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Search Results: 1 - 10 of 190922 matches for " Dana G.; "
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A Safe Protocol for Amalgam Removal
Dana G. Colson
Journal of Environmental and Public Health , 2012, DOI: 10.1155/2012/517391
Abstract: Today's environment has different impacts on our body than previous generations. Heavy metals are a growing concern in medicine. Doctors and individuals request the removal of their amalgam (silver mercury) restorations due to the high mercury content. A safe protocol to replace the silver mercury filling will ensure that there is minimal if any absorption of materials while being removed. Strong alternative white composite and lab-processed materials are available today to create a healthy and functioning mouth. Preparation of the patient prior to the procedure and after treatment is vital to establish the excretion of the mercury from the body.
Dana G?RDU
Revista Roman? de Statistic? , 2011,
Abstract: The high performing East Asian development model sparked controversies in the academia: its success was ascribed alternatively to nation-states, markets, and sociocultural factors. This paper undertakes a comparative assessment of the last two generations of submodels, i.e. ASEAN-4 and China, by quantifying and interpreting their total factor productivity (TFP) using the Solow Model. Results show that capital accumulation was their major growth driver before the beginning of the millennium. Subsequently growth is led by technical change in ASEAN-32, and capital inputs respectively in late industrialising economies, i.e., China and the Philippines. The main differences between the two submodels consist in levels in growth rates and technical progress contributions, which are strongly sped up in China by transition and integration in global production networks. For ASEAN-4 average null or negligible TFP values in the 1990s point to structural vulnerabilities that surface during the Asian financial crisis. ASEAN-3’s recovery is led by technical change though.
An Assessment of Three Northeast Asian Economies’ Total Factor Productivity
Dana G?RDU
Revista Roman? de Statistic? , 2011,
Abstract: East Asian economies have achieved spectacular growth rates in a relatively short timespan outstripping the rest of the developing world. Hence the concern of both scholarly and policymaking circles for their peculiar development strategies. Both their spectacular rise and provisional decline after the Asian financial crisis (AFC) were explained from three major perspectives: statism, neoliberalism, and neoconfucianism.The paper purports to quantify and interpret the pre-crisis total factor productivity (TFP) of three Northeast Asian economies by using the Solow Model. The interdependencies between their TFP dynamics were investigated via a VAR Model. The findings suggest that labour contribution has decreased over time in favour of capital inputs and/or TFP as speedy industrialisation, and a gradual refinement of international specialisation proceeded. However low or even negative TFP during the 1990s signal the emergence of structural problems that decelerate growth, and increase these economies’ vulnerability to exogenous shocks.
Depression as a risk factor for coronary heart disease—How strong is the evidence?  [PDF]
Hans G. Stampfer, Dana A. Hince, Simon B. Dimmitt
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.24040
Abstract: A critical appraisal is made of the evidence that depression is a causal risk factor for coronary heart disease. PubMed and Science Citation Index were searched for relevant papers. Forty eight papers satisfying inclusion criteria and reporting an association between a measure of depression and a coronary disease outcome were compared in terms of baseline assessment, exposure and endpoint definition, covariates measured and whether changes in, or treatment of, depression was assessed during follow-up. There was considerable variation in the definition of depression and coronary heart disease and contradictory findings are reported. Conventional risk factors for coronary heart disease were not assessed consistently or adequately. Only three of the forty-eight papers gave consideration to the time course of depression during follow-up and prior to study entry. Potentially confounding variables such as anxiety, personality traits and other psychiatric disorders were not taken into consideration in the majority of papers. Treatment of depression during the follow-up period was not mentioned in any of the papers. In light of identified methodological shortcomings and the inconsistent findings reported we suggest that there is as yet no convincing evidence that depression is an independent causal risk factor for coronary heart disease.
