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Search Results: 1 - 10 of 325385 matches for " Daniel J. Caruso "
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Predictors of Response to Intradetrusor Botulinum Toxin-A Injections in Patients with Idiopathic Overactive Bladder
Brian L. Cohen,Daniel J. Caruso,Prashanth Kanagarajah,Angelo E. Gousse
Advances in Urology , 2009, DOI: 10.1155/2009/328364
Abstract: Objectives. To evaluate whether there are any demographic or urodynamic differences in patients with idiopathic overactive bladder (I-OAB) that respond and do not respond to intradetrusor injections of botulinum toxin-A (BTX-A). Methods. This represents a secondary analysis of data collected from an investigator initiated randomized trial designed to evaluate clinical differences in outcomes for 100 versus 150 U BTX-A in patients with I-OAB. Preinjection demographic and urodynamic data were collected. Patients were evaluated 12 weeks after injection and were determined to be responders or nonresponders as defined by our criteria. Statistical comparisons were made between groups. Results. In patients with overactive bladder without incontinence (OAB-Dry), there were no variables that could be used to predict response to BTX-A. On univariate analysis, younger patients with overactive bladder with incontinence (OAB-Wet) were more likely to respond to BTX-A than older patients. However, this relationship was no longer statistically significant on multivariate analysis. Conclusions. We were unable to identify any preinjection demographic or urodynamic parameters that could aid in predicting which patients will achieve clinical response to BTX-A. Future studies are necessary to further evaluate this question.
Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial
A Daniel Martin, Barbara K Smith, Paul D Davenport, Eloise Harman, Ricardo J Gonzalez-Rothi, Maher Baz, A Joseph Layon, Michael J Banner, Lawrence J Caruso, Harsha Deoghare, Tseng-Tien Huang, Andrea Gabrielli
Critical Care , 2011, DOI: 10.1186/cc10081
Abstract: We conducted a single center, single-blind, randomized controlled trial to test whether inspiratory muscle strength training (IMST) would improve weaning outcome in FTW patients. Of 129 patients evaluated for participation, 69 were enrolled and studied. 35 subjects were randomly assigned to the IMST condition and 34 to the SHAM treatment. IMST was performed with a threshold inspiratory device, set at the highest pressure tolerated and progressed daily. SHAM training provided a constant, low inspiratory pressure load. Subjects completed 4 sets of 6-10 training breaths, 5 days per week. Subjects also performed progressively longer breathing trials daily per protocol. The weaning criterion was 72 consecutive hours without MV support. Subjects were blinded to group assignment, and were treated until weaned or 28 days.Groups were comparable on demographic and clinical variables at baseline. The IMST and SHAM groups respectively received 41.9 ± 25.5 vs. 47.3 ± 33.0 days of MV support prior to starting intervention, P = 0.36. The IMST and SHAM groups participated in 9.7 ± 4.0 and 11.0 ± 4.8 training sessions, respectively, P = 0.09. The SHAM group's pre to post-training maximal inspiratory pressure (MIP) change was not significant (-43.5 ± 17.8 vs. -45.1 ± 19.5 cm H2O, P = 0.39), while the IMST group's MIP increased (-44.4 ± 18.4 vs. -54.1 ± 17.8 cm H2O, P < 0.0001). There were no adverse events observed during IMST or SHAM treatments. Twenty-five of 35 IMST subjects weaned (71%, 95% confidence interval (CI) = 55% to 84%), while 16 of 34 (47%, 95% CI = 31% to 63%) SHAM subjects weaned, P = .039. The number of patients needed to be treated for effect was 4 (95% CI = 2 to 80).An IMST program can lead to increased MIP and improved weaning outcome in FTW patients compared to SHAM treatment.ClinicalTrials.gov: NCT00419458Failure to wean (FTW) from mechanical ventilation (MV) is a significant clinical and economic problem. In 2003, approximately 300,00 patients required MV suppo
Cigarette Design Features in Low-, Middle-, and High-Income Countries
Rosalie V. Caruso,Richard J. O'Connor
Journal of Environmental and Public Health , 2012, DOI: 10.1155/2012/269576
Abstract: Previous studies have shown that country income grouping is correlated with cigarette engineering. Cigarettes (=111 brands) were purchased during 2008–2010 from 11 low-, middle-, and high-income countries to assess physical dimensions and an array of cigarette design features. Mean ventilation varied significantly across low- (7.5%), middle- (15.3%), and high-income (26.2%) countries (≤0.001). Differences across income groups were also seen in cigarette length (=0.001), length of the tipping paper (=0.01), filter weight (=0.017), number of vent rows (=0.003), per-cigarette tobacco weight (=0.04), and paper porosity (=0.008). Stepwise linear regression showed ventilation and tobacco length as major predictors of ISO tar yields in low-income countries (=0.909, 0.047), while tipping paper (<0.001), filter length (<0.001), number of vent rows (=0.014), and per-cigarette weight (=0.015) were predictors of tar yields in middle-income countries. Ventilation (<0.001), number of vent rows (=0.009), per-cigarette weight (<0.001), and filter diameter (=0.004) predicted tar yields in high-income countries. Health officials must be cognizant of cigarette design issues to provide effective regulation of tobacco products.
