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Search Results: 1 - 10 of 326187 matches for " D.E. Panayotounakos "
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General Parametric Solution of the Panleve-Ince Nonlinear ODE and of Some Relative Equations in Mathematical Physics
D.E. Panayotounakos,Th. I. Zarmpoutis,G. Kostogiannis
IAENG International Journal of Applied Mathematics , 2012,
Abstract:
Conventional and novel strategies in the treatment of adrenocortical cancer
Schteingart, D.E.;
Brazilian Journal of Medical and Biological Research , 2000, DOI: 10.1590/S0100-879X2000001000009
Abstract: adrenocortical carcinoma is a highly malignant neoplasm with an incidence of two per million people per year. several treatment strategies have resulted in temporary or partial tumor regression but very few cases have attained long survival. surgical resection of the primary tumor and metastases is most effective. several chemotherapeutic protocols have been employed with variable success. mitotane (o,p'-ddd) is an adrenalytic drug effective in inducing a tumor response in 33% of patients treated. mitotane requires metabolic transformation for therapeutic action. tumors may vary in their ability to metabolize mitotane and the ability of tumors to transform mitotane may predict the clinical response to the drug. preliminary data show a possible correlation between metabolic activity of neoplastic adrenocortical tissue and response to mitotane. we have attempted to develop mitotane analogs with enhanced adrenalytic effect. compared to mitotane, a di-chloro compound, the bromo-chloro and di-bromo analogs appear to have a greater effect. future approaches to the treatment of adrenocortical carcinoma are likely to be based on blocking or reversing the biological mechanisms of tumorigenesis. angiogenic and chemotactic mechanisms may play a role in adrenal tumor growth and inhibition of these mechanisms may result in inhibition of tumor growth. new mitotane analogs with greater adrenalytic potential could be a promising approach to developing more effective and selective therapies for adrenal cancer. alternative approaches should attempt to suppress tumor growth by means of compounds with anti-angiogenic and anti-chemotactic activity.
Phytochemicals, Vitamins and Mineral Contents of Two Nigerian Medicinal Plants
D.E. Okwu
International Journal of Molecular Medicine and Advance Sciences , 2011,
Abstract: Samples of two Nigerian medicinal plants (Garcinia Kola Heckel) and (Aframomum melegueta) were analyzed for their phytochemical composition, vitamins and minerals constituents. The result revealed the presence of bioactive constituents comprising: flavonoids (5.76-1.98 mg 100 1g), phenols (0.09-0.11 mg 100 1g), saponins (1.24-11.48 mg 100 1g), tannins, (0.26-0.38 mg/100g). The medicinal plants contained ascorbic acid (12.32-23.10 mg 100 1g), niacin (0.05-1.60 mg 100 1g), riboflavin (0.22- 0.26 mg 100 1g) and thiamin (0.24-0.45 mg 100 1g). The plants are good sources of minerals such as: Ca, P, K, Mg, Na. Fe, Zn, Mn and Cu. These substances may be responsible for the health related properties of the plants, which are based on their antioxidant, anticancer, anti-tumor antiviral, anti-inflammatory and anti-allergic activities. These supports the popular use of G. Kola and A. melegueta in herbal medicine in South Eastern Nigeria.
The Astabrata, Saptadewawrtti, and Nagarakrtagama VII:1-2
D.E. Weatherbee
Bijdragen tot de Taal-, Land- en Volkenkunde , 1994,
Abstract:
La Valutazione Contingente di beni culturali in regioni marginali
D.E. Massimo
Aestimum , 1997,
Abstract:
Traceability of processed animal proteins with varying texture in feed: determination with microscopic and polymerase Chain Reaction methods
Hormisch D.E.
Biotechnologie, Agronomie, Société et Environnement , 2004,
Abstract: To test the traceability of different animal components that could enter the feed chain two methods for the determination of processed animal proteins (PAPs) in feed classical microscopy and polymerase chain reaction (PCR)-analysis were applied in the following study. To determine PAPs of varying but defined structure different animal meals were produced artificially and analysed after spiking to a set of 13 compound feed samples. The aims of the study were (i) to compare the capacity and the limits of both methods with respect to the determination of animal constituents of varying composition, (ii) to verify a correct interpretation of the results from each method and (iii) to determine an optimum application area for each method. Both methods complemented each other. The microscopic approach allowed a reproducible, high sensitive and quantitative determination of animal ingredients with morphological detectable structures, and in the presence of bone fragments a d i fferentiation between fish and terrestrial animals was possible simultaneously. The PCR-analysis provided the detection of animal ingredients in feed even in absence of visible structures but fishmeal was not detected in a sufficient manner by the chosen screening setup. However, the PCR-method enabled to differentiate between animal groups or species and to identify animal species. The methods complemented each other not only in the analytical features but also regarding the results produced by the detection of two different analytical targets of PAPs, morphological structures and gene sequences, r e s p e c t i v e l y. Suitable data regarding the presence of their analytical targets were produced by each method, but a combination of both methods enabled furthermore to report correct results regarding the presence of the artificially composed PAPs in the feed samples. It was concluded that a combination of microscopy and PCR-analysis is reasonable for special application purposes to determine PAPs in feed: while microscopy provides reliable results also in highly processed feed with wellpreserved morphological animal structures even with highly degraded genomic material, PCR provides applicable results in feed samples with preserved genomic animal material even after the separation of morphological structures. These specialties have to be considered for the choice of capable analytical methods and even for a correct evaluation of the results obtained from these methods in highly processed feed. An interpretation scheme based on the results of the study was proposed.
