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Search Results: 1 - 10 of 191793 matches for " D. Mohana Geetha "
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Performance Analysis and Optimization of Lumped Parameters of Electrostatic Actuators for Optical MEMS Switches
D. Mohana Geetha,M. Madheswaran
Physics , 2010,
Abstract: This Paper deals design and simulation of electrostatically actuated clamped clamped beam and cantilever beam using finite element analysis method (FEM). A detailed study and performance analysis for various bias voltages is provided in this paper. The pull in voltages for different dimensions of the beams and the natural or the dominant modes and the corresponding eigenvalues have been studied for different bias voltages. The displacement of the beam is also studied for various dimensions of the beam. The results were obtained for the length and the width of both clamped clamped beam and cantilever beam through extensive simulations. The results obtained shows that pull in voltages varies from 2348V to 772V and the natural frequencies vary from 102.92 KHz to 916.35 KHz.
Site-Specific Labeling of the Type 1 Ryanodine Receptor Using Biarsenical Fluorophores Targeted to Engineered Tetracysteine Motifs
James D. Fessenden, Mohana Mahalingam
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064686
Abstract: The type 1 ryanodine receptor (RyR1) is an intracellular Ca2+ release channel that mediates skeletal muscle excitation contraction coupling. While the overall shape of RyR1 has been elucidated using cryo electron microscopic reconstructions, fine structural details remain elusive. To better understand the structure of RyR1, we have previously used a cell-based fluorescence resonance energy transfer (FRET) method using a fused green fluorescent protein (GFP) donor and a fluorescent acceptor, Cy3NTA that binds specifically to short poly-histidine ‘tags’ engineered into RyR1. However, the need to permeabilize cells to allow Cy3NTA entry as well as the noncovalent binding of Cy3NTA to the His tag limits future applications of this technique for studying conformational changes of the RyR. To overcome these problems, we used a dodecapeptide sequence containing a tetracysteine (Tc) motif to target the biarsenical fluorophores, FlAsH and ReAsH to RyR1. These compounds freely cross intact cell membranes where they then bind covalently to the tetracysteine motif. First, we used this system to conduct FRET measurements in intact cells by fusing a yellow fluorescent protein (YFP) FRET donor to the N-terminus of RyR1 and then targeting the FRET acceptor, ReAsH to an adjacent Tc tag. Moderate energy transfer (~33%) was observed whereas ReAsH incubation of a YFPRyR1 fusion protein lacking the Tc tag resulted in no detectable FRET. We also developed a FRET-based system that did not require RyR fluorescent protein fusions by labeling N-terminal Tc-tagged RyR1 with FlAsH, a FRET donor and then targeting the FRET acceptor Cy3NTA to an adjacent decahistidine (His10) tag. A high degree of energy transfer (~66%) indicated proper binding of both compounds to these unique recognition sequences in RyR1. Thus, these two systems should provide unprecedented flexibility in future FRET-based structural determinations of RyR1.
Nano ZnO structures synthesized in presence of anionic and cationic surfactant under hydrothermal process
T. Thilagavathi,D. Geetha
Applied Nanoscience , 2013, DOI: 10.1007/s13204-012-0183-8
Abstract: Uniform ZnO nano structures are synthesized in the presence of anionic surfactant, sodium dodecyl benzene sulfonate (SDBS) and cationic surfactant, cetyl tri methyl ammonium bromide (CTAB) at 100 °C using NaOH as the reactant. The particle size, morphology and structure of the nano ZnO particles are collected by X-ray diffraction, scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectra. Rod and cone shaped ZnO nano structure is observed. It may vary in morphology from pure ZnO structure due to the presence of surfactants. The results show that there is an extrinsic relation between the morphology of the samples. Based on the relation, we proposed that there might be two kinds of interactions between SDBS and CTAB with ZnO particles, i.e., inter- and intra-interactions.
Performance Analysis of TORA & DSR Routing Protocols in Mobile Ad-hoc Networks
D GEETHA,T SARIKA
International Journal of Electronics and Computer Science Engineering , 2013,
Abstract: Mobile ad hoc network (MANET) is an autonomous system of mobile nodes connected by wireless links. Each node operates not only as an end system, but also as a router to forward packets. The nodes are free to move about and organize themselves into a network. These nodes change position frequently. The main classes of routing protocols are Proactive, Reactive and Hybrid. A Reactive (on-demand) routing strategy is a popular routing category for wireless ad hoc routing. It is a relatively new routing philosophy that provides a scalable solution to relatively large network topologies. The design follows the idea that each node tries to reduce routing overhead by sending routing packets whenever a communication is requested. In this paper an attempt has been made to compare the performance of two prominent on demand reactive routing protocols for MANETs: Temporally Ordered Routing Algorithm (TORA), Dynamic Source Routing (DSR) protocols. This subjected the protocols to identical loads and environmental conditions and evaluates their relative performance with respect to quantitative metrics; throughput, average delay, packet delivery ratio and routing load. From the detailed simulation results and analysis of presented, we use NS-2 simulator for simulation of DSR and TORA protocol and variation occurs in mobility of packets, time interval between the packets sent and packet size of packets sent in throughout the protocols.