Early Hypothalamic FTO Overexpression in Response to Maternal Obesity – Potential Contribution to Postweaning Hyperphagia
Vanni Caruso,Hui Chen,Margaret J. Morris
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0025261
Abstract: Intrauterine and postnatal overnutrition program hyperphagia, adiposity and glucose intolerance in offspring. Single-nucleotide polymorphisms (SNPs) of the fat mass and obesity associated (FTO) gene have been linked to increased risk of obesity. FTO is highly expressed in hypothalamic regions critical for energy balance and hyperphagic phenotypes were linked with FTO SNPs. As nutrition during fetal development can influence the expression of genes involved in metabolic function, we investigated the impact of maternal obesity on FTO.
Solving a two-electron quantum dot model in terms of polynomial solutions of a Biconfluent Heun Equation
F. Caruso,J. Martins,V. Oguri
Physics , 2013, DOI: 10.1016/j.aop.2014.04.023
Abstract: The effects on the non-relativistic dynamics of a system compound by two electrons interacting by a Coulomb potential and with an external harmonic oscillator potential, confined to move in a two dimensional Euclidean space, are investigated. In particular, it is shown that it is possible to determine exactly and in a closed form a finite portion of the energy spectrum and the associated eigeinfunctions for the Schr\"odinger equation describing the relative motion of the electrons, by putting it into the form of a biconfluent Heun equation. In the same framework, another set of solutions of this type can be straightforwardly obtained for the case when the two electrons are submitted also to an external constant magnetic field.
Some algorithms for skew polynomials over finite fields
Xavier Caruso,Jérémy Le Borgne
Mathematics , 2012,
Abstract: In this paper, we study the arithmetics of skew polynomial rings over finite fields, mostly from an algorithmic point of view. We give various algorithms for fast multiplication, division and extended Euclidean division. We give a precise description of quotients of skew polynomial rings by a left principal ideal, using results relating skew polynomial rings to Azumaya algebras. We use this description to give a new factorization algorithm for skew polynomials, and to give other algorithms related to factorizations of skew polynomials, like counting the number of factorizations as a product of irreducibles.
Maternal Cigarette Smoke Exposure Contributes to Glucose Intolerance and Decreased Brain Insulin Action in Mice Offspring Independent of Maternal Diet
Hui Chen, Miguel A. Iglesias, Vanni Caruso, Margaret J. Morris
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027260
Abstract: Background Maternal smoking leads to intrauterine undernutrition and is associated with low birthweight and higher risk of offspring obesity. Intrauterine smoke exposure (SE) may alter neuroendocrine mediators regulating energy homeostasis as chemicals in cigarette smoke can reach the fetus. Maternal high-fat diet (HFD) consumption causes fetal overnutrition; however, combined effects of HFD and SE are unknown. Thus we investigated the impact of combined maternal HFD and SE on adiposity and energy metabolism in offspring. Method Female Balb/c mice had SE (2 cigarettes/day, 5 days/week) or were sham exposed for 5 weeks before mating. Half of each group was fed HFD (33% fat) versus chow as control. The same treatment continued throughout gestation and lactation. Female offspring were fed chow after weaning and sacrificed at 12 weeks. Results Birthweights were similar across maternal groups. Faster growth was evident in pups from SE and/or HFD dams before weaning. At 12 weeks, offspring from HFD-fed dams were significantly heavier than those from chow-fed dams (chow-sham 17.6±0.3 g; chow-SE 17.8±0.2 g; HFD-sham 18.7±0.3 g; HFD-SE 18.8±0.4 g, P<0.05 maternal diet effect); fat mass was significantly greater in offspring from chow+SE, HFD+SE and HFD+sham dams. Both maternal HFD and SE affected brain lactate transport. Glucose intolerance and impaired brain response to insulin were observed in SE offspring, and this was aggravated by maternal HFD consumption. Conclusion While maternal HFD led to increased body weight in offspring, maternal SE independently programmed adverse health outcomes in offspring. A smoke free environment and healthy diet during pregnancy is desirable to optimize offspring health.
