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Isolation and identification of bioactive compounds responsible for the anti-bacterial efficacy of Lotus corniculatus var. S o Gabriel
Dalmarco Juliana,Dalmarco Eduardo,Koelzer Janaina,Pizzolatti Moacir
International Journal of Green Pharmacy , 2010,
Abstract: Lotus corniculatus (Fabaceae) is considered a forage plant utilized as food for ruminants in the south of Brazil. This herb is also actually used to treat intestinal infection in these animals. In our experiments, we evaluated the anti-bacterial activity of crude extract from L. corniculatus var. Sγo Gabriel were assayed against Gram-positive and Gram-negative bacterium. The crude extracted did not show any anti-bacterial activity, but the hexane fraction did on Bacillus cereus (MIC=100 μg/mL) and on Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Staphylococcus epidermidis, Acinetobacter calcoaceticus, and Providencia alcalifaciens (MIC=600, 800 or 1000 μg/mL). The Ethyl acetate fraction (AcOEt) also showed important anti-bacterial activity on Bacillus cereus, E. faecalis, and Acinetobacter calcoaceticus (MIC=800 μg/mL). The oleanolic acid isolated from hexane fraction showed the same effect on Staphylococcus aureus methycillin-resistant (MIC=100 μg/mL), L. monocytogenes (MIC=25 μg/mL), and Bacillus cereus (MIC=25 μg/mL). Further, Kaempferitrin isolated from ethyl acetate fraction has also shown anti-bacterial activity on Shighella flexinerii (MIC=100 μg/mL), Salmonella typhimurium (MIC=100 μg/mL), A. calcoaceticus (MIC=100 μg/mL), E. faecalis (MIC=3.9 μg/mL), and Bacillus cereus (MIC=8.5 μg/mL). This study suggests that L. corniculatus var. Sγo Gabriel have potential pharmacological property for a new anti-bacterial drug development.
Evaluation of the antiinflammatory efficacy of Lotus pedunculatus
Pereira Diana,Koelzer Janaina,Dalmarco Juliana,Pizzolatti Moacir
International Journal of Green Pharmacy , 2009,
Abstract: The aim of this study was to investigate the antiinflammatory effect of the crude extract of Lotus pedunculatus. Aerial parts of Lotus pedunculatus were extracted by maceration with ethanol 96%. The solvent was evaporated under low pressure at 55°C to dryness, yielding crude extract. The antiinflammatory effects of Lotus pedunculatus were analyzed using carrageenan-induced mouse pleurisy. Significance was determined by analysis of variance, Dunnett′s or Student′s t -tests. Values of P < 0.05 were considered significant. The crude extract of Lotus pedunculatus inhibited leukocyte, neutrophil, myeloperoxidase, and adenosine-deaminase activities, as well as exudation, nitric oxide, interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels ( P < 0.05). These results indicate that Lotus pedunculatus has an important antiinflammatory action and its inhibitory activity may be due to not only to the inhibition of proinflammatory mediators, but also to the inhibition of the activated leukocytes.
Carvedilol atenua o estresse oxidativo na cardiopatia chagásica cr?nica
Budni, Patrícia;Pedrosa, Roberto Coury;Garlet, Thais Regina;Dalmarco, Eduardo Monguilhott;Dalmarco, Juliana Bastos;Lino, Manuel Rosa de Oliveira;Simionato, Edésio Luiz;Amara, Jorge Ant?nio;Frode, Tania Sílvia;Wilhelm Filho, Danilo;
Arquivos Brasileiros de Cardiologia , 2012, DOI: 10.1590/S0066-782X2012005000015
Abstract: background: there is increasing evidence suggesting that chagas disease involves oxidative damage and contributes to heart disease progression. objective: to evaluate the effect of carvedilol on oxidative stress markers in chronic chagas disease. methods: the study population included 42 patients with chagas cardiomyopathy and oxidative stress biomarkers were measured before and after a period of six months of treatment with carvedilol (37.5 mg/day). patients were considered according to the los andes classification and the activity of superoxide dismutase, catalase, glutathione peroxidase, s-transferase and reductase, myeloperoxidase and adenosine deaminase; levels of reduced glutathione, thiobarbituric acid reactive species, carbonyl protein, vitamin e and nitric oxide were measured in blood. results: after treatment with carvedilol, all groups showed significant reductions in levels of carbonyl protein and reduced glutathione, whereas the levels of nitric oxide and adenosine activity increased significantly only in group ia. moreover, most of the antioxidant enzymes showed decrease in activity in groups ia and ib. conclusion: the data suggest that treatment with carvedilol was effective in attenuating oxidative damage, an effect that may be particularly important in patients with chronic chagas' disease cardiomyopathy.
