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Search Results: 1 - 10 of 191350 matches for " D. Mormann "
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La idealización en la matemática
Discusiones Filosóficas , 2012,
Abstract: the aim of this paper is to elucidate the role of idealizations in the evolution of mathematical knowledge inspired by some ideas of ernst cassirer's neokantian philosophy of science and mathematics. usually, in contemporary philosophy of science it is taken for granted that the issue of idealization is concerned only with idealizations in the empirical sciences, in particular in physics. in contrast, cassirer contended that idealization in mathematics as well as in the sciences has the same conceptual and epistemological basis. more precisely, this "sameness thesis" is scrutinized by investigating a variety of examples of idealizations taken from algebra, topology, lattice theory, and physical geometry. idealizations in mathematical as well as in physical knowledge can be charac--te-rized by the introduction of ideal elements leading to completions. in both areas these ideal elements play essentially the same role, namely, to replace an incomplete manifold of objects by a complete "idealized" conceptual manifold.
Infinitesimals as an issue in neo-Kantian philosophy of science
Thomas Mormann,Mikhail G. Katz
Mathematics , 2013,
Abstract: We seek to elucidate the philosophical context in which one of the most important conceptual transformations of modern mathematics took place, namely the so-called revolution in rigor in infinitesimal calculus and mathematical analysis. Some of the protagonists of the said revolution were Cauchy, Cantor, Dedekind, and Weierstrass. The dominant current of philosophy in Germany at the time was neo-Kantianism. Among its various currents, the Marburg school (Cohen, Natorp, Cassirer, and others) was the one most interested in matters scientific and mathematical. Our main thesis is that Marburg neo-Kantian philosophy formulated a sophisticated position towards the problems raised by the concepts of limits and infinitesimals. The Marburg school neither clung to the traditional approach of logically and metaphysically dubious infinitesimals, nor whiggishly subscribed to the new orthodoxy of the "great triumvirate" of Cantor, Dedekind, and Weierstrass that declared infinitesimals conceptus nongrati in mathematical discourse. Rather, following Cohen's lead, the Marburg philosophers sought to clarify Leibniz's principle of continuity, and to exploit it in making sense of infinitesimals and related concepts.
Ion-induced effects in GEM & GEM/MHSP gaseous photomultipliers for the UV and the visible spectral range
A. Breskin,D. Mormann,A. Lyashenko,R. Chechik,F. D. Amaro,J. M. Maia,J. F. C. A. Veloso,J. M. F. dos Santos
Physics , 2005, DOI: 10.1016/j.nima.2005.08.005
Abstract: We report on the progress in the study of cascaded GEM and GEM/MHSP gas avalanche photomultipliers operating at atmospheric pressure, with CsI and bialkali photocathodes. They have single-photon sensitivity, ns time resolution and good localization properties. We summarize operational aspects and results, with the highlight of a high-gain stable gated operation of a visible-light device. Of particular importance are the results of a recent ion-backflow reduction study in different cascaded multipliers, affecting the detector's stability and the photocathode's liftime. We report on the significant progress in ion-blocking and provide first results on bialkali-photocathode aging under gas multiplication.
Tools, objects, and chimeras: Connes on the role of hyperreals in mathematics
Vladimir Kanovei,Mikhail G. Katz,Thomas Mormann
Mathematics , 2012, DOI: 10.1007/s10699-012-9316-5
Abstract: We examine some of Connes' criticisms of Robinson's infinitesimals starting in 1995. Connes sought to exploit the Solovay model S as ammunition against non-standard analysis, but the model tends to boomerang, undercutting Connes' own earlier work in functional analysis. Connes described the hyperreals as both a "virtual theory" and a "chimera", yet acknowledged that his argument relies on the transfer principle. We analyze Connes' "dart-throwing" thought experiment, but reach an opposite conclusion. In S, all definable sets of reals are Lebesgue measurable, suggesting that Connes views a theory as being "virtual" if it is not definable in a suitable model of ZFC. If so, Connes' claim that a theory of the hyperreals is "virtual" is refuted by the existence of a definable model of the hyperreal field due to Kanovei and Shelah. Free ultrafilters aren't definable, yet Connes exploited such ultrafilters both in his own earlier work on the classification of factors in the 1970s and 80s, and in his Noncommutative Geometry, raising the question whether the latter may not be vulnerable to Connes' criticism of virtuality. We analyze the philosophical underpinnings of Connes' argument based on Goedel's incompleteness theorem, and detect an apparent circularity in Connes' logic. We document the reliance on non-constructive foundational material, and specifically on the Dixmier trace (featured on the front cover of Connes' magnum opus) and the Hahn-Banach theorem, in Connes' own framework. We also note an inaccuracy in Machover's critique of infinitesimal-based pedagogy.
