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Search Results: 1 - 10 of 32712 matches for " Daniel Weghuber "
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Rs9939609 Variant of the Fat Mass and Obesity-Associated Gene and Trunk Obesity in Adolescents
Harald Mangge,Wilfried Renner,Gunter Almer,Daniel Weghuber,Reinhard M ller,Renate Horejsi
Journal of Obesity , 2011, DOI: 10.1155/2011/186368
Abstract: A common T/A polymorphism (rs9939609) in the fat mass and obesity associated (FTO) gene was found associated with early-onset and severe obesity in both adults and children. However, recent observations failed to find associations of FTO with obesity. To investigate the genetic background of early obesity, we analysed the single nucleotide polymorphism (SNP) rs9939609 of FTO in 371 styrian adolescents towards degree of obesity, subcutaneous adipose tissue (SAT)-distribution determined by lipometry, early metabolic and preatherosclerotic symptoms. The percentage of AA homozygotes for the rs9939609 SNP of FTO was significantly increased in the obese adolescents. Compared to the TT wildtype, AA homozygotes showed significantly elevated values of SAT thickness at the trunk-located lipometer measure points neck and frontal chest, body weight, body mass index, waist, and hip circumference. No associations were found with carotis communis intima media thickness, systolic, diastolic blood pressure, ultrasensitive C-reactive protein (US-CRP), homocystein, total cholesterol, triglycerides, HDL cholesterol, oxidized LDL, fasted glucose, insulin, HOMA-index, liver transaminases, uric acid, and adipokines like resistin, leptin, and adiponectin. Taken together, to the best of our knowledge we are the first to report that the rs9939609 FTO SNP is associated with trunk weighted obesity as early as in adolescence.
Serum Neopterin Is Not Increased in Obese Juveniles
Harald Mangge,Florian Freytag,Gunter Almer,Daniel Weghuber,Carmen Bauer-Denk,Dietmar Fuchs
Journal of Obesity , 2011, DOI: 10.1155/2011/946795
Abstract: Objective. Cardiovascular disease is associated with inflammation and immune activation, concentrations of immune activation markers like neopterin predict outcome in adults. Methods. Serum neopterin concentrations and early metabolic and pre-atherosclerotic symptoms were analyzed in 295 obese juveniles and 101 normal weight controls of similar age. Additionally, the influence of a 12 months weight reduction program on neopterin levels was investigated in 31 obese juveniles. Results. Intima-media thickness of common carotid arteries (IMT) and the concentrations of C-reactive protein (CRP) were increased in the obese juveniles (<.001). Also triglycerides, oxidized LDL, fasted insulin levels, HOMA-index, leptin, liver transaminases and uric acid were increased compared to the controls. However, serum neopterin was decreased in the obese versus non-obese juveniles (<.03). The intervention consisting of regular sports, nutritional devices, and a psychologic attendance led after 12 months to an increase of neopterin concentration (<.05; paired test). Conclusions. Neopterin concentrations in juvenile obesity behaved considerably different from what was demonstrated in adults, levels did not correlate with metabolic and pre-atherosclerotic symptoms found in early phases although early vascular burden and chronic low grade inflammation was indicated by increased IMT and CRP. Neopterin concentrations increased after a 12 months intervention program.
Association of Symptoms of Attention-Deficit/Hyperactivity Disorder with Physical Activity, Media Time, and Food Intake in Children and Adolescents
Andreas W. A. van Egmond-Fr?hlich, Daniel Weghuber, Martina de Zwaan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049781
Abstract: Introduction The aim of the study was to assess the association between attention deficit/hyperactivity disorder (ADHD) symptoms and potentially obesogenic behaviors. Methods Data of 11,676 German children and adolescents (6–17 years) were analyzed. Television/video exposure, physical activity, food frequency and portion size were assessed using questionnaires. A dietary quality index, energy density and volumes of consumed food, and total energy intake were calculated. The parent-rated hyperactivity/inattention subscale of the Strengths and Difficulties Questionnaire (SDQ-HI) was used as a continuous measure of ADHD symptoms. Associations were analyzed with general linear models adjusting for sex, age, socioeconomic status, migrant status, parental BMI, and parental smoking. Results SDQ-HI scores correlated positively with physical activity, average energy density of food, volume of beverages, total energy intake, and television exposure and negatively with the nutritional quality score (HuSKY) even after adjustment for parental variables (BMI, smoking, socioeconomic status, migrant status), age, sex, as well as the other SDQ subscales. The adjusted association of the SDQ-HI scores with the nutritional quality score was stronger in girls and the associations with food volume, food energy, and total energy intake was significant only in girls. Conclusions Poor nutritional quality, high energy intake and television exposure appear to be independently associated with ADHD symptoms. The relationship between food energy intake and ADHD symptoms was especially pronounced in girls and this may help to explain the reported association of ADHD symptoms with overweight in adolescent girls.
