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Search Results: 1 - 10 of 62559 matches for " Daniel Cristian Ferreira Soares "
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Mesoporous Silica SBA-16 Functionalized with Alkoxysilane Groups: Preparation, Characterization, and Release Profile Study
Gracielle Ferreira Andrade,Daniel Cristian Ferreira Soares,Ramon Kenned de Sousa Almeida,Edésia Martins Barros Sousa
Journal of Nanomaterials , 2012, DOI: 10.1155/2012/816496
Abstract: A mesoporous material sphere based on silica, SBA-16, was chemically modified with alkoxysilane using two different solvents: methanol and toluene. The influence of the chemical modification of the matrix on the release rate of a model drug was also studied. The structural characteristics of the materials were evaluated by small-angle X-ray diffraction, N2 adsorption, and transmission electron microscopy. The functionalization of the matrix was evaluated using thermal analysis, FTIR spectroscopy, 13C and 29Si solid-state nuclear magnetic resonance, and elemental analysis, CHN. The results show that alkoxysilane groups have been chemically bonded to silicon atoms on the surface of cubic Im3m mesoporous silica. The influence of the release rate of atenolol molecules from chemically modified mesoporous SBA-16 could be identified, since significant differences could be observed among the release patterns of the different materials.
Multifunctional Nanostructured Materials Applied in Controlled Radiopharmaceuticals Release  [PDF]
Raquel Cristina de Sousa Azevedo, Daniel Crístian Ferreira Soares, Ricardo Geraldo de Sousa, Edésia Martins Barros de Sousa
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.32022
Abstract: The metaiodobenzylguanidine (MIBG) radiopharmaceutical, an analogue of norepinephrine, has been used to diagnose certain diseases in the cardiovascular system when radiolabeled with 123I. This radiopharmaceutical can also be used to treat tumors, such as neuroblastomas and pheochromocytomas, when radiolabeled with 131I. Its clinical use is often accompanied by a slow intravenous administration, where a significant dose of radiation can directly affect workers in nuclear medicine services. To overcome this problem, the incorporation and controlled release of radiopharmaceuticals from the matrix of mesoporous systems based on silica, such as SBA-15 and hybrid [SBA-15/P(N-iPAAm)], can lead to a significant reduction in radiation doses received by workers. In the present study, silica matrices SBA-15 and hybrid [SBA-15/P(N-iPAAm)] containing the radiopharmaceutical MIBG were prepared and physicochemically characterized through FTIR, SEM, and small angle X-ray diffraction techniques. The release profiles of MIBG from SBA-15 and [SBA-15/P(N-iPAAm)] were studied in a simulated body fluid (SBF) to evaluate their potential application as vehicles for controlled releases. Furthermore, in vitro studies were performed to assess the cytotoxicity of matrices as compared to human lung fibroblast cells (MRC-5). The results revealed that the amount of MIBG incorporated within the studied matrices was indeed quite different, showing that only the hybrid [SBA-15/P(N-iPAAm)] system allowed for a more adequate release profile of MIGB. Taking all results into consideration, it can be concluded that the hybrid matrix [SBA-15/P(N-iPAAm)] can be considered a potential alternative material for the controlled release delivery of radio-pharmaceuticals.
Fermentative and Bromatological Characteristics of Piata Palisadegrass Ensiled with Energetic Brans  [PDF]
Rozana Castro Perim, Kátia Aparecida de Pinho Costa, Patrícia Soares Epifanio, Wender Ferreira de Souza, Ricardo Francischini, Daniel Augusto Alves Teixeira, Walkíria Guimar?es Carvalho, Divino Rosa dos Santos Jr.
