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Search Results: 1 - 10 of 191704 matches for " D. Fink "
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In-Situ cosmogenic10Be,26Al and36Cl studies in the earth sciences at the antares AMS facility
D. Fink
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02891424
It's Elementary: Science Buddies Bring Biology to Life
Rachel D. Fink
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1000182
It's Elementary: Science Buddies Bring Biology to Life
Rachel D. Fink
PLOS Biology , 2009, DOI: 10.1371/journal.pbio.1000182
Glacial history of the Central Plateau, Tasmania, using in-situ10Be and36Cl
D. Fink,D. Hild,D. Hannan
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02891427
Konservative Therapie von Harninkontinenz, Drangsymptomen und Genitaldeszensus
Betschart C,Scheiner D,Fink D,Perucchini D
Journal für Urologie und Urogyn?kologie , 2008,
Abstract: Die Grenze zwischen physiologischem und subjektiv st rendem, unwillkürlichem Urinverlust ist flie end. Falls der Urinverlust unter standardisierten Tests objektivierbar ist und der Patientin Anlass zu Beschwerden gibt, ist gem International Continence Society (ICS) 2002 die Definition der Urininkontinenz erfüllt. Die Pr valenz der Harninkontinenz variiert bei 15- bis 64-j hrigen Frauen zwischen 10 30 % und steigt bei betagten Frauen auf bis zu 35 40 % an. Die Pr valenz des Genitaldeszensus ist tiefer. Bis zu 34 % der Frauen zeigen einen Deszensus. Das Life-Time-Risiko im Alter von 80 Jahren für eine Deszensus- oder Inkontinenzoperation betr gt 11,1 %. In diesem Artikel werden die g ngigen konservativen Therapien der Harninkontinenz, der Drangsymptome und des Genitaldeszensus er rtert und die Evidenzgrade der Verhaltenstherapie und des Beckenbodentrainings bei Harninkontinenz, der anticholinergen und hormonellen Therapie bei Drangbeschwerden und der Pessartherapie bei Genitaldeszensus neben weniger etablierten Behandlungen gem NICE-Guideline erfasst. Harninkontinenz, Drangsymptome und Deszensus sind multifaktorielle Krankheitsbilder und ben tigen für den individuellen Behandlungserfolg ganzheitliche Therapieans tze, den Einbezug der Lebensumst nde der Patientin sowie Ausdauer und Motivation vonseiten der Betroffenen und des Therapieteams. Die konservativen Therapien sollten der Patientin als prim re Behandlungsoptionen bekannt und vor operativer Therapie ausgesch pft sein.
Principles of microbial alchemy: insights from the Streptomyces coelicolor genome sequence
Charles J Thompson, Doris Fink, Liem D Nguyen
Genome Biology , 2002, DOI: 10.1186/gb-2002-3-7-reviews1020
Abstract: Streptomyces, which belong to the bacterial order Actinomycetales, are similar in appearance to fungi and undergo a program of colonial morphogenesis that is coordinated with the excretion of bioactive compounds that are often colored (Figure 1) [1]. The biosynthesis of these compounds, many of which are antibiotics, occurs typically in response to a breakdown of balanced metabolism that interrupts or arrests growth [2,3]. On solid media this triggers formation of aerial filaments that septate and mature into a chain of spores.Streptomyces species are considered exceptionally well endowed for 'chemical warfare', presumably allowing them to eliminate bacterial and fungal competitors in soil ecosystems. This was first realized over fifty years ago, and since then the majority of known antibiotics have been isolated from Streptomyces. Although thousands of antibiotics have been described, these are thought to represent only a small fraction of the repertoire of bioactive compounds produced by Streptomyces [4,5]. In addition, empirical screening using various assays has revealed that Streptomyces culture supernatants contain other pharmaceutically active compounds, such as anti-viral and anti-cancer compounds, modulators of immune responses, and various enzyme inhibitors, as well as herbicides, insecticides, and anti-parasitic compounds [4,6,7]. Furthermore, chemical screening methods have uncovered the remarkable structural diversity of these compounds. Genome sequences of Streptomyces species are now providing an overview of the genetic elements responsible for this metabolic diversity, both within one bacterium and the entire genus. Analysis of the completed genome sequence of Streptomyces coelicolor [8] and its comparison with other species will give further insights into availability and nature of potentially useful bacterial metabolites.Dozens of different Streptomyces species (Figure 1a) [1] can be selectively isolated from virtually any rich soil sample. Tens of
Evaluation and comparison of mammalian subcellular localization prediction methods
Sprenger Josefine,Fink J Lynn,Teasdale Rohan D
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-s5-s3