Chemical composition similarity between the essential oils isolated from male and female specimens of each five Baccharis species
Besten, Michele A.;Jasinski, Vanessa C. G.;Costa, ?ngela de G. L. C.;Nunes, Domingos S.;Sens, Sávio L.;Wisniewski Jr., Alberto;Simionatto, Edesio L.;Riva, Dilamara;Dalmarco, Juliana B.;Granato, Daniel;
Journal of the Brazilian Chemical Society , 2012, DOI: 10.1590/S0103-50532012000600007
Abstract: in the few studies published on essential oils from female and male specimens of baccharis species, strong differences between the compositions of both samples were always found. the experiments conducted in this study make use of strategies to minimize the interference from genetic and environmental factors. essential oils from leaves of female and male specimens of five baccharis species were investigated by gas chromatography-mass spectrometry plus flame ionization detector (gc-ms-fid): b. caprariaefolia and b. dracunculifolia, which have been previously studied with similar aims; and b. coridifolia, b. semiserrata var. elaegnoides and b. pentaptera, the latter two not yet mentioned in the literature. the results were followed by hierarchical cluster analysis, verifying the formation of groups indicative of the great similarity of essential oils from male and female specimens of all five species. the study reinforces the value of field observation in natural product research and points genetic and ecological factors as main responsible for differences in the secondary metabolites of the studied plants.
The Silent Run: New Issues and Outcomes for University-Industry Relations in Brazil
Zawislak,Paulo Ant?nio; Dalmarco,Gustavo;
Journal of technology management & innovation , 2011, DOI: 10.4067/S0718-27242011000200005
Abstract: in order to develop innovations, companies are establishing university-industry (u-i) relations which are explained in theories like the triple helix. maybe this traditional view it is not enough to describe what happens in brazil. followed by a growth of articles published internationally, companies in technologically stable industries seem to be incorporating high-tech outcomes from universities, boosting sectors that once were apparently inert. this research will propose a different approach on u-i relations, focusing on the knowledge flow. results show that agriculture companies are increasing their relations as much as engineering companies. such relations are mainly based on raw technologies or applied solutions. start-up firms' relations are mainly based on informal contacts and patents are not used to protect technologies. the silent run shows that companies which appear to be technologically stable are now upgrading trough u-i, and patents does not seem to be the first option when protecting new technologies.
Methotrexate inhibits integrin adhesion molecules in the mouse model of pleurisy induced by carrageenan
Dalmarco, Eduardo Monguilhott;Fr?de, Tania Silvia;
Brazilian Archives of Biology and Technology , 2007, DOI: 10.1590/S1516-89132007000500005
Abstract: the aim of this work was to analyze the effect of methotrexate (mtx) upon leukocyte migration and expression of adhesion molecules cd11a/cd18 in the lung, 4 and 48 h after inflammation induction by carrageenan in mice. the results showed that mtx significantly decreased leukocyte influx and cd11a expression in the lung at 4 and 48 h of pleurisy (p < 0.01). mtx also inhibited cd18 expression at 4 h but not 48 h of pleurisy (p < 0.01). these results proved that mtx at the studied doses had important anti-inflammatory properties, acting primarily on leukocyte migration from the pleural cavity to the lung via inhibition of cd11a/cd18 expression in the mouse model of inflammation.
