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Search Results: 1 - 10 of 192120 matches for " D. Shrestha "
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Assessment of Genetic Diversity in Nepalese Populations of Swertia chirayita (Roxb. Ex Fleming) H. Karst Using RAPD-PCR Technique  [PDF]
J. K. Chhipi Shrestha, T. Bhattarai, J. Sijapati, N. Rana, J. Maharjan, D. S. Rawal, B. B. Raskoti, S. Shrestha
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.48196

Owing to the high demand, Swertia chirayita populations in the wild are being depleted beyond its regeneration capacity. S. chirayita is one of the most valuable medicinal plants of Nepal in trade. Present Molecular investigation was undertaken to understand the level of genetic diversity in five S. chirayita populations of Nepal using Polymerase Chain Reaction (PCR)-based Random amplified polymorphic DNA (RAPD) technique. Thirty four accessions of S. chirayita along with six outlier accessions were analyzed using 26 arbitrary primers. Of the total 285 amplified bands scored for S. chirayita, 263 bands (92.28%) were polymorphic. Two major clusters were revealed in the phenogram generated from cluster analysis using NTSYS-PC software (version 2.21i) for the geographic populations under study. Principal Coordinate Analysis further substantiated the results of the phenograms. Swertia chirayita populations from Sankhuwasabha and Terathum were

Management of Pediatric Displaced Distal Metaphyseal Forearm Fracture: Comparison between Cast Immobilization and Percutaneous Kirschner Wire Fixation
D Shrestha,D Dhoju,N Parajuli,G Dhakal,R Shrestha
Nepal Orthopaedic Association Journal , 2011, DOI: 10.3126/noaj.v2i1.8133
Abstract: Background: Distal metaphyseal forearm fracture is one of the common injuries in children. Closed reduction and above elbow cast is the standard method of treatment but reported to be associated with redisplacement rate of 7-25%. Closed reduction and fixation with percutaneous Kirschner wire is an alternative treatment option to prevent redisplacement. Methods: Thirty five children (group I) of age between 6 to 13 yrs with displaced ( more than 50% of cortical diameter) or angulated (more than 20°) distal metaphyseal forearm fracture managed with closed reduction and above elbow cast were compared with 21 children (group II) managed with closed reduction and percutaneous crossed Kirschner fixation. Clinical outcomes and complications were compared in both groups after 12 weeks of follow up. Results: Preoperative variables in both the groups were comparable. Mean loss of elbow flexion and extension (12° vs. 4°, p =0.08), wrist dorsflexion and palmerflexion (27° vs. 14°, p=0.12) and forearm supination and pronation (27° vs. 15°, p= 0.143) were more in group I but were statistically not significant. Complications rate (28.4% vs. 19.04%, p= 0.04) was higher in group I (such as fracture redisplacement and swelling) than in group II (pin tract infection). Conclusions : Grossly displaced or angulated distal metaphyseal forearm both bone fracture in children treated with either closed reduction and above elbow cast or closed reduction with crossed Kirschner wire fixation have no statistically significant clinical outcomes in terms of loss of movement of elbow, wrist and forearm but complication rate is higher in cast group. Percutaneous Kirschner wire fixation prevents redisplacement. DOI: http://dx.doi.org/10.3126/noaj.v2i1.8133 Nepal Orthopaedic Association Journal Vol.2(1) 2011: 1-6
Relevance of patch testing in patients with nummular dermatitis
Krupa Shankar D,Shrestha Shristi
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract: Background: A chronic dermatosis like nummular dermatitis may be complicated by contact dermatitis due to an impaired cutaneous barrier. This study is aimed at evaluating secondary contact dermatitis in patients with nummular dermatitis. Methods: Patch testing with the Indian Standard Series was performed in 50 of 78 patients with a clinical diagnosis of nummular eczema. Significant reactions were graded as per ICDRG criteria. Results: Significant reactions were noted in 23 of 50 tested patients. The most frequent sensitizers were colophony, nitrofurazone, neomycin sulfate and nickel sulfate (7.14% each) Reactions to antigens in topical medications, cosmetics and toiletries constituted 64.28% of all the reactions. Conclusions: Patients with nummular dermatitis are at significant risk of developing secondary allergic contact dermatitis, which contributes to the severity and chronicity of their dermatitis. Patch testing has the potential to improve the quality of life in these patients. Hence, patients with chronic recalcitrant nummular dermatitis must be patch tested.
Partial-wave analysis of π-p {\to} ηn and π-p {\to} K0Λ reactions
M. Shrestha,D. M. Manley
Physics , 2012, DOI: 10.1103/PhysRevC.86.045204
Abstract: We investigate the hadronic reactions {\pi}N {\to} {\eta}N and {\pi}N {\to} K{\Lambda} via single-energy partial-wave analyses in the c.m. energy range 1080 to 2100 MeV. Our results for the K{\Lambda} channel are consistent with prior works; however, for the {\eta}N channel our results differ significantly from previous energy-dependent partial-wave analyses that violate the S-matrix unitarity. We present the first (new) results of {\eta}N and K{\Lambda} partial-wave amplitudes constrained by a unitary energy-dependent model. We obtain excellent predictions of integrated cross sections for the two reactions from a global energy-dependent solution. Our results imply that the region just above S11 (1535) has a major contribution from P11 (1710) for {\pi}-p {\to} {\eta}n, whereas the large peak near 1700 MeV in {\pi}-p {\to} K0{\Lambda} is dominated by contributions from both S11 (1650) and P11 (1710).
