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Search Results: 1 - 10 of 191316 matches for " D. Schwaab "
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Multifocal reading of printed media: Research’s paths
Reges Schwaab
Verso e Reverso , 2011,
Abstract:
A sustentabilidade na pauta: apontamentos para a leitura deste discurso
Reges Toni Schwaab
Conex?o : Comunica??o e Cultura , 2008,
Abstract: Este artigo, de caráter teórico, tem como principal objetivo discutir elementos necessários para analisar o discurso da sustentabilidade no contemporaneo, pensado sempre na rela o texto-contexto. Considera, ainda, que a sustentabilidade é, atualmente, o principal eixo de mobiliza o da problemática ambiental na esfera midiática, fen meno esse que se ancora também na carga simbólica que a quest o ecológica encerra em si. O presente texto compreende dois exercícios de reflex o: o primeiro, de reconstru o de percursos do conceito de sustentabilidade, puxando alguns fios que ajudaram a tecer a trama semantica acerca do tema. O segundo, de pensar caminhos de análise dessa temática, ou seja, de ler como esse discurso significa.
Modular Type-Safety Proofs using Dependant Types
Christopher Schwaab,Jeremy G. Siek
Computer Science , 2012,
Abstract: While methods of code abstraction and reuse are widespread and well researched, methods of proof abstraction and reuse are still emerging. We consider the use of dependent types for this purpose, introducing a completely mechanical approach to proof composition. We show that common techniques for abstracting algorithms over data structures naturally translate to abstractions over proofs. We first introduce a language composed of a series of smaller language components tied together by standard techniques from Malcom (1990). We proceed by giving proofs of type preservation for each language component and show that the basic ideas used in composing the syntactic data structures can be applied to their semantics as well.
Regulatory T-Cells and Associated Pathways in Metastatic Renal Cell Carcinoma (mRCC) Patients Undergoing DC-Vaccination and Cytokine-Therapy
Adrian Schwarzer, Benita Wolf, Jan L. Fisher, Thomas Schwaab, Sven Olek, Udo Baron, Craig R. Tomlinson, John D. Seigne, Nancy A. Crosby, Jiang Gui, Thomas H. Hampton, Camilo E. Fadul, John A. Heaney, Marc S. Ernstoff
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046600
Abstract: Purpose To evaluate CD4+CD25+FOXP3+ T regulatory cells (TREG) and associated immune-regulatory pathways in peripheral blood lymphocytes (PBL) of metastatic renal cell carcinoma (mRCC) patients and healthy volunteers. We subsequently investigated the effects of immunotherapy on circulating TREG combining an extensive phenotype examination, DNA methylation analysis and global transcriptome analysis. Design Eighteen patients with mRCC and twelve volunteers (controls) were available for analysis. TREG phenotype was examined using flow cytometry (FCM). TREG were also quantified by analyzing the epigenetic status of the FOXP3 locus using methylation specific PCR. As a third approach, RNA of the PBL was hybridized to Affymetrix GeneChip Human Gene 1.0 ST Arrays and the gene signatures were explored using pathway analysis. Results We observed higher numbers of TREG in pre-treatment PBL of mRCC patients compared to controls. A significant increase in TREG was detected in all mRCC patients after the two cycles of immunotherapy. The expansion of TREG was significantly higher in non-responders than in responding patients. Methylation specific PCR confirmed the FCM data and circumvented the variability and subjectivity of the FCM method. Gene Set Enrichment Analysis (GSEA) of the microarray data showed significant enrichment of FOXP3 target genes, CTLA-4 and TGF-? associated pathways in the patient cohort. Conclusion Immune monitoring of the peripheral blood and tumor tissue is important for a wide range of diseases and treatment strategies. Adoption of methodology for quantifying TREG with the least variability and subjectivity will enhance the ability to compare and interpret findings across studies.
O tema como operador de sentidos no jornalismo de revista
Reges Toni Schwaab,Frederico de Mello Brand?o Tavares
Galáxia , 2010,
Abstract: O presente texto reflete sobre o tema como um objeto de estudo no Jornalismo. Especificamente, partimos do universo do jornalismo de revista para pensá-lo n o apenas como referente, mas como operador de sentidos no ambito das rotinas produtivas e dos produtos aí envolvidos. Para isso, problematizamos e complexificamos a ideia de tema, tendo em vista sua presen a em revistas semanais e especializadas. A partir deste percurso, realizamos o cruzamento e tensionamento de quest es discursivas e conceituais, buscando contribuir com os estudos de jornalismo e jornalismo de revista.