Effects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy
Eduardo Monguilhott Dalmarco,Tania Silvia Fr de,Yara Santos Medeiros
Mediators of Inflammation , 2002, DOI: 10.1080/09629350210000015700
Abstract: Background: The model of pleurisy induced by carrageenan exhibits a biphasic response (4 and 48 h) and permits the quantification of exudate, cell migration and certain enzymes such as myeloperoxidase (MPO) and adenosine-deaminase (ADA) that are markers of activated leukocytes.
As Certifica es Sustentáveis e Sua Relevancia Para o Consumo Consciente e os Negócios
Kavita Miadaira Hamza,Denise de Abreu Sofiatti Dalmarco
Reunir : Revista de Administra??o, Contabilidade e Sustentabilidade , 2012,
Abstract: This paper addresses the topic of sustainable consumption and ecolabelling, and the impact that these issues have for organizations, especially as regards the production of consumer goods and its marketing/sales. It starts with a literature review focusing on the movement of conscious consumption and the development of the theme of sustainable certifications, ending with an assessment of Brazil in this context, where it was found that few academic studies have been conducted on this topic in general. Then we report the results of an exploratory qualitative research, conducted through in-depth interviews. The results of the research indicates a low level of knowledge and use of sustainable labels. There is a lack of information to consumers, aiming to facilitate the choice of more sustainable products. We noticed that people have not realized the influence they have with their power of choice, showing that consumption can be a space for political debate, both by the problems associated with it, and by understanding the consumers have power to change the business as usual.
Diagnostics, rehabilitation and models of Parkinson’s disease  [PDF]
Juliana Dushanova
Health (Health) , 2012, DOI: 10.4236/health.2012.431178
Abstract: Diagnostics and rehabilitation of Parkinson’s disease (PD) presents the current information pertaining to etiology, early biomarkers for diagnostics, novel methods to evaluate symptoms, multidisciplinary rehabilitation, new applications of brain imaging and invasive methods to the study of PD. Researchers have only recently begun to focus on the non-motor symptoms of PD, which are poorly recognized and inadequately treated by clinicians. The non-motor symptoms of PD have a significant impact on patient quality of life and mortality, and include cognitive impairments, autonomic, gastrointestinal, and sensory symptoms. Indepth discussion of the use of imaging tools to study disease mechanisms is also provided, with emphasis on the abnormal network organization in parkinsonism. Deep brain stimulation management is a paradigm-shifting therapy for PD, essential tremor and dystonia. In the recent years, new approaches of early diagnostics, training programmes and treatments have vastly improved the lives of people with PD, substantially reducing symptoms and significantly delaying disability. PD results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction and oxidative stress, may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cas-cade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
Universities' Intellectual Property: Path for Innovation or Patent Competition?
Dalmarco,Gustavo; Dewes,Mariana de Freitas; Zawislak,Paulo Antonio; Padula,Antonio Domingos;
Journal of technology management & innovation , 2011, DOI: 10.4067/S0718-27242011000300012
Abstract: technological innovation is represented by the conversion of knowledge into new products and processes which, when commercialized, generate wealth. in relations with companies, universities' role is to develop scientific knowledge, fostering industry's r&d activities. this article proposes an analysis of the technology transfer process performed by public universities in brazil. results demonstrate that universities are facing difficulties in requesting and licensing patents based on scientific results, due to lack of commercial contact with companies and their limitations in adapting available technologies. the increase in scientific output is not being effectively transformed into new technologies for products and services, exposing the necessity for new policies to approach university-industry relations. for universities, this may mean rethinking the role of patents in the technology transfer process, such as increasing co-authorship with companies and have companies support technological research within the university, instead of investing in legal protection, distant from market needs.
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