A Machine Learning Approach for Identifying Amino Acid Signatures in the HIV Env Gene Predictive of Dementia
Alexander G. Holman, Dana Gabuzda
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049538
Abstract: The identification of nucleotide sequence variations in viral pathogens linked to disease and clinical outcomes is important for developing vaccines and therapies. However, identifying these genetic variations in rapidly evolving pathogens adapting to selection pressures unique to each host presents several challenges. Machine learning tools provide new opportunities to address these challenges. In HIV infection, virus replicating within the brain causes HIV-associated dementia (HAD) and milder forms of neurocognitive impairment in 20–30% of patients with unsuppressed viremia. HIV neurotropism is primarily determined by the viral envelope (env) gene. To identify amino acid signatures in the HIV env gene predictive of HAD, we developed a machine learning pipeline using the PART rule-learning algorithm and C4.5 decision tree inducer to train a classifier on a meta-dataset (n = 860 env sequences from 78 patients: 40 HAD, 38 non-HAD). To increase the flexibility and biological relevance of our analysis, we included 4 numeric factors describing amino acid hydrophobicity, polarity, bulkiness, and charge, in addition to amino acid identities. The classifier had 75% predictive accuracy in leave-one-out cross-validation, and identified 5 signatures associated with HAD diagnosis (p<0.05, Fisher’s exact test). These HAD signatures were found in the majority of brain sequences from 8 of 10 HAD patients from an independent cohort. Additionally, 2 HAD signatures were validated against env sequences from CSF of a second independent cohort. This analysis provides insight into viral genetic determinants associated with HAD, and develops novel methods for applying machine learning tools to analyze the genetics of rapidly evolving pathogens.
Identification of Toxoplasma gondii Genes Responsive to the Host Immune Response during In Vivo Infection
Sini Skariah, Dana G. Mordue
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046621
Abstract: Toxoplasma gondii is an obligate intracellular protozoa parasite that causes the disease toxoplasmosis. It resides within host cells in a parasitophorous vacuole distinct from the host cell endocytic system. T. gondii was used as a model to investigate how obligate intracellular parasites alter their gene expression in response to the host immune response during infection compared to growth in host cells in vitro. While bacterial pathogens clearly alter gene expression to adapt to the host environment during infection, the degree to which the external environment affects gene expression by obligate intracellular pathogens sequestered within host cells is less clear. The global transcriptome of T. gondii was analyzed in vivo in the presence and absence of the IFN-γ-dependent host innate immune response. The parasites' in vivo transcriptome was also compared to its transcriptome in vitro in fibroblast cells. Our results indicate that the parasite transcriptome is significantly altered during in vivo infection in the presence, but not absence, of IFN–γ-dependent immunity compared with fibroblasts infected in vitro. Many of the parasite genes increased in vivo appear to be common to an early general stress response by the parasite; surprisingly putative oocyst stage specific genes were also disproportionately increased during infection.
Revisiting the Competitiveness of Romanian Manufacturing Industry
Ovidiu RUJAN,Dana G?RDU
Annals of Dun?rea de Jos University. Fascicle I : Economics and Applied Informatics , 2007,
Abstract: Since the early 1990s the Romanian manufacturing industry has improved in many ways. This headway concerns the labour-intensive sector rather than the technology-intensive one. Apart from local entrepreneurship, foreign direct investments (FDI) have been instrumental in enhancing industrial competitiveness. TheLisbon Agenda revival and Romania’s EU accession will be further inducements for Western businesses to shift production here to fight back both low-cost producers (typically from emerging Asia) and more quality-oriented producers (typically from OECD countries). Hopefully, the FDI spillover effects will send positive vibrationsacross the economy, and tone down the asymmetry at the core of the manufacturing industry.