Measurements of DNA Methylation at Seven Loci in Various Tissues of CD1 Mice
Laurynas Daugela, Nicole Nüsgen, Maja Walier, Johannes Oldenburg, Rainer Schwaab, Osman El-Maarri
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044585
Abstract: In humans, considerable variation in methylation at single loci and repetitive elements in various cells and tissues is observed. Recently, several inter- and intra-tissue correlations for DNA methylation have been reported. To investigate the extent and reproducibility of such correlations, we investigated inter- and intra-tissue methylation correlations among seven different loci in 9 different tissues in a population of 100 healthy seven-week-old CD1 outbred mice. We used a highly quantitative approach to measure methylation levels to high accuracy at two single loci in the alpha-actin and myosine light chain promoters, at three differentially methylated regions of the Peg3, Snrpn and Lit1 genes associated with imprinted loci, and at two repetitive elements in the Line-1 and IAP-LTR genes in the various tissues. In this population of mice, methylation at several loci was sex-associated and intra-tissue correlations among the studied loci were observed for brain and spleen. Inter-tissue correlations were rarely observed. To investigate method-dependent experimental variability, we re-analyzed the same spleen and tongue samples using SIRPH and pyrosequencing methods and reconfirmed intra-tissue correlations for spleen and sex-associated correlations for DNA methylation for tongue. When we repeated DNA methylation measurements for a second mouse population raised under similar conditions three months later, we did not detect sex-associated or intra-tissues correlations. Additional studies that examine large numbers of loci may be required to further understand the factors that influence stability of DNA methylation.
Prophylaxis of Thromboembolic Events in Patients With Atrial Fibrillation After Coronary Stent Implantation, A Retrospective Analysis of 30-days Bleeding and Embolic Events
1Axel Schlitt,1Gunnar H. Heine,[2]Sabine Heine,1Bernhard Schwaab
The Cardiology , 2005,
Abstract: Prophylactic oral anticoagulation is indicated in patients with Atrial Fibrillation (AF) and high risk for thrombembolic events. The anticoagulant regimen is not standardized for patients with AF after coronary stenting, which requires dual antiplatelet therapy comprising aspirin and ADP -antagonists for at least four Weeks. Low Molecular Weight Heparin (LMWH) is widely used in these patients.We retrospectively compared two groups of patients with permanent AF who underwent coronary stent implantation. 47 patients in group I received 320 mg aspirin Once Daily (OD) and 250 mg ticlopidine twice daily (BID) for four weeks without additional anticoagulantion. In group II 11 patients received 320 mg aspirin OD, 250 mg ticlopidine BID and additionaly subcutaneously administered LMWH in a therapeutic dosage. Within four weeks after coronary intervention, 5 vascular or bleeding complications occured in group I (8%) and 4 in group II (36%) (p=0.035 by Fisher`s exact test). One embolic event was observed in group I, whereas no embolic event occured in group II (p=0.08).The results of our study suggest that the combination of dual antiplatelet therapy in addition to anticoagulation with LMWH may significantly raise the risk of vascular and bleeding events in patients with AF after coronary stent implantation. However, as we observed one embolic event in the patients without additional anticoagulation, data from a prospective randomized trial are needed in order to clarify the optimal therapeutic approach to patients with AF undergoing coronary stent implantation.
Measurement of the Transverse Beam Spin Asymmetry in Elastic Electron Proton Scattering and the Inelastic Contribution to the Imaginary Part of the Two-Photon Exchange Amplitude
F. E. Maas,K. Aulenbacher,S. Baunack,L. Capozza,J. Diefenbach,B. Gl?ser,Y. Imai,T. Hammel,D. von Harrach,E. -M. Kabub,R. Kothe,J. H. Lee,A. Sanchez-Lorente,E. Schilling,D. Schwaab,G. Stephan,G. Weber,C. Weinrich,I. Altarev,J. Arvieux,M. Elyakoubi,R. Frascaria,R. Kunne,M. Morlet,S. Ong,J. Vandewiele,S. Kowalski,R. Suleiman,S. Taylor
Physics , 2004, DOI: 10.1103/PhysRevLett.94.082001
Abstract: We report on a measurement of the asymmetry in the scattering of transversely polarized electrons off unpolarized protons, A$_\perp$, at two Q$^2$ values of \qsquaredaveragedlow (GeV/c)$^2$ and \qsquaredaveragedhighII (GeV/c)$^2$ and a scattering angle of $30^\circ < \theta_e < 40^\circ$. The measured transverse asymmetries are A$_{\perp}$(Q$^2$ = \qsquaredaveragedlow (GeV/c)$^2$) = (\experimentalasymmetry alulowcorr $\pm$ \statisticalerrorlow$_{\rm stat}$ $\pm$ \combinedsyspolerrorlowalucor$_{\rm sys}$) $\times$ 10$^{-6}$ and A$_{\perp}$(Q$^2$ = \qsquaredaveragedhighII (GeV/c)$^2$) = (\experimentalasymme tryaluhighcorr $\pm$ \statisticalerrorhigh$_{\rm stat}$ $\pm$ \combinedsyspolerrorhighalucor$_{\rm sys}$) $\times$ 10$^{-6}$. The first errors denotes the statistical error and the second the systematic uncertainties. A$_\perp$ arises from the imaginary part of the two-photon exchange amplitude and is zero in the one-photon exchange approximation. From comparison with theoretical estimates of A$_\perp$ we conclude that $\pi$N-intermediate states give a substantial contribution to the imaginary part of the two-photon amplitude. The contribution from the ground state proton to the imaginary part of the two-photon exchange can be neglected. There is no obvious reason why this should be different for the real part of the two-photon amplitude, which enters into the radiative corrections for the Rosenbluth separation measurements of the electric form factor of the proton.