Positive Edge Effects on Forest-Interior Cryptogams in Clear-Cuts
Alexandro Caruso, J?rgen Rudolphi, H?kan Rydin
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027936
Abstract: Biological edge effects are often assessed in high quality focal habitats that are negatively influenced by human-modified low quality matrix habitats. A deeper understanding of the possibilities for positive edge effects in matrix habitats bordering focal habitats (e.g. spillover effects) is, however, essential for enhancing landscape-level resilience to human alterations. We surveyed epixylic (dead wood inhabiting) forest-interior cryptogams (lichens, bryophytes, and fungi) associated with mature old-growth forests in 30 young managed Swedish boreal forest stands bordering a mature forest of high conservation value. In each young stand we registered species occurrences on coarse dead wood in transects 0–50 m from the border between stand types. We quantified the effect of distance from the mature forest on the occurrence of forest-interior species in the young stands, while accounting for local environment and propagule sources. For comparison we also surveyed epixylic open-habitat (associated with open forests) and generalist cryptogams. Species composition of epixylic cryptogams in young stands differed with distance from the mature forest: the frequency of occurrence of forest-interior species decreased with increasing distance whereas it increased for open-habitat species. Generalists were unaffected by distance. Epixylic, boreal forest-interior cryptogams do occur in matrix habitats such as clear-cuts. In addition, they are associated with the matrix edge because of a favourable microclimate closer to the mature forest on southern matrix edges. Retention and creation of dead wood in clear-cuts along the edges to focal habitats is a feasible way to enhance the long-term persistence of epixylic habitat specialists in fragmented landscapes. The proposed management measures should be performed in the whole stand as it matures, since microclimatic edge effects diminish as the matrix habitat matures. We argue that management that aims to increase habitat quality in matrix habitats bordering focal habitats should increase the probability of long-term persistence of habitat specialists.
INTERANNUAL VARIABILITY OF THE KUROSHIO CURRENT INTRUSION IN THE SOUTH CHINA SEA
Caruso,Michael J; Beardsley,Robert C; Gawarkiewicz,Glen G;
Gayana (Concepción) , 2004, DOI: 10.4067/S0717-65382004000200017
Abstract: the interannual variability of the kuroshio current intrusion into the south china sea is investigated using a combination of satellite remote sensing data and in situ measurements. this research was conducted as part of the asian seas international acoustic experiment (asiaex). the circulation of the south china sea has been studied for years and is predominantly wind-forced by the northeast winter and southwest summer monsoons. there remains some uncertainty to the interannual nature of the circulation and the effect of kuroshio intrusions on mesoscale features in the northeast south china sea. satellite observations of sea surface temperature (sst) from the tropical rainfall measuring mission (trmm) and sea surface height anomalies (ssha) from topex/poseidon are used to analyze the interannual variability in the intrusion and the effect on the region. analysis of sst and ssha shows the formation of a kuroshio intrusion varies considerably each winter. since the circulation in the south china sea is primarily wind-driven, ocean surface wind vectors from the nasa quikscat satellite scatterometer are used to evaluate the relationship between wind stress or wind stress curl and the intensity of the winter kuroshio intrusion into the south china sea
QUANTIFICA??O DE LACTOSE EM QUEIJOS MINAS FRESCAL
Caruso, E.C.;Oliveira, A.J. de;
Scientia Agricola , 1999, DOI: 10.1590/S0103-90161999000100033
Abstract: the main objective of this work was to study the applicability of the method of acton to estimate the lactose concentration in minas frescal cheese. recovery experiments were carried out, with recoveries for lactose ranging from 99.1% to 103.7%., for samples containing up to 40mg lactose/ml. cheese samples were purchased randomly in piracicaba, sp, brasil with two days of shelf life, from three batches, with three samples per batch. lactose was determined in the same day and its concentration varied from 2.36% to 2.47% for batch 1; 2.58% to 3.03% for batch 2; and from 2.19% to 2.48% for batch 3. a high uniformity was observed among batches, with little variation among samples. all values were within the range tipically found for this kind of cheese.
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