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Search Results: 1 - 10 of 528406 matches for " D. M. Walsh "
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Non-uniqueness in conformal formulations of the Einstein constraints
D. M. Walsh
Physics , 2006, DOI: 10.1088/0264-9381/24/8/002
Abstract: Standard methods in non-linear analysis are used to show that there exists a parabolic branching of solutions of the Lichnerowicz-York equation with an unscaled source. We also apply these methods to the extended conformal thin sandwich formulation and show that if the linearised system develops a kernel solution for sufficiently large initial data then we obtain parabolic solution curves for the conformal factor, lapse and shift identical to those found numerically by Pfeiffer and York. The implications of these results for constrained evolutions are discussed.
Collision of High Frequency Plane Gravitational and Electromagnetic Waves
P. A. Hogan,D. M. Walsh
Physics , 2003, DOI: 10.1142/S0218271803003748
Abstract: We study the head-on collision of linearly polarized, high frequency plane gravitational waves and their electromagnetic counterparts in the Einstein-Maxwell theory. The post-collision space-times are obtained by solving the vacuum Einstein-Maxwell field equations in the geometrical optics approximation. The head-on collisions of all possible pairs of these systems of waves is described and the results are then generalised to non-linearly polarized waves which exhibit the maximum two degrees of freedom of polarization.
A Novel ABCA12 Mutation in Two Families with Congenital Ichthyosis
D. M. Walsh,S. H. Shah,M. A. Simpson,N. V. Morgan
Scientifica , 2012, DOI: 10.6064/2012/649090
Recent Common Ancestry of Ebola Zaire Virus Found in a Bat Reservoir
Roman Biek,Peter D Walsh,Eric M Leroy,Leslie A Real
PLOS Pathogens , 2006, DOI: 10.1371/journal.ppat.0020090
Local Stressors Reduce Coral Resilience to Bleaching
Jessica E. Carilli, Richard D. Norris, Bryan A. Black, Sheila M. Walsh, Melanie McField
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006324
Abstract: Coral bleaching, during which corals lose their symbiotic dinoflagellates, typically corresponds with periods of intense heat stress, and appears to be increasing in frequency and geographic extent as the climate warms. A fundamental question in coral reef ecology is whether chronic local stress reduces coral resistance and resilience from episodic stress such as bleaching, or alternatively promotes acclimatization, potentially increasing resistance and resilience. Here we show that following a major bleaching event, Montastraea faveolata coral growth rates at sites with higher local anthropogenic stressors remained suppressed for at least 8 years, while coral growth rates at sites with lower stress recovered in 2–3 years. Instead of promoting acclimatization, our data indicate that background stress reduces coral fitness and resilience to episodic events. We also suggest that reducing chronic stress through local coral reef management efforts may increase coral resilience to global climate change.
On The Use of Entropy to Predict Boundary Layer Stability
Ed J. Walsh,Mark R.D. Davies,Donald M. McEligot
Entropy , 2004, DOI: 10.3390/e6040375
Abstract: Boundary layer transition is a critical parameter in the design of fluid flow systems. This situation is due to the dramatic change in both entropy production and heat transfer that accompanies it. It is well recognized that many parameters affect the location of transition onset, however, no models exist which unify all these parameters. This paper presents a new hypothesis that the driving force of boundary layer transition onset is the entropy generation rate alone, with all other parameters being functions of this higher order quantity. At present this hypothesis is speculative, but encouraging since good compatibility is found with more established transition models.