Evidence for Strange Quark Contributions to the Nucleon's Form Factors at $Q^2$ = 0.108 (GeV/c)$^2$
F. E. Maas,K. Aulenbacher,S. Baunack,L. Capozza,J. Diefenbach,B. Gl?ser,T. Hammel,D. von Harrach,Y. Imai,E. -M. Kabu?,R. Kothe,J. H. Lee,A. Lorente,E. Schilling,D. Schwaab,M. Sikora,G. Stephan,G. Weber,C. Weinrich,I. Altarev,J. Arvieux,M. El-Yakoubi,R. Frascaria,R. Kunne,M. Morlet,S. Ong,J. van de Wiele,S. Kowalski,B. Plaster,R. Suleiman,S. Taylor
Physics , 2004, DOI: 10.1103/PhysRevLett.94.152001
Abstract: We report on a measurement of the parity violating asymmetry in the elastic scattering of polarized electrons off unpolarized protons with the A4 apparatus at MAMI in Mainz at a four momentum transfer value of $Q^2$ = \Qsquare (GeV/c)$^2$ and at a forward electron scattering angle of 30$^\circ < \theta_e < 40^\circ$. The measured asymmetry is $A_{LR}(\vec{e}p)$ = (\Aphys $\pm$ \Deltastat$_{stat}$ $\pm$ \Deltasyst$_{syst}$) $\times$ 10$^{-6}$. The expectation from the Standard Model assuming no strangeness contribution to the vector current is A$_0$ = (\Azero $\pm$ \DeltaAzero) $\times$ 10$^{-6}$. We have improved the statistical accuracy by a factor of 3 as compared to our previous measurements at a higher $Q^2$. We have extracted the strangeness contribution to the electromagnetic form factors from our data to be $G_E^s$ + \FakGMs $G_M^s$ = \GEsGMs $\pm $ \DeltaGEsGMs at $Q^2$ = \Qsquare (GeV/c)$^2$. As in our previous measurement at higher momentum transfer for $G_E^s$ + 0.230 $G_M^s$, we again find the value for $G_E^s$ + \FakGMs $G_M^s$ to be positive, this time at an improved significance level of 2 $\sigma$.
Prophylaxis of Thromboembolic Events in Patients With Atrial Fibrillation After Coronary Stent Implantation, A Retrospective Analysis of 30-days Bleeding and Embolic Events
1Axel Schlitt,1Gunnar H. Heine,[2]Sabine Heine,1Bernhard Schwaab,3Armin Heisel
The Cardiology , 2011,
Abstract: Prophylactic oral anticoagulation is indicated in patients with Atrial Fibrillation (AF) and high risk for thrombembolic events. The anticoagulant regimen is not standardized for patients with AF after coronary stenting, which requires dual antiplatelet therapy comprising aspirin and ADP -antagonists for at least four Weeks. Low Molecular Weight Heparin (LMWH) is widely used in these patients.We retrospectively compared two groups of patients with permanent AF who underwent coronary stent implantation. 47 patients in group I received 320 mg aspirin Once Daily (OD) and 250 mg ticlopidine twice daily (BID) for four weeks without additional anticoagulantion. In group II 11 patients received 320 mg aspirin OD, 250 mg ticlopidine BID and additionaly subcutaneously administered LMWH in a therapeutic dosage. Within four weeks after coronary intervention, 5 vascular or bleeding complications occured in group I (8%) and 4 in group II (36%) (p=0.035 by Fisher`s exact test). One embolic event was observed in group I, whereas no embolic event occured in group II (p=0.08).The results of our study suggest that the combination of dual antiplatelet therapy in addition to anticoagulation with LMWH may significantly raise the risk of vascular and bleeding events in patients with AF after coronary stent implantation. However, as we observed one embolic event in the patients without additional anticoagulation, data from a prospective randomized trial are needed in order to clarify the optimal therapeutic approach to patients with AF undergoing coronary stent implantation.
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