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Search Results: 1 - 10 of 488406 matches for " Daniel A Leongamornlert "
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Large-Scale Population Study of Human Cell Lines Indicates that Dosage Compensation Is Virtually Complete
Colette M Johnston,Frances L Lovell,Daniel A Leongamornlert,Barbara E Stranger,Emmanouil T Dermitzakis,Mark T Ross
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.0040009
Abstract: X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed.
Telomere Length Shows No Association with BRCA1 and BRCA2 Mutation Status
Emma Killick, Malgorzata Tymrakiewicz, Clara Cieza-Borrella, Paula Smith, Deborah J. Thompson, Karen A. Pooley, Doug F. Easton, Elizabeth Bancroft, Elizabeth Page, Daniel Leongamornlert, The IMPACT collaborators , Zsofia Kote-Jarai, Rosalind A. Eeles
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086659
Abstract: This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrolment and blood donation, 21 of whom have developed prostate cancer whilst on study. The second group consisted of 283 female BRCA1/2 mutation carriers and controls (mean age 48 years), half of whom had been diagnosed with breast cancer prior to enrolment. TL was quantified by qPCR from DNA extracted from peripheral blood lymphocytes. Weighted and unweighted Cox regressions and linear regression analyses were used to assess whether TL was associated with BRCA1/2 mutation status or cancer risk. We found no evidence for association between developing cancer or being a BRCA1 or BRCA2 mutation carrier and telomere length. It is the first study investigating TL in a cohort of genetically predisposed males and although TL and BRCA status was previously studied in females our results don't support the previous finding of association between hereditary breast cancer and shorter TL.
Fine-Mapping the HOXB Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer
Edward J. Saunders,Tokhir Dadaev,Daniel A. Leongamornlert,Sarah Jugurnauth-Little,Malgorzata Tymrakiewicz,Fredrik Wiklund,Ali Amin Al Olama,Sara Benlloch,David E. Neal equal contributor,Freddie C. Hamdy equal contributor,Jenny L. Donovan equal contributor,Graham G. Giles equal contributor,Gianluca Severi equal contributor,Henrik Gronberg equal contributor,Markus Aly equal contributor,Christopher A. Haiman equal contributor,Fredrick Schumacher equal contributor,Brian E. Henderson equal contributor,Sara Lindstrom equal contributor,Peter Kraft equal contributor,David J. Hunter equal contributor,Susan Gapstur equal contributor,Stephen Chanock equal contributor,Sonja I. Berndt equal contributor,Demetrius Albanes equal contributor,Gerald Andriole equal contributor,Johanna Schleutker equal contributor,Maren Weischer equal contributor,B?rge G. Nordestgaard equal contributor,Federico Canzian equal contributor,Daniele Campa equal contributor,Elio Riboli equal contributor,Tim J. Key equal contributor,Ruth C. Travis equal contributor,Sue A. Ingles equal contributor,Esther M. John equal contributor,Richard B. Hayes equal contributor,Paul Pharoah equal contributor,Kay-Tee Khaw equal contributor,Janet L. Stanford equal contributor,Elaine A. Ostrander equal contributor,Lisa B. Signorello equal contributor,Stephen N. Thibodeau equal contributor,Daniel Schaid equal contributor,Christiane Maier equal contributor,Adam S. Kibel equal contributor,Cezary Cybulski equal contributor
PLOS Genetics , 2014, DOI: doi/10.1371/journal.pgen.1004129
Abstract: The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the HOXB genetic locus at 17q21 and PrCa risk. This involved genotyping 700 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of 3195 SNPs in 20,440 PrCa cases and 21,469 controls in The PRACTICAL consortium. We identified a cluster of highly correlated common variants situated within or closely upstream of HOXB13 that were significantly associated with PrCa risk, described by rs117576373 (OR 1.30, P = 2.62×10?14). Additional genotyping, conditional regression and haplotype analyses indicated that the newly identified common variants tag a rare, partially correlated coding variant in the HOXB13 gene (G84E, rs138213197), which has been identified recently as a moderate penetrance PrCa susceptibility allele. The potential for GWAS associations detected through common SNPs to be driven by rare causal variants with higher relative risks has long been proposed; however, to our knowledge this is the first experimental evidence for this phenomenon of synthetic association contributing to cancer susceptibility.