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.57107

The objectives of this study were to evaluate the fermentative and bromatological characteristics of Piata palisadegrass that was ensiled with energetic brans and to assess the costs of different additive levels. This experiment was conducted at the Goiano Federal Institute on the Rio Verde campus in Goiás State, Brazil. The experimental design was entirely random with four replications in a 4 × 5 factorial scheme that included four energetic brans (millet, maize, sorghum and wheat) and five levels (0%, 8%, 16%, 24% and 32%). The energetic brans can be considered as a good source of additives for Piata palisadegrass ensiling, which improves the qualitative and nutritional fermentative characteristics of the silage. The maize and wheat brans were the most efficient for improving the fermentative characteristics of the silage. However, millet bran was the most efficient for improving the bromatological characteristics. In addition, the wheat bran had the greatest influence on the final production cost and the sorghum and millet brans were the most economically feasible. Overall, the addition of 24% bran is recommended due to its beneficial impact on silage quality and the average final production cost of the silage.

Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans?
Daniel Y. Bargieri,Irene S. Soares,Fabio T. M. Costa,Catarina J. Braga,Luis C. S. Ferreira,Mauricio M. Rodrigues
Journal of Parasitology Research , 2011, DOI: 10.1155/2011/965369
Abstract: In the past 25 years, the development of an effective malaria vaccine has become one of the biggest riddles in the biomedical sciences. Experimental data using animal infection models demonstrated that it is possible to induce protective immunity against different stages of malaria parasites. Nonetheless, the vast body of knowledge has generated disappointments when submitted to clinical conditions and presently a single antigen formulation has progressed to the point where it may be translated into a human vaccine. In parallel, new means to increase the protective effects of antigens in general have been pursued and depicted, such as the use of bacterial flagellins as carriers/adjuvants. Flagellins activate pathways in the innate immune system of both mice and humans. The recent report of the first Phase I clinical trial of a vaccine containing a Salmonella flagellin as carrier/adjuvant may fuel the use of these proteins in vaccine formulations. Herein, we review the studies on the use of recombinant flagellins as vaccine adjuvants with malarial antigens in the light of the current state of the art of malaria vaccine development. The available information indicates that bacterial flagellins should be seriously considered for malaria vaccine formulations to the development of effective human vaccines. 1. Whole Parasite Vaccines 1.1. Preerythrocytic Stages The seminal work using radiation-attenuated sporozoites has been reproduced in multiple experimental systems, demonstrating that attenuated infective forms of Plasmodium sp. administered by the endovenous route can provide solid vaccination status against any symptoms of malaria [1]. However, the use of radiation-attenuated, viable live sporozoites imposes a number of restrictions because if the radiation fails, then these parasites would cause the disease, thereby nullifying any protective effects. To definitively solve this problem, a number of genetically attenuated lines of parasites have been recently generated. These genetically attenuated parasites are now being pursued as possible antigenic sources for vaccine development for humans, and Phase I and II studies are about to begin [2–5]. 1.2. Erythrocytic Stages Likewise, genetically attenuated blood-stage forms of rodent malaria parasites have been successfully generated in the past few years and have been proposed as an antigen source for human vaccination trials [5–7]. To our knowledge, none of these parasite lines are being tested in Phase I or II trials. Although it is technically feasible to produce large amounts of genetically attenuated
Influência da limita??o da amplitude de movimento sobre a melhora da flexibilidade do ombro após um treino de seis semanas
Azevedo, Daniel Camara;Carvalho, Silvia Coda de;Leal, Elisa Westin Prado Soares;Damasceno, Sara Peres;Ferreira, Manuela Loureiro;
Revista Brasileira de Medicina do Esporte , 2008, DOI: 10.1590/S1517-86922008000200007
Abstract: previous research has shown that pre-training aerobic and strength status can influence on the training results, with untrained individuals presenting a more pronounced improvement. no study has investigated this correlation in a flexibility program so far. the purpose of this study was to observe the influence of the range of motion (rom) limitation on rom gain after a six-week shoulder external rotation stretching training. 30 volunteer physiotherapy students, with limited shoulder external rotation rom were randomly assigned to one of three groups: control group (cg), experimental group 1 (eg1), with wider rom limitation, and experimental group 2 (eg2), with narrower rom limitation. subjects in the experimental groups were submitted to a 6-week program of active shoulder external rotation stretching. one-way anova showed a significant difference in mean external rotation rom gains among all three groups (p=0.001), with eg1 having the highest rom increase (30.1° ± 8.6°), followed by eg2 (15.2° ± 7.5°) and cg (1.1° ± 5.8°). the pearson correlation analysis showed a significant negative correlation between previous rom and rom improvement (r= -0.70, p=0.001).the results of our study showed that shoulder external rotation rom limitation influences rom improvement after a six-week stretching program in a healthy young population. subjects with more pronounced rom limitation respond with a more remarkable rom improvement.