Multichannel parametrization of πN scattering amplitudes and extraction of resonance parameters
M. Shrestha,D. M. Manley
Physics , 2012, DOI: 10.1103/PhysRevC.86.055203
Abstract: We present results of a new multichannel partial-wave analysis for \pi N scattering in the c.m. energy range 1080 to 2100 MeV. This work explicitly includes \eta N and K \Lambda channels and the single pion photoproduction channel. Resonance parameters were extracted by fitting partial-wave amplitudes from all considered channels using a multichannel parametrization that is consistent with S-matrix unitarity. The resonance parameters so obtained are compared to predictions of quark models.
Pattern Of Skin Diseases In A Rural Village Development Community Of Nepal
R Shrestha,DP Shrestha,L Lama,D Gurung,I Rosdahl
Nepal Journal of Dermatology, Venereology & Leprology , 2014, DOI: 10.3126/njdvl.v12i1.10595
Abstract: 72 Introduction: Skin diseases are a common cause of morbidity in Nepal as per the health services report. There is limited information on the prevalence and pattern of skin diseases in the community. The objective of this study was to determine the pattern of skin diseases in a rural village development community of Nepal. Materials and methods:? Two? dermatologic? health camps were conducted, during which, the villagers were examined by dermatologists. The skin diseases diagnosed were recorded in a proforma. Results: There were 433 individuals examined and 359 (male-47.9%; female-52.1%) had skin disease identified clinically (camp prevalence- 83%). The age of patients ranged from 1 to 80 years (mean-24.5; SD±15.9), with majority in the age group of 10-19 years. The most common skin disease category was eczemas (36.4%), followed by infections (28.4%), acne (22%), pigment disorders (34%) and urticaria (12.3%). Conclusion: Skin diseases were common in the community. The five most common Skin disease categories were eczemas, infections, acne and pigment disorders were the more common conditions. DOI: http://dx.doi.org/10.3126/njdvl.v12i1.10595 Nepal Journal of Dermatology, Venereology & Leprology Vol.12(1) 2014 pp.41-44 ?
Addisonian Crisis Precipitated By Thyroxine Therapy In A Patient With Type 2 Autoimmune Polyglandular Syndrome
Sunil Pokharel,A Shrestha,D Maksey,B Shrestha,P Paudel,B Shrestha,BM Dhital
Journal of Chitwan Medical College , 2013, DOI: 10.3126/jcmc.v3i4.9557
Abstract: Primary hypoadrenalism(Addison’s disease) refers to glucocorticoid deficiency occurring in the setting of adre-nal disease(mostly due to autoimmune adrenalitis), whereas secondary hypoadrenalism arises because of deficiency of ACTH(mostly due to pituitary disease) . A major distinction between these two is that mineralocorticoid deficiency invari-ably accompanies primary hypoadrenalism, but this does not occur in secondary hypoadrenalism because only ACTH is de-ficient; the renin-angiotensin-aldosterone axis is intact and in primary hypoadrenalism skin pigmentation is always present due to increased ACTH secretion(unless of short duration) but it is absent in secondary hypoadrenalism. Addison’s disease or primary adrenocortical failure was first described by English physician Thomas Addison, who found it in six patients with adrenal tuberculosis in 1855(1). Addisonian crisis is a potentially fatal condition associated mainly with an acute defi-ciency of the glucocorticoid cortisol and, to a lesser extent, the mineralocorticoid aldosterone. This is a rare condition with an estimated incidence in the developed world of 0.8 cases per 100,000 and prevalence of 4 to 11 cases/100,000 population. Despite optimised life-saving glucocorticoid replacement and mineralocorticoid-replacement therapy, it is life threatening if overlooked(2-3). Hypothyroidism may mask the addison’s disease so in patients with panhypopituitarism and autoim-mune polyglandular syndrome type 2 thyroxine replacement without adequate steroid replacement may precipitate acute addisonian crisis. Journal of Chitwan Medical College 2013; 3(4); 54-56 DOI: http://dx.doi.org/10.3126/jcmc.v3i4.9557
An unusual cause of hypoglycemia: A case report
S Pokharel,A Shrestha,D Maskey,B Shrestha,P Poudel,B Shrestha,KN Poudel,G Kandel
Journal of Chitwan Medical College , 2014, DOI: 10.3126/jcmc.v4i2.10865
Abstract: Hypoglycemia is characterized by a reduction in plasma glucose concentration to a level that may induce symptoms or signs such as altered mental status or sympathetic nervous system stimulation. Glucose levels <55 mg/dL (3.0 mmol/L) with symptoms that are relieved promptly after the glucose level is raised document hypoglycemia. 1 Hypoglycemia is most convincingly documented by Whipple’s triad: (1) symptoms consistent with hypoglycemia, (2) a low plasma glucose concentration measured with a precise method (not a glucose monitor), and (3) relief of those symptoms after the plasma glucose level is raised[1]. Hypoglycemia is most commonly a result of the treatment of diabetes, however it can also be seen in patients with critical organ failure (hepatic, renal or cardiac failure), severe sepsis, pancreatic tumors, adrenal or pituitary insufficiency, alcohol use or who have had stomach surgery. There are very few case reports of patients presenting as hypoglycemia caused by panhypopituitarism. 2 The potentially life-threatening consequences of sudden, unexpected hy-poglycemia may endanger not only the affected person but others as well (eg, hypoglycemia in a driver of a motor vehicle). DOI: http://dx.doi.org/10.3126/jcmc.v4i2.10865 Journal of Chitwan Medical College 2014; 4(2): 48-50