Effects of Bradyrhizobium japonicum Inoculation and Supplementation with Phosphorus on Macronutrients Uptake in Cowpea (Vigna unguiculata (L.) Walp)  [PDF]
Daniel Nyoki, Patrick A. Ndakidemi
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.54058

The current study was conducted to assess the effects of phosphorus supplementation and Bradyrhizobium japonicum inoculation on the availability and uptake of N, P, K, Mg, Ca and Na on cowpea. The experiment was laid out in a split plot design where the main plots comprised two inoculation levels (with and without inoculation of B. japonicum ) and sub plots contained four different levels of phosphorus (0, 20, 40, and 80 kg P/ha). The results indicated that B. japonicum inoculation and phosphorus supplementation significantly improved the uptake of N, P, K, Mg, Ca and Na in different cowpea tissues such as roots, pods, shoots, and whole plant relative to the control. The results also indicated that there was a significant interaction of B. japonicum and phosphorus on the uptake of sodium in the roots and whole cowpea plant in the screen house. Rhizobia inoculation and supplementation of phosphorus at 40 kg P/ha resulted in the improved uptake of the most elements over other treatments tested.

Influence of Bradyrhizobium japonicum and Phosphorus on Micronutrient Uptake in Cowpea. A Case Study of Zinc (Zn), Iron (Fe), Copper (Cu) and Manganese (Mn)  [PDF]
Daniel Nyoki, Patrick A. Ndakidemi
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.54056

The field and screen house experiments were carried out in the 2013 cropping season to assess the effects of B. japonicum inoculation and phosphorus supplementation on the uptake of micronutrients in the cowpea. The experiment was laid out in a split plot design where the main plots comprised two inoculation treatments (with and without B. japonicum inoculation) and sub plots included four different levels of phosphorus (0, 20, 40, and 80 kg P/ha). The results showed a significant improvement in the uptake of micronutrients in the B. japonicum inoculated treatments over the control. Phosphorus supplementation (40 kg P/ha) also showed a significant increase in the uptake of some micronutrients while decreasing the uptake of Zn in some plant organs. There was also a significant interaction between B. japonicum inoculation and phosphorus in the root uptake of Zn for the field experiment.

The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine
Hayley C. Whitaker,Zsofia Kote-Jarai,Helen Ross-Adams,Anne Y. Warren,Johanna Burge,Anne George,Elizabeth Bancroft,Sameer Jhavar,Daniel Leongamornlert,Malgorzata Tymrakiewicz,Edward Saunders,Elizabeth Page,Anita Mitra,Gillian Mitchell,Geoffrey J. Lindeman,D. Gareth Evans,Ignacio Blanco,Catherine Mercer,Wendy S. Rubinstein,Virginia Clowes,Fiona Douglas,Shirley Hodgson,Lisa Walker,Alan Donaldson,Louise Izatt,Huw Dorkins,Alison Male,Kathy Tucker,Alan Stapleton,Jimmy Lam,Judy Kirk,Hans Lilja,Douglas Easton,Colin Cooper,Rosalind Eeles,David E. Neal
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013363
Abstract: Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.
Quantization and Stable Attractors in a DissipativeOrbital Motion  [PDF]
Daniel L. Nascimento, Antonio L. A. Fonseca
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.24030
Abstract: We present a method for determining the motion of an electron in a hydrogen atom, which starts from a field Lagrangean foundation for non-conservative systems that can exhibit chaotic behavior. As a consequence, the problem of the formation of the atom becomes the problem of finding the possible stable orbital attractors and the associated transition paths through which the electron mechanical energy varies continuously until a stable energy state is reached.