Experimental validation of convection-diffusion discretisation scheme employed for computational modelling of biological mass transport
Gráinne T Carroll, Paul D Devereux, David N Ku, Timothy M McGloughlin, Michael T Walsh
BioMedical Engineering OnLine , 2010, DOI: 10.1186/1475-925x-9-34
Abstract: An idealised aneurysm model was selected for the experimental and computational mass-transport analysis of species concentration due to its well-defined recirculation region within the aneurysmal sac, allowing species concentration to vary slowly with time. The experimental results were obtained from fluid samples extracted from a glass aneurysm model, using the direct spectrophometric concentration measurement technique. The computational analysis was conducted using the four convection-diffusion discretisation schemes available to the Fluent user, including the First-Order Upwind, the Power Law, the Second-Order Upwind and the Quadratic Upstream Interpolation for Convective Kinetics (QUICK) schemes. The fluid has a diffusivity of 3.125 × 10-10 m2/s in water, resulting in a Peclet number of 2,560,000, indicating strongly convection-dominated flow.The discretisation scheme applied to the solution of the convection-diffusion equation, for blood-side mass-transport within the vasculature, has a significant influence on the resultant species concentration field. The First-Order Upwind and the Power Law schemes produce similar results. The Second-Order Upwind and QUICK schemes also correlate well but differ considerably from the concentration contour plots of the First-Order Upwind and Power Law schemes. The computational results were then compared to the experimental findings. An average error of 140% and 116% was demonstrated between the experimental results and those obtained from the First-Order Upwind and Power Law schemes, respectively. However, both the Second-Order upwind and QUICK schemes accurately predict species concentration under high Peclet number, convection-dominated flow conditions.Convection-diffusion discretisation scheme selection has a strong influence on resultant species concentration fields, as determined by CFD. Furthermore, either the Second-Order or QUICK discretisation schemes should be implemented when numerically modelling convection-domin
What are the current barriers to effective cancer care coordination? A qualitative study
Jennifer Walsh, James D Harrison, Jane M Young, Phyllis N Butow, Michael J Solomon, Lindy Masya
BMC Health Services Research , 2010, DOI: 10.1186/1472-6963-10-132
Abstract: A qualitative study was undertaken in which semi-structured individual interviews and focus groups were conducted with those best placed to identify issues; patients who had been treated for a range of cancers and their carers as well as health professionals involved in providing cancer care. Data collection continued until saturation of concepts was reached. A grounded theory influenced approach was used to explore the participants' experiences and views of cancer care coordination.Overall, 20 patients, four carers and 29 health professionals participated. Barriers to cancer care coordination related to six aspects of care namely, recognising health professional roles and responsibilities, implementing comprehensive multidisciplinary team meetings, transitioning of care: falling through the cracks, inadequate communication between specialist and primary care, inequitable access to health services and managing scarce resources.This study has identified a number of barriers to coordination of cancer care. Development and evaluation of interventions based on these findings is now required.Cancer is a complex condition that often requires multiple interventions provided by a variety of health professionals over prolonged periods of time. In one UK study [1], it was found that patients, who had been treated for cancer for less than a one year period, saw 28 doctors on average, and this figure does not include other health professionals involved in their care. This adds complexity to health care service delivery and creates challenges for health professionals in both hospital and community settings to effectively work together to deliver high quality coordinated patient care.Care coordination encompasses numerous aspects of health service provision including appropriate care that is timely and provided by a multidisciplinary team comprising of medical, nursing and allied health professionals. Other key elements intrinsic to care coordination include psychosocial assessme
Surveillance of invasive infections in children and adults admitted to QECH, Blantyre, 1996 - 2002
LK Wilson, A Phiri, D Soko, M Mbvwinji, AL Walsh, ME Molyneux
Malawi Medical Journal , 2003,
Abstract: This is a report of blood and CSF isolates from the adult medical and paediatric wards of QECH, Blantyre, cultured and identified at the Wellcome Trust Research Laboratories during 1996-2002. The commonest causes of adult and childhood bacteraemia were non-typhoidal Salmonella (35% of all blood isolates for adults and children) and Streptococcus pneumoniae (14% and 13% respectively). Cryptococcus neoformans was the commonest isolate from CSF of adults with meningitis (67%) but was very rare in children. S.pneumoniae was the commonest cause of bacterial meningitis in children and adults (38% and 28% of all CSF isolates respectively). Haemophilus influenzae type b was also a common cause of meningitis in children (27%). Data of in vitro antibiotic sensitivity are also reported. A major concern is the recent marked rise of chloramphenicol resistance among Salmonella enteritidis and Salmonella typhimurium to over 80% resistance. [Malawi Med J, Vol.15(2) 2003: 52-55]
Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010
Chakshu Sharma,Karim M Eltawil,Paul D Renfrew,Mark J Walsh
World Journal of Gastroenterology , 2011,
Abstract: Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic.
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