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Search Results: 1 - 10 of 211342 matches for " D. Senthil Kumar "
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Decision Support System for Medical Diagnosis Using Data Mining
D Senthil Kumar,G Sathyadevi,S Sivanesh
International Journal of Computer Science Issues , 2011,
Abstract: The healthcare industry collects a huge amount of data which is not properly mined and not put to the optimum use. Discovery of these hidden patterns and relationships often goes unexploited. Our research focuses on this aspect of Medical diagnosis by learning pattern through the collected data of diabetes, hepatitis and heart diseases and to develop intelligent medical decision support systems to help the physicians. In this paper, we propose the use of decision trees C4.5 algorithm, ID3 algorithm and CART algorithm to classify these diseases and compare the effectiveness, correction rate among them.
DESIGN AND DEVELOPMENT OF PACLITAXEL - LOADED MICROSPHERES FOR TARGETED DRUG DELIVERY TO THE COLON
SENTHIL KUMAR B.,SENTHIL KUMAR K.L.,PREM ANAND D.C.,SARAVANAKUMAR M.
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v1i2.62
Abstract: The purpose of this investigation was to prepare and evaluate the colon-specific microspheres of Paclitaxel for the treatment of colon cancer. Core microspheres of alginate were prepared by the modified emulsification method in liquid paraffin and by cross-linking with calcium chloride. The core microspheres were coated with Eudragit S-100 by the solvent evaporation technique to prevent drug release in the stomach and small intestine. The microspheres were characterized by shape, size, surface morphology, size distribution, incorporation efficiency, and in vitro drug release studies. The outer surfaces of the core and coated microspheres, which were spherical in shape, were rough and smooth, respectively. The size of the core microspheres ranged from 20 to 52 μm, and the size of the coated microspheres ranged from 107 to 178 μm. The core microspheres sustained the drug release for 10 hours. The release studies of coated microspheres were performed in a pH progression medium mimicking the conditions of the gastrointestinal tract. Release was sustained for up to 20 hours in formulations with core microspheres to a Eudragit S-100 coat ratio of 1:7, and there were no changes in the size, shape, drug content, differential scanning calorimetry thermogram, and in vitro drug release after storage at 40 °C/75% relative humidity for 6 months.
DESIGN AND DEVELOPMENT OF PACLITAXEL - LOADED MICROSPHERES FOR TARGETED DRUG DELIVERY TO THE COLON
SENTHIL KUMAR B.,SENTHIL KUMAR K.L.,PREM ANAND D.C.,SARAVANAKUMAR M.
International Journal of Biomedical Research , 2011, DOI: 10.7439/ijbr.v1i2.62
Abstract: The purpose of this investigation was to prepare and evaluate the colon-specific microspheres of Paclitaxel for the treatment of colon cancer. Core microspheres of alginate were prepared by the modified emulsification method in liquid paraffin and by cross-linking with calcium chloride. The core microspheres were coated with Eudragit S-100 by the solvent evaporation technique to prevent drug release in the stomach and small intestine. The microspheres were characterized by shape, size, surface morphology, size distribution, incorporation efficiency, and in vitro drug release studies. The outer surfaces of the core and coated microspheres, which were spherical in shape, were rough and smooth, respectively. The size of the core microspheres ranged from 20 to 52 μm, and the size of the coated microspheres ranged from 107 to 178 μm. The core microspheres sustained the drug release for 10 hours. The release studies of coated microspheres were performed in a pH progression medium mimicking the conditions of the gastrointestinal tract. Release was sustained for up to 20 hours in formulations with core microspheres to a Eudragit S-100 coat ratio of 1:7, and there were no changes in the size, shape, drug content, differential scanning calorimetry thermogram, and in vitro drug release after storage at 40°C/75% relative humidity for 6 months.