The effect of gestation and lactation on bone calcium, phosphorus and magnesium in dairy cows
D.E. Beighle
Journal of the South African Veterinary Association , 2012, DOI: 10.4102/jsava.v70i4.782
Abstract: A study was conducted to monitor changes in cortical bone mineral in the dairy cow in response to demands of lactation and pregnancy using rib bone biopsies in serial sampling. Sixteen Friesian cows from the University dairy herd were used to collect 9 samples during the lactation period and 5 samples during the dry period. The data were analysed using a split-plot design analysis of variance. There were no significant (P > 0.05) differences in cortical bone phosphorus concentrations in rib bone during the lactation period, but calcium concentrations in cortical bone were significantly (P < 0.05) higher at parturition and during the first 30 days of lactation compared to the next 30 days and between 90 and 120 days. Results reported here indicate that the cow resorbs cortical bone during the middle of the lactation period and not during the periparturient period as previously thought. Magnesium concentrations were also significantly (P < 0.05) higher at the beginning of lactation compared to some of the other sampling times, but cortical bone was significantly (P < 0.05) thinner at the beginning of lactation compared to several of the other sampling times. There were no significant (P > 0.05) differences in cortical bone Ca or Mg concentrations during the gestation period. Cortical bone P concentrations significantly (P < 0.05) decreased during the first 180 days, but significantly (P < 0.05) increased at 181-230 days and significantly (P < 0.05) decreased again at 231 days to term. Cortical bone thickness decreased significantly (P < 0.05) from the beginning of gestation to term. There were no significant (P > 0.05) differences in cortical bone thickness or Ca or Mg concentrations in cortical bone during the dry period, but cortical bone P concentrations were significantly (P < 0.05) greater at the end of the dry period compared to the first 30 days of the period. In general, cortical bone Ca and Mg values decreased as milk production increased up to 20 kg/day and cortical bone P values and bone thickness increased. In animals producing over 20 kg/day, however, cortical bone mineral values were greater and cortical bone thickness was lower compared to those animals producing less than 20 kg.
Bone, blood and faecal response to an acidogenic lick for range cattle using different concentrations of ammonium chloride
D.E. Beighle
Journal of the South African Veterinary Association , 2012, DOI: 10.4102/jsava.v71i4.717
Abstract: Thirty Brahman-Angus cross heifers at breeding age on extensive grazing were used to test the effectiveness of NH4Cl as an acidogenic agent at 15, 18, 21 and 26 %of a dicalcium phosphate lick (A+), compared to a lick of 5 parts dicalcium phosphate and 3 parts salt (A-). Blood and faecal phosphorus (P), faecal calcium (Ca) and faecal magnesium (Mg) were significantly (P < 0.05) higher in A+ compared to A- animals at different stages of the experiment. Bone P did not increase in response to NH4Cl but bone Ca was significantly (P < 0.05) higher in A+animals offered 18 % NH4Cl and significantly (P < 0.05) lower at 15 and 26 %. Bone Mgin A+animals was significantly (P < 0.05) higher at 15 and 18 % NH4Cl and lower at 26 % NH4Cl compared to A- animals. Percentage ash in bone increased linearly from 62.5 to 64.9 % in A+ animals as NH4Cl was increased in the lick from 15 to 21 % and then decreased to 63.3 % but was significantly (P < 0.05) greater than the percentage ash in A- animals when the NH4Cl was increased to 26 %. Bone mineral status was only marginally improved by adding NH4Cl to the lick in this study but blood P was significantly (P < 0.05) improved in A+ compared to A- animals when the lick contained 15, 21 and 26 % NH4Cl. Based on bone mineral results reported here, it is recommended that, when NH4Cl is used as an acidogenic agent in licks for range cattle, the amount in the lick should not exceed 21 %.
The mineral nutrition of livestock (3rd edition), E.J. Underwood and N.F. Suttle : book review
D.E. Beighle
Journal of the South African Veterinary Association , 2012, DOI: 10.4102/jsava.v71i2.697
Abstract:
Conventional and novel strategies in the treatment of adrenocortical cancer
Schteingart D.E.
Brazilian Journal of Medical and Biological Research , 2000,
Abstract: Adrenocortical carcinoma is a highly malignant neoplasm with an incidence of two per million people per year. Several treatment strategies have resulted in temporary or partial tumor regression but very few cases have attained long survival. Surgical resection of the primary tumor and metastases is most effective. Several chemotherapeutic protocols have been employed with variable success. Mitotane (o,p'-DDD) is an adrenalytic drug effective in inducing a tumor response in 33% of patients treated. Mitotane requires metabolic transformation for therapeutic action. Tumors may vary in their ability to metabolize mitotane and the ability of tumors to transform mitotane may predict the clinical response to the drug. Preliminary data show a possible correlation between metabolic activity of neoplastic adrenocortical tissue and response to mitotane. We have attempted to develop mitotane analogs with enhanced adrenalytic effect. Compared to mitotane, a di-chloro compound, the bromo-chloro and di-bromo analogs appear to have a greater effect. Future approaches to the treatment of adrenocortical carcinoma are likely to be based on blocking or reversing the biological mechanisms of tumorigenesis. Angiogenic and chemotactic mechanisms may play a role in adrenal tumor growth and inhibition of these mechanisms may result in inhibition of tumor growth. New mitotane analogs with greater adrenalytic potential could be a promising approach to developing more effective and selective therapies for adrenal cancer. Alternative approaches should attempt to suppress tumor growth by means of compounds with anti-angiogenic and anti-chemotactic activity.
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