Initial growth of six forest tree species in differents spacing conditions
Daniel Ferreira do Nascimento,Paulo Sérgio dos Santos Leles,Sílvio Nolasco de Oliveira Neto,Rodrigo Teixeira Soares Moreira
CERNE , 2012,
Abstract: This work veriflied the influence of planting spacing on the initial growth of six forest species, at the age of 22 months, in plantations of forest recomposition in the Guandu River Basin. The experiment was installed in the SFE - thermoelectric power plants Barbosa Lima Sobrinho, located in the City of Seropédica-RJ. Forty eight tree species were planted, using the spacings, 1.0 x 1.0, 1.5 x 1.5, 2.0 and 2.0 x 3.0 x 2.0 m, which are the study treatments. At 22 months after planting, it was evaluated the growth in height, diameter at ground level (DNS) and area of the canopy for the species, Anadenanthera macrocarpa Benth. Brenan (angico vermelho), Schinus terebinthifolius Raddi (aroeira pimenteira), Schizolobium parahyba Blake (guapuruvu) Chorisia speciosa St. Hill (paineira), Cordia sp. (babosa branca) and Inga marginata (ingá). It was found that the studied species behaved in a different way in the differents spacing of planting, and that the planting density significantly influenced on the initial growth of all the species. In general, in wider planting spacings, the plants had higher growth.
Impact of gluon polarization on Higgs plus jet production at the LHC
Daniel Boer,Cristian Pisano
Physics , 2014, DOI: 10.1103/PhysRevD.91.074024
Abstract: In this paper we consider Higgs plus jet production as a process that is sensitive to the linear polarization of gluons inside the unpolarized protons of the LHC. The leading order expressions for the transverse momentum distribution of the Higgs plus jet pair are provided in terms of transverse momentum dependent quark and gluon distributions. This includes both angular independent and azimuthal angular dependent contributions, presented directly in the laboratory frame. Lacking experimental constraints on the linearly polarized gluon distribution, we study its effects on Higgs plus jet production using two different models to illustrate the generic features and maximal effects. It is found that the $\cos 2 \phi$ distribution may be the most promising observable, as it is driven by only one initial linearly polarized gluon. The potential advantages of the Higgs plus jet process compared to other processes sensitive to the linear polarization of gluons are discussed.
JURA : Journal of Urban and Regional Analysis , 2009,
Abstract: In the strategies of regional development, a bigger and bigger importance is given to identifying the possibilities of endogenous development which, besides the exogenous impulses, contributes to an optimal development of local economies. Gorj County is one of the counties which registered a major economic decline following the restructuring processes of the economic activities. These counties need interventions at the strategic level, in order to identify the development alternatives, based on the capitalization of localresources. Following the analysis of the relation between the enterprise initiative and development, the way in which it has become fundamental for the development of a geographical space was clearly underlined. The analysis of this determination offers a well documented scientific support to the local and central authorities; this support regards the development of the enterprise initiative in territorial profile and, on this basis, it offers concretesolutions, based on decisional chains, which will have as a result the attenuation of the disequilibrium within the territorial profile. The endogenous development of the territorial systems may contribute to the sustainability of the cohesion process at local, regional andnational level.