Pharmacognostical Studies on the Bark of Artocarpus hirsutus Lam
Dibinlal . D,Sathish Saker . D,Senthil Kumar K . L
Hygeia : Journal for Drugs and Medicines , 2010,
Abstract: Artocarpus hirsutus Lam.,(Wild jack) belonging to the family Moraceae a large evergreen tree up to 70m height, found up to an altitude of 1200M in evergreen India. The wood is straight blackish brown in color; it is very strong tree and has main advantage of lightness. It is used for the treatment of ulcers, diarrhea and pimples. The present study includes Pharmacognostical studies of the bark of Artocarpus hirsutus Lam.
Intelligent Fractured Image Retrieval From Medical Image Databases
H. Khanna Nehemiah,A. Kannan,D. Senthil Kumar
Asian Journal of Information Technology , 2012,
Abstract: The retrieval of stored medical images matching an input medical image is an imperative form of content-based retrieval. For efficient similarity image retrieval and integration, the medical images should be processed systematically to extract a representing feature space vector for each member image. This study explains a system, which takes a fractured image as a query image and retrieves the similar images from the image database using distance metrics and also provides the radiologists with details about the type of fracture and the treatment recommended. The key objective of present research is to retrieve similar X-ray images of fractured reports using K-Nearest Neighbor. Images are matched using color in gray level and texture attributes. Similarity between images is established based on the respective numeric values (Signature). Features are extracted from X-ray images. Indexing is also performed on extracted features using a k-d tree data structure for images and is stored in a backend database for effective retrieval.
Outbreak of Bacterial Haemorrhagic Septicaemia in Fresh Water Carps in Thanjavur Region of Tamil Nadu
Basheer Ahamad. D,Punniamurthy. N,Senthil Kumar. V,Malmarugan. S
Advanced Biotech , 2013,
Abstract: In a private fresh water pond of one acre size, 3900 numbers of carps consisting of Catla (Catla catla), Rohu (Labeo rohita), Grass carps (Ctenopharyngodon idella), Mrigal (Cirrhinus mriqala)) and Common carp (Cyprinus carpio) were cultured at Orathanadu, Thanjavur, the aquaculture belt of Tamilnadu. The bacterial haemorrhagic septicaemia disease outbreak due to Aeromonas hydrophila in a fresh water carps pond was investigated in the year 2011. The clinical signs included anorexia, slow movement in water surface, chronic rubbing of body due to irritation, 16% mortality and 100% morbidity. Bacteriological examination of moribund fish and traditional biochemical methods were used for identification of A. hydrophila. The gross and hisopathological changes were studied. The vascular changes such as congestion and hemorrhage in the outside surface of the affected fish were the main gross lesion. Petechial and ecchymotic haemorrhages, erosions and ulcers were found in the skin. The vascular changes such as congestion and haemorrhages were recorded in the mouths, eyes, opercula and the base of fins and around the anus. The blood tinched serous fluid was recorded in the abdomen. The vital organs showed generalized congestion and enlargement with petechial and ecchymotic haemorrhages. The histopathological changes are characterized by generalised haemosiderine pigment deposition in all vital organs. In addition, vacuolar degeneration and necrosis in the dermis and subcutis, congestion and haemohhages with serous exudation in gill-lamellae, acute haemorrhagic myocarditis, cloudy swelling to hydropic degeneration with multifocal necrosis of liver, acute haemorrhagic enteritis and acute haemorrhagic nephritis were observed.The moribund fishes in the farm was treated with tetracycline and Curcumin longa.
A Comparative Study on the Milling Speed for the Synthesis of Nano-Structured Al 6063 Alloy Powder by Mechanical Alloying  [PDF]
Hafeez Ahamed, V. Senthil Kumar
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.106038
Abstract: The present article reports on characterization studies performed on amorphized nanostructured Al 6063 alloy powder synthesized by mechanical alloying (MA). The as-milled powder was characterized by X-ray diffraction (XRD) for investigating the development of crystallite nature and determining the different phases of the materials present, scanning electron microscope (SEM) was used for in depth morphological study and High Resolution-transmission electron microscope (HR-TEM) was employed to ensure the development of a nano-structured nature of the Al 6063 matrix. In the present work alloyed powder was milled for 20 h and 40 h at 300 rpm; and 20 h at 700 rpm in a hardened stainless steel medium. Using Williamson-Hall equation; crystallite size, lattice strain and lattice parameter of Al 6063 nanostructure alloy powder was estimated with broadening of XRD peaks. XRD results showed that the crystallite size of Al 6063 alloy powder reached 32 and 53 nm after 20 h at 700 rpm and 40 h at 300 rpm respectively.