Comparative prevalence of MRSA in two Nepalese tertiary care hospitals  [PDF]
Bidya Shrestha
Open Journal of Clinical Diagnostics (OJCD) , 2013, DOI: 10.4236/ojcd.2013.32013
Abstract: This comparative study has been focused on the prevalence of MRSA types and their antibiotic resistance in two tertiary care hospitals of Nepal. During November 2007 to June 2009, clinical samples from patients with nosocomial infection from two Nepali hospitals, Kathmandu Based Hospital (KBH) and Lalitpur Based Hospital (LBH) were cultured and antibiotic susceptibility tests done following standard methodology in Microbiology laboratory, Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Occurrence of MRSA (52.9% of 304 Staphylococcus aureus isolates) in KBH and that of MSSA (62% of 100 S. aureus isolates) in LBH were significant. No association of age was observed with MRSA or MSSA. Among MSSA from both hospitals, the highest resistance was found against penicillin. KBH urinary isolates were resistant to norfloxacin (51.4%), while isolates from other sites were resistant to ciprofloxacin (30.6%), erythromycin (12%), gentamicin (10.3%). LBH isolates were resistant to co-trimoxazole (22.6%), erythromycin (17.2%), ciprofloxacin (13.8%), gentamicin (12.9%). Among MRSA, most of the isolates from both hospitals were resistant to a wide array of antibiotics. A majority of the MSSA and MRSA isolates were susceptible to rifampicin and chloramphenicol. Most of KBH MRSA were homogeneous MRSA, 80.5% (significant), of which, 99.2% were multiresistant oxacillin resistant S. aureus (MORSA). And among the heterogeneous MRSA isolates from KBH, 71% were MORSA. On the other hand, among LBH MRSA isolates, 52.6% were homogeneous MRSA, cent percent of which were MORSA while 47.4% were heterogeneous MRSA of which 44.5% were MORSA. Since almost all of the homogeneous MRSA and most of the heterogeneous MRSA from both hospitals were MORSA, there is a possibility that a hospital acquired S. aureus could be MORSA. Hence, every infected patient should be considered as a potential source of MORSA.
Quality of care provided to newborns by nursing personnel at BP Koirala Institute of Health Sciences
M Shrestha,R Singh,D Upreti
Kathmandu University Medical Journal , 2009, DOI: 10.3126/kumj.v7i3.2729
Abstract: Background: Birth is a major challenge for the newborn to negotiate successfully from intrauterine to extra uterine life. The first few hours since birth is the most crucial period in the life of an infant for further growth and development, which is largely determined by the quality of care that the newborn receives. Objective: The aim of this study is to assess the quality of care provided by nursing personnel to newborn in the labour room. Materials and methods: This study was conducted in BP Koirala Institute of Health Science. Cross sectional, non participatory observational research design was adopted for the study. Care provided by nursing personnel to 814 normal newborns was observed. Samples were chosen by non probability purposive sampling technique. Data was collected through observational method by trained nursing personnel, using 46 items pre-tested, validated and self developed observational checklist. Care provided to newborns was observed from birth to two hours and categorised as good, average and poor based on scores obtained. Data was entered and analysed using SPSS-10. Descriptive statistics- [Mean, percentage, frequencies and standard deviation] was used to describe the quality of care provided to the newborn babies. Results: Overall quality of care was good in 42.36%, average in 57.64% and none of them received poor care. Overall mean score for quality of care was 34.75/46 (75.54 %). Regarding subscales quality of care was good in majority of newborns in areas such as Preparation to receive the baby (76.1%), Initiation of breathing (100%), Maintaining thermoregulation (77.3%), Physical assessment (90.9%), and other aspects of care (95.2%). However the quality of care was poor in majority of newborns in establishment of breast feeding (58.23%) and average in prevention of infection (76.9%). Conclusion: Study findings highlight the need for focus in establishment of breast feeding and prevention of infection.
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