Adjuvant requirement for successful immunization with recombinant derivatives of Plasmodium vivax merozoite surface protein-1 delivered via the intranasal route
Bargieri, Daniel Y;Rosa, Daniela S;Lasaro, Melissa Ang Sim?es;Ferreira, Luis Carlos S;Soares, Irene S;Rodrigues, Mauricio M;
Memórias do Instituto Oswaldo Cruz , 2007, DOI: 10.1590/S0074-02762007005000039
Abstract: recently, we generated two bacterial recombinant proteins expressing 89 amino acids of the c-terminal domain of the plasmodium vivax merozoite surface protein-1 and the hexa-histidine tag (his6msp119). one of these recombinant proteins contained also the amino acid sequence of the universal pan allelic t-cell epitope (his6msp119-padre). in the present study, we evaluated the immunogenic properties of these antigens when administered via the intra-nasal route in the presence of distinct adjuvant formulations. we found that c57bl/6 mice immunized with either recombinant proteins in the presence of the adjuvants cholera toxin (ct) or the escherichia coli heat labile toxin (lt) developed high and long lasting titers of specific serum antibodies. the induced immune responses reached maximum levels after three immunizing doses with a prevailing igg1 subclass response. in contrast, mice immunized by intranasal route with his6msp119-padre in the presence of the synthetic oligonucleotides adjuvant cpg odn 1826 developed lower antibody titers but when combined to ct, cpg addition resulted in enhanced igg responses characterized by lower igg1 levels. considering the limitations of antigens formulations that can be used in humans, mucosal adjuvants can be a reliable alternative for the development of new strategies of immunization using recombinant proteins of p. vivax.
Enriquecimento e aloca??o de 13C em plantas de eucalipto
Machado, Daniel Nolasco;Novais, Roberto Ferreira;Silva, Ivo Ribeiro da;Loureiro, Marcelo Ehlers;Milagres, Jo?o José;Soares, Emanuelle Mercês Barros;
Revista Brasileira de Ciência do Solo , 2011, DOI: 10.1590/S0100-06832011000300020
Abstract: in the last decades the use of stable isotopes has gained importance in several research areas, e.g., for metabolic flux and pathway analysis and studies on effects of biotic and abiotic plant stresses and on soil organic matter (som). studies on the alterations and dynamics of som based on the variation in natural 13c abundance require variations in the c isotopic composition, which are not always observed. one alternative is to label the plant material with 13c by 13co2 fixation, so that the c isotope ratio is different from that of native som. the objective of this study was to investigate the magnitude and homogeneity of 13c labeling in the different plant parts of eucalypts. three 4-month-old eucalypt plants grown in nutrient solution were labeled, using a pulse technique. plants were exposed to a 13co2 enriched atmosphere in a 448 dm3 glass chamber, at around 24 oc. the co2 concentration and the 13c/12c ratio were monitored by gas sample analysis in an isotope ratio mass spectrometer (irms) during the pulse-labeling period (126 days, three 13co2 pulses per week). after the labeling period the plants were separated in leaves (leaf-source and leaf-sink), branches, bark, stem, and roots and analyzed in an irms. the results were expressed in parts per one thousand (‰) relative to the pee-dee belemnite standard (δ13cpdb). the δ13cpdb were: 828.07 ‰ for young leaves, 645.7 ‰ for mature leaves, 672.5 ‰ for branches, 691.9 ‰ for bark, 632.02 ‰ for stem, and 536.6 ‰ for roots. the 13c allocation and enrichment pattern among plant parts was homogeneous (statistically equal), although variations in δ13cpdb of 291 ‰ between plant parts were observed. the eucalypt plants maintained a high co2 absorption, and consequently photosynthetic rates well above the normal atmospheric co2 concentration (8.64 mmol l-1 - 380 ppmv), even at high co2 concentrations (180.4 mmol l-1 - 7.934 ppmv). the 13c fixed during the day was proportionally less respired at night in comparison to 12c.
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