Rs9939609 Variant of the Fat Mass and Obesity-Associated Gene and Trunk Obesity in Adolescents
Harald Mangge,Wilfried Renner,Gunter Almer,Daniel Weghuber,Reinhard M?ller,Renate Horejsi
Journal of Obesity , 2011, DOI: 10.1155/2011/186368
Abstract: A common T/A polymorphism (rs9939609) in the fat mass and obesity associated (FTO) gene was found associated with early-onset and severe obesity in both adults and children. However, recent observations failed to find associations of FTO with obesity. To investigate the genetic background of early obesity, we analysed the single nucleotide polymorphism (SNP) rs9939609 of FTO in 371 styrian adolescents towards degree of obesity, subcutaneous adipose tissue (SAT)-distribution determined by lipometry, early metabolic and preatherosclerotic symptoms. The percentage of AA homozygotes for the rs9939609 SNP of FTO was significantly increased in the obese adolescents. Compared to the TT wildtype, AA homozygotes showed significantly elevated values of SAT thickness at the trunk-located lipometer measure points neck and frontal chest, body weight, body mass index, waist, and hip circumference. No associations were found with carotis communis intima media thickness, systolic, diastolic blood pressure, ultrasensitive C-reactive protein (US-CRP), homocystein, total cholesterol, triglycerides, HDL cholesterol, oxidized LDL, fasted glucose, insulin, HOMA-index, liver transaminases, uric acid, and adipokines like resistin, leptin, and adiponectin. Taken together, to the best of our knowledge we are the first to report that the rs9939609 FTO SNP is associated with trunk weighted obesity as early as in adolescence. 1. Introduction Juvenile obesity usually leads to obesity in adulthood which causes life threatening sequels such as diabetes, cardiovascular disease, hypertension, stroke, and cancer [1]. In foregoing studies, we detected an increased carotid intima-media thickness (IMT) paralleled by a subclinical inflammation in obese adolescents and we provided the first evidence that preatherosclerosis is associated with individual risk profiles characterised by subcutaneous adipose tissue (SAT) topography and altered biomarkers [2–4]. In this paper, we analysed the single nucleotide polymorphism (SNP) rs9939609 of the fat mass and obesity-associated (FTO) gene in obese styrian adolescents and in normal weight controls of the same age and gender distribution. FTO is a gene located in chromosome region 16q12.2. Recently, it was brought into connection with the central control of energy homeostasis and fat cell lipolysis [5, 6]. The single-nucleotide polymorphisms (SNPs) rs1421085, rs17817449, and rs9939609, of FTO were reported to be linked to body mass index (BMI) and obesity in both adults and children [7–9]. However, Li et al. failed to find associations of FTO with
Serum Neopterin Is Not Increased in Obese Juveniles
Harald Mangge,Florian Freytag,Gunter Almer,Daniel Weghuber,Carmen Bauer-Denk,Dietmar Fuchs
Journal of Obesity , 2011, DOI: 10.1155/2011/946795
Abstract: Objective. Cardiovascular disease is associated with inflammation and immune activation, concentrations of immune activation markers like neopterin predict outcome in adults. Methods. Serum neopterin concentrations and early metabolic and pre-atherosclerotic symptoms were analyzed in 295 obese juveniles and 101 normal weight controls of similar age. Additionally, the influence of a 12 months weight reduction program on neopterin levels was investigated in 31 obese juveniles. Results. Intima-media thickness of common carotid arteries (IMT) and the concentrations of C-reactive protein (CRP) were increased in the obese juveniles ( ). Also triglycerides, oxidized LDL, fasted insulin levels, HOMA-index, leptin, liver transaminases and uric acid were increased compared to the controls. However, serum neopterin was decreased in the obese versus non-obese juveniles ( ). The intervention consisting of regular sports, nutritional devices, and a psychologic attendance led after 12 months to an increase of neopterin concentration ( ; paired test). Conclusions. Neopterin concentrations in juvenile obesity behaved considerably different from what was demonstrated in adults, levels did not correlate with metabolic and pre-atherosclerotic symptoms found in early phases although early vascular burden and chronic low grade inflammation was indicated by increased IMT and CRP. Neopterin concentrations increased after a 12 months intervention program. 1. Introduction Nowadays, the role of inflammation and immune activation in atherogenesis is well established [1], and the activation of macrophages appears to be of critical relevance within this process [1, 2]. Cardiovascular disease (CVD) is also associated with increased neopterin concentrations [3–10], and predictive information is provided by neopterin in patients at risk of myocardial infarction [11–16]. A recent study in 2312 patients undergoing angiography demonstrated that neopterin is an independent predictor of total and cardiovascular mortality [17]. Likewise, in patients with diabetes, both neopterin and C-reactive protein (CRP) were independent predictors of fatal ischemic heart disease [18]. Neopterin is produced by human monocyte-derived macrophages and dendritic cells preferentially upon stimulation with Th1-type cytokine interferon-γ (IFN-γ) [19, 20]. Thus, neopterin concentrations reflect activation of the Th1-type immune response [21]. In humans, increased neopterin concentrations are detected in patients with virus infections including human immunodeficiency virus, infections by intracellular bacteria and
A Positive Association between T. gondii Seropositivity and Obesity
Gloria M. Reeves,Annette M. Hartmann,Marion Friedl,Daniel Weghuber,David B. Allison,Teodor T. Postolache
Frontiers in Public Health , 2013, DOI: 10.3389/fpubh.2013.00073
Abstract: Obesity is a global public health problem that is linked with morbidity, mortality, and functional limitations and has limited options for sustained interventions. Novel targets for prevention and intervention require further research into the pathogenesis of obesity. Consistently, elevated markers of inflammation have been reported in association with obesity, but their causes and consequences are not well understood. An emerging field of research has investigated the association of infections and environmental pathogens with obesity, potential causes of low grade inflammation that may mediate obesity risk. In this study, we estimate the possible association between Toxoplasma gondii (T. gondii) infection and obesity in a sample of 999 psychiatrically healthy adults. Individuals with psychiatric conditions, including personality disorders, were excluded because of the association between positive serology to T. gondii and various forms of serious mental illness that have a strong association with obesity. In our sample, individuals with positive T. gondii serology had twice the odds of being obese compared to seronegative individuals (p = 0.01). Further, individuals who were obese had significant higher T. gondii IgG titers compared to individuals who were non-obese. Latent T. gondii infection is very common worldwide, so potential public health interventions related to this parasite can have a high impact on associated health concerns.