Ultrasonic Studies on Lamivudine: β-Cyclodextrin and Polymer Inclusion Complexes
A. Panneer Selvam,D. Geetha
Pakistan Journal of Biological Sciences , 2008,
Abstract: The aim of the present study is to enhance the solubility and stability of drugs in addition of water-soluble polymer and carbohydrate complexes. The data show that the polymer polyvinyl alcohol (PVA) interacts with the free Lamivudine and with the Lamivudine; β-cyclodextrin (β-CD) inclusion complex, in both cases with particular intermolecular interaction was studied using ultrasonic technique under different concentrations at a temperature 303 K. Consequently, the reason of this study was to improve the biological performance of the drug through enhancing its solubility and stability. The binary and ternary mixtures prepared inclusion complexes of Lamivudine in β-CD and PVA. The presence of PVA, changes the drug: β-CD interaction, a Lamivudine: β-CD: PVA complex was formed. In addition, the presence of PVA produces a strong increase in the binding constant at a particular concentration (1.25%). In the ternary complex, the Lamivudine is wrapped at both ends for the β-CD. In this complex, the polymer seems to act as a bridge between both β-CD molecules that bind the Lamivudine.
Evaluation Strategy for Ranking and Rating of Knowledge Sharing Portal Usability
D. Venkata Subramanian,Angelina Geetha
International Journal of Computer Science Issues , 2012,
Abstract: Knowledge Sharing portals are the primary gateways for users to access all the information they need for their activity with adequate safety, security and in the best quality. The usability of a Knowledge Sharing Portal plays an important role in every organization and higher learning institutions, as it helps to increase the user satisfaction, reuse of knowledge assets, consistency of information and simplification of the maintenance process, regardless of the context, order or type of users. The primary goal of this paper is to propose a strategy for the ranking and rating of usability of the KM system. In this proposed work, we first describe the ways to design and develop the quality factors, using a multi-dimensional metric model for measuring usability along with other supporting factors. Secondly we have shown the ways to apply the Weighted Average Mean (WAM) on the usability factor and other relevant factors for evaluation. Using the weights and values generated in the metric database, the usability of the KM system can be ranked and rated both manually and automatically.
Formulation of taste masked oro-dispersible tablets of ambroxol hydrochloride
Venkatesh D,Geetha Rao C
Asian Journal of Pharmaceutics , 2008,
Abstract: Ambroxol hydrochloride (HCL) is a potent mucolytic capable of inducing bronchial secretion. It is used in the treatment of asthma, bronchitis, and cough. But it is a very bitter drug and slightly soluble in water. Thus, in the work under taken, an attempt was made to mask the taste and to formulate into a oro-dispersible tablet by complexation with ion exchange resins, which also acts as super disintegrating agents. Since, these tablets can be swallowed in the form of dispersion, it is suitable dosage form for pediatric and geriatric patients. Cation exchange resins like Indion-204 and Indion-234 were utilized for the sorption of drug. Drug-resinates were prepared in drug to resin ratio of 1:5 and 1:6. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, taste evaluation, mouth feel, wetting time, in vitro and in vivo disintegration time, and in vitro dissolution studies. Tablets with both the resins have shown quick disintegrating features, i.e., within 20 s, which is very characteristic of oro-dispersible tablets. Also, the dispersion not showing any bitter taste, indicate the capability of ion exchange resins used, both as taste masking and super disintegrating agents. Almost more than 90 percent of drug was released from both the formulations within 1 h. Further formulations were subjected to stability testing for 3 months at temperatures 25±5°C/60±5%RH and 40±5°C/75±5%RH. Both tablets have shown no appreciable changes with respect to taste, disintegration, and dissolution profiles.
Discovery of Frequent Closed Itemsets using Reduced Pattern Count Tree
Geetha M,R.J. D'Souza
Lecture Notes in Engineering and Computer Science , 2008,
Abstract:
A NOVEL DESIGN OF REVERSIBLE SERIAL AND PARALLEL ADDER/SUBTRACTOR
KRISHNAVENI.D,,GEETHA PRIYA.M
International Journal of Engineering Science and Technology , 2011,
Abstract: Under ideal conditions, Reversible logic gates produce zero power dissipation. So these can be used for low power VLSI design. This paper proposes a new reversible parallel adder/subtractor using 4*4 Reversible DKG gate that can work singly as a reversible full adder and a full subtractor. A serial adder/subtractor is also designed in this paper using Reversible Universal Shift registers and DKG gate.This paper provides a threshold to build more complex arithmetic systems using reversible logic.
Study of onychomycosis
Vijaya D,Anandkumar B,Geetha S
Indian Journal of Dermatology, Venereology and Leprology , 2004,
Abstract:
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