Neuronal Shot Noise and Brownian 1/f2 Behavior in the Local Field Potential
Joshua Milstein, Florian Mormann, Itzhak Fried, Christof Koch
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004338
Abstract: We demonstrate that human electrophysiological recordings of the local field potential (LFP) from intracranial electrodes, acquired from a variety of cerebral regions, show a ubiquitous 1/f2 scaling within the power spectrum. We develop a quantitative model that treats the generation of these fields in an analogous way to that of electronic shot noise, and use this model to specifically address the cause of this 1/f2 Brownian noise. The model gives way to two analytically tractable solutions, both displaying Brownian noise: 1) uncorrelated cells that display sharp initial activity, whose extracellular fields slowly decay in time and 2) rapidly firing, temporally correlated cells that generate UP-DOWN states.
Monitoring spike train synchrony
Thomas Kreuz,Daniel Chicharro,Conor Houghton,Ralph G Andrzejak,Florian Mormann
Physics , 2012,
Abstract: Recently, the SPIKE-distance has been proposed as a parameter-free and time-scale independent measure of spike train synchrony. This measure is time-resolved since it relies on instantaneous estimates of spike train dissimilarity. However, its original definition led to spuriously high instantaneous values for event-like firing patterns. Here we present a substantial improvement of this measure which eliminates this shortcoming. The reliability gained allows us to track changes in instantaneous clustering, i.e., time-localized patterns of (dis)similarity among multiple spike trains. Additional new features include selective and triggered temporal averaging as well as the instantaneous comparison of spike train groups. In a second step, a causal SPIKE-distance is defined such that the instantaneous values of dissimilarity rely on past information only so that time-resolved spike train synchrony can be estimated in real-time. We demonstrate that these methods are capable of extracting valuable information from field data by monitoring the synchrony between neuronal spike trains during an epileptic seizure. Finally, the applicability of both the regular and the real-time SPIKE-distance to continuous data is illustrated on model electroencephalographic (EEG) recordings.
The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS) in Corynebacterium glutamicum
Lars Gaigalat, Jan-Philip Schlüter, Michelle Hartmann, Sascha Mormann, Andreas Tauch, Alfred Pühler, J?rn Kalinowski
BMC Molecular Biology , 2007, DOI: 10.1186/1471-2199-8-104
Abstract: Four transcripts of the extended fructose-PTS gene cluster that comprise the genes sugR-cg2116, ptsI, cg2118-fruK-ptsF, and ptsH, respectively, were characterized. In addition, it was shown that transcription of the fructose-PTS gene cluster is enhanced during growth on glucose or fructose when compared to acetate. Subsequently, the two genes sugR and cg2118 encoding for DeoR-type regulators were mutated and PTS gene transcription was found to be strongly enhanced in the presence of acetate only in the sugR deletion mutant. The SugR regulon was further characterized by microarray hybridizations using the sugR mutant and its parental strain, revealing that also the PTS genes ptsG and ptsS belong to this regulon. Binding of purified SugR repressor protein to a 21 bp sequence identified the SugR binding site as an AC-rich motif. The two experimentally identified SugR binding sites in the fructose-PTS gene cluster are located within or downstream of the mapped promoters, typical for transcriptional repressors. Effector studies using electrophoretic mobility shift assays (EMSA) revealed the fructose PTS-specific metabolite fructose-1-phosphate (F-1-P) as a highly efficient, negative effector of the SugR repressor, acting in the micromolar range. Beside F-1-P, other sugar-phosphates like fructose-1,6-bisphosphate (F-1,6-P) and glucose-6-phosphate (G-6-P) also negatively affect SugR-binding, but in millimolar concentrations.In C. glutamicum ATCC 13032 the DeoR-type regulator SugR acts as a pleiotropic transcriptional repressor of all described PTS genes. Thus, in contrast to most DeoR-type repressors described, SugR is able to act also on the transcription of the distantly located genes ptsG and ptsS of C. glutamicum. Transcriptional repression of the fructose-PTS gene cluster is observed during growth on acetate and transcription is derepressed in the presence of the PTS sugars glucose and fructose. This derepression of the fructose-PTS gene cluster is mainly modulated by
Functional genomics and expression analysis of the Corynebacterium glutamicum fpr2-cysIXHDNYZ gene cluster involved in assimilatory sulphate reduction
Christian Rückert, Daniel J Koch, Daniel A Rey, Andreas Albersmeier, Sascha Mormann, Alfred Pühler, J?rn Kalinowski
BMC Genomics , 2005, DOI: 10.1186/1471-2164-6-121
Abstract: The genome sequence of C. glutamicum was searched for genes involved in the assimilatory reduction of inorganic sulphur compounds. A cluster of eight candidate genes could be identified by combining sequence similarity searches with a subsequent synteny analysis between C. glutamicum and the closely related C. efficiens. Using mutational analysis, seven of the eight candidate genes, namely cysZ, cysY, cysN, cysD, cysH, cysX, and cysI, were demonstrated to be involved in the reduction of inorganic sulphur compounds. For three of the up to now unknown genes possible functions could be proposed: CysZ is likely to be the sulphate permease, while CysX and CysY are possibly involved in electron transfer and cofactor biosynthesis, respectively. Finally, the candidate gene designated fpr2 influences sulphur utilisation only weakly and might be involved in electron