Removal of Moisture Content in Paper Machine Using Soft Computing Techniques  [PDF]
M. Senthil Kumar, K. Mahadevan
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.79220
Abstract: The choice of this investigation is to tune the proportional-integral-derivative (PID) parameters separately for controlling the moisture content in paper industry by using Particle Swarm Optimization (PSO). This paper boon a new algorithm for PID controller tuning based particle swarm optimization. PSO algorithm has recently developed as a very powerful method for real parameter optimization. This new process is proposed to combine both the algorithms to get better optimization values. The proposed algorithm tuned the PID parameters and its performance has been compared with PID algorithm. Compared to PID algorithm technique, dynamic performance requirements such as rise time settling time and peak overshoot optimal values produced by PSO. The plant model represented by the transfer function is obtained by the system identification toolbox.
IN VITRO EVALUATION OF ANTIOXIDANT POTENTIAL OF VARIOUS EXTRACTS OF WHOLE PLANT OF Bridelia Scandens (Roxb) Willd.
D.SENTHIL KUMAR, A.KOTTAI MUTHU*,D.SATHEESH KUMAR AND R.MANAVALAN
International Journal of Drug Development & Research , 2010,
Abstract: The antioxidant activities of various extracts of whole plant of Bridelia scandens (Roxb) Willd, wasinvestigated in dif erent in-vitro methods. The antioxidant activity was evaluated by Total antioxidant activity(Phosphomolybdic acid method), FRAP assay with reference standard Ascorbate and total flavonoids contentrespectively. The methanolic extract of Bridelia scandens was the most ef ective total antioxidant activityamong the extracts. The IC50 values of the methanolic extract of Bridelia scandens and ascorbate was found tobe 100μg/ml and 410μg/ml respectively. The methanolic extract of Bridelia scandens was found more ef ectivein FRAP assay than that of petroleum ether and ethyl acetate extracts. But when compare to the all the threeextracts with ascorbate (standard), the methanolic extract of the Bridelia scandens showed the significantresult. The methanolic extract of Bridelia scandens contains high amount of flavonoids than that of other twoextracts. Moreover, the results were observed in a concentration dependent manner. So, the in-vitro studiesclearly showed that the methanolic extract of Bridelia scandens has a significant antioxidant activity. These invitro assays indicate that this plant extracts is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses
Evaluation of Anti-inflammatory activity of Nerium oleander.
Senthil Kumar
Pharmacia , 2010,
Abstract: Oleander (Nerium oleander L., Apocynaceae) is an evergreen urbanite shrub, widely used for ornamental purposes in Egypt. Although this plant is naturally protected from several herbivores by its defensive secondary metabolites, it harbors many phytophagous pests. In the present study the anti-inflammatory and antipyretic activity of Chloroform, alcoholic and aqueous extract of Oleander leaf was evaluated. Paw edema was induces by administration of 0.1 ml of 1% w/v carrageenan in saline. Antipyratic effect was studied by Brewer’s yeast-induced pyrexia in rats. The obtained data was statistically evaluated and it was observed that Oleander leaf shows its significant activity as anti-inflammatory and antipyretic agent. The antipyretic effect was almost equivalent to the paracetamol. The chloroform and alcoholic extracts of N. Oleander produced significant (p < 0.05) anti-inflammatory activity, while petroleum ether and aqueous extracts did not. Significant reduction of paw oedema was observed 40 min and 3 h after carrageenan injection, for alcoholic and chloroform extracts, respectively. Chloroform extract significantly decreased the elevated rectal temperature 3 h after the administration of a dose of 400 mg/kg.
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