Comparative Analysis of Instructional Language Issues in Ethiopia and the United States  [PDF]
Daniel S. Alemu, Abebayehu A. Tekleselassie
Creative Education (CE) , 2011, DOI: 10.4236/ce.2011.24058
Abstract: Crafting and implementing language policies that address the needs of language minority students have always been challenging. The major challenges include addressing such concerns as: How do we address the language needs of minority students, while keeping the academic standards high? Should the role of minority langue be cultural maintenance or the facilitation of instruction through the mother tongue? To what extent does the use of minority language prepare the child for the global world? Through comparative analysis of practices in the United States and Ethiopia, this paper explores the background, approaches, and challenges/controversies in implementing polices that cater for language minority children in the two countries.
Are Asian Americans Disadvantaged by Residing More in the West? Migration, Region, and Earnings among Asian American Men  [PDF]
Isao Takei, Arthur Sakamoto, Daniel A. Powers
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.22021
Abstract: In studying labor market inequality of Asian Americans, the role of region and migration remain key factors that have not been much taken into account in the prior research. Using the 2003 National Survey of College Graduates (NSCG), this study examines whether native-born and 1.5-generation Asian Americans are more likely than whites to reside in the West. We also investigate whether native-born and 1.5-generation Asian Americans have higher earnings than whites when broken down by West versus non-West. In addition to an OLS regression model, a switching regression model is used in order to account the possibility of sample selectivity between wages and region among men who are observed to reside in the West and in the non-West. This study can therefore ask, net of demographic and socioeconomic factors and selectivity, if there is no differential in earnings between Asian Americans and whites in the West, as well as in the non-West. The results of this study indicate that Asian Americans are more likely than whites to currently reside in the West, regardless of age category and nativity. This study also finds that Asian American men do not face a substantial disadvantage in the US labor market, net of demographic and class factors. Finally, switching regression models demonstrate that both younger native-born and younger 1.5-generation Asian Americans in the West and 1.5-generation Asian Americans in the non-West have significantly higher average earnings than whites, after further controlling for selectivity. This indicates that the estimated earnings differentials for younger Asian Americans and whites are obscured when using OLS, which does not account for selectivity. In regard to selectivity, there is a positive selection into living in the West, while the selection is negative living into the non-West.
Laparoscopic colorectal surgery is safe and may be beneficial in patients eighty years of age and over  [PDF]
Mathew A. Kozman, Daniel R. Kozman
Open Journal of Gastroenterology (OJGas) , 2012, DOI: 10.4236/ojgas.2012.22016
Abstract: Objective: To establish that the laparoscopic approach to colorectal resection is safe with regards to post- operative morbidity and mortality in patients eighty years of age and over. Methods: Prospectively collect- ed data for consecutive patients aged eighty years and older who underwent laparoscopic colorectal resec-tion by the same surgeon (Dr Daniel R. Kozman) from 1st January 2009 till 31st March 2011, were retrospectively analysed. Data collected included baseline demographic information, operative indication, American Society of Anaesthesiologists (ASA) grading, procedure type, length of procedure, post-operative course, length of hospital stay, dis-charge destination and complications. Results: Thirty-one patients underwent laparoscopic colectomy during the study period, 28 for adenocarcinoma. The median age was 85.5 (range 80 - 92) years, 15 patients were male and 25 patients were from home. The mean operating time was 118.4 minutes (range 45 - 271). Conversion was required in only 4 of 31 cases (13%). The mortality rate was 10% in total, and 0% in elective cases. Three patients required re-operation, 2 of which initially presented in the emergency setting and were subsequently deceased. For survivors, the length of hospital stay was 8.1 days (range 3 - 30) with 100% returning to original place of residence. Conclusion/ Interpretation: Laparoscopic surgery in patients eighty years and over is safe and may be beneficial in the elective setting. This is evident by low complication rate, fast return to bowel function, short length of hospital stay, and likely return to pre-operative place of residence and low mortality rate in elective patients. Careful consideration should be given to its use in an emergency setting.
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