transport for the reduction of sulphite. Real-time RT-PCR experiments revealed that cysIXHDNYZ form an operon and that transcription of the extended cluster fpr2 cysIXHDNYZ is strongly influenced by the availability of inorganic sulphur, as well as L-cysteine. Mapping of the fpr2 and cysIXHDNYZ promoters using RACE-PCR indicated that both promoters overlap with binding-sites of the transcriptional repressor McbR, suggesting an involvement of McbR in the observed regulation. Comparative genomics revealed that large parts of the extended cluster are conserved in 11 of 17 completely sequenced members of the Actinomycetales.The set of C. glutamicum genes involved in assimilatory sulphate reduction was identified and four novel genes involved in this pathway were found. The high degree of conservation of this cluster among the Actinomycetales supports the hypothesis that a different metabolic pathway for the reduction of inorganic sulphur compounds than that known from the well-studied model organisms E. coli and B. subtilis is used by members of this order, providing the basis for further biochemical studies.In many m
Random mutagenesis in Corynebacterium glutamicum ATCC 13032 using an IS6100-based transposon vector identified the last unknown gene in the histidine biosynthesis pathway
Sascha Mormann, Alexander L?mker, Christian Rückert, Lars Gaigalat, Andreas Tauch, Alfred Pühler, J?rn Kalinowski
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-205
Abstract: A comprehensive transposon mutant library comprising 10,080 independent clones was constructed by electrotransformation of the restriction-deficient derivative of strain ATCC 13032, C. glutamicum RES167, with an IS6100-containing non-replicative plasmid. Transposon mutants had stable cointegrates between the transposon vector and the chromosome. Altogether 172 transposon integration sites have been determined by sequencing of the chromosomal inserts, revealing that each integration occurred at a different locus. Statistical target site analyses revealed an apparent absence of a target site preference. From the library, auxotrophic mutants were obtained with a frequency of 2.9%. By auxanography analyses nearly two thirds of the auxotrophs were further characterized, including mutants with single, double and alternative nutritional requirements. In most cases the nutritional requirement observed could be correlated to the annotation of the mutated gene involved in the biosynthesis of an amino acid, a nucleotide or a vitamin. One notable exception was a clone mutagenized by transposition into the gene cg0910, which exhibited an auxotrophy for histidine. The protein sequence deduced from cg0910 showed high sequence similarities to inositol-1(or 4)-monophosphatases (EC Subsequent genetic deletion of cg0910 delivered the same histidine-auxotrophic phenotype. Genetic complementation of the mutants as well as supplementation by histidinol suggests that cg0910 encodes the hitherto unknown essential L-histidinol-phosphate phosphatase (EC in C. glutamicum. The cg0910 gene, renamed hisN, and its encoded enzyme have putative orthologs in almost all Actinobacteria, including mycobacteria and streptomycetes.The absence of regional and sequence preferences of IS6100-transposition demonstrate that the established system is suitable for efficient genome-scale random mutagenesis in the sequenced type strain C.glutamicum ATCC 13032. The identification of the hisN g
Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism
Alexander Semmler, Sven Hermann, Florian Mormann, Marc Weberpals, Stephan A Paxian, Thorsten Okulla, Michael Sch?fers, Markus P Kummer, Thomas Klockgether, Michael T Heneka
Journal of Neuroinflammation , 2008, DOI: 10.1186/1742-2094-5-38
Abstract: To investigate the relation of electrophysiological, metabolic and morphological changes caused by SE, we simultaneously assessed systemic circulation, regional cerebral blood flow and cortical electroencephalography in rats exposed to bacterial lipopolysaccharide. Additionally, cerebral glucose uptake, astro- and microglial activation as well as changes of inflammatory gene transcription were examined by small animal PET using [18F]FDG, immunohistochemistry, and real time PCR.While the systemic hemodynamic did not change significantly, regional cerebral blood flow was decreased in the cortex paralleled by a decrease of alpha activity of the electroencephalography. Cerebral glucose uptake was reduced in all analyzed neocortical areas, but preserved in the caudate nucleus, the hippocampus and the thalamus. Sepsis enhanced the transcription of several pro- and anti-inflammatory cytokines and chemokines including tumor necrosis factor alpha, interleukin-1 beta, transforming growth factor beta, and monocot chemoattractant protein 1 in the cerebrum. Regional analysis of different brain regions revealed an increase in ED1-positive microglia in the cortex, while total and neuronal cell counts decreased in the cortex and the hippocampus.Together, the present study highlights the complexity of sepsis induced early impairment of neuronal metabolism and activity. Since our model uses techniques that determine parameters relevant to the clinical setting, it might be a useful tool to develop brain specific therapeutic strategies for human septic encephalopathy.Sepsis and its complications are the leading causes of mortality in intensive care units accounting for 10–50% of deaths. Up to 71% of septic patients develop potentially irreversible acute cerebral dysfunction [1-3]. This sepsis-induced encephalopathy is caused by systemic inflammation in the absence of direct brain infection and clinically characterized by slowing of mental processes, impaired attention, disorientation,
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