasons of software industry cluster is not clear yet. Furthermore, reasonable explanations of the bewilderment in the economical practice of software industry cluster are urgently needed.
The Economic Growth Effect of Logistics Industry FDI Analysis  [PDF]
Yang Wang, Luqian Wang
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.24049
Abstract: Based on the direction of the international FDI changed, from manufacturing to service industries, we should concern about the influence of the introduction of China’s logistics industry FDI to the national economy. The paper sets up regression model to examine logistics FDI and GDP in two aspects of time series and growth rate, we find that the logistics FDI reaches a high correlation with GDP, and logistics FDI is one of the major driving forces of economic development. Therefore, China should expand the introduction of logistics FDI, improve the quality of foreign investment, develop the positive economic growth effect of logistics FDI and promote the change of China’s economic growth pattern to ensure the development of China’s economy.
The Predictive Effects of Online Communication on Well-Being among Chinese Adolescents  [PDF]
Jinliang Wang, Haizhen Wang
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24056
Abstract: Based on theories and previous studies on online communication, we proposed two hypotheses to better under- stand the effects of online communication on subjective well-being with a sample of Chinese adolescents (n = 190). The results of liner regression analysis found that online communication was positively related to adoles- cents’ subjective well-being. For boys, the coefficient of determination of online communication on subjective well-being was .143, and for girls the coefficient of determination was .040, indicating that boys benefit more from online communication than do girls.
The Impact of Radical Prostatectomy on the Survival of Patients with Carcinosarcoma of the Prostate  [PDF]
Jue Wang, Fenwei Wang
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.24064
Abstract: Background: The objective of this study was to evaluate the impact of radical prostatectomy on carcinosarcoma of the prostate. Methods: Patients diagnosed with carcinosarcoma of the prostate from 1977 through 2007 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Outcomes were examined with Kaplan-Meier survival analysis and Cox models. The association between clinical and demographic characteristics and survival of carcinosarcoma of the prostate was examined. Results: A total of fifty-four cases of histology confirmed carcinosarcoma of the prostate were identified. Median age of the patients was 74 years (range 28 - 94). Of the patients with a known tumor stage, all but one patient had a locally advanced or distant stage; all of the patients with known histology grade had poorly or undifferentiated histology. Twenty (37%) patients underwent transurethral resection only and Fourteen (25.9%) patients underwent radical prostatectomy. Eight (14%) patients received radiation therapy in combination with surgery. The median cancer specific survival was 16 months (95% CI 0 - 32 months). 1-, 3-, and 5- year cancer specific survival rate were 55.1%, 32.3% and 21.1%. In a multivariate analysis, radical prostatectomy was found to be a significant prognostic factor for cancer-specific survival. Conclusions: Carcinosarcoma of the prostate commonly occurs in older patients and associated with aggressive disease and poor prognosis. Radical prostatectomy is the only treatment modality that significantly improves survival. Emphasis on early diagnosis and detection and multimodality therapy of this disease is needed to improve the outcome for patients with this malignancy.
A Research on the Relationship between FDI and Jiangsu’s Regional Economy Disparity  [PDF]
Baoqian Wang, Cheng Wang
Technology and Investment (TI) , 2012, DOI: 10.4236/ti.2012.33018
Abstract: Through reading and summarizing relevant articles, the authors analyze two different kinds of effects that FDI influence the regional economy. Location and digesting ability reflects such non-equilibrium. By using regression analysis, the authors discover, in south Jiangsu, which the unit FDI increase contributes most to the GDP development, with middle and north Jiangsu lagging behind. The regression coefficient is 1.198, 0.429 and 0.572 respectively. Considering the index of digestion ability, unit FDI increase and unit GDP contribution rate still share strong relevant relationship. However, the coefficients change. The effects that FDI stimulate GDP growth are weakened, been made up by the endogenous ability. The granger test shows that in south Jiangsu, there exists a cycle of accumulative effect, namely both the FDI increase and the GDP growth do well with each other. However, in the rest of Jiangsu province, such effect is not obvious. Considering the elements of location and digesting ability, this paper offers tactics for Jiangsu for a better coordinate of future development.
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