Cytomegalovirus infection in pediatric rheumatic diseases: a review
Eli M Eisenstein, Dana G Wolf
Pediatric Rheumatology , 2010, DOI: 10.1186/1546-0096-8-17
Abstract: Human cytomegalovirus (HCMV) is a ubiquitous beta-herpesvirus that causes symptoms primarily in immune-compromised individuals. Fully assembled virus is comprised of a DNA-containing capsid surrounded by a tegument layer and lipid envelope. The viral genome contains over 200 open reading frames [1].HCMV is well-known to pediatric rheumatologists as an opportunistic pathogen. However, this virus also possesses immuno-modulatory properties, and may be a co-factor in the pathogenesis of certain forms of rheumatic disease. In this review, we discuss clinical and immunologic aspects of HCMV infection relevant to the practice of pediatric rheumatology.Sero-epidemiologic data indicate that between 30-70% of children in the United States have been infected with HCMV by school age [2]. The prevalence of anti-HCMV IgG antibodies is higher in minority children and those in developing countries, and continues to increase throughout life [3]. Humans are the only known host for HCMV, and infection requires contact with infected secretions. Common routes of infection include horizontal passage among family members, sexual transmission, vertical intra-uterine transmission, and breastfeeding. Children may continue to secrete virus for months or even years following primary infection, making them an important reservoir of infectious virus. Infection may be acquired though sexual contact in adolescents and adults [4]. Vertical transmission from mother to fetus can occur throughout pregnancy. Primary infection during the first trimester confers the greatest risk for severe congenital disease [5]. Transfusion of infected blood products and transplantation of infected organs are important sources of HCMV infection in the nosocomial setting.HCMV exists in two forms: as an actively replicating virus, and in a latent form. Latency is defined as persistence of non-replicating viral DNA in cells, that has the potential to re-activate and form infectious virus under propitious conditions [6].
Cryotherapy and ankle motion in chronic venous disorders  [PDF]
Teresa J. Kelechi, Martina Mueller, Jane G. Zapka, Dana E. King
Open Journal of Nursing (OJN) , 2012, DOI: 10.4236/ojn.2012.24056
Abstract: This study compared ankle range of motion (AROM) including dorsiflexion, plantar flexion, inversion and eversion, and venous refill time (VRT) in leg skin inflamed by venous disorders, before and after a new cryotherapy ulcer prevention treatment. Fifty-seven individuals participated in the randomized clinical trial; 28 in the experimental group and 29 received usual care only. Results revealed no statistically significant differences between the experimental and usual care groups although AROM measures in the experimental group showed a consistent, non-clinically relevant decrease compared to the usual care group except for dorsiflexion. Within treatment group comparisons of VRT results showed a statistically significant increase in both dorsiflexion and plantar flexion for patients with severe VRT in the experimental group (6.9 ± 6.8; p = 0.002 and 5.8 ± 12.6; p = 0.02, respectively). Cryotherapy did not further restrict already compromised AROM, and in some cases, there were minor improvements.
Venlafaxine and desvenlafaxine in the management of menopausal hot flashes
Johnson,Emily D.; Carroll,Dana G.;
Pharmacy Practice (Internet) , 2011, DOI: 10.4321/S1886-36552011000300001
Abstract: vasomotor flushes are common complaints of women during and after menopause, affecting about 75 percent of this population. estrogen therapy is the most effective treatment for hot flashes. however, there are a significant number of women who have contraindications or choose not to use estrogen due to potential risks such as breast cancer and thromboembolic disorders. these women need alternative options. the selective norepinephrine reuptake inhibitors, venlafaxine and desvenlafaxine, have shown efficacy in alleviating hot flashes. objective: the purpose of this review is to assess the efficacy and tolerability of these two agents for treatment of hot flashes in healthy postmenopausal women. methods: a literature search of the medline and ovid databases from inception to june 2011 was conducted. randomized controlled trials, published in english, with human participants were included. studies included postmenopausal women, and trials with breast cancer only populations were excluded. results: venlafaxine reduced hot flashes by 37 to 61 percent and desvenlafaxine by 55 to 69 percent. both agents were well tolerated. the most common adverse effects were headache, dry mouth, nausea, insomnia, somnolence, and dizziness. conclusion: based on the evidence, venlafaxine and desvenlafaxine are both viable options for reducing the frequency and severity of hot flashes.
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