Normal Weight Estonian Prepubertal Boys Show a More Cardiovascular-Risk-Associated Adipose Tissue Distribution than Austrian Counterparts
Sandra J. Wallner-Liebmann,Reinhard Moeller,Renate Horejsi,Toivo Jürim?e,Jaak Jürim?e,Jarek M?estu,Priit Purge,Meeli Saar,Erwin Tafeit,Petra Kaimbacher,Renate Kruschitz,Daniel Weghuber,Wolfgang J. Schnedl,Harald Mangge
ISRN Obesity , 2013, DOI: 10.1155/2013/506751
Abstract: Objective. Risk phenotypes for cardiovascular disease (CVD) differ markedly between countries, like the reported high difference in CVD mortality in Austria and Estonia. Hitherto, the goal of this study was to find out risk profiles in body fat distribution yet present in childhood, paving the way for later clinical end points. Methods. he subcutaneous adipose tissue (SAT) distribution patterns in 553 Austrian (A) and Estonian (E) clinically healthy normal weight boys aged 11.1 (±0.8) years were analysed. We applied the patented optical device Lipometer which determines the individual subcutaneous adipose tissue topography (SAT-Top). Results. Total body fat did not differ significantly between E and A boys. A discriminant analysis using all Lipometer data, BMI, and the total body fat (TBF) yielded 84.6% of the boys correctly classified in Estonians and Austrians by 9 body sites. A factor analysis identified the SAT distribution of E as critically similar to male adult patients with coronary heart disease (CHD). Conclusions. We show in normal weight Estonian boys a highly significant decreased fat accumulation on the lower body site compared to age matched Austrian males. This SAT-Top phenotype may play an important role for the increased cardiovascular risk seen in the Estonian population. 1. Introduction The risk for populational diseases differs markedly between geographic regions and countries, as, for example, the reported greater rate of cardiovascular mortality in Estonia compared to Austria. The latest age standardised ischemic heart disease (IHD) mortality data per 100 000 population are for Austria 80,68, while for Estonia 254,25 [1]. So far, the studies investigating cardiovascular disease (CVD) risk factors focused on adult obesity and associated metabolic disorders. However, for the assessment of populational health, it is of outmost interest to gain a better insight in the pediatric roots of CVD. Although it is well established that obesity and the subcutaneous adipose tissue (SAT) phenotype are essentially involved in CVD risk, little information exists about risk phenotypes in prepubertal obese children. Notably, the prevalence of childhood obesity increased 4-fold during the last 20 years [2], and this represents a strong risk factor for obesity of adulthood [3]. The SAT phenotype in children is of growing interest for later on CVD risk. An improved understanding of individual subcutaneous body fat distribution and body composition in children may essentially support the development of effective preventive strategies [4–7] for the
Gesundheitskommunikation in der Adipositaspr vention und -therapie
Weghuber D,Ardelt-Gattinger E,D?mon S,Miller K
Journal für Ern?hrungsmedizin , 2010,
Abstract:
Quantification and Kinetic Analysis of Grb2-EGFR Interaction on Micro-Patterned Surfaces for the Characterization of EGFR-Modulating Substances
Peter Lanzerstorfer, Daniela Borgmann, Gerhard Schütz, Stephan M. Winkler, Otmar H?glinger, Julian Weghuber
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092151
Abstract: The identification of the epidermal growth factor receptor (EGFR) as an oncogene has led to the development of several anticancer therapeutics directed against this receptor tyrosine kinase. However, drug resistance and low efficacy remain a severe challenge, and have led to a demand for novel systems for an efficient identification and characterization of new substances. Here we report on a technique which combines micro-patterned surfaces and total internal reflection fluorescence (TIRF) microscopy (μ-patterning assay) for the quantitative analysis of EGFR activity. It does not simply measure the phosphorylation of the receptor, but instead quantifies the interaction of the key signal transmitting protein Grb2 (growth factor receptor-bound protein 2) with the EGFR in a live cell context. It was possible to demonstrate an EGF dependent recruitment of Grb2 to the EGFR, which was significantly inhibited in the presence of clinically tested EGFR inhibitors, including small tyrosine kinase inhibitors and monoclonal antibodies targeting the EGF binding site. Importantly, in addition to its potential use as a screening tool, our experimental setup offers the possibility to provide insight into the molecular mechanisms of bait-prey interaction. Recruitment of the EGFR together with Grb2 to clathrin coated pits (CCPs) was found to be a key feature in our assay. Application of bleaching experiments enabled calculation of the Grb2 exchange rate, which significantly changed upon stimulation or the presence of EGFR activity inhibiting drugs.
Poetry Teaching and Multimodality: Theory into Practice  [PDF]
Daniel Xerri
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.34077
Abstract: This article discusses the theoretical concepts underpinning a multimodal approach to poetry teaching and considers a number of ways in which this can be adopted in practice. It discusses what is entailed by the concept of multimodality and examines the claims made about the benefits of employing a multimodal approach. It reviews the literature on multimodality and examines how teachers may blend a variety of techniques and resources in order not just to engage their students with poetry but also to activate language learning. In particular, this article examines how by tapping students’ visual and digital literacy skills they are enabled to create video poems, podcasts, hypertexts and wikis, all of which represent new ways of using language and experiencing poetry. Through constant reference to the research carried out so far, this article seeks to show how by means of a multimodal approach poetry can act as a springboard for the development of students’ language proficiency and creative engagement.
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