Abstract: Background Determination of the subcellular location of a protein is essential to understanding its biochemical function. This information can provide insight into the function of hypothetical or novel proteins. These data are difficult to obtain experimentally but have become especially important since many whole genome sequencing projects have been finished and many resulting protein sequences are still lacking detailed functional information. In order to address this paucity of data, many computational prediction methods have been developed. However, these methods have varying levels of accuracy and perform differently based on the sequences that are presented to the underlying algorithm. It is therefore useful to compare these methods and monitor their performance. Results In order to perform a comprehensive survey of prediction methods, we selected only methods that accepted large batches of protein sequences, were publicly available, and were able to predict localization to at least nine of the major subcellular locations (nucleus, cytosol, mitochondrion, extracellular region, plasma membrane, Golgi apparatus, endoplasmic reticulum (ER), peroxisome, and lysosome). The selected methods were CELLO, MultiLoc, Proteome Analyst, pTarget and WoLF PSORT. These methods were evaluated using 3763 mouse proteins from SwissProt that represent the source of the training sets used in development of the individual methods. In addition, an independent evaluation set of 2145 mouse proteins from LOCATE with a bias towards the subcellular localization underrepresented in SwissProt was used. The sensitivity and specificity were calculated for each method and compared to a theoretical value based on what might be observed by random chance. Conclusion No individual method had a sufficient level of sensitivity across both evaluation sets that would enable reliable application to hypothetical proteins. All methods showed lower performance on the LOCATE dataset and variable performance on individual subcellular localizations was observed. Proteins localized to the secretory pathway were the most difficult to predict, while nuclear and extracellular proteins were predicted with the highest sensitivity.
Descensus urogenitalis der Frau
Klingler HC,Dietersdorfer F,D?rfler C,Fink KG
Journal für Urologie und Urogyn?kologie , 2011,
Improving care for women living with HIV: initial outcomes of an integration experience
V Fink,D Zurita,M Tejo,H Perez
Journal of the International AIDS Society , 2012, DOI: 10.7448/ias.15.6.18088
Abstract: Background: Women living with HIV are at higher risk of developing HPV-related diseases. Albeit they are systematically referred for cervical cancer screening, difficulties in obtaining timely appointments are the main barrier for an adequate gynecological care. In our unit, according to a previous survey, 67% of women reported this problem. Therefore, in January 2011 the integration of HIV and gynecological care was sought through the provision of gynecological care within the Infectious Diseases Unit in our hospital. Methods: A weekly specific clinic for women living with HIV cared by HIV and gynecological specialists was implemented. Appointments are given at the HIV clinic, with no need of referral. Pap smear and colposcopy are offered in the same place. Data are collected through standardized forms. Baseline data from the first hundred patients referred are presented. Results: Ninety-six women were assisted. Median age was 40 years (IQR 36–46.5). Median time from HIV diagnosis was 10.6 years (IQR 4.9–16.4). 82% patients were on HAART. Median CD4 cell count was 473 cells/cc (IQR: 287–614) and 49% had viral load<50. 48% lacked a gynecological control for the last 2 years. 24% had been previously diagnosed and/or treated for HPV-related pathology. Cervical Pap smear results (n=94): 59% were negative; 20% had LGSIL and 2% had HGSIL. Of those diagnosed with SIL, 29% had history of HPV-related lesions. Of note, 23% had infections or inflammatory results. Clinically significant abnormal colposcopies were seen in 21/93 (23%) patients. Of those, 30% were diagnosed SIL in the Pap smear. Conclusions: Integrating the gynecologist with the ID Unit allowed women living with HIV easier access to gynecological control. The high number of abnormalities in the Pap smears detected in this pilot study reinforces the need of improving cervical cancer screening for prevention and early treatment through integrated approaches.
An ensemble approach to the analysis of weighted networks
S. E. Ahnert,D. Garlaschelli,T. M. Fink,G. Caldarelli
Physics , 2006, DOI: 10.1103/PhysRevE.76.016101
Abstract: We present a new approach to the calculation of measures in weighted networks, based on the translation of a weighted network into an ensemble of edges. This leads to a straightforward generalization of any measure defined on unweighted networks, such as the average degree of the nearest neighbours, the clustering coefficient, the `betweenness', the distance between two nodes and the diameter of a network. All these measures are well established for unweighted networks but have hitherto proven difficult to define for weighted networks. Further to introducing this approach we demonstrate its advantages by applying the clustering coefficient constructed in this way to two